메뉴 건너뛰기




Volumn 7, Issue 1, 2014, Pages

LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD4+ and CD8+) as well as a reduction of parasitism after challenge with Leishmania infantum plus salivary gland of Lutzomyia longipalpis

Author keywords

Canine visceral leishmaniasis; Experimental challenge; Immunogenicity; LBSapSal vaccine; Leishmania infantum; Saliva of Lutzomyia longipalpis

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; LEISHMANIA BRAZILIENSIS ANTIGEN; LEISHMANIA VACCINE; NITRIC OXIDE; PARASITE ANTIGEN; SALIVA PROTEIN; SAPONIN; UNCLASSIFIED DRUG; PROTOZOON ANTIBODY;

EID: 84893712790     PISSN: None     EISSN: 17563305     Source Type: Journal    
DOI: 10.1186/1756-3305-7-61     Document Type: Article
Times cited : (22)

References (58)
  • 3
    • 77953960733 scopus 로고    scopus 로고
    • Immunity to Leishmania and the rational search for vaccines against canine leishmaniasis
    • Review 10.1016/j.pt.2010.04.005 20488751
    • Immunity to Leishmania and the rational search for vaccines against canine leishmaniasis. Reis AB, Giunchetti RC, Carrillo E, Martins-Filho OA, Moreno J, Trends Parasitol 2010 26 7 341 349 Review 10.1016/j.pt.2010.04.005 20488751
    • (2010) Trends Parasitol , vol.26 , Issue.7 , pp. 341-349
    • Reis, A.B.1    Giunchetti, R.C.2    Carrillo, E.3    Martins-Filho, O.A.4    Moreno, J.5
  • 4
    • 15244360706 scopus 로고    scopus 로고
    • Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes
    • 10.1016/j.vaccine.2004.11.061 15780731
    • Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes. Lemesre JL, Holzmuller P, Cavaleyra M, Goncalves RB, Hottin G, Papierok G, Vaccine 2005 23 2825 2840 10.1016/j.vaccine.2004.11.061 15780731
    • (2005) Vaccine , vol.23 , pp. 2825-2840
    • Lemesre, J.L.1    Holzmuller, P.2    Cavaleyra, M.3    Goncalves, R.B.4    Hottin, G.5    Papierok, G.6
  • 5
    • 34247484942 scopus 로고    scopus 로고
    • Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: Double-blind randomized efficacy field trial
    • 10.1016/j.vaccine.2007.02.083 17395339
    • Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomized efficacy field trial. Lemesre JL, Holzmuller P, Goncalves RB, Bourdoiseau G, Hugnet C, Cavaleyra M, Papierok G, Vaccine 2007 25 4223 4234 10.1016/j.vaccine.2007.02.083 17395339
    • (2007) Vaccine , vol.25 , pp. 4223-4234
    • Lemesre, J.L.1    Holzmuller, P.2    Goncalves, R.B.3    Bourdoiseau, G.4    Hugnet, C.5    Cavaleyra, M.6    Papierok, G.7
  • 11
    • 0033193856 scopus 로고    scopus 로고
    • A Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes
    • 10543378
    • A Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes. Lasri S, Sahibi H, Sadak A, Jaffe CL, Rhalem A, Vet Res 1999 30 441 449 10543378
    • (1999) Vet Res , vol.30 , pp. 441-449
    • Lasri, S.1    Sahibi, H.2    Sadak, A.3    Jaffe, C.L.4    Rhalem, A.5
  • 18
    • 84863676331 scopus 로고    scopus 로고
    • Use of a LiESP/QA-21 vaccine (CaniLeish) stimulates an appropriate Th1-dominated cell-mediated immune response in dogs
    • 10.1371/journal.pntd.0001683 22724031
    • Use of a LiESP/QA-21 vaccine (CaniLeish) stimulates an appropriate Th1-dominated cell-mediated immune response in dogs. Moreno J, Vouldoukis I, Martin V, McGahie D, Cuisinier AM, Gueguen S, PLoS Negl Trop Dis 2012 6 6 1683 10.1371/journal.pntd.0001683 22724031
    • (2012) PLoS Negl Trop Dis , vol.6 , Issue.6 , pp. 51683
    • Moreno, J.1    Vouldoukis, I.2    Martin, V.3    McGahie, D.4    Cuisinier, A.M.5    Gueguen, S.6
  • 19
    • 4444350068 scopus 로고    scopus 로고
    • Progress in vaccine research and possible effector mechanisms in visceral leishmaniasis
    • 10.2174/1566524043360212 15357218
    • Progress in vaccine research and possible effector mechanisms in visceral leishmaniasis. Ravindran R, Ali N, Curr Mol Med 2004 4 6 697 709 10.2174/1566524043360212 15357218
    • (2004) Curr Mol Med , vol.4 , Issue.6 , pp. 697-709
    • Ravindran, R.1    Ali, N.2
  • 20
    • 4444307813 scopus 로고    scopus 로고
    • Double-blind randomized efficacy field trial of alum precipitated autoclaved Leishmania major vaccine mixed with BCG against canine visceral leishmaniasis in Meshkin-Shahr district, I.R. Iran
    • 10.1016/j.vaccine.2004.03.058 15364462
    • Double-blind randomized efficacy field trial of alum precipitated autoclaved Leishmania major vaccine mixed with BCG against canine visceral leishmaniasis in Meshkin-Shahr district, I.R. Iran. Mohebali M, Khamesipour A, Mobedi I, Zarei Z, Hashemi-Fesharki R, Vaccine 2004 22 4097 4100 10.1016/j.vaccine.2004.03.058 15364462
    • (2004) Vaccine , vol.22 , pp. 4097-4100
    • Mohebali, M.1    Khamesipour, A.2    Mobedi, I.3    Zarei, Z.4    Hashemi-Fesharki, R.5
  • 21
    • 0023899355 scopus 로고
    • Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity
    • 10.1126/science.3344436 3344436
    • Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity. Titus RG, Ribeiro JM, Science 1988 239 4845 1306 1308 10.1126/science.3344436 3344436
    • (1988) Science , vol.239 , Issue.4845 , pp. 1306-1308
    • Titus, R.G.1    Ribeiro, J.M.2
  • 22
    • 0026053944 scopus 로고
    • A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva
    • 10.1084/jem.173.1.49 1985126
    • A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva. Samuelson J, Lerner E, Tesh R, Titus R, J Exp Med 1991 173 1 49 54 10.1084/jem.173.1.49 1985126
    • (1991) J Exp Med , vol.173 , Issue.1 , pp. 49-54
    • Samuelson, J.1    Lerner, E.2    Tesh, R.3    Titus, R.4
  • 23
    • 0028782112 scopus 로고
    • Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis
    • 10.1098/rstb.1994.0097
    • Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis. Warburg A, Saraiva E, Lanzaro GC, Titus RG, Neva F, Philos Trans R Soc B 1994 345 1312 223 230 10.1098/rstb.1994.0097
    • (1994) Philos Trans R Soc B , vol.345 , Issue.1312 , pp. 223-230
    • Warburg, A.1    Saraiva, E.2    Lanzaro, G.C.3    Titus, R.G.4    Neva, F.5
  • 24
    • 0029825449 scopus 로고    scopus 로고
    • Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice
    • 8945606
    • Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice. Lima HC, Titus RG, Infect Immun 1996 64 12 5442 5445 8945606
    • (1996) Infect Immun , vol.64 , Issue.12 , pp. 5442-5445
    • Lima, H.C.1    Titus, R.G.2
  • 26
    • 0032538905 scopus 로고    scopus 로고
    • Development of a natural model of cutaneous leishmaniasis: Powerful effects of vector saliva and saliva pre-exposure on the long-term outcome of Leishmania major infection in the mouse ear dermis
    • 10.1084/jem.188.10.1941 9815271
    • Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva pre-exposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. Belkaid Y, Kamhawi S, Modi G, Valenzuela J, Noben-Trauth N, Rowton E, Ribeiro J, Sacks DL, J Exp Med 1998 188 10 1941 1953 10.1084/jem.188.10.1941 9815271
    • (1998) J Exp Med , vol.188 , