Prevention of high altitude illness

Travel Medicine and Infectious Disease

Volumn 12, Issue 1, 2014, Pages 29-39

  Zafren, Ken ^a,b,c,d  

^a ALASKA NATIVE MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c Himalayan Rescue Association   (Nepal)

^d International Commission for Mountain Emergency Medicine (ICAR MEDCOM)   (United States)

Author keywords

Acclimatization; Acute mountain sickness; High altitude; High altitude cerebral edema; High altitude pulmonary edema

Indexed keywords

ACETAMINOSALOL; ACETAZOLAMIDE; ACETYLSALICYLIC ACID; ANTACID AGENT; ANTIOXIDANT; CAFFEINE; CALCIUM CHANNEL BLOCKING AGENT; CARBON DIOXIDE; DEXAMETHASONE; GABAPENTIN; GINKGO BILOBA EXTRACT; IBUPROFEN; MAGNESIUM; MEDROXYPROGESTERONE; NAPROXEN; NIFEDIPINE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; SALMETEROL; SPIRONOLACTONE; SUMATRIPTAN; TADALAFIL; TEMAZEPAM;

ACUTE DISEASE; ACUTE MOUNTAIN DISEASE; ACUTE MOUNTAIN SICKNESS; ADULT; ALTITUDE; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; ATMOSPHERIC PRESSURE; BOLIVIA; BRAIN EDEMA; CHILD; CLIMBING; COCA; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG HYPERSENSITIVITY; GINKGO BILOBA; HEADACHE; HERBAL MEDICINE; HIGH ALTITUDE CEREBRAL EDEMA; HIGH ALTITUDE PULMONARY EDEMA; HUMAN; HYPERBARIC CHAMBER; HYPOBARISM; HYPOXIA; LUNG EDEMA; NONCARDIOGENIC LUNG EDEMA; NONHUMAN; PARESTHESIA; PATIENT COUNSELING; PERU; PILL; PRACTICE GUIDELINE; PREDICTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RASH; RECOMMENDED DRUG DOSE; REST; REVIEW; RISK ASSESSMENT; SLEEP DISORDER; SLEEP QUALITY; TEA; TRAVEL;

ACCLIMATIZATION; ACUTE MOUNTAIN SICKNESS; HIGH ALTITUDE; HIGH ALTITUDE CEREBRAL EDEMA; HIGH ALTITUDE PULMONARY EDEMA;

ALTITUDE SICKNESS; BRAIN EDEMA; HUMANS; MOUNTAINEERING; RISK;

EID: 84893744608     PISSN: 14778939     EISSN: 18730442     Source Type: Journal    
DOI: 10.1016/j.tmaid.2013.12.002     Document Type: Review

References (110)

