Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: Development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy

Organic and Biomolecular Chemistry

Volumn 7, Issue 9, 2009, Pages 1868-1877

  Yoshida, Keisuke ^a   Yamaguchi, Kazuya ^a   Mizuno, Akira ^a   Unno, Yuka ^b   Asai, Akira ^b   Sone, Takayuki ^a   Yokosawa, Hideyoshi ^a   Matsuda, Akira ^a   Arisawa, Mitsuhiro ^a   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID EQUIVALENTS; ACTIVE COMPOUNDS; ANTI-CANCER DRUGS; BIOLOGICAL EVALUATIONS; DIVERSITY-ORIENTED APPROACHES; LACTACYSTIN; PROTEASOME INHIBITORS; REGIO-ISOMERS; REGIOISOMER; SYNTHETIC PRECURSORS; TARGET COMPOUNDS; THREE-DIMENSIONAL STRUCTURES;

AMINATION; AMINES; AMINO ACIDS; CHEMICAL COMPOUNDS; ISOMERS; LEAD COMPOUNDS; ORGANIC ACIDS; PROPANE; STEREOCHEMISTRY; THREE DIMENSIONAL;

STRATEGIC PLANNING;

BELACTOSIN A; ENZYME INHIBITOR; PEPTIDE; PROTEASOME;

ARTICLE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HELA CELL; HUMAN; ISOMERISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CELL SURVIVAL; ENZYME INHIBITORS; HELA CELLS; HUMANS; ISOMERISM; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64549086299     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b900384c     Document Type: Article

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