Effect of repeated normobaric hypoxia exposures during sleep on acute mountain sickness, exercise performance, and sleep during exposure to terrestrial altitude

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 2, 2011, Pages

  Fulco, Charles S ^a   Muza, Stephen R ^a   Beidleman, Beth A ^a   Demes, Robby ^a   Staab, Janet E ^a   Jones, Juli E ^a   Cymerman, Allen ^a  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

Arterial oxygen saturation; Hypobaric hypoxia; Physical performance; Ventilatory acclimatization

Indexed keywords

ADULT; ALTITUDE ACCLIMATIZATION; ARTICLE; BLOOD OXYGEN TENSION; CONTROLLED STUDY; END TIDAL CARBON DIOXIDE TENSION; EXERCISE; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOBARISM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEA LEVEL; SLEEP; TREADMILL;

ACCLIMATIZATION; ADULT; ALTITUDE; ALTITUDE SICKNESS; ANOXIA; ATMOSPHERIC PRESSURE; CARBON DIOXIDE; ERYTHROPOIETIN; EXERCISE; FEMALE; HEART RATE; HEMATOCRIT; HEMOGLOBINS; HUMANS; HYDROCORTISONE; MALE; NOREPINEPHRINE; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; PHYSICAL EXERTION; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; SLEEP; YOUNG ADULT;

EID: 79551565644     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00633.2010     Document Type: Article

References (28)

1. Beidleman BA, Fulco CS, Muza SR, Rock PB, Staab JE, Forte VA Jr, Brothers MD, Cymerman A. Effect of six days of staging on physiological adjustments and acute mountain sickness during ascent to 4,300 m. High Alt Med Biol 10: 253-260, 2009.
2. Beidleman BA, Muza SR, Fulco CS, Cymerman A, Ditzler D, Stulz D, Staab JE, Robinson SR, Skrinar GS, Lewis SF, Sawka MN. Intermittent altitude exposures improve muscular performance at 4,300 m. J Appl Physiol 95: 1824-1832, 2003.
3. Beidleman BA, Muza SR, Fulco CS, Cymerman A, Ditzler D, Stulz D, Staab JE, Skrinar GS, Lewis SF, Sawka MN. Intermittent altitude exposures reduce acute mountain sickness at 4300 m. Clin Sci (Lond) 106: 321-328, 2004.
4. Beidleman BA, Muza SR, Fulco CS, Cymerman A, Sawka MN, Lewis SF, Skrinar GS. Seven intermittent exposures to altitude improves exercise performance at 4300 m. Med Sci Sports Exerc 40: 141-148, 2008.
5. Beidleman BA, Muza SR, Fulco CS, Jones JE, Lammi E, Staab JE, Cymerman A. Intermittent hypoxic exposure does not improve endurance performance at altitude. Med Sci Sports Exerc 41: 1317-1325, 2009.
6. Beidleman BA, Muza SR, Fulco CS, Rock PB, Cymerman A. Validation of a shortened electronic version of the environmental symptoms questionnaire. High Alt Med Biol 8: 192-199, 2007.
7. Bisgard GE, Forster HV. Ventilatory responses to acute and chronic hypoxia. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 4, p. 1207-1239.
8. Borg GAV. Psychophysical basis of perceived exertion. Med Sci Sports Exerc 14: 377-381, 1982.
9. Burgess KR, Johnson P, Edwards N, Cooper J. Acute mountain sickness is associated with sleep desaturation at high altitude. Respirology 9: 485-492, 2004.
10. Conkin J, Wessel JH. Critique of the equivalent air altitude model. Aviat Space Environ Med 79: 975-982, 2008.
11. Fulco CS, Kambis KW, Friedlander AL, Rock PB, Muza SR, Cymerman A. Carbohydrate supplementation improves time-trial cycle performance during energy deficit at 4,300 m altitude. J Appl Physiol 99: 867-876, 2005.
12. Fulco CS, Muza SR, Beidleman BA, Jones J, Staab J, Rock PB, Cymerman A. Exercise performance of sea-level residents at 4300 m after 6 days at 2200 m. Aviat Space Environ Med 80: 955-961, 2009.
13. Ge RL, Witkowski S, Zhang Y, Alfrey C, Sivieri M, Karlsen T, Resaland GK, Harber M, Stray-Gundersen J, Levine BD. Determinants of erythropoietin release in response to short-term hypobaric hypoxia. J Appl Physiol 92: 2361-2367, 2002.
14. Hackett PH, Roach RC. High-altitude illness. N Engl J Med 345: 107-114, 2001.
15. Jeukendrup A, Saris WHM, Brouns F, Kester ADM. A new validated endurance performance test. Med Sci Sports Exerc 28: 266-270, 1996.
16. Jones JE, Muza SR, Fulco CS, Beidleman BA, Tapia M, Cymerman A. Intermittent hypoxic exposures do not improve sleep at 4300 m. High Alt Med Biol 9: 281-287, 2008.
17. Katayama K, Fujita H, Sato K, Ishida K, Iwasaki Ki, Miyamura M. Effect of repeated series of intermittent hypoxic exposures on ventilatory response in humans. High Alt Med Biol 6: 50-59, 2005.
18. 2 during hypoxic exercise and hypoxic chemosensitivity. J Appl Physiol 90: 1431-1440, 2001.
19. Klausen T, Poulsen TD, Fogh-Andersen N, Richalet JP, Nielsen OJ, Olsen NV. Diurnal variations of serum erythropoietin at sea level and altitude. Eur J Appl Physiol Occup Physiol 72: 297-302, 1996.
20. Kolb JC, Ainslie PN, Ide K, Poulin MJ. Effects of five consecutive nocturnal hypoxic exposures on the cerebrovascular responses to acute hypoxia and hypercapnia in humans. J Appl Physiol 96: 1745-1754, 2004.
21. Mazzeo RS, Fulco CS. Physiological systems and their responses with exposure to hypoxia. In: ACSM's Advanced Exercise Physiology, edited by Tipton C. Philadelphia, PA: Lippincott Williams & Wilkins, 2006, p. 564-580.
22. Muza SR. Military applications of hypoxic training for high altitude operations. Med Sci Sports Exerc 39: 1625-1631, 2007.
23. Muza SR, Rock PB, Fulco CS, Zamudio S, Braun B, Cymerman A, Butterfield GE, Moore LG. Women at altitude: ventilatory acclimatization at 4,300 m. J Appl Physiol 91: 1791-1799, 2001.
24. Reeves JT, McCullough RE, Moore LG, Cymerman A, Weil JV. Sea-level PCO2 relates to ventilatory acclimatization at 4,300 m. J Appl Physiol 75: 1117-1122, 1993.
25. Savourey G, Garcia N, Caravel JP, Gharib C, Pouzeratte N, Martin S, Bittel J. Pre-adaptation, adaptation and de-adaptation to high altitude in humans: hormonal and biochemical changes at sea level. Eur J Appl Physiol 77: 37-43, 1998.
26. Savourey G, Launay JC, Besnard Y, Guinet A, Travers S. Normo- and hypobaric hypoxia: are there any physiological differences? Eur J Appl Physiol 89: 122-126, 2003.
27. Schommer K, Wiesegart N, Menold E, Haas U, Lahr K, Burl H, Bartsch P, Dehert C. Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559 m. High Alt Med Biol 11: 19-25, 2010.
28. Young AJ, Reeves JL. Human adaptation to high terrestrial altitude. In: Medical Aspects of Harsh Environments, edited by Lounsbury DE, Bellamy RF, Zajtchuk R. Washington, DC: Office of the Surgeon General, Borden Institute, 2002, p. 647-691.