메뉴 건너뛰기




Volumn 102, Issue 5, 2009, Pages 341-348

Oral antioxidant supplementation does not prevent acute mountain sickness: Double blind, randomized placebo-controlled trial

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; PLACEBO; SILDENAFIL; THIOCTIC ACID;

EID: 65449175766     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcp026     Document Type: Article
Times cited : (87)

References (44)
  • 1
    • 0013940601 scopus 로고
    • Cerebral blood flow in man at high altitude. Role of cerebrospinal fluid pH in normalization of flow in chronic hypocapnia
    • Severinghaus JW, Chiodi H, Eger EI, Brandstater B, Hornbein TF. Cerebral blood flow in man at high altitude. Role of cerebrospinal fluid pH in normalization of flow in chronic hypocapnia. Circ Res 1966; 19 274-82.
    • (1966) Circ Res , vol.19 , pp. 274-282
    • Severinghaus, J.W.1    Chiodi, H.2    Eger, E.I.3    Brandstater, B.4    Hornbein, T.F.5
  • 3
    • 0016805468 scopus 로고
    • Cerebral form of high-altitude illness
    • Houston CS, Dickinson J. Cerebral form of high-altitude illness. Lancet 1975; 2:758-61.
    • (1975) Lancet , vol.2 , pp. 758-761
    • Houston, C.S.1    Dickinson, J.2
  • 4
    • 41349105527 scopus 로고    scopus 로고
    • Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: A longitudinal cohort study
    • Sutherland AI, Morris DS, Owen CG, Bron AJ, Roach RC. Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: A longitudinal cohort study. Br J Sports Med 2008; 42 183-8.
    • (2008) Br J Sports Med , vol.42 , pp. 183-188
    • Sutherland, A.I.1    Morris, D.S.2    Owen, C.G.3    Bron, A.J.4    Roach, R.C.5
  • 5
    • 0032501354 scopus 로고    scopus 로고
    • High-altitude cerebral edema evaluated with magnetic resonance imaging: Clinical correlation and patho-physiology
    • Hackett PH, Yarnell PR, Hill R, Reynard K, Heit J, McCormick J. High-altitude cerebral edema evaluated with magnetic resonance imaging: clinical correlation and patho-physiology. JAMA 1998; 280 1920-5.
    • (1998) JAMA , vol.280 , pp. 1920-1925
    • Hackett, P.H.1    Yarnell, P.R.2    Hill, R.3    Reynard, K.4    Heit, J.5    McCormick, J.6
  • 6
    • 0024987155 scopus 로고
    • Pathogenesis of vasogenic edema in focal cerebral ischemia. Role of superoxide radicals
    • Chan PH, Fishman RA, Wesley MA, Longar S. Pathogenesis of vasogenic edema in focal cerebral ischemia. Role of superoxide radicals. Adv Neurol 1990; 52:177-83.
    • (1990) Adv Neurol , vol.52 , pp. 177-183
    • Chan, P.H.1    Fishman, R.A.2    Wesley, M.A.3    Longar, S.4
  • 7
    • 0030797118 scopus 로고    scopus 로고
    • Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin-dependent diabetes mellitus
    • Maxwell SR, Thomason H, Sandler D, LeGuen C, Baxter MA, Thorpe GH, et al. Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin-dependent diabetes mellitus. Eur J Clin Invest 1997; 27:484-90.
    • (1997) Eur J Clin Invest , vol.27 , pp. 484-490
    • Maxwell, S.R.1    Thomason, H.2    Sandler, D.3    LeGuen, C.4    Baxter, M.A.5    Thorpe, G.H.6
  • 8
    • 34248566913 scopus 로고    scopus 로고
    • Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude
    • Baillie JK, Bates MG, Thompson AA, Waring WS, Partridge RW, Schnopp MF, et al. Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude. Chest 2007; 131:1473-8.
    • (2007) Chest , vol.131 , pp. 1473-1478
    • Baillie, J.K.1    Bates, M.G.2    Thompson, A.A.3    Waring, W.S.4    Partridge, R.W.5    Schnopp, M.F.6
  • 9
    • 0034038044 scopus 로고    scopus 로고
    • Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood- CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis
    • Hooper DC, Scott GS, Zborek A, Mikheeva T, Kean RB, Koprowski H, et al. Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood- CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis. FASEB J 2000; 14:691-8.
