The 15-deoxy-d12,14-prostaglandin J2 inhibits LPS-stimulated inflammation via enhancement of the platelet-activating factor acetylhydrolase activity in human retinal pigment epithelial cells

International Journal of Molecular Medicine

Volumn 33, Issue 2, 2014, Pages 449-456

  Jung, Won Kyo ^a   Lee, Chang Min ^b   Lee, Dae Sung ^c   Na, Giyoun ^d   Lee, Da Young ^d   Choi, Inhak ^d   Park, Sae Gwang ^d   Seo, Su Kil ^d   Yang, Jae Wook ^e   Choi, Jung Sik ^f   Lee, Young Min ^f   Park, Won Sun ^g   Choi, Il Whan ^d  

^a Pukyong National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Pohang University of Science and Technology (POSTECH)   (South Korea)

^d Inje University   (South Korea)

^e Departments of Ophthalmology   (South Korea)

^f Inje University College of Medicine   (South Korea)

^g Kangwon National University   (South Korea)

Author keywords

14 prostaglandin J2; 15 deoxy d12; Human retinal pigment epithelial cells; Ocular inflammation; PAF acetylhydrolase; Platelet activating factor

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; 15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; [2 METHOXY 3 (N OCTADECYLCARBAMOYLOXY)PROPYL] (2 THIAZOLIOETHYL) PHOSPHATE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; ANTIINFLAMMATORY AGENT; CCL2 PROTEIN, HUMAN; DRUG DERIVATIVE; PROSTAGLANDIN D2;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RESPONSE; DNA BINDING; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; EYE INFLAMMATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; INFLAMMATION; METABOLISM; PHOSPHORYLATION;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; CHEMOKINE CCL2; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; NF-KAPPA B; PHOSPHORYLATION; PPAR GAMMA; PROSTAGLANDIN D2; RETINAL PIGMENT EPITHELIUM;

EID: 84893814962     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1588     Document Type: Article

References (40)

