메뉴 건너뛰기




Volumn 233, Issue 1, 2014, Pages 149-156

Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFκB invivo

Author keywords

Atherosclerosis; CRP; Epicatechin; Inflammation; NF B; Polyphenol

Indexed keywords

ATHEROSCLEROSIS; CRP; EPICATECHIN; INFLAMMATION; NFΚB; POLYPHENOL;

EID: 84893842605     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.12.027     Document Type: Article
Times cited : (76)

References (50)
  • 1
    • 81255188900 scopus 로고    scopus 로고
    • Atherosclerosis: current pathogenesis and therapeutic options
    • Weber C., Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011, 17:1410-1422.
    • (2011) Nat Med , vol.17 , pp. 1410-1422
    • Weber, C.1    Noels, H.2
  • 2
    • 84875787136 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with a Mediterranean diet
    • Estruch R., Ros E., Salas-Salvado J., et al. Primary prevention of cardiovascular disease with a Mediterranean diet. NEngl J Med 2013, 368:1279-1290.
    • (2013) NEngl J Med , vol.368 , pp. 1279-1290
    • Estruch, R.1    Ros, E.2    Salas-Salvado, J.3
  • 3
    • 70349566169 scopus 로고    scopus 로고
    • Dietary patterns and incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
    • Nettleton J.A., Polak J.F., Tracy R., Burke G.L., Jacobs D.R. Dietary patterns and incident cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr 2009, 90:647-654.
    • (2009) Am J Clin Nutr , vol.90 , pp. 647-654
    • Nettleton, J.A.1    Polak, J.F.2    Tracy, R.3    Burke, G.L.4    Jacobs, D.R.5
  • 4
    • 77958198870 scopus 로고    scopus 로고
    • Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients
    • Siri-Tarino P.W., Sun Q., Hu F.B., Krauss R.M. Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr Atheroscler Rep 2010, 12:384-390.
    • (2010) Curr Atheroscler Rep , vol.12 , pp. 384-390
    • Siri-Tarino, P.W.1    Sun, Q.2    Hu, F.B.3    Krauss, R.M.4
  • 5
    • 24144459909 scopus 로고    scopus 로고
    • Thematic review series: the immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?
    • Chait A., Han C.Y., Oram J.F., Heinecke J.W. Thematic review series: the immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?. JLipid Res 2005, 46:389-403.
    • (2005) JLipid Res , vol.46 , pp. 389-403
    • Chait, A.1    Han, C.Y.2    Oram, J.F.3    Heinecke, J.W.4
  • 8
    • 60549099385 scopus 로고    scopus 로고
    • Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents
    • Holt E.M., Steffen L.M., Moran A., et al. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. JAm Diet Assoc 2009, 109:414-421.
    • (2009) JAm Diet Assoc , vol.109 , pp. 414-421
    • Holt, E.M.1    Steffen, L.M.2    Moran, A.3
  • 9
    • 76649143720 scopus 로고    scopus 로고
    • Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study
    • Detopoulou P., Panagiotakos D.B., Chrysohoou C., et al. Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study. Eur J Clin Nutr 2010, 64:161-168.
    • (2010) Eur J Clin Nutr , vol.64 , pp. 161-168
    • Detopoulou, P.1    Panagiotakos, D.B.2    Chrysohoou, C.3
  • 10
    • 0034001951 scopus 로고    scopus 로고
    • Fruits and vegetables in the prevention of cancer and cardiovascular disease
    • van't Veer P., Jansen M.C., Klerk M., Kok F.J. Fruits and vegetables in the prevention of cancer and cardiovascular disease. Public Health Nutr 2000, 3:103-107.
    • (2000) Public Health Nutr , vol.3 , pp. 103-107
    • van't Veer, P.1    Jansen, M.C.2    Klerk, M.3    Kok, F.J.4
  • 11
    • 12844272321 scopus 로고    scopus 로고
    • Polyphenols and disease risk in epidemiologic studies
    • Arts I.C., Hollman P.C. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 2005, 81:317S-325S.
    • (2005) Am J Clin Nutr , vol.81
    • Arts, I.C.1    Hollman, P.C.2
  • 12
    • 78149327504 scopus 로고    scopus 로고
    • Flavanols and cardiovascular disease prevention
    • Heiss C., Keen C.L., Kelm M. Flavanols and cardiovascular disease prevention. Eur Heart J 2010, 31:2583-2592.
    • (2010) Eur Heart J , vol.31 , pp. 2583-2592
    • Heiss, C.1    Keen, C.L.2    Kelm, M.3
  • 13
    • 0036228345 scopus 로고    scopus 로고
    • Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study
    • Geleijnse J.M., Launer L.J., Van der Kuip D.A., Hofman A., Witteman J.C. Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am J Clin Nutr 2002, 75:880-886.
    • (2002) Am J Clin Nutr , vol.75 , pp. 880-886
    • Geleijnse, J.M.1    Launer, L.J.2    Van der Kuip, D.A.3    Hofman, A.4    Witteman, J.C.5
  • 14
    • 49449084483 scopus 로고    scopus 로고
    • The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies
    • Kuriyama S. The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies. JNutr 2008, 138:1548S-1553S.
    • (2008) JNutr , vol.138
    • Kuriyama, S.1
  • 15
    • 33644599022 scopus 로고    scopus 로고
    • Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study
    • Buijsse B., Feskens E.J., Kok F.J., Kromhout D. Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study. Arch Intern Med 2006, 166:411-417.
    • (2006) Arch Intern Med , vol.166 , pp. 411-417
    • Buijsse, B.1    Feskens, E.J.2    Kok, F.J.3    Kromhout, D.4
  • 16
    • 84867569839 scopus 로고    scopus 로고
    • Chocolate consumption and risk of stroke: a prospective cohort of men and meta-analysis
    • Larsson S.C., Virtamo J., Wolk A. Chocolate consumption and risk of stroke: a prospective cohort of men and meta-analysis. Neurology 2012, 79:1223-1229.
    • (2012) Neurology , vol.79 , pp. 1223-1229
    • Larsson, S.C.1    Virtamo, J.2    Wolk, A.3
  • 17
    • 84891921502 scopus 로고    scopus 로고
    • Tea and non-tea flavonol intakes in relation to atherosclerotic vascular disease mortality in older women
    • Ivey K.L., Lewis J.R., Prince R.L., Hodgson J.M. Tea and non-tea flavonol intakes in relation to atherosclerotic vascular disease mortality in older women. Br J Nutr 2013, 1-8.
    • (2013) Br J Nutr , pp. 1-8
    • Ivey, K.L.1    Lewis, J.R.2    Prince, R.L.3    Hodgson, J.M.4
  • 18
    • 84878939956 scopus 로고    scopus 로고
    • Cardioprotective effects of cocoa: clinical evidence from randomized clinical intervention trials in humans
    • Arranz S., Valderas-Martinez P., Chiva-Blanch G., et al. Cardioprotective effects of cocoa: clinical evidence from randomized clinical intervention trials in humans. Mol Nutr Food Res 2013, 57(6):936-947.
    • (2013) Mol Nutr Food Res , vol.57 , Issue.6 , pp. 936-947
    • Arranz, S.1    Valderas-Martinez, P.2    Chiva-Blanch, G.3
  • 19
    • 46649098436 scopus 로고    scopus 로고
    • Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials
    • Hooper L., Kroon P.A., Rimm E.B., et al. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008, 88:38-50.
    • (2008) Am J Clin Nutr , vol.88 , pp. 38-50
    • Hooper, L.1    Kroon, P.A.2    Rimm, E.B.3
  • 20
    • 84866130599 scopus 로고    scopus 로고
    • Intake estimation of total and individual flavan-3-ols, proanthocyanidins and theaflavins, their food sources and determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    • Knaze V., Zamora-Ros R., Lujan-Barroso L., et al. Intake estimation of total and individual flavan-3-ols, proanthocyanidins and theaflavins, their food sources and determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Nutr 2012, 108:1095-1108.
    • (2012) Br J Nutr , vol.108 , pp. 1095-1108
    • Knaze, V.1    Zamora-Ros, R.2    Lujan-Barroso, L.3
  • 21
    • 0035214759 scopus 로고    scopus 로고
    • Dietary catechins in relation to coronary heart disease death among postmenopausal women
    • Arts I.C., Jacobs D.R., Harnack L.J., Gross M., Folsom A.R. Dietary catechins in relation to coronary heart disease death among postmenopausal women. Epidemiology 2001, 12:668-675.
    • (2001) Epidemiology , vol.12 , pp. 668-675
    • Arts, I.C.1    Jacobs, D.R.2    Harnack, L.J.3    Gross, M.4    Folsom, A.R.5
  • 22
    • 84878919961 scopus 로고    scopus 로고
    • Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice
    • Noll C., Lameth J., Paul J.L., Janel N. Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice. Eur J Nutr 2013, 52:1243-1250.
    • (2013) Eur J Nutr , vol.52 , pp. 1243-1250
    • Noll, C.1    Lameth, J.2    Paul, J.L.3    Janel, N.4
  • 23
    • 77950902298 scopus 로고    scopus 로고
    • Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction
    • Loke W.M., Proudfoot J.M., Hodgson J.M., et al. Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler Thromb Vasc Biol 2010, 30:749-757.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 749-757
    • Loke, W.M.1    Proudfoot, J.M.2    Hodgson, J.M.3
  • 24
  • 25
    • 44049089850 scopus 로고    scopus 로고
    • Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis
    • Kleemann R., Verschuren L., van Erk M.J., et al. Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol 2007, 8:R200.
    • (2007) Genome Biol , vol.8
    • Kleemann, R.1    Verschuren, L.2    van Erk, M.J.3
  • 26
    • 80052273994 scopus 로고    scopus 로고
    • Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human invitro and invivo models
    • Kleemann R., Verschuren L., Morrison M., et al. Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human invitro and invivo models. Atherosclerosis 2011, 218:44-52.
    • (2011) Atherosclerosis , vol.218 , pp. 44-52
    • Kleemann, R.1    Verschuren, L.2    Morrison, M.3
  • 27
    • 77953623163 scopus 로고    scopus 로고
    • Diet-induced obesity increases NF-kappaB signaling in reporter mice
    • Carlsen H., Haugen F., Zadelaar S., et al. Diet-induced obesity increases NF-kappaB signaling in reporter mice. Genes Nutr 2009, 4:215-222.
    • (2009) Genes Nutr , vol.4 , pp. 215-222
    • Carlsen, H.1    Haugen, F.2    Zadelaar, S.3
  • 28
    • 84886772717 scopus 로고    scopus 로고
    • Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet
    • Yakala G.K., Wielinga P.Y., Suarez M., et al. Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet. Mol Nutr Food Res 2013, 57(11):2039-2048.
    • (2013) Mol Nutr Food Res , vol.57 , Issue.11 , pp. 2039-2048
    • Yakala, G.K.1    Wielinga, P.Y.2    Suarez, M.3
  • 29
    • 79953647391 scopus 로고    scopus 로고
    • Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation
    • Wielinga P.Y., Yakala G.K., Heeringa P., Kleemann R., Kooistra T. Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation. PLoS One 2011, 6:e18432.
    • (2011) PLoS One , vol.6
    • Wielinga, P.Y.1    Yakala, G.K.2    Heeringa, P.3    Kleemann, R.4    Kooistra, T.5
  • 30
    • 84870346435 scopus 로고    scopus 로고
    • Systems biology analysis unravels the complementary action of combined rosuvastatin and ezetimibe therapy
    • Verschuren L., Radonjic M., Wielinga P.Y., et al. Systems biology analysis unravels the complementary action of combined rosuvastatin and ezetimibe therapy. Pharmacogenet Genomics 2012, 22:837-845.