    • (2000) FASEB J , vol.14 , pp. 691-698
    • Hooper, D.C.1    Scott, G.S.2    Zborek, A.3    Mikheeva, T.4    Kean, R.B.5    Koprowski, H.6
  • 10
    • 0025988702 scopus 로고
    • Prevention of high-altitude pulmonary edema by nifedipine [see comments]
    • Bartsch P, Maggiorini M, Ritter M, Noti C, Vock P, Oelz O. Prevention of high-altitude pulmonary edema by nifedipine [see comments]. N Engl J Med 1991; 325:1284-9.
    • (1991) N Engl J Med , vol.325 , pp. 1284-1289
    • Bartsch, P.1    Maggiorini, M.2    Ritter, M.3    Noti, C.4    Vock, P.5    Oelz, O.6
  • 11
    • 0035942152 scopus 로고    scopus 로고
    • High-altitude pulmonary edema is initially caused by an increase in capillary pressure
    • Maggiorini M, Melot C, Pierre S, Pfeiffer F, Greve I, Sartori C, et al. High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 2001; 103:2078-83.
    • (2001) Circulation , vol.103 , pp. 2078-2083
    • Maggiorini, M.1    Melot, C.2    Pierre, S.3    Pfeiffer, F.4    Greve, I.5    Sartori, C.6
  • 12
    • 0036569777 scopus 로고    scopus 로고
    • Pathogenesis of high-altitude pulmonary edema: Inflammation is not an etiologic factor
    • Swenson ER, Maggiorini M, Mongovin S, Gibbs JS, Greve I, Mairbaurl H, et al. Pathogenesis of high-altitude pulmonary edema: Inflammation is not an etiologic factor. JAMA 2002; 287:2228-35.
    • (2002) JAMA , vol.287 , pp. 2228-2235
    • Swenson, E.R.1    Maggiorini, M.2    Mongovin, S.3    Gibbs, J.S.4    Greve, I.5    Mairbaurl, H.6
  • 15
    • 0029930628 scopus 로고    scopus 로고
    • Production of superoxide from hemoglobin-bound oxygen under hypoxic conditions
    • Balagopalakrishna C, Manoharan PT, Abugo OO, Rifkind JM. Production of superoxide from hemoglobin-bound oxygen under hypoxic conditions. Biochemistry 1996; 35:6393-8.
    • (1996) Biochemistry , vol.35 , pp. 6393-6398
    • Balagopalakrishna, C.1    Manoharan, P.T.2    Abugo, O.O.3    Rifkind, J.M.4
  • 16
    • 0035100461 scopus 로고    scopus 로고
    • Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia
    • Hoshikawa Y, Ono S, Suzuki S, Tanita T, Chida M, Song C, et al. Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J Appl Physiol 2001; 90:1299-306.
    • (2001) J Appl Physiol , vol.90 , pp. 1299-1306
    • Hoshikawa, Y.1    Ono, S.2    Suzuki, S.3    Tanita, T.4    Chida, M.5    Song, C.6
  • 18
    • 0031007438 scopus 로고    scopus 로고
    • The effect of endurance exercise at moderate altitude on serum lipid peroxidation and antioxidative functions in humans
    • Vasankari TJ, Kujala UM, Rusko H, Sarna S, Ahotupa M. The effect of endurance exercise at moderate altitude on serum lipid peroxidation and antioxidative functions in humans. Eur J Appl Physiol 1997; 75 396-9.
    • (1997) Eur J Appl Physiol , vol.75 , pp. 396-399
    • Vasankari, T.J.1    Kujala, U.M.2    Rusko, H.3    Sarna, S.4    Ahotupa, M.5
  • 19
    • 0032869471 scopus 로고    scopus 로고
    • Effect of antioxidant supplementation on urine and blood markers of oxidative stress during extended moderate-altitude training
    • Pfeiffer JM, Askew EW, Roberts DE, Wood SM, Benson JE, Johnson SC, et al. Effect of antioxidant supplementation on urine and blood markers of oxidative stress during extended moderate-altitude training. Wilderness Environ Med 1999; 10:66-74.
    • (1999) Wilderness Environ Med , vol.10 , pp. 66-74
    • Pfeiffer, J.M.1    Askew, E.W.2    Roberts, D.E.3    Wood, S.M.4    Benson, J.E.5    Johnson, S.C.6
  • 20
    • 0025173559 scopus 로고
    • The influence of vitamin E on rheological parameters in high altitude mountaineers
    • Simon-Schnass I, Korniszewski L. The influence of vitamin E on rheological parameters in high altitude mountaineers. Int J Vitam Nutr Res 1990; 60:26-34.