1. R.C. Roach, P. Bärtsch, P.H. Hackett, O. Oelz, and The Lake Louise AMS Scoring Consensus Committee The Lake Louise acute mountain sickness scoring system S. Wood, R. Roach, Hypoxia and molecular medicine 1993 Queen City Printers Burlington, VT 272 274
2. P.H. Hackett, and R.C. Roach High-altitude illness N Engl J Med 345 2 Jul 12 2001 107 114
3. I. Singh, P.K. Khanna, M.C. Srivastava, M. Lal, S.B. Roy, and C.S. Subramanyam Acute mountain sickness N Engl J Med 280 4 Jan 23 1969 175 184
4. P. Bartsch High altitude pulmonary edema Respiration 64 6 1997 435 443
5. H.N. Hultgren, W.B. Spickard, K. Hellriegel, and C.S. Houston High altitude pulmonary edema Medicine (Baltimore) 40 Sep 1961 289 313
6. J.T. Reeves, J. Wagner, K. Zafren, B. Honigman, and R.S. Schoene Seasonal variation in barometric pressure and temperature in Summit County: effect on altitude illness J.R. Sutton, C.S. Houston, G. Coates, Hypoxia and molecular medicine 1993 Queen City Printers 277 281
7. T.M. Hyers, C.H. Scoggin, D.H. Will, R.F. Grover, and J.T. Reeves Accentuated hypoxemia at high altitude in subjects susceptible to high-altitude pulmonary edema J Appl Physiol 46 1 Jan 1979 41 46
8. A. Kawashima, K. Kubo, T. Kobayashi, and M. Sekiguchi Hemodynamic responses to acute hypoxia, hypobaria, and exercise in subjects susceptible to high-altitude pulmonary edema J Appl Physiol 67 5 Nov 1989 1982 1989
9. H.N. Hultgren, and E.A. Marticorena High altitude pulmonary edema. Epidemiologic observations in Peru Chest 74 4 Oct 1978 372 376
10. C.H. Scoggin, T.M. Hyers, J.T. Reeves, and R.F. Grover High-altitude pulmonary edema in the children and young adults of Leadville, Colorado N Engl J Med 297 23 Dec 8 1977 1269 1272
11. J.R. Sutton, C.S. Houston, A.L. Mansell, M.D. McFadden, P.M. Hackett, and J.R. Rigg et al. Effect of acetazolamide on hypoxemia during sleep at high altitude N Engl J Med 301 24 Dec 13 1979 1329 1331
12. J.B. West, R.M. Peters Jr., G. Aksnes, K.H. Maret, J.S. Milledge, and R.B. Schoene Nocturnal periodic breathing at altitudes of 6,300 and 8,050 m J Appl Physiol (1985) 61 1 Jul 1986 280 287
13. J.D. Anholm, A.C. Powles, R. Downey 3rd, C.S. Houston, J.R. Sutton, and M.H. Bonnet et al. Operation Everest II: arterial oxygen saturation and sleep at extreme simulated altitude Am Rev Respir Dis 145 4 Pt 1 Apr 1992 817 826
14. K.E. Bloch, A.J. Turk, M. Maggiorini, T. Hess, T. Merzv, and M.M. Bosch et al. Effect of ascent protocol on acute mountain sickness and success at Muztagh Ata, 7546 m High Alt Med Biol 10 1 Spring 2009 25 32
15. B.A. Beidleman, C.S. Fulco, S.R. Muza, P.B. Rock, J.E. Staab, and V.A. Forte et al. Effect of six days of staging on physiologic adjustments and acute mountain sickness during ascent to 4300 meters High Alt Med Biol 10 3 Fall 2009 253 260
16. S.R. Muza, B.A. Beidleman, and C.S. Fulco Altitude preexposure recommendations for inducing acclimatization High Alt Med Biol 11 2 Summer 2010 87 92
17. K. Zafren, and B. Honigman High-altitude medicine Emerg Med Clin North Am 15 1 Feb 1997 191 222
18. A.M. Luks, S.E. McIntosh, C.K. Grissom, P.S. Auerbach, G.W. Rodway, and R.B. Schoene et al. Wilderness Medical Society consensus guidelines for the prevention and treatment of acute altitude illness Wilderness Environ Med 21 2 Jun 2010 146 155
19. C.F. Consolazio, L.O. Matoush, H.L. Johnson, H.J. Krzywicki, T.A. Daws, and G.J. Isaac Effects of high-carbohydrate diets on performance and clinical symptomatology after rapid ascent to high altitude Fed Proc 28 3 May-Jun 1969 937 943
