Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis

Molecular Vision

Volumn 16, Issue , 2010, Pages 1382-1388

  Suzuki, Misa ^a,b,c   Noda, Kousuke ^b,d   Kubota, Shunsuke ^b,c   Hirasawa, Manabu ^b,c   Ozawa, Yoko ^b,c   Tsubota, Kazuo ^c   Mizuki, Nobuhisa ^a   Ishida, Susumu ^b,d  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ICOSAPENTAENOIC ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LECTIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE INFLAMMATION; IN VIVO STUDY; LEUKOCYTE ADHERENCE; MALE; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RETINA BLOOD VESSEL; UVEITIS; VITREOUS BODY;

ANIMALS; CELL ADHESION MOLECULES; CELL MOVEMENT; CHOROID; EICOSAPENTAENOIC ACID; ENDOTOXINS; INFLAMMATION; INFLAMMATION MEDIATORS; LEUKOCYTES; MICE; MICE, INBRED C57BL; NF-KAPPA B; RETINAL PIGMENT EPITHELIUM; RETINAL VESSELS; UVEITIS;

EID: 77955703750     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Androulakis ES, Tousoulis D, Papageorgiou N, Tsioufis C, Kallikazaros I, Stefanadis C. Essential hypertension: is there a role for inflammatory mechanisms? Cardiol Rev 2009; 17:216-21.
2. Hansson GK. Atherosclerosis-an immune disease: The Anitschkov Lecture 2007. Atherosclerosis 2009; 202:2-10.
3. Kolb H, Mandrup-Poulsen T. The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia 2010; 53:10-20.
4. Wilson PW. Evidence of systemic inflammation and estimation of coronary artery disease risk: a population perspective. Am J Med 2008; 121:S15-20.
5. Dinh W, Futh R, Nickl W, Krahn T, Ellinghaus P, Scheffold T, Bansemir L, Bufe A, Barroso MC, Lankisch M. Elevated plasma levels of TNF-alpha and Interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol 2009; 8:58.
6. Luc G, Bard JM, Juhan-Vague I, Ferrieres J, Evans A, Amouyel P, Arveiler D, Fruchart JC, Ducimetiere P. C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study. Arterioscler Thromb Vasc Biol 2003; 23:1255-61.
7. Ceriello A, Testa R. Antioxidant anti-inflammatory treatment in type 2 diabetes. Diabetes Care 2009; 32:S232-6.
8. Deans KA, Sattar N. "Anti-inflammatory" drugs and their effects on type 2 diabetes. Diabetes Technol Ther 2006; 8:18-27.
9. Klingenberg R, Hansson GK. Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies. Eur Heart J 2009; 30:2838-44.
10. Heller AR, Rossler S, Litz RJ, Stehr SN, Heller SC, Koch R, Koch T. Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med 2006; 34:972-9.
11. Pontes-Arruda A, Aragao AM, Albuquerque JD. Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. Crit Care Med 2006; 34:2325-33.
12. Singer P, Theilla M, Fisher H, Gibstein L, Grozovski E, Cohen J. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med 2006; 34:1033-8.
13. Kromann N, Green A. Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950- 1974. Acta Med Scand 1980; 208:401-6.
14. Calder PC. The relationship between the fatty acid composition of immune cells and their function. Prostaglandins Leukot Essent Fatty Acids 2008; 79:101-8.
15. Fetterman JW Jr, Zdanowicz MM. Therapeutic potential of n-3 polyunsaturated fatty acids in disease. Am J Health Syst Pharm 2009; 66:1169-79.
16. Lau CS. Collateral benefits of fish oil therapy for rheumatoid arthritis. J Rheumatol 2006; 33:1931-3.
17. Kürkçüoglu N, Tandogdu R. The effect of 'MaxEPA' in the treatment of patients with Behcet's disease. Br J Dermatol 1989; 121:667-8.
18. Bagga D, Wang L, Farias-Eisner R, Glaspy JA, Reddy ST. Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proc Natl Acad Sci USA 2003; 100:1751-6.
19. Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006; 83:1505S-19S.
20. Koto T, Nagai N, Mochimaru H, Kurihara T, Izumi-Nagai K, Satofuka S, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Oike Y, Ishida S. Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice. Invest Ophthalmol Vis Sci 2007; 48:4328-34.
21. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR. Endotoxininduced uveitis in rats as a model for human disease. Nature 1980; 286:611-3.
22. Noda K, Miyahara S, Nakazawa T, Almulki L, Nakao S, Hisatomi T, She H, Thomas KL, Garland RC, Miller JW, Gragoudas ES, Kawai Y, Mashima Y, Hafezi-Moghadam A. Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitis. FASEB J 2008; 22:1094-103.
23. Becker MD, Nobiling R, Planck SR, Rosenbaum JT. Digital video-imaging of leukocyte migration in the iris: intravital microscopy in a physiological model during the onset of endotoxin-induced uveitis. J Immunol Methods 2000; 240:23-37.