    • (2012) Pharmacogenet Genomics , vol.22 , pp. 837-845
    • Verschuren, L.1    Radonjic, M.2    Wielinga, P.Y.3
  • 31
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C., Williamson G., Morand C., Scalbert A., Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005, 81:230S-242S.
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 32
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker P.M., Hennekens C.H., Buring J.E., Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. NEngl J Med 2000, 342:836-843.
    • (2000) NEngl J Med , vol.342 , pp. 836-843
    • Ridker, P.M.1    Hennekens, C.H.2    Buring, J.E.3    Rifai, N.4
  • 34
    • 33646417915 scopus 로고    scopus 로고
    • Serum amyloid A: the "other" inflammatory protein
    • O'Brien K.D., Chait A. Serum amyloid A: the "other" inflammatory protein. Curr Atheroscler Rep 2006, 8:62-68.
    • (2006) Curr Atheroscler Rep , vol.8 , pp. 62-68
    • O'Brien, K.D.1    Chait, A.2
  • 35
    • 20144387658 scopus 로고    scopus 로고
    • Serum amyloid A and lipoprotein retention in murine models of atherosclerosis
    • O'Brien K.D., McDonald T.O., Kunjathoor V., et al. Serum amyloid A and lipoprotein retention in murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 2005, 25:785-790.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 785-790
    • O'Brien, K.D.1    McDonald, T.O.2    Kunjathoor, V.3
  • 36
    • 16244412633 scopus 로고    scopus 로고
    • Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells
    • Lee H.Y., Kim M.K., Park K.S., et al. Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells. Biochem Biophys Res Commun 2005, 330:989-998.
    • (2005) Biochem Biophys Res Commun , vol.330 , pp. 989-998
    • Lee, H.Y.1    Kim, M.K.2    Park, K.S.3
  • 37
    • 82855164033 scopus 로고    scopus 로고
    • Serum amyloid A directly accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    • Dong Z., Wu T., Qin W., et al. Serum amyloid A directly accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Mol Med 2011, 17:1357-1364.
    • (2011) Mol Med , vol.17 , pp. 1357-1364
    • Dong, Z.1    Wu, T.2    Qin, W.3
  • 38
    • 0023661285 scopus 로고
    • Inducible and tissue-specific expression of human C-reactive protein in transgenic mice
    • Ciliberto G., Arcone R., Wagner E.F., Ruther U. Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J 1987, 6:4017-4022.
    • (1987) EMBO J , vol.6 , pp. 4017-4022
    • Ciliberto, G.1    Arcone, R.2    Wagner, E.F.3    Ruther, U.4
  • 39
    • 73449130797 scopus 로고    scopus 로고
    • For the Emerging Risk Factors Collaboration. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    • Kaptoge S., Di Angelantonio E., Lowe G., et al. for the Emerging Risk Factors Collaboration. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 2010, 375:132-140.
    • (2010) Lancet , vol.375 , pp. 132-140
    • Kaptoge, S.1    Di, A.E.2    Lowe, G.3
  • 40
    • 19944429519 scopus 로고    scopus 로고
    • Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease
    • Nissen S.E., Tuzcu E.M., Schoenhagen P., et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. NEngl J Med 2005, 352:29-38.
    • (2005) NEngl J Med , vol.352 , pp. 29-38
    • Nissen, S.E.1    Tuzcu, E.M.2    Schoenhagen, P.3
  • 41
    • 77954583040 scopus 로고    scopus 로고
    • Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice
    • Rotzius P., Thams S., Soehnlein O., et al. Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice. Am J Pathol 2010, 177:493-500.
    • (2010) Am J Pathol , vol.177 , pp. 493-500
    • Rotzius, P.1    Thams, S.2    Soehnlein, O.3
  • 42
    • 84858630089 scopus 로고    scopus 로고
    • Multiple roles for neutrophils in atherosclerosis
    • Soehnlein O. Multiple roles for neutrophils in atherosclerosis. Circ Res 2012, 110:875-888.