20. E.B. Larson, R.C. Roach, R.B. Schoene, and T.F. Hornbein Acute mountain sickness and acetazolamide. Clinical efficacy and effect on ventilation J Am Med Assoc 248 3 Jul 16 1982 328 332
21. A.J. Davies, N.S. Kalson, S. Stokes, M.D. Earl, A.G. Whitehead, and H. Frost et al. Determinants of summiting success and acute mountain sickness on Mt Kilimanjaro (5895 m) Wilderness Environ Med 20 4 Winter 2009 311 317
22. S.J. Jackson, J. Varley, C. Sellers, K. Josephs, L. Codrington, and G. Duke et al. Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro High Alt Med Biol 11 3 Fall 2010 217 222
23. B. Basnyat, D. Subedi, J. Sleggs, J. Lemaster, G. Bhasyal, and B. Aryal et al. Disoriented and ataxic pilgrims: an epidemiological study of acute mountain sickness and high-altitude cerebral edema at a sacred lake at 4300 m in the Nepal Himalayas Wilderness Environ Med 11 2 Summer 2000 89 93
24. P. Bartsch, E.R. Swenson, A. Paul, B. Julg, and E. Hohenhaus Hypoxic ventilatory response, ventilation, gas exchange, and fluid balance in acute mountain sickness High Alt Med Biol 3 4 Winter 2002 361 376
25. 2 values during short-term exposure to hypoxia High Alt Med Biol 5 3 Fall 2004 335 340
26. C. Schirlo, V. Pavlicek, A. Jacomet, J.S. Gibbs, E. Koller, and O. Oelz et al. Characteristics of the ventilatory response in subjects susceptible to high altitude pulmonary edema during acute and prolonged hypoxia High Alt Med Biol 3 3 Fall 2002 267 276
27. S. Grant, N. MacLeod, J.W. Kay, M. Watt, S. Patel, and A. Peterson et al. Sea level and acute responses to hypoxia: do they predict physiological responses and acute mountain sickness at altitude? Br J Sports Med 36 2 Apr 2002 141 146
28. J.P. Richalet, P. Larmignat, E. Poitrine, M. Letournel, and F. Canoui-Poitrine Physiological risk factors for severe high-altitude illness: a prospective cohort study Am J Respir Crit Care Med 185 2 Jan 15 2011 192 198
29. N.J. Cochand, M. Wild, J.V. Brugniaux, P.J. Davies, K.A. Evans, and R.G. Wise et al. Sea-level assessment of dynamic cerebral autoregulation predicts susceptibility to acute mountain sickness at high altitude Stroke 42 12 Dec 2011 3628 3630
30. P.A. Modesti, S. Rapi, R. Paniccia, G. Bilo, M. Rivera, and P. Agostini et al. Index measured at an intermediate altitude to predict impending acute mountain sickness Med Sci Sports Exerc 43 10 Oct 2011 1811 1818
31. K. Zafren Prediction of acute mountain sickness by pulse oximetry: what are the right questions? Wilderness Environ Med 23 4 Dec 2012 377 378
32. H.C. Chen, W.L. Lin, J.Y. Wu, S.H. Wang, T.F. Chiu, and Y.M. Weng et al. Change in oxygen saturation does not predict acute mountain sickness on Jade mountain Wilderness Environ Med 23 2 Jun 2012 122 127
33. D.R. Wagner, J.R. Knott, and J.P. Fry Oximetry fails to predict acute mountain sickness or summit success during a rapid ascent to 5640 meters Wilderness Environ Med 23 2 Jun 2012 114 121
34. R.C. Roach, E.R. Greene, R.B. Schoene, and P.H. Hackett Arterial oxygen saturation for prediction of acute mountain sickness Aviat Space Environ Med 69 12 Dec 1998 1182 1185
35. H.M. Karinen, J.E. Peltonen, M. Kahonen, and H.O. Tikkanen Prediction of acute mountain sickness by monitoring arterial oxygen saturation during ascent High Alt Med Biol 11 4 Winter 2012 325 332
36. J.F. Kasic, M. Yaron, R.A. Nicholas, J.A. Lickteig, and R. Roach Treatment of acute mountain sickness: hyperbaric versus oxygen therapy Ann Emerg Med 20 10 Oct 1991 1109 1112
