메뉴 건너뛰기




Volumn 65, Issue 1, 2013, Pages 164-172

Apigenin inhibits TGF-β1 induced fibroblast-to- myofibroblast transition in human lung fibroblast populations

Author keywords

Apigenin; Asthma; Human bronchial fibroblasts; IMR 90 cells; Myofibroblasts; Transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; APIGENIN; MESSENGER RNA; TENASCIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84875775046     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(13)70974-5     Document Type: Article
Times cited : (35)

References (49)
  • 2
    • 73549109887 scopus 로고    scopus 로고
    • Is the prevalence of asthma declining? Systematic review of epidemiological studies
    • Anandan C, Nurmatov U, van Schayck OC, Sheikh A: Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy, 2010, 65, 152-167.
    • (2010) Allergy , vol.65 , pp. 152-167
    • Anandan, C.1    Nurmatov, U.2    Van Schayck, O.C.3    Sheikh, A.4
  • 3
    • 12844272321 scopus 로고    scopus 로고
    • Polyphenols and disease risk in epidemiologic studies
    • Arts IC, Hollman PC: Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr, 2005, 81, 317-325.
    • (2005) Am J Clin Nutr , vol.81 , pp. 317-325
    • Arts, I.C.1    Hollman, P.C.2
  • 4
    • 33845975665 scopus 로고    scopus 로고
    • Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cd Tyr311
    • Balasubramanian S, Zhu L, Eckert RL: Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cd Tyr311. J Biol Chem, 2006, 281, 36162-36172.
    • (2006) J Biol Chem , vol.281 , pp. 36162-36172
    • Balasubramanian, S.1    Zhu, L.2    Eckert, R.L.3
  • 5
    • 33644784718 scopus 로고    scopus 로고
    • Corticosteroids: The drugs to beat
    • Barnes PJ: Corticosteroids: the drugs to beat. Eur J Pharmacol, 2006, 8, 2-14.
    • (2006) Eur J Pharmacol , vol.8 , pp. 2-14
    • Barnes, P.J.1
  • 6
    • 80052028124 scopus 로고    scopus 로고
    • Treatment of allergic asthma: Modulation of Th2 cells and their responses
    • Bosnjak B, Stelzmueller B, Erb KJ, Epstein MM: Treatment of allergic asthma: modulation of Th2 cells and their responses. Respir Res, 2011, 25, 102-114.
    • (2011) Respir Res , vol.25 , pp. 102-114
    • Bosnjak, B.1    Stelzmueller, B.2    Erb, K.J.3    Epstein, M.M.4
  • 8
    • 0037841704 scopus 로고    scopus 로고
    • Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type i and type III collagen expression
    • Chakir J, Shannon J, Molet S, Fukakusa M, Elias J, Laviolette M, Boulet LP, Hamid Q: Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol, 2003, 111, 1293-1298.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1293-1298
    • Chakir, J.1    Shannon, J.2    Molet, S.3    Fukakusa, M.4    Elias, J.5    Laviolette, M.6    Boulet, L.P.7    Hamid, Q.8
  • 9
    • 79952277053 scopus 로고    scopus 로고
    • Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: Implications for therapy of lung fibrosis
    • Chen CY, Peng WH, Wu LC, Wu CC, Hsu SL: Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: implications for therapy of lung fibrosis. J Agric Food Chem, 2010, 24, 11653-11661.
    • (2010) J Agric Food Chem , vol.24 , pp. 11653-11661
    • Chen, C.Y.1    Peng, W.H.2    Wu, L.C.3    Wu, C.C.4    Hsu, S.L.5
  • 11
    • 13244277580 scopus 로고    scopus 로고
    • Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro
    • Czyż J, Madeja Z, Irmer U, Korohoda W, Hülser DF: Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. Int J Cancer, 2005, 10, 12-18.