    • (2012) Circ Res , vol.110 , pp. 875-888
    • Soehnlein, O.1
  • 43
    • 0032530560 scopus 로고    scopus 로고
    • Regulation of serum amyloid A protein expression during the acute-phase response
    • Jensen L.E., Whitehead A.S. Regulation of serum amyloid A protein expression during the acute-phase response. Biochem J 1998, 334(Pt 3):489-503.
    • (1998) Biochem J , vol.334 , Issue.PART 3 , pp. 489-503
    • Jensen, L.E.1    Whitehead, A.S.2
  • 44
    • 0037438377 scopus 로고    scopus 로고
    • Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation
    • Kleemann R., Gervois P.P., Verschuren L., Staels B., Princen H.M., Kooistra T. Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation. Blood 2003, 101:545-551.
    • (2003) Blood , vol.101 , pp. 545-551
    • Kleemann, R.1    Gervois, P.P.2    Verschuren, L.3    Staels, B.4    Princen, H.M.5    Kooistra, T.6
  • 45
    • 34548343614 scopus 로고    scopus 로고
    • Aselective NFkappaB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice
    • Chiba T., Kondo Y., Shinozaki S., et al. Aselective NFkappaB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice. JAtheroscler Thromb 2006, 13:308-313.
    • (2006) JAtheroscler Thromb , vol.13 , pp. 308-313
    • Chiba, T.1    Kondo, Y.2    Shinozaki, S.3
  • 46
    • 77958508103 scopus 로고    scopus 로고
    • Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-kappaB activity and lowering of cholesterol
    • de Vries-van der Weij J., Toet K., Zadelaar S., et al. Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-kappaB activity and lowering of cholesterol. Atherosclerosis 2010, 213:241-246.
    • (2010) Atherosclerosis , vol.213 , pp. 241-246
    • de Vries-van der Weij, J.1    Toet, K.2    Zadelaar, S.3
  • 47
    • 54849412805 scopus 로고    scopus 로고
    • Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis
    • Gareus R., Kotsaki E., Xanthoulea S., et al. Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 2008, 8:372-383.
    • (2008) Cell Metab , vol.8 , pp. 372-383
    • Gareus, R.1    Kotsaki, E.2    Xanthoulea, S.3
  • 48
    • 1342268337 scopus 로고    scopus 로고
    • Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells
    • Mackenzie G.G., Carrasquedo F., Delfino J.M., Keen C.L., Fraga C.G., Oteiza P.I. Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells. FASEB J 2004, 18:167-169.
    • (2004) FASEB J , vol.18 , pp. 167-169
    • Mackenzie, G.G.1    Carrasquedo, F.2    Delfino, J.M.3    Keen, C.L.4    Fraga, C.G.5    Oteiza, P.I.6
  • 49
    • 65349159271 scopus 로고    scopus 로고
    • Epicatechin suppresses IL-6, IL-8 and enhances IL-10 production with NF-kappaB nuclear translocation in whole blood stimulated system
    • Al-Hanbali M., Ali D., Bustami M., et al. Epicatechin suppresses IL-6, IL-8 and enhances IL-10 production with NF-kappaB nuclear translocation in whole blood stimulated system. Neuro Endocrinol Lett 2009, 30:131-138.
    • (2009) Neuro Endocrinol Lett , vol.30 , pp. 131-138
    • Al-Hanbali, M.1    Ali, D.2    Bustami, M.3
  • 50
    • 75549090203 scopus 로고    scopus 로고
    • Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells
    • Granado-Serrano A.B., Martin M.A., Haegeman G., Goya L., Bravo L., Ramos S. Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells. Br J Nutr 2010, 103:168-179.
    • (2010) Br J Nutr , vol.103 , pp. 168-179
    • Granado-Serrano, A.B.1    Martin, M.A.2    Haegeman, G.3    Goya, L.4    Bravo, L.5    Ramos, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.