37. K. Freeman, M. Shalit, and G. Stroh Use of the Gamow Bag by EMT-basic park rangers for treatment of high-altitude pulmonary edema and high-altitude cerebral edema Wilderness Environ Med 15 3 Fall 2004 198 201
38. R.L. Taber Protocols for the use of a portable hyperbaric chamber for the treatment of high altitude disorders J Wilderness Med 1 1990 181 192
39. J.A. Robertson, and D.R. Shlim Treatment of moderate acute mountain sickness with pressurization in a portable hyperbaric (Gamow™) bag J Wilderness Med 2 1991 268 273
40. C.K. Grissom, R.C. Roach, F.H. Sarnquist, and P.H. Hackett Acetazolamide in the treatment of acute mountain sickness: clinical efficacy and effect on gas exchange Ann Intern Med 116 6 Mar 15 1992 461 465
41. B. Basnyat, J.H. Gertsch, E.W. Johnson, F. Castro-Marin, Y. Inoue, and C. Yeh Efficacy of low-dose acetazolamide (125 mg BID) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial High Alt Med Biol 4 1 Spring 2003 45 52
42. B. Basnyat, J.H. Gertsch, P.S. Holck, E.W. Johnson, A.M. Luks, and B.P. Donha et al. Acetazolamide 125 mg BD is not significantly different from 375 mg BD in the prevention of acute mountain sickness: the prophylactic acetazolamide dosage comparison for efficacy (PACE) trial High Alt Med Biol 7 1 Spring 2006 17 27
43. M.C. van Patot, G. Leadbetter, L.E. Keyes, K.M. Maakestad, S. Olson, and P.H. Hackett Prophylactic low-dose acetazolamide reduces the incidence and severity of acute mountain sickness High Alt Med Biol 9 4 Winter 2008 289 293
44. L. Dumont, C. Mardirosoff, and M.R. Tramer Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review BMJ 321 7256 Jul 29 2000 267 272
45. S.C. Zell, and P.H. Goodman Acetazolamide and dexamethasone in the prevention of acute mountain sickness West J Med 148 5 May 1988 541 545
46. K. Zafren Prophylaxis for acute mountain sickness Ann Emerg Med 60 5 Nov 2012 671 [author reply 672]
47. N.D. Ritchie, A.V. Baggott, and W.T. Andrew Todd Acetazolamide for the prevention of acute mountain sickness - a systematic review and meta-analysis J Travel Med 19 5 Sep-Oct 2012 298 307
48. B. Kayser, L. Dumont, C. Lysakowski, C. Combescure, G. Haller, and M.R. Tramer Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis High Alt Med Biol 13 2 Jun 2012 82 92
49. E.V. Low, A.J. Avery, V. Gupta, A. Schedlbauer, and M.P. Grocott Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness: systematic review and meta-analysis BMJ 345 2012 e6779
50. A.M. Luks, and E.R. Swenson Medication and dosage considerations in the prophylaxis and treatment of high-altitude illness Chest 133 3 Mar 2008 744 755
51. A.J. Ellsworth, E.B. Larson, and D. Strickland A randomized trial of dexamethasone and acetazolamide for acute mountain sickness prophylaxis Am J Med 83 6 Dec 1987 1024 1030
52. A.J. Ellsworth, E.F. Meyer, and E.B. Larson Acetazolamide or dexamethasone use versus placebo to prevent acute mountain sickness on Mount Rainier West J Med 154 3 Mar 1991 289 293
53. B.D. Levine, K. Yoshimura, T. Kobayashi, M. Fukushima, T. Shibamoto, and G. Ueda Dexamethasone in the treatment of acute mountain sickness N Engl J Med 321 25 Dec 21 1989 1707 1713
54. P.B. Rock, T.S. Johnson, R.F. Larsen, C.S. Fulco, L.A. Trad, and A. Cymerman Dexamethasone as prophylaxis for acute mountain sickness. Effect of dose level Chest 95 3 Mar 1989 568 573
55. P.H. Hackett, R.C. Roach, R.A. Wood, R.G. Foutch, R.T. Meehan, and D. Rennie et al. Dexamethasone for prevention and treatment of acute mountain sickness Aviat Space Environ Med 59 10 Oct 1988 950 954
