Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling

Molecular Immunology

Volumn 46, Issue 7, 2009, Pages 1374-1386

  Leung, Kar Wah ^a   Barnstable, Colin J ^a,b   Tombran Tink, Joyce ^a,b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokine; Cytokine receptor; Inflammation; Lipopolysaccharide; Retinal degenerative diseases; Retinal pigment epithelial cells

Indexed keywords

ALPHA INTERFERON RECEPTOR; ENDOTOXIN; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GAMMA INTERFERON RECEPTOR 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; SMALL INTERFERING RNA; VASCULOTROPIN;

ARTICLE; AUTOCRINE EFFECT; CELL DEGENERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INFLAMMATION; NUCLEOTIDE SEQUENCE; PIGMENT EPITHELIUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AUTOCRINE COMMUNICATION; BACTERIAL PROTEINS; CELLS, CULTURED; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXINS; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CYTOKINE; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM; TISSUE DISTRIBUTION;

BACTERIA (MICROORGANISMS);

EID: 62549142650     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.12.001     Document Type: Article

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