    • (2005) Int J Cancer , vol.10 , pp. 12-18
    • Czyz, J.1    Madeja, Z.2    Irmer, U.3    Korohoda, W.4    Hülser, D.F.5
  • 13
    • 80052267387 scopus 로고    scopus 로고
    • What effect does asthma treatment have on airway remodeling? Current perspectives
    • Durrani SR, Viswanathan RK, Busse WW: What effect does asthma treatment have on airway remodeling? Current perspectives. J Allergy Clin Immunol, 2011, 128, 439-448.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 439-448
    • Durrani, S.R.1    Viswanathan, R.K.2    Busse, W.W.3
  • 14
    • 70449711373 scopus 로고    scopus 로고
    • The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism
    • Franzen CA, Amargo E, Todoroviæ V, Desai BV, Huda S, Mirzoeva S, Chiu K et al.: The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism. Cancer Prev Res (Phila), 2009, 9, 830-841.
    • (2009) Cancer Prev Res (Phila) , vol.9 , pp. 830-841
    • Franzen, C.A.1    Amargo, E.2    Todoroviæ, V.3    Desai, B.V.4    Huda, S.5    Mirzoeva, S.6    Chiu, K.7
  • 15
  • 16
    • 58149296253 scopus 로고    scopus 로고
    • The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells
    • Galanty A, Michalik M, Sȩdek L, Podolak I: The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells. Cell Mol Biol Lett, 2008, 13, 585-598.
    • (2008) Cell Mol Biol Lett , vol.13 , pp. 585-598
    • Galanty, A.1    Michalik, M.2    Sȩdek, L.3    Podolak, I.4
  • 18
    • 0033143762 scopus 로고    scopus 로고
    • Serotonin 5-HT2A receptor induces TGF-β1 expression in mesangial cells via ERK: Proliferative and fibrotic signals
    • Grewal JS, Mukhin YV, Garnovskaya MN, Raymond JR, Greene EL: Serotonin 5-HT2A receptor induces TGF-β1 expression in mesangial cells via ERK: proliferative and fibrotic signals. Am J Physiol, 1999, 276, F922-930.
    • (1999) Am J Physiol , vol.276
    • Grewal, J.S.1    Mukhin, Y.V.2    Garnovskaya, M.N.3    Raymond, J.R.4    Greene, E.L.5
  • 19
    • 84863119124 scopus 로고    scopus 로고
    • Apigenin attenuates neointima formation via suppression of vascular smooth muscle cell phenotypic transformation
    • Guan H, Gao L, Zhu L, Yan L, Fu M, Chen C, Dong X et al.: Apigenin attenuates neointima formation via suppression of vascular smooth muscle cell phenotypic transformation. J Cell Biochem, 2012, 113, 1198-1207.
    • (2012) J Cell Biochem , vol.113 , pp. 1198-1207
    • Guan, H.1    Gao, L.2    Zhu, L.3    Yan, L.4    Fu, M.5    Chen, C.6    Dong, X.7
  • 21
    • 67649947512 scopus 로고    scopus 로고
    • Emerging concepts in the pathogenesis of lung fibrosis
    • Hardie WD, Glasser SW, Hagood JS: Emerging concepts in the pathogenesis of lung fibrosis. Am J Pathol, 2009, 175, 3-16.
    • (2009) Am J Pathol , vol.175 , pp. 3-16
    • Hardie, W.D.1    Glasser, S.W.2    Hagood, J.S.3
  • 22
    • 2642580606 scopus 로고    scopus 로고
    • Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils
    • Hirano T, Higa S, Arimitsu J, Naka T, Shima Y, Ohshima S, Fujimoto M et al.: Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int Arch Allergy Immunol, 2004, 134, 135-140.
    • (2004) Int Arch Allergy Immunol , vol.134 , pp. 135-140
    • Hirano, T.1    Higa, S.2    Arimitsu, J.3    Naka, T.4    Shima, Y.5    Ohshima, S.6    Fujimoto, M.7
  • 23
    • 77956623567 scopus 로고    scopus 로고
    • Alook at the pathogenesis of asthma: The need for a change in direction
    • Holgate ST: Alook at the pathogenesis of asthma: the need for a change in direction. DiscovMed, 2010, 9, 439-447.