56. P.B. Rock, T.S. Johnson, A. Cymerman, R.L. Burse, L.J. Falk, and C.S. Fulco Effect of dexamethasone on symptoms of acute mountain sickness at Pikes Peak, Colorado (4,300 m) Aviat Space Environ Med 58 7 Jul 1987 668 672
57. B.A. Beidleman, S.R. Muza, C.S. Fulco, A. Cymerman, D. Ditzler, and D. Stulz et al. Intermittent altitude exposures reduce acute mountain sickness at 4300 m Clin Sci (Lond) 106 3 Mar 2004 321 328
58. R.L. Burse, and V.A. Forte Jr. Acute mountain sickness at 4500 m is not altered by repeated eight-hour exposures to 3200-3550 m normobaric hypoxic equivalent Aviat Space Environ Med 59 10 Oct 1988 942 949
59. C.S. Fulco, S.R. Muza, B.A. Beidleman, B.A. Beidleman, R. Demes, and J.E. Staab et al. Effect of repeated normobaric hypoxia exposures during sleep on acute mountain sickness, exercise performance, and sleep during exposure to terrestrial altitude Am J Physiol Regul Integr Comp Physiol 300 2 Feb 2011 R428 R436
60. K. Schommer, N. Wiesegart, E. Menold, U. Haas, K. Lahr, and H. Buhl et al. Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m High Alt Med Biol 11 1 Spring 2010 19 25
61. B. Basnyat, J. Lemaster, and J.A. Litch Everest or bust: a cross sectional, epidemiological study of acute mountain sickness at 4243 meters in the Himalayas Aviat Space Environ Med 70 9 Sep 1999 867 873
62. T.A. Cumbo, B. Basnyat, J. Graham, A.G. Lescano, and S. Gambert Acute mountain sickness, dehydration, and bicarbonate clearance: preliminary field data from the Nepal Himalaya Aviat Space Environ Med 73 9 Sep 2002 898 901
63. G.S. Lipman, N.C. Kanaan, P.S. Holck, B.B. Constance, and J.H. Gertsch Ibuprofen prevents altitude illness: a randomized controlled trial for prevention of altitude illness with nonsteroidal anti-inflammatories Ann Emerg Med 59 6 Jun 2012 484 490
64. J.H. Gertsch, G.S. Lipman, P.S. Holck, A. Merritt, A. Mulcahy, and R.S. Fisher et al. Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT) Wilderness Environ Med 21 3 Sep 2010 236 243
65. G. Leadbetter, L.E. Keyes, K.M. Maakestad, S. Olson, M.C. Tissot van Patot, and P.H. Hackett Ginkgo biloba does - and does not - prevent acute mountain sickness Wilderness Environ Med 20 1 Spring 2009 66 71
66. J.H. Gertsch, T.B. Seto, J. Mor, and J. Onopa Ginkgo biloba for the prevention of severe acute mountain sickness (AMS) starting one day before rapid ascent High Alt Med Biol 3 1 Spring 2002 29 37
67. J.P. Roncin, F. Schwartz, and P. D'Arbigny EGb 761 in control of acute mountain sickness and vascular reactivity to cold exposure Aviat Space Environ Med 67 5 May 1996 445 452
68. F.A. Moraga, A. Flores, J. Serra, C. Esnaola, and C. Barriento Ginkgo biloba decreases acute mountain sickness in people ascending to high altitude at Ollague (3696 m) in northern Chile Wilderness Environ Med 18 4 Winter 2007 251 257
69. T. Chow, V. Browne, H.L. Heileson, D. Wallace, J. Anholm, and S.M. Green Ginkgo biloba and acetazolamide prophylaxis for acute mountain sickness: a randomized, placebo-controlled trial Arch Intern Med 165 3 Feb 14 2005 296 301
70. J.H. Gertsch, B. Basnyat, E.W. Johnson, J. Onopa, and P.S. Holck Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT) BMJ 328 7443 Apr 3 2004 797
71. S. Jafarian, F. Gorouhi, S. Salimi, and J. Lotfi Sumatriptan for prevention of acute mountain sickness: randomized clinical trial Ann Neurol 62 3 Sep 2007 273 277
72. S. Jafarian, R. Abolfazli, F. Gorouhi, S. Rezaie, and J. Lotfi Gabapentin for prevention of hypobaric hypoxia-induced headache: randomized double-blind clinical trial J Neurol Neurosurg Psychiatry 79 3 Mar 2008 321 323
