JNK inhibitor SP600125 enhances TGF-β-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner

Molecular Medicine Reports

Volumn 8, Issue 6, 2013, Pages 1623-1629

  Lin, Youzhi ^a   Zhang, Binhao ^a   Liang, Huifang ^a   Lu, Yulei ^b   Ai, Xi ^a   Zhang, Bixiang ^a   Chen, Xiaoping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cholangiocarcinoma; Smad; SP600125; Transforming growth factor

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE; CASPASE INHIBITOR; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CARCINOMA CELL; CONTROLLED STUDY; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; BILE DUCT TUMOR; DRUG EFFECTS; ENZYMOLOGY; INTRAHEPATIC BILE DUCT; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ANTHRACENES; APOPTOSIS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CASPASES; CELL LINE, TUMOR; CHOLANGIOCARCINOMA; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84893752303     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1711     Document Type: Article

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