Gabapentin for prevention of hypobaric hypoxia-induced headache: Randomized double-blind clinical trial

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 79, Issue 3, 2008, Pages 321-323

  Jafarian, Sirous ^a   Abolfazli, R ^b   Gorouhi, F ^a   Rezaie, S ^a   Lotfi, J ^c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

GABAPENTIN; PLACEBO;

ADOLESCENT; ADULT; AGED; ALTITUDE DISEASE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DIZZINESS; DRUG EFFICACY; FATIGUE; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; HYPOXIA; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PREVENTION AND CONTROL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; ALTITUDE SICKNESS; AMINES; ANOXIA; CYCLOHEXANECARBOXYLIC ACIDS; DISORDERS OF EXCESSIVE SOMNOLENCE; DOUBLE-BLIND METHOD; FEMALE; GAMMA-AMINOBUTYRIC ACID; HEADACHE; HUMANS; MALE; MIDDLE AGED;

EID: 39749134862     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2007.124727     Document Type: Article

References (18)

1. Hackett P, Roach RC. High altitude sickness. N Engl J Med 2001;345:107-14.
2. Honigman B, Theis MK, Koziol-McLain J, et al. Acute mountain sickness in a general tourist population at moderate altitudes. Ann Int Med 1993;118:587-92.
3. West JB. The physiologic basis of high-altitude diseases. Ann Int Med 2004;141:789-800.
4. Frediani F. Anticonvulsant drugs in primary headaches prophylaxis. Neurol Sci 2004;25:S161-6.
5. Cheng JK, Chiou LC. Mechanisms of the antinociceptive action of gabapentin. J Pharmacol Sci 2006;100:471-86.
6. Jafarian S, Gorouhi F, Salimi S, et al. Low-dose gabapentin in treatment of high-altitude headache. Cephalalgia 2007;27:1274- 7.
7. Roach RC, Bartsch P, Hackett PH. Hypoxia and molecular medicine. Burlington: Queen City Printers, 1993:272-4.
8. Silber E, Sonnenberg P, Collier DJ, et al. Clinical features of headache at altitude: a prospective study. Neurology 2003;60:1167-71.
9. Taylor CP, Gee NS, Su TZ, et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998;29:233- 49.
10. Hasnaoui RE, Launay T, Pichon A, et al. Role of EPO and NMDA receptors in ventilatory acclimatization to hypoxia in a model of anemic transgenic mice [abstract]. High Alt Med Biol 2006;7:326.
11. Petioff OA, Rothnan DL, Behan KL. The effect of gabapentin on brain gama-aminobutyric acid in patients with epilepsy. Ann Neurol 1996;39:95-9.
12. Dumont L, Mardirosoff C, Tramer MR. Efficacy and harm of pharmacological prevention of acute mountain sickness: guantitative systematic review. BMJ 2000;321:267-72.
13. Mathew NT, Rapoport A, Saper J, et al. Efficacy of gabapentin in migraine prophylaxis. Headache 2001;41:119-28.
14. Khan OA. Gabapentin relieves trigeminal neuralgia in multiple sclerosis patients. Neurology 1998;51:611-4.
15. Leandri M, Luzzani M, Cruccu G, et al. Drugresistant cluster headache responding to gabapentin: a pilot study. Cephalalgia 2001;21:744-6.
16. Mariano Da Silva H, Alcantara MC, Bordini CA, et al. Strictly unilateral headache reminiscent of hemicraniacontinua resistant to indomethacin but responsive to gabapentin. Cephalalgia 2002;22:409-10.
17. França MC Jr, Costa ALC, Maciel JA Jr. Gabapentin- responsive idiopathic stabbing headache. Cephalalgia 2004;24:993- 6.
18. Baillie JK, Power I. The mechanism of action of gabapentin in neuropathic pain. Curr Opin Investig Drugs 2006;7:33-9.