Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-κB and AP-1

Journal of Food Science

Volumn 75, Issue 1, 2010, Pages

  Fong, Yaou ^a   Shen, Kun Hung ^a,b,c   Chiang, Tai An ^d   Shih, Yuan Wei ^a  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

Author keywords

Acacetin; Invasion; JNK; Migration; MMP 2; U PA

Indexed keywords

ACACETIN; FLAVONE DERIVATIVE; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PHORBOL 13 ACETATE 12 MYRISTATE; RNA; TRANSCRIPTION FACTOR AP 1; UROKINASE;

ARTICLE; CELL ADHESION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; LUNG TUMOR; MALE; METABOLISM; MORTALITY; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

CELL ADHESION; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; FLAVONES; HUMANS; LUNG NEOPLASMS; MALE; MAP KINASE KINASE 4; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 74249121743     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2009.01438.x     Document Type: Article

References (39)

1. Aguirre Ghiso JA, Alonso DF, Farias EF, Gomez DE, de Kier Joffe EB. 1999. Deregulation of the signaling pathways controlling urokinase production: its relationship with the invasive phenotype. Eur J Biochem 263 : 295 304.
2. Bernhard EJ, Gruber SB, Muschel RJ. 1994. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA 91 : 4293 4297.
3. Chan-Hui PY, Weaver R. 1998. Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades. Biochem J 336 : 599 609.
4. Chen PN, Hsieh YS, Chiou HL, Chu SC. 2005. Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chem Biol Interact 156 : 141 150.
5. Chu SC, Chiou HL, Chen PN, Yang SF, Hsieh YS. 2004. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol Carcinog 40 : 143 149.
6. Chung TW, Moon SK, Chang YC, Ko JH, Lee YC, Cho G, Kim SH, Kim JG, Kim CH. 2004. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J 18 : 1670 1681.
7. Duffy MJ, Duggan C. 2004. The urokinase plasminogen activator system: a rich source of tumour markers for the individualized management of patients with cancer. Clin Biochem 37 : 541 548.
8. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. 2001. Cancer statistics. CA Cancer J Clin 51 : 15 36.
9. Hoppe-Seyler F, Butz K, Rittmuller C, von Knebel Doeberitz M. 1991. A rapid microscale procedure for the simultaneous preparation of cytoplasmic RNA, nuclear DNA binding proteins and enzymatically active luciferase extracts. Nucleic Acids Res 19 : 5080.
10. Hsu YL, Kuo PL, Lin CC. 2004a. Acacetin inhibits the proliferation of HepG2 by blocking cell cycle progression and inducing apoptosis. Biochem Pharmacol 67 : 823 829.
11. Hsu YL, Kuo PL, Liu CF, Lin CC. 2004b. Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells. Cancer Lett 212 : 53 60.
12. Huang Q, Shen HM, Ong CN. 2004. Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol 68 : 361 371.
13. Huang SC, Ho CT, Lin-Shiau SY, Lin JK. 2005. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun. Biochem Pharmacol 69 : 221 232.
14. Ibañez-Tallon I, Caretti G, Blasi F, Crippa MP. 1999. In vivo analysis of the state of the human uPA enhancer following stimulation by TPA. Oncogene 18 : 2836 2845.
15. Itoh Y, Nagase H. 2002. Matrix metalloproteinases in cancer. Essays Biochem 38 : 21 36.
16. Jang BC, Park YK, Choi IH, Kim SP, Hwang JB, Baek WK, Suh MH, Mun KC, Suh SI. 2007. 12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells. Int J Oncol 31 : 1439 1447.
17. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ. 2005. Cancer statistics, 2005. CA Cancer J Clin 55 : 10 30.
18. Kim D, Kim S, Koh H, Yoon SO, Chung AS, Cho KS, Chung J. 2001. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 15 : 1953 1962.
19. Kleiner DE, Stetler-Stevenson WG. 1999. Matrix metalloproteinases and metastasis. Cancer Chemother Pharmacol 43 : S42 S51.
20. Kraft C, Jenett-Siems K, Siems K, Jakupovic J, Mavi S, Bienzle U, Eich E. 2003. In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe. Phytother Res 17 : 123 128.
21. Kwon GT, Cho HJ, Chung WY, Park KK, Moon A, Park JH. 2008. Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. J Nutr Biochem 20 : 663 676.
22. Lee SJ, Park SS, Lee US, Kim WJ, Moon SK. 2008. Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. Int Immunopharmacol 8 : 1821 1826.
23. Ma W, Lim W, Gee K, Aucoin S, Nandan D, Kozlowski M, Diaz-Mitoma F, Kumar A. 2001. The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharidestimulated human macrophages. J Biol Chem 276 : 13664 13674.
24. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 : 55 63.
25. Nagase H, Woessner Jr. JF. 1999. Matrix metalloproteinases. J Biol Chem 274 : 21491 21494.
26. Ochi Y, Atsumi S, Aoyagi T, Umezawa K. 1993. Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A. Anticancer Res 13 : 1421 1424.
27. Pan MH, Lai CS, Hsu PC, Wang YJ. 2005. Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species. J Agric Food Chem 53 : 620 630.
28. Pan MH, Lai CS, Wang YJ, Ho CT. 2006. Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem Pharmacol 72 : 1293 1303.
29. Shim HY, Park JH, Paik HD, Nah SY, Kim DS, Han YS. 2007. Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria- mediated death signaling and SAPK/JNK1/2-c-Jun activation. Mol Cells 24 : 95 104.
30. Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF. 2003. Apoptosis and lung cancer: a review. J Cell Biochem 88 : 885 898.
31. Singh RP, Agrawal P, Yim D, Agarwal C, Agarwal R. 2005. Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis 26 : 845 854.
32. Sliva D. 2004. Signaling pathways responsible for cancer cell invasion as targets for cancer therapy. Curr Cancer Drug Targets 4 : 327 336.
33. Stetler-Stevenson WG, Aznavoorian S, Liotta LA. 1993. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 9 : 541 573.
34. Trusolino L, Comoglio PM. 2002. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat Rev Cancer 2 : 289 300.
35. Turner NA, Aley PK, Hall KT, Warburton P, Galloway S, Midgley L, O'regan DJ, Wood IC, Ball SG. Porter KE. 2007. Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms. J Mol Cell Cardio 43 : 168 176.
36. Volpi N. 2004. Separation of flavonoids and phenolic acids from propolis by capillary zone electrophoresis. Electrophoresis 25 : 1872 1878.
37. Weiss L. 1990. Metastatic inefficiency. Adv Cancer Res 54 : 159 211.
38. Westermarck J, Kahari VM. 1999. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 13 : 781 792.
39. Yin Y, Gong FY, Wu XX, Sun Y, Li YH, Chen T, Xu Q. 2008. Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. J Ethnopharmacol 120 : 1 6.