    • (1990) Int J Vitam Nutr Res , vol.60 , pp. 26-34
    • Simon-Schnass, I.1    Korniszewski, L.2
  • 21
    • 0023894996 scopus 로고
    • Influence of vitamin E on physical performance
    • Simon-Schnass I, Pabst H. Influence of vitamin E on physical performance. Int J Vitam Nutr Res 1988; 58:49-54.
    • (1988) Int J Vitam Nutr Res , vol.58 , pp. 49-54
    • Simon-Schnass, I.1    Pabst, H.2
  • 22
    • 0035027583 scopus 로고    scopus 로고
    • Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude
    • Bailey DM, Davies B. Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude. High Alt Med Biol 2001; 2:21-9.
    • (2001) High Alt Med Biol , vol.2 , pp. 21-29
    • Bailey, D.M.1    Davies, B.2
  • 23
    • 0024955813 scopus 로고
    • Vitamin E as an in vitro and in vivo antioxidant
    • Burton GW, Ingold KU. Vitamin E as an in vitro and in vivo antioxidant. Ann N Y Acad Sci 1989; 570:7-22.
    • (1989) Ann N Y Acad Sci , vol.570 , pp. 7-22
    • Burton, G.W.1    Ingold, K.U.2
  • 24
    • 0027209389 scopus 로고
    • Strategies of antioxidant defense
    • Sies H. Strategies of antioxidant defense. Eur J Biochem 1993; 215:213-9.
    • (1993) Eur J Biochem , vol.215 , pp. 213-219
    • Sies, H.1
  • 25
    • 0024562114 scopus 로고
    • Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol
    • Scholich H, Murphy ME, Sies H. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol. Biochim Biophys Acta 1989; 1001:256-61.
    • (1989) Biochim Biophys Acta , vol.1001 , pp. 256-261
    • Scholich, H.1    Murphy, M.E.2    Sies, H.3
  • 26
    • 85184971217 scopus 로고    scopus 로고
    • The Lake Louise Consensus on the Definition and Quantification of Altitude Illness. In: Coates G, Houston CS, eds. Hypoxia and Mountain Medicine. Burlington/Vermont, Queen City Printers, 1992.
    • The Lake Louise Consensus on the Definition and Quantification of Altitude Illness. In: Coates G, Houston CS, eds. Hypoxia and Mountain Medicine. Burlington/Vermont, Queen City Printers, 1992.
  • 28
    • 34247132702 scopus 로고    scopus 로고
    • Reliability and utility of a visual analog scale for the assessment of acute mountain sickness
    • Wagner DR, Tatsugawa K, Parker D, Young TA. Reliability and utility of a visual analog scale for the assessment of acute mountain sickness. High Alt Med Biol 2007; 8:27-31.
    • (2007) High Alt Med Biol , vol.8 , pp. 27-31
    • Wagner, D.R.1    Tatsugawa, K.2    Parker, D.3    Young, T.A.4
  • 29
    • 0030035208 scopus 로고    scopus 로고
    • Is arterialized earlobe blood PO2 an acceptable substitute for arterial blood PO2?
    • l'Ava-Santucci J, Dessanges JF, nh Xuan AT, Lockhart A. Is arterialized earlobe blood PO2 an acceptable substitute for arterial blood PO2? Eur Respir J 1996; 9:1329-30.
    • (1996) Eur Respir J , vol.9 , pp. 1329-1330
    • l'Ava-Santucci, J.1    Dessanges, J.F.2    nh Xuan, A.T.3    Lockhart, A.4
  • 30
  • 31
    • 0002905048 scopus 로고
    • The Lake Louise acute mountain sickness scoring system
    • Sutton JR, Houston CS, Coates G, eds, Burlington/Vermont, Queen City Printers
    • Roach RC, Bartsch P, Oelz O, Hackett PH. The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Houston CS, Coates G, eds. Hypoxia and Molecular Medicine. Burlington/Vermont, Queen City Printers, 1993:272-4.
    • (1993) Hypoxia and Molecular Medicine , pp. 272-274
    • Roach, R.C.1    Bartsch, P.2    Oelz, O.3    Hackett, P.H.4
  • 34
    • 1842506452 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: The prevention of high altitude illness trial (PHAIT)
    • Gertsch JH, Basnyat B, Johnson EW, Onopa J, Holck PS. Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: The prevention of high altitude illness trial (PHAIT). Br Med J 2004; 328:797.
    • (2004) Br Med J , vol.328 , pp. 797
    • Gertsch, J.H.1    Basnyat, B.2    Johnson, E.W.3    Onopa, J.4    Holck, P.S.5
  • 36
    • 0034067261 scopus 로고    scopus 로고
    • In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy
    • Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo 2000; 14:327-30.
    • (2000) In Vivo , vol.14 , pp. 327-330
    • Androne, L.1    Gavan, N.A.2    Veresiu, I.A.3    Orasan, R.4
  • 37
    • 33845499323 scopus 로고    scopus 로고
    • Oral treatment with α-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial
    • Ziegler D, Ametov A, Barinov A, Dyck PJ, Gurieva I, Low PA, et al. Oral treatment with α-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care 2006; 29 2365-70.
    • (2006) Diabetes Care , vol.29 , pp. 2365-2370
    • Ziegler, D.1    Ametov, A.2    Barinov, A.3    Dyck, P.J.4    Gurieva, I.5    Low, P.A.6
  • 38
    • 0037465515 scopus 로고    scopus 로고
    • Antioxidants and atherosclerosis: Don't throw out the baby with the bath water
    • Jialal I, Devaraj S. Antioxidants and atherosclerosis: Don't throw out the baby with the bath water. Circulation 2003; 107:926-8.
    • (2003) Circulation , vol.107 , pp. 926-928
    • Jialal, I.1    Devaraj, S.2
  • 39
    • 0034574694 scopus 로고    scopus 로고
    • Protective effect of a novel vitamin E derivative on experimental traumatic brain edema in rats - preliminary study
    • Ikeda Y, Mochizuki Y, Nakamura Y, Dohi K, Matsumoto H, Jimbo H, et al Protective effect of a novel vitamin E derivative on experimental traumatic brain edema in rats - preliminary study. Acta Neurochir Suppl 2000; 76:343-5.
    • (2000) Acta Neurochir Suppl , vol.76 , pp. 343-345
    • Ikeda, Y.1    Mochizuki, Y.2    Nakamura, Y.3    Dohi, K.4    Matsumoto, H.5    Jimbo, H.6
  • 41
    • 11144251210 scopus 로고    scopus 로고
    • Hypoxic pulmonary vasoconstriction: Redox events in oxygen sensing
    • Waypa GB, Schumacker PT. Hypoxic pulmonary vasoconstriction: Redox events in oxygen sensing. J Appl Physiol 2005; 98:404-14.
    • (2005) J Appl Physiol , vol.98 , pp. 404-414
    • Waypa, G.B.1    Schumacker, P.T.2
  • 42
    • 22444433668 scopus 로고    scopus 로고
    • Oxidant and redox signaling in vascular oxygen sensing mechanisms: Basic concepts, current controversies, and potential importance of cytosolic NADPH
    • Wolin MS, Ahmad M, Gupte SA. Oxidant and redox signaling in vascular oxygen sensing mechanisms: Basic concepts, current controversies, and potential importance of cytosolic NADPH. Am J Physiol Lung Cell Mol Physiol 2005; 289:L159-73.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289
    • Wolin, M.S.1    Ahmad, M.2    Gupte, S.A.3
  • 43
    • 0031836524 scopus 로고    scopus 로고
    • Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs
    • Weissmann N, Grimminger F, Voswinckel R, Conzen J, Seeger W. Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs. Am J Physiol 1998; 274(5 Pt 1): L721-7.
    • (1998) Am J Physiol , vol.274 , Issue.5 PART 1
    • Weissmann, N.1    Grimminger, F.2    Voswinckel, R.3    Conzen, J.4    Seeger, W.5
  • 44
    • 33847000570 scopus 로고    scopus 로고
    • Red blood cells prevent inhibition of hypoxic pulmonary vasoconstriction by nitrite in isolated, perfused rat lungs
    • Deem S, Min JH, Moulding JD, Eveland R, Swenson ER. Red blood cells prevent inhibition of hypoxic pulmonary vasoconstriction by nitrite in isolated, perfused rat lungs. Am J Physiol Heart Circ Physiol 2007; 292:H963-70.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Deem, S.1    Min, J.H.2    Moulding, J.D.3    Eveland, R.4    Swenson, E.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.