    • (2010) DiscovMed , vol.9 , pp. 439-447
    • Holgate, S.T.1
  • 24
    • 0033431062 scopus 로고    scopus 로고
    • Genetic and environmental interaction in allergy and asthma
    • Holgate ST: Genetic and environmental interaction in allergy and asthma. J Allergy Clin Immunol, 1999, 104, 1139-1146.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 1139-1146
    • Holgate, S.T.1
  • 25
    • 57349181198 scopus 로고    scopus 로고
    • Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase
    • Hu XW, Meng D, Fang J: Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase. Carcinogenesis, 2008, 29, 2369-2376.
    • (2008) Carcinogenesis , vol.29 , pp. 2369-2376
    • Hu, X.W.1    Meng, D.2    Fang, J.3
  • 26
    • 78650679401 scopus 로고    scopus 로고
    • The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells
    • Hwang YP, Oh KN, Yun HJ, Jeong HG: The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells. J Dermatol Sci, 2011, 61, 23-31.
    • (2011) J Dermatol Sci , vol.61 , pp. 23-31
    • Hwang, Y.P.1    Oh, K.N.2    Yun, H.J.3    Jeong, H.G.4
  • 27
    • 79961154310 scopus 로고    scopus 로고
    • Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells
    • Kang OH, Lee JH, Kwon DY: Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells. Immunopharmacol Immunotoxicol, 2011, 33, 473-479.
    • (2011) Immunopharmacol Immunotoxicol , vol.33 , pp. 473-479
    • Kang, O.H.1    Lee, J.H.2    Kwon, D.Y.3
  • 30
    • 33750567782 scopus 로고    scopus 로고
    • Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha
    • Kumazawa Y, Kawaguchi K, Takimoto H: Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha. Curr Pharm Des, 2006, 12, 4271-4279.
    • (2006) Curr Pharm des , vol.12 , pp. 4271-4279
    • Kumazawa, Y.1    Kawaguchi, K.2    Takimoto, H.3
  • 31
    • 0030796989 scopus 로고    scopus 로고
    • Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin
    • Lepley DM, Pelling JC, Lepley DM, Pelling JC: Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin. Mol Carcinog, 1997, 19, 74-82.
    • (1997) Mol Carcinog , vol.19 , pp. 74-82
    • Lepley, D.M.1    Pelling, J.C.2    Lepley, D.M.3    Pelling, J.C.4
  • 32
    • 77955492155 scopus 로고    scopus 로고
    • Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma
    • Li RR, Pang LL, Du Q, Shi Y, Dai WJ, Yin KS: Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma. Immunopharmacol Immunotoxicol, 2010, 32, 364-370.
    • (2010) Immunopharmacol Immunotoxicol , vol.32 , pp. 364-370
    • Li, R.R.1    Pang, L.L.2    Du, Q.3    Shi, Y.4    Dai, W.J.5    Yin, K.S.6
  • 33
    • 34447116385 scopus 로고    scopus 로고
    • The regulatory role of TGF-beta in airway remodeling in asthma
    • Makinde T, Murphy RF, Agrawal DK: The regulatory role of TGF-beta in airway remodeling in asthma. Immunol Cell Biol, 2007, 85, 348-356.
    • (2007) Immunol Cell Biol , vol.85 , pp. 348-356
    • Makinde, T.1    Murphy, R.F.2    Agrawal, D.K.3
  • 35
    • 33847676783 scopus 로고    scopus 로고
    • Fibroblasts and myofibroblasts: Their source, function and role in disease
    • McAnulty RJ: Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol, 2007, 39, 666-671.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 666-671
    • McAnulty, R.J.1
  • 36
    • 67650689569 scopus 로고    scopus 로고
    • Asthmatic bronchial fibroblasts demonstrate enhanced potential to differentiate into myofibroblasts in culture
    • Michalik M, Pierzchalska M, Legutko A, Ura M, Ostaszewska A, Soja J, Sanak M: Asthmatic bronchial fibroblasts demonstrate enhanced potential to differentiate into myofibroblasts in culture. Med Sci Monit, 2009, 15, 194-201.
    • (2009) Med Sci Monit , vol.15 , pp. 194-201
    • Michalik, M.1    Pierzchalska, M.2    Legutko, A.3    Ura, M.4    Ostaszewska, A.5    Soja, J.6    Sanak, M.7
  • 38
    • 84875777974 scopus 로고    scopus 로고
    • Lithium attenuates TGF-β1-induced fibroblasts to myofibroblasts transition in bronchial fibroblasts derived from asthmatic patients
    • 2012, doi: 10.1155/2012/206109
    • MichalikM,Wójcik KA, Jakieła B, Szpak K, Pierzchalska M, Sanak M, Madeja Z, Czyż J: Lithium attenuates TGF-β1-induced fibroblasts to myofibroblasts transition in bronchial fibroblasts derived from asthmatic patients. J Allergy, 2012, 2012:206109, doi: 10.1155/2012/206109.
    • (2012) J Allergy , pp. 206109
    • Michalik, M.1    Wójcik, K.A.2    Jakieła, B.3    Szpak, K.4    Pierzchalska, M.5    Sanak, M.6    Madeja, Z.7    Czyz, J.8
  • 39
    • 77953696958 scopus 로고    scopus 로고
    • ISAAC Phase Two Study Group: Effect of diet on asthma and allergic sensitisation in the International Study on Allergies and Asthma in Childhood (ISAAC) Phase Two
    • Nagel G, Weinmayr G, Kleiner A, Garcia-Marcos L, Strachan DP: ISAAC Phase Two Study Group: Effect of diet on asthma and allergic sensitisation in the International Study on Allergies and Asthma in Childhood (ISAAC) Phase Two. Thorax, 2010, 65, 516-522.
    • (2010) Thorax , vol.65 , pp. 516-522
    • Nagel, G.1    Weinmayr, G.2    Kleiner, A.3    Garcia-Marcos, L.4    Strachan, D.P.5
  • 40
    • 79251523895 scopus 로고    scopus 로고
    • The protective effect of the Mediterranean diet: Focus on cancer and cardiovascular risk
    • Pauwels EK: The protective effect of the Mediterranean diet: focus on cancer and cardiovascular risk. Med Princ Pract, 2011, 20, 103-111.
    • (2011) Med Princ Pract , vol.20 , pp. 103-111
    • Pauwels, E.K.1
  • 41
    • 33646940431 scopus 로고    scopus 로고
    • Uncontrolled asthma: A review of the prevalence, disease burden and options for treatment
    • Peters SP, Ferguson G, Deniz Y, Reisner C: Uncontrolled asthma: a review of the prevalence, disease burden and options for treatment. Respir Med, 2006, 100, 1139-1151.
    • (2006) Respir Med , vol.100 , pp. 1139-1151
    • Peters, S.P.1    Ferguson, G.2    Deniz, Y.3    Reisner, C.4
  • 44
    • 77953189137 scopus 로고    scopus 로고
    • Apigenin: A promising molecule for cancer prevention
    • Shukla S, Gupta S: Apigenin: a promising molecule for cancer prevention. Pharm Res, 2010, 27, 962-978.
    • (2010) Pharm Res , vol.27 , pp. 962-978
    • Shukla, S.1    Gupta, S.2
  • 45
    • 34248157606 scopus 로고    scopus 로고
    • Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells
    • Shukla S, Gupta S: Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell Cycle, 2007, 2, 1102-1114.
    • (2007) Cell Cycle , vol.2 , pp. 1102-1114
    • Shukla, S.1    Gupta, S.2
  • 46
    • 79953170980 scopus 로고    scopus 로고
    • IL-17-expressing cells as a potential therapeutic target for treatment of immunological disorders
    • Strzȩpa A, Szczepanik M: IL-17-expressing cells as a potential therapeutic target for treatment of immunological disorders. Pharmacol Rep, 2011, 63, 30-44.
    • (2011) Pharmacol Rep , vol.63 , pp. 30-44
    • Strzȩpa, A.1    Szczepanik, M.2
  • 48
    • 60649102339 scopus 로고    scopus 로고
    • Pulmonary fibrosis: Pathogenesis, etiology and regulation
    • Wilson MS, Wynn TA: Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol, 2009, 2, 103-121.
    • (2009) Mucosal Immunol , vol.2 , pp. 103-121
    • Wilson, M.S.1    Wynn, T.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.