Transforming TRP channel drug discovery using medium-throughput electrophysiological assays

Journal of Biomolecular Screening

Volumn 19, Issue 3, 2014, Pages 468-477

  Chambard, Jean Marie ^a   Tagat, Eric ^a   Boudeau, Philippe ^a   Partiseti, Michel ^a  

^a SANOFI   (France)

Author keywords

automated patch clamp; electrophysiology; ion channel; pharmacology; TRP

Indexed keywords

A 967079; AP 18; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; RUTHENIUM RED; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATED PATCH CLAMP; COMPUTER SYSTEM; DRUG SCREENING; DRUG TARGETING; ELECTROPHYSIOLOGICAL PROCEDURES; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; ION CONDUCTANCE; MEDICAL DEVICE; NUCLEOTIDE SEQUENCE; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL;

AUTOMATED PATCH-CLAMP; ELECTROPHYSIOLOGY; ION CHANNEL; PHARMACOLOGY; TRP;

ANIMALS; CELL LINE; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; PATCH-CLAMP TECHNIQUES; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84893854627     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113499632     Document Type: Article

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