Ginkgo biloba and acetazolamide prophylaxis for acute mountain sickness: A randomized, placebo-controlled trial

Archives of Internal Medicine

Volumn 165, Issue 3, 2005, Pages 296-301

  Chow, Tony ^a   Browne, Vaughn ^a,c   Heileson, Heather L ^a,d   Wallace, Desiree ^a   Anholm, James ^b   Green, Steven M ^a  

^a LOMA LINDA UNIVERSITY MEDICAL CENTER   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d ROSE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; GINKGO BILOBA EXTRACT; PLACEBO;

ABDOMINAL DISTENSION; ACUTE DISEASE; ADULT; AGED; ALTITUDE; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; ARTHRALGIA; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DIARRHEA; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFECT; EAR DISEASE; EXCITEMENT; FEMALE; HEADACHE; HEART DISEASE; HUMAN; INCIDENCE; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; NERVOUSNESS; NOSE DISEASE; PARESTHESIA; PRIORITY JOURNAL; PROPHYLAXIS; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SIDE EFFECT; SMELLING DISORDER; SORE THROAT; SYMPTOM; SYNCOPE; TASTE DISORDER; TIME; URINARY FREQUENCY; URTICARIA; VERTIGO; XEROSTOMIA;

ACETAZOLAMIDE; ADULT; ALTITUDE SICKNESS; CARBONIC ANHYDRASE INHIBITORS; DOUBLE-BLIND METHOD; FEMALE; GINKGO BILOBA; HUMANS; MALE; MIDDLE AGED; PHYTOTHERAPY; PLANT PREPARATIONS; STATISTICS, NONPARAMETRIC;

EID: 13444300988     PISSN: 00039926     EISSN: None     Source Type: Journal    
DOI: 10.1001/archinte.165.3.296     Document Type: Article

References (23)

1. Hackett PH, Roach RC. High-altitude illness. N Engl J Med. 2001;345:107-114.
2. Montgomery AB, Mills J, Luce JM. Incidence of acute mountain sickness at intermediate altitude. JAMA. 1989;261:732-734.
3. Honigman B, Theis MK, Koziol-McLain J, et al. Acute mountain sickness in a general tourist population at moderate altitudes. Ann Intern Med. 1993;118:587-592.
4. Hackett PH, Rennie D, Levine HD. The incidence, importance and prophylaxis of acute mountain sickness. Lancet. 1976;2:1149-1155.
5. Zell SC, Goodman PH. Acetazolamide and dexamethasone in the prevention of acute mountain sickness. West J Med. 1988;148:541-545.
6. Sierpina VS, Wollschlaeger B, Blumenthal M. Ginkgo biloba. Am Fam Physician. 2003;68:923-926.
7. Roncin JP, Schwartz F, D'Arbigny P. EGb 761 in control of acute mountain sickness and vascular reactivity to cold exposure. Aviat Space Environ Med. 1996;67:445-452.
8. Maakestad K, Leadbetter G, Olson S, Hackett PH. Ginkgo biloba reduces incidence and severity of acute mountain sickness [abstract]. Wilderness Environ Med. 2001;12:51.
9. Gertsch JH, Seto TB, Mor J, Onopa J. Ginkgo biloba for the prevention of severe acute mountain sickness starting one day before rapid ascent. High Alt Med Biol. 2002;3:29-37.
10. Moraga F, Flores A, Zapata J, Ramos P, Madariaga M, Serra J. Ginkgo biloba decreases acute mountain sickness at 3700 m [abstract]. High Alt Med Biol. 2003;3:453.
11. Gertsch JH, Basnyat B, Johnson W, Onopa J. Randomised, double blind, placebo controlled comparison of Ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT). BMJ. 2004;328:797.
12. Leadbetter GW, Hackett P. Comparison of Ginkgo biloba, acetazolamide, and placebo for prevention of acute mountain sickness [abstract]. High Alt Med Biol. 2003;3:455.
13. Hackett PH, Roach RC. High altitude medicine. In: Auerbach PS, ed. Wilderness Medicine. 4th ed. St Louis, Mo: Mosby-Year Book Inc; 2001:2-43.
14. Roach RC, Bartsch P, Hackett PH, Oelz O. The Lake Louise Acute Mountain Sickness Scoring System. In: Sutton JR, Coates G, Houston CS, eds. Hypoxia and Molecular Medicine: Proceedings of the 8th International Hypoxia Symposium, Lake Louise, Alberta, Canada. Burlington, Vt: Queen City Printers; 1993:272-274.
15. Savourey G, Guinet A, Besnard Y, Garcia N, Hanniquet AM, Bittel J. Evaluation of the Lake Louise Acute Mountain Sickness Scoring System in a hypobaric chamber. Aviat Space Environ Med. 1995;66:963-967.
16. Maggiorini M, Muller A, Hofstetter D, Bartsch P, Oelz O. Assessment of acute mountain sickness by different score protocols in the Swiss Alps. Aviat Space Environ Med. 1998;69:1186-1192.
17. Ellsworth AJ, Meyer EF, Larson EB. Acetazolamide or dexamethasone use versus placebo to prevent acute mountain sickness on Mount Rainier. West J Med. 1991;154:289-293.
18. Daniel WW. Applied Nonparametric Statistics. Boston, Mass: PWS-Kent Publishing; 1990:97-101.
19. Ang-Lee MK, Moss J, Yuan C. Herbal medicines and perioperative care. JAMA. 2001;286:208-216.
20. De Smet P. Herbal remedies. N Engl J Med. 2002;347:2046-2056.
21. Gilroy CM, Steiner JF, Byers T, Shapiro H, Georgian W. Echinacea and truth in labeling. Arch Intern Med. 2003;163:699-704.
22. Kressmann S, Muller WE, Blume HH. Pharmaceutical quality of different Ginkgo biloba brands. J Pharm Pharmacol. 2002;54:661-669.
23. Blumenthal M, ed. The Complete German Commission E Monographs. Boston, Mass: Integrative Medicine Communications; 1998.