1. Shen DF, Chang MA, Matteson DM, Buggage R, Kozhich AT and Chan CC: Biphasic ocular inflammatory response to endotoxin-induced uveitis in mouse. Arch Ophthalmol 118: 521-527, 2000.
2. Joussen AM, Poulaki V, Le M, et al: A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 18: 1450-1452, 2004.
3. Rodrigues EB: Inflammation in dry age-related macular degeneration. Ophthalmologica 221: 143-152, 2007.
4. Strauss O: The retinal pigment epithelium in visual function. Physiol Rev 85: 845-881, 2005.
5. Kumaki N, Anderson DM, Cosman D and Kumaki S: Expression of interleukin-15 and its receptor by human fetal retinal pigment epithelial cells. Curr Eye Res 15: 876-882, 1996.
6. McLaren MJ: Kinetics of rod outer segment phagocytosis by cultured retinal pigment epithelial cells. Relationship to cell morphology. Invest Ophthalmol Vis Sci 37: 1213-1224, 1996.
7. Yu FS and Hazlett LD: Toll-like receptors and the eye. Invest Ophthalmol Vis Sci 47: 1255-1263, 2006.
8. Ishii S and Shimizu T: Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res 39: 41-82, 2000.
9. Han SJ, Choi JH, Ko HM, et al: Glucocorticoids prevent NF-kappaB activation by inhibiting the early release of platelet-activating factor in response to lipopolysaccharide. Eur J Immunol 29: 1334-1341, 1999.
10. Camussi G, Tetta C and Baglioni C: The role of platelet activating factor in inflammation. Clin Immun Immunopathol 57: 331-338, 1990.
11. Lotner GZ, Lynch JM, Betz SJ and Henson PM: Human neutrophil-derived platelet activating factor. J Immunol 124: 676-684, 1980.
12. Triggiani M, Schleimer RP, Warner JA and Chilton FH: Differential synthesis of 1-acyl-2-acetyl-sn-glycero-3-phospho-choline and platelet-activating factor by human inflammatory cells. J Immunol 147: 660-666, 1991.
13. Sumita C, Maeda M, Fujio Y, et al: Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. Biochim Biophys Acta 1673: 115-121, 2004.
14. Tjoelker LW, Wilder C, Eberhardt C, et al: Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374: 549-553, 1995.
15. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA and Evans RM: PPAR? promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93: 241-252, 1998.
16. Mueller E, Sarraf P, Tontonoz P, et al: Terminal differentiation of human breast cancer through PPAR?. Mol Cell 1: 465-470, 1998.
17. Buckingham RE: Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection. Hepatol Res 33: 167-170, 2005.
18. Consoli A and Devangelio E: Thiazolidinediones and inflammation. Lupus 14: 794-797, 2005.
19. Drew PD and Chavis JA: The cyclopentone prostaglandin 15-deoxy-d12,14 prostaglandin J2 represses nitric oxide, TNF-, and IL-12 production by microglial cells. J Neuroimmunol 115: 28-35, 2001.
20. Garg TK and Chang JY: Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: Prevention of cell death by AG126 and 15-deoxy-delta12,14-PGJ2. BMC Ophthalmol 3: 5, 2003.
21. Surh YJ, Na HK, Park JM, et al: 15-Deoxy-?12,14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling. Biochem Pharmacol 82: 1335-1351, 2011.
22. Abdelrahman M, Sivarajah A and Thiemermann C: Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock. Cardiovasc Res 65: 772-781, 2005.
23. Rosenbaum JT, Angell E, Wilson D, Broquet C, Boney RS and Braquet P: Intravitreally injected platelet activating factor induces retinitis in experimental animals. Curr Eye Res 18: 342-348, 1999.
24. Bulger EM, Arbabi S, Garcia I and Maier RV: The macrophage response to endotoxin requires platelet activating factor. Shock 17: 173-179, 2002.
25. Cousin SW, Guss RB, Howes EL Jr and Rosenbaum JT: Endotoxin-induced uveitis in the rat: Observations on alters vascular permeability, clinical findings and histology. Exp Eye Res 35: 665-676, 1984.
26. Suzuki M, Noda K, Kubota S, et al: Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. Mol Vis 16: 1382-1388, 2010.
27. Leung KW, Barnstable CJ and Tombran-Tink J: Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. Mol Immunol 46: 1374-1386, 2009.
28. Planck SR, Dang TT, Graves D, Tara D, Ansel JC and Rosenbaum JT: Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1. Invest Ophthalmol Vis Sci 33: 78-82, 1992.
29. Feghali CA and Wright TM: Cytokines in acute and chronic inflammation. Front Biosci 2: D12-d26, 1997.
30. Biswas PS, Banerjee K, Kinchington PR and Rouse BT: Involvement of IL-6 in the paracrine production of VEGF in ocular HSV-1 infection. Exp Eye Res 82: 46-54, 2006.
31. De Vos AF, Hoekzema R and Kijlstra A: Cytokines and uveitis, a review. Curr Eye Res 11: 581-597, 1992.
32. Verma MJ, Lloyd A, Rager H, et al: Chemokines in acute anterior uveitis. Curr Eye Res 16: 1202-1208, 1997.
33. Nakazawa T, Hisatomi T, Nakazawa C, et al: Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. Proc Natl Acad Sci USA 104: 2425-2430, 2007.
34. Kanagawa T, Matsuda S, Mikawa Y, et al: Role of ICAM-1 and LFA-1 in endotoxin-induced uveitis in mice. Jpn J Ophthalmol 40: 174-180, 1996.
35. Tsuji F and Shirasawa E: The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs. Curr Eye Res 17: 501-505, 1998.
36. Zhang JZ, Cavet ME, VanderMeid KR, Salvador-Silva M, López FJ and Ward KW: BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells. Mol Vis 15: 2606-2616, 2009.
37. Rodrigues CE, Sanches TR, Volpini RA, et al: Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multi-organ dysfunction. PLoS One 7: E29893, 2012.
38. Straus DS, Pascual G, Li M, et al: 15-deoxy-delta12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci USA 97: 4844-4849, 2000.
39. Inoue H, Tanabe T and Umeson K: Feedback control of cyclooxygenase-2 expression through PPARgamma. J Biol Chem 275: 28028-28032, 2000.
40. Thieringer R, Fenyk-Melody JE, Le Grand CB, et al: Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo. J Immunol 164: 1046-1054, 2000.