73. R.T. Meehan, A. Cymerman, P. Rock, C.S. Fulco, J. Hoffman, and C. Abernathy et al. The effect of naproxen on acute mountain sickness and vascular responses to hypoxia Am J Med Sci 292 1 Jul 1986 15 20
74. S.C. Jain, M.V. Singh, V.M. Sharma, S.B. Rawal, and A.K. Tyagi Amelioration of acute mountain sickness: comparative study of acetazolamide and spironolactone Int J Biometeorol 30 4 Dec 1986 293 300
75. R.F. Larsen, P.B. Rock, C.S. Fulco, B. Edelman, A.J. Young, and A. Cymerman Effect of spironolactone on acute mountain sickness Aviat Space Environ Med 57 6 Jun 1986 543 547
76. B. Basnyat, P.S. Holck, M. Pun, S. Halverson, P. Szawarski, and J. Gertsch et al. Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group) Wilderness Environ Med 22 1 Mar 2011 15 22
77. R.C. Roach, E.B. Larson, T.F. Hornbein, C.S. Houston, S. Bartlett, and J. Hardesty et al. Acute mountain sickness, antacids, and ventilation during rapid, active ascent of Mount Rainier Aviat Space Environ Med 54 5 May 1983 397 401
78. L. Dumont, C. Lysakowski, M.R. Tramer, J.D. Junod, C. Mardirosoff, and E. Tassony et al. Magnesium for the prevention and treatment of acute mountain sickness Clin Sci (Lond) 106 3 Mar 2004 269 277
79. E. Hohenhaus, F. Niroomand, S. Goerre, P. Vock, O. Oelz, and P. Bartsch Nifedipine does not prevent acute mountain sickness Am J Respir Crit Care Med 150 3 Sep 1994 857 860
80. A.D. Wright, M.F. Beazley, A.R. Bradwell, I.M. Chesner, R.N. Clayton, and P.J. Forster et al. Medroxyprogesterone at high altitude. The effects on blood gases, cerebral regional oxygenation, and acute mountain sickness Wilderness Environ Med 15 1 Spring 2004 25 31
81. J.K. Baillie, A.A. Thompson, J.B. Irving, M.G. Bates, A.I. Sutherland, and W. Macnee et al. Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial QJM 102 5 May 2009 341 348
82. I. Singh, C.C. Kapila, P.K. Khanna, R.B. Nanda, and B.D. Rao High-altitude pulmonary oedema Lancet 1 7379 Jan 30 1965 229 234
83. P.H. Hackett, D. Rennie, and H.D. Levine The incidence, importance, and prophylaxis of acute mountain sickness Lancet 2 7996 Nov 27 1976 1149 1155
84. P. Bartsch, M. Maggiorini, M. Ritter, C. Noti, P. Vock, and O. Oelz Prevention of high-altitude pulmonary edema by nifedipine N Engl J Med 325 18 Oct 31 1991 1284 1289
85. C. Sartori, Y. Allemann, H. Duplain, M. Lepori, M. Egli, and E. Lipp et al. Salmeterol for the prevention of high-altitude pulmonary edema N Engl J Med 346 21 May 23 2002 1631 1636
86. M. Maggiorini, H.P. Brunner-La Rocca, S. Peth, M. Fischler, T. Bohm, and A. Bernheim et al. Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema: a randomized trial Ann Intern Med 145 7 Oct 3 2006 497 506
87. C. Hohne, M.O. Krebs, M. Seiferheld, W. Boemke, G. Kaczmarczyk, and E.R. Swenson Acetazolamide prevents hypoxic pulmonary vasoconstriction in conscious dogs J Appl Physiol 97 2 Aug 2004 515 521
88. L.A. Shimoda, T. Luke, J.T. Sylvester, H.W. Shih, A. Jain, and E.R. Swenson Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition Am J Physiol Lung Cell Mol Physiol 292 4 Apr 2007 L1002 L1012
89. L.J. Teppema, G.M. Balanos, C.D. Steinback, A.D. Brown, G.E. Foster, and J. Duff et al. Effects of acetazolamide on ventilatory, cerebrovascular, and pulmonary vascular responses to hypoxia Am J Respir Crit Care Med 175 3 Feb 1 2007 277 281
90. B. Basnyat, J. Hargrove, P.S. Holck, S. Srivastav, K. Alekh, and L.V. Ghimire et al. Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans High Alt Med Biol 9 3 Fall 2008 209 216