24. Planck SR, Becker MD, Crespo S, Choi D, Galster K, Garman KL, Nobiling R, Rosenbaum JT. Characterizing extravascular neutrophil migration in vivo in the iris. Inflammation 2008; 31:105-11.
25. Hafezi-Moghadam A, Noda K, Almulki L, Iliaki EF, Poulaki V, Thomas KL, Nakazawa T, Hisatomi T, Miller JW, Gragoudas ES. VLA-4 blockade suppresses endotoxininduced uveitis: in vivo evidence for functional integrin upregulation. FASEB J 2007; 21:464-74.
26. Miyahara S, Kiryu J, Miyamoto K, Katsuta H, Hirose F, Tamura H, Musashi K, Honda Y, Yoshimura N. In vivo threedimensional evaluation of leukocyte behavior in retinal microcirculation of mice. Invest Ophthalmol Vis Sci 2004; 45:4197-201.
27. Miyamoto K, Ogura Y, Hamada M, Nishiwaki H, Hiroshiba N, Honda Y. In vivo quantification of leukocyte behavior in the retina during endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 1996; 37:2708-15.
28. Sierra S, Lara-Villoslada F, Comalada M, Olivares M, Xaus J. Dietary eicosapentaenoic acid and docosahexaenoic acid equally incorporate as decosahexaenoic acid but differ in inflammatory effects. Nutrition 2008; 24:245-54.
29. Tull SP, Yates CM, Maskrey BH, O'Donnell VB, Madden J, Grimble RF, Calder PC, Nash GB, Rainger GE. Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biol 2009; 7:e1000177.
30. Sharif S, Broman M, Babcock T, Ong E, Jho D, Rudnicki M, Helton WS, Espat NJ. A priori dietary omega-3 lipid supplementation results in local pancreatic macrophage and pulmonary inflammatory response attenuation in a model of experimental acute edematous pancreatitis (AEP). JPEN J Parenter Enteral Nutr 2006; 30:271-6.
31. McMenamin PG, Crewe J. Endotoxin-induced uveitis. Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body. Invest Ophthalmol Vis Sci 1995; 36:1949-59.
32. Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 2002; 21:495-505.
33. Hoekzema R, Verhagen C, van Haren M, Kijlstra A. Endotoxininduced uveitis in the rat. The significance of intraocular interleukin-6. Invest Ophthalmol Vis Sci 1992; 33:532-9.
34. Ohta K, Yamagami S, Taylor AW, Streilein JW. IL-6 antagonizes TGF-beta and abolishes immune privilege in eyes with endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 2000; 41:2591-9.
35. Satofuka S, Ichihara A, Nagai N, Yamashiro K, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Suzuki F, Oike Y, Ishida S. Suppression of ocular inflammation in endotoxininduced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci 2006; 47:2686-92.
36. Gu L, Tseng SC, Rollins BJ. Monocyte chemoattractant protein-1. Chem Immunol 1999; 72:7-29.
37. Miyazaki A, Kitaichi N, Ohgami K, Iwata D, Jin XH, Iwabuchi K, Morohashi T, Ohno S, Onoé K. Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxininduced uveitis in rats. Graefes Arch Clin Exp Ophthalmol 2008; 246:747-57.
38. Mo JS, Matsukawa A, Ohkawara S, Yoshinaga M. Role and regulation of IL-8 and MCP-1 in LPS-induced uveitis in rabbits. Exp Eye Res 1999; 68:333-40.
39. Nagai N, Oike Y, Noda K, Urano T, Kubota Y, Ozawa Y, Shinoda H, Koto T, Shinoda K, Inoue M, Tsubota K, Yamashiro K, Suda T, Ishida S. Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor. Invest Ophthalmol Vis Sci 2005; 46:2925-31.
40. Mayadas TN, Cullere X. Neutrophil beta2 integrins: moderators of life or death decisions. Trends Immunol 2005; 26:388-95.
41. Ross GD. Role of the lectin domain of Mac-1/CR3 (CD11b/ CD18) in regulating intercellular adhesion. Immunol Res 2002; 25:219-27.
42. Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001; 13:85-94.
43. Barnes PJ. Nuclear factor-kappa B. Int J Biochem Cell Biol 1997; 29:867-70.
44. Novotny NM, Markel TA, Crisostomo PR, Meldrum DR. Differential IL-6 and VEGF secretion in adult and neonatal mesenchymal stem cells: role of NFkB. Cytokine 2008; 43:215-9.
45. Ueda A, Okuda K, Ohno S, Shirai A, Igarashi T, Matsunaga K, Fukushima J, Kawamoto S, Ishigatsubo Y, Okubo T. NFkappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J Immunol 1994; 153:2052-63.
46. Wang Y, Rangan GK, Goodwin B, Tay YC, Harris DC. Lipopolysaccharide-induced MCP-1 gene expression in rat tubular epithelial cells is nuclear factor-kappaB dependent. Kidney Int 2000; 57:2011-22.
47. Spencer L, Mann C, Metcalfe M, Webb M, Pollard C, Spencer D, Berry D, Steward W, Dennison A. The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential. Eur J Cancer 2009; 45:2077-86.