Ibuprofen prevents altitude illness: A randomized controlled trial for prevention of altitude illness with nonsteroidal anti-inflammatories

Annals of Emergency Medicine

Volumn 59, Issue 6, 2012, Pages 484-490

  Lipman, Grant S ^a   Kanaan, Nicholas C ^a   Holck, Peter S ^b   Constance, Benjamin B ^a   Gertsch, Jeffrey H ^c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; PLACEBO;

ADULT; ALTITUDE DISEASE; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; MORBIDITY; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RISK; SYMPTOM; TREATMENT OUTCOME; UNITED STATES;

ADULT; ALTITUDE SICKNESS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IBUPROFEN; MALE; QUESTIONNAIRES; TREATMENT OUTCOME;

EID: 84861529922     PISSN: 01960644     EISSN: 10976760     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2012.01.019     Document Type: Article

References (60)

1. R.C. Roach, P. Bartsch, O. Oelz Lake Louise AMS Scoring Consensus Committee The Lake Louise acute mountain sickness scoring system J.R. Sutton, C.S. Houston, G. Coates, Hypoxia and Molecular Medicine 1993 Queens City Printers Burlington, VT 272 274
2. M. Maggiorini, P. Bartsch, O. Oelz Association between raised body temperature and acute mountain sickness: cross sectional study BMJ 315 1997 403 404
3. B. Honigman, M.K. Theis, J. Koziol-McLain Acute mountain sickness in a general tourist population at moderate altitudes Ann Intern Med 118 1993 587 592
4. D.R. Murdoch Altitude illness among tourists flying to 3740 meters elevation in the Nepal Himalayas J Travel Med 2 1995 255 256
5. J.H. Gertsch, B. Basnyat, E.W. Johnson Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the Prevention of High Altitude Illness Trial (PHAIT) BMJ 328 2004 797
6. D.R. Wagner, K. D'Zatko, K. Tatsugawa Mt. Whitney: determinants of summit success and acute mountain sickness Med Sci Sports Exerc 40 2008 1820 1827
7. P.H. Hackett, R.C. Roach High-altitude illness N Engl J Med 345 2001 107 114
8. R.C. Roach, P.H. Hackett Frontiers of hypoxia research: acute mountain sickness J Exp Biol 204 pt 18 2001 3161 3170
9. S.S. Purkayastha, U.S. Ray, B.S. Arora Acclimatization at high altitude in gradual and acute induction J Appl Physiol 79 1995 487 492
10. B.A. Beidleman, C.S. Fulco, S.R. Muza Effect of six days of staging on physiologic adjustments and acute mountain sickness during ascent to 4300 meters High Alt Med Biol 10 2009 253 260
11. J.P. Richalet, A. Hornych, C. Rathat Plasma prostaglandins, leukotrienes and thromboxane in acute high altitude hypoxia Respir Physiol 85 1991 205 215
12. M.C. Tissot van Patot, G. Leadbetter, L.E. Keyes Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness J Appl Physiol 98 2005 1626 1629
13. A.B. Montgomery, J.M. Luce, P. Michael Effects of dexamethasone on the incidence of acute mountain sickness at two intermediate altitudes JAMA 261 1989 734 736
14. P.B. Rock, T.S. Johnson, R.F. Larsen Dexamethasone as prophylaxis for acute mountain sickness Effect of dose level Chest 95 1989 568 573
15. T.S. Johnson, P.B. Rock, C.S. Fulco Prevention of acute mountain sickness by dexamethasone N Engl J Med 310 1984 683 686
16. G. Ferrazzini, M. Maggiorini, S. Kriemler Successful treatment of acute mountain sickness with dexamethasone Br Med J (Clin Res Ed) 294 1987 1380 1382
17. P.H. Hackett, R.C. Roach, R.A. Wood Dexamethasone for prevention and treatment of acute mountain sickness Aviat Space Environ Med 59 1988 950 954
18. H.R. Keller, M. Maggiorini, P. Bartsch Simulated descent v dexamethasone in treatment of acute mountain sickness: a randomised trial BMJ 310 1995 1232 1235
19. B.D. Levine, K. Yoshimura, T. Kobayashi Dexamethasone in the treatment of acute mountain sickness N Engl J Med 321 1989 1707 1713
20. C.J. Ray, M.R. Abbas, A.M. Coney Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies J Physiol 544 pt 1 2002 195 209
21. R.T. Meehan, A. Cymerman, P. Rock The effect of naproxen on acute mountain sickness and vascular responses to hypoxia Am J Med Sci 292 1986 15 20
22. B. Kayser, R. Hulsebosch, F. Bosch Low-dose acetylsalicylic acid analog and acetazolamide for prevention of acute mountain sickness High Alt Med Biol 9 2008 15 23
23. M. Burtscher, R. Likar, W. Nachbauer Ibuprofen versus sumatriptan for high-altitude headache Lancet 346 1995 254 255
24. J.H. Gertsch, G.S. Lipman, P.S. Holck Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT) Wilderness Environ Med 21 2010 236 243
25. Albin K, Kanaan N, Goodblatt M, et al. Surveying physiological factors associated with acute mountain sickness on White Mountain Peak. Presented at: 16th International Hypoxia Symposium; March 10, 2009, Alberta, Canada.
26. R: A Language and Environment for Statistical Computing [computer program] 2010 R Foundation for Statistical Computing Vienna, Austria