91. P.H. Hackett, R.C. Roach, G.L. Harrison, R.B. Schoene, and W.J. Mills Jr. Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine versus acetazolamide Am Rev Respir Dis 135 4 Apr 1987 896 898
92. H. Wickramasinghe, and J.D. Anholm Sleep and breathing at high altitude Sleep Breath 3 3 1999 89 102
93. M. Beaumont, D. Batejat, C. Pierard, P. Van Beers, M. Phillipe, and D. Leger et al. Zaleplon and zolpidem objectively alleviate sleep disturbances in mountaineers at a 3,613 meter altitude Sleep 30 11 Nov 1 2007 1527 1533
94. J.C. Jouanin, C. Dussault, P. Van Beers, C. Pierard, and M. Beaumont Short half-life hypnotics preserve physical fitness and altitude tolerance during military mountainous training Mil Med 174 9 Sep 2009 964 970
95. A.H. Nickol, J. Leverment, P. Richards, P. Seal, G.A. Harris, and J. Cleland et al. Temazepam at high altitude reduces periodic breathing without impairing next-day performance: a randomized cross-over double-blind study J Sleep Res 15 4 Dec 2006 445 454
96. J.B. Tanner, S.M. Tanner, G.B. Thapa, Y. Chang, K.L. Watson, and E. Staunton et al. A randomized trial of temazepam versus acetazolamide in high altitude sleep disturbance High Alt Med Biol 14 3 Sep 2013 234 239
97. A.J. Pollard, S. Niermeyer, P. Barry, P. Bärtsch, F. Berghold, and R.A. Bishop et al. Children at high altitude: an international consensus statement by an ad hoc committee of the International Society for Mountain Medicine, March 12, 2001 High Alt Med Biol 2 3 Fall 2001 389 403
98. M. Yaron, and S. Niermeyer Travel to high altitude with young children: an approach for clinicians High Alt Med Biol 9 4 Winter 2008 265 269
99. S. Niermeyer The pregnant altitude visitor Adv Exp Med Biol 474 1999 65 77
100. D. Jean, C. Leal, S. Kriemler, H. Meijer, and L.G. Moore Medical recommendations for women going to altitude High Alt Med Biol 6 1 Spring 2005 22 31
101. D. Jean, and L.G. Moore Travel to high altitude during pregnancy: frequently asked questions and recommendations for clinicians High Alt Med Biol 13 2 Jun 2012 73 81
102. R.C. Roach, C.S. Houston, B. Honigman, R.A. Nicholas, M. Yaron, and C. Grissom et al. How well do older persons tolerate moderate altitude? West J Med 162 1 Jan 1995 32 36
103. K. Mieske, G. Flaherty, and T. O'Brien Journeys to high altitude - risks and recommendations for travelers with preexisting medical conditions J Travel Med 17 1 Jan-Feb 2010 48 62
104. T.Y. Wu, S.Q. Ding, J.L. Liu, M.T. Yu, J.H. Jia, and Z.C. Chai et al. Who should not go high: chronic disease and work at altitude during construction of the Qinghai-Tibet railroad High Alt Med Biol 8 2 Summer 2007 88 107
105. A. Lockhart, and B. Saiag Altitude and the human pulmonary circulation Clin Sci (Lond) 60 6 Jun 1981 599 605
106. A.M. Luks, and E.R. Swenson Travel to high altitude with pre-existing lung disease Eur Respir J 29 4 Apr 2007 770 792
107. A.M. Luks, K. Stout, and E.R. Swenson Evaluating the safety of high-altitude travel in patients with adult congenital heart disease Congenit Heart Dis 5 3 May-Jun 2010 220 232
108. R.W. Baumgartner, A.M. Siegel, and P.H. Hackett Going high with preexisting neurological conditions High Alt Med Biol 8 2 Summer 2007 108 116
109. A.M. Luks, R.J. Johnson, and E.R. Swenson Chronic kidney disease at high altitude J Am Soc Nephrol 19 12 Dec 2008 2262 2271
110. B.H. Subedi, J. Pokharel, T.L. Goodman, S. Amatya, L. Freer, and N. Banskota et al. Complications of steroid use on Mt. Everest Wilderness Environ Med 21 4 Dec 2010 345 348