27. A.M. Luks, S.E. McIntosh, C.K. Grissom Wilderness Medical Society consensus guidelines for the prevention and treatment of acute altitude illness Wilderness Environ Med 21 2010 146 155
28. M.C. Tissot van Patot, G. Leadbetter 3rd, L.E. Keyes Prophylactic low-dose acetazolamide reduces the incidence and severity of acute mountain sickness High Alt Med Biol 9 2008 289 293
29. B. Basnyat, D.R. Murdoch High-altitude illness Lancet 361 2003 1967 1974
30. L. Dumont, C. Mardirosoff, M.R. Tramer Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review BMJ 321 2000 267 272
31. J.W. Severinghaus Sightings: Diamox debate High Alt Med Biol 2 2001 9
32. P. Bartsch, M. Schneider Same ascent rates must be used to assess effectiveness of different doses of acetazolamide BMJ 322 2001 48
33. S.M. Fishman, J.C. Ballantyne, J.P. Rathmell Bonica's Management of Pain 4th ed. 2009 Lippincott Williams & Wilkins Philadelphia, PA
34. Motrin, ibuprofen [package insert] 1999 Pharmacia & Upjohn Co Kalamazoo, MI
35. B. Schimmer, K. Parker Toxicity of Adrenocortical Steroids 10th ed. 2001 McGraw Hill New York, NY
36. B.H. Subedi, J. Pokharel, T.L. Goodman Complications of steroid use on Mt. Everest Wilderness Environ Med 21 2010 345 348
37. P.H. Hackett, D. Rennie, H.D. Levine The incidence, importance, and prophylaxis of acute mountain sickness Lancet 2 1976 1149 1155
38. A.J. Ellsworth, E.B. Larson, D. Strickland A randomized trial of dexamethasone and acetazolamide for acute mountain sickness prophylaxis Am J Med 83 1987 1024 1030
39. J.B. Jensen, A.D. Wright, N.A. Lassen Cerebral blood flow in acute mountain sickness J Appl Physiol 69 1990 430 433
40. D.J. Dubowitz, E.A. Dyer, R.J. Theilmann Early brain swelling in acute hypoxia J Appl Physiol 107 2009 244 252
41. R.W. Baumgartner, P. Bartsch, M. Maggiorini Enhanced cerebral blood flow in acute mountain sickness Aviat Space Environ Med 65 1994 726 729
42. S.Y. Huang, L.G. Moore, R.E. McCullough Internal carotid and vertebral arterial flow velocity in men at high altitude J Appl Physiol 63 1987 395 400
43. S.M. Otis, M.E. Rossman, P.A. Schneider Relationship of cerebral blood flow regulation to acute mountain sickness J Ultrasound Med 8 1989 143 148
44. D.A. Dorward, A.A. Thompson, J.K. Baillie Change in plasma vascular endothelial growth factor during onset and recovery from acute mountain sickness Respir Med 101 2007 587 594
45. G.G. Schoonman, P.S. Sandor, A.C. Nirkko Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging study J Cereb Blood Flow Metab 28 2008 198 206
46. K. Kallenberg, D.M. Bailey, S. Christ Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness J Cereb Blood Flow Metab 27 2007 1064 1071
47. J.R. Sutton, N. Lassen Pathophysiology of acute mountain sickness and high altitude pulmonary oedema: an hypothesis Bull Eur Physiopathol Respir 15 1979 1045 1052
48. D.M. Bailey, P. Bartsch, M. Knauth Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological Cell Mol Life Sci 66 2009 3583 3594
49. T. Soejima, Y.L. Yamamoto, E. Meyer Protective effects of steroids on the corticomicrocirculation injured by cold J Neurosurg 51 1979 188 200
50. J.B. Long, J.W. Holaday Blood-brain barrier: endogenous modulation by adrenal-cortical function Science 227 1985 1580 1583
51. C.G. Julian, A.W. Subudhi, M.J. Wilson Acute mountain sickness, inflammation and permeability: new insights from a blood biomarker study J Appl Physiol 111 2011 392 399
52. M. Burtscher, R. Likar, W. Nachbauer Aspirin for prophylaxis against headache at high altitudes: randomised, double blind, placebo controlled trial BMJ 316 1998 1057 1058
53. M. Burtscher, R. Likar, W. Nachbauer Effects of aspirin during exercise on the incidence of high-altitude headache: a randomized, double-blind, placebo-controlled trial Headache 41 2001 542 545
54. A.M. Strassman, S.A. Raymond, R. Burstein Sensitization of meningeal sensory neurons and the origin of headaches Nature 384 1996 560 564
55. A.M. Strassman, D. Levy Response properties of dural nociceptors in relation to headache J Neurophysiol 95 2006 1298 1306
56. M. Sanchez Del Rio, M. Moskowitz High altitude headache: lessons from headaches at sea level Adv Exp Med Biol 474 1999 145 153
57. J.D. Anholm The VIIIth World Congress of High Altitude Medicine and Physiology High Alt Med Biol 11 2010 381 383
58. P. Bartsch, E.R. Swenson, A. Paul Hypoxic ventilatory response, ventilation, gas exchange, and fluid balance in acute mountain sickness High Alt Med Biol 3 2002 361 376
59. M. Basu, R.C. Sawhney, S. Kumar Glucocorticoids as prophylaxis against acute mountain sickness Clin Endocrinol (Oxf) 57 2002 761 767
60. A.W. Subudhi, A.C. Dimmen, C.G. Julian Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia J Appl Physiol 110 2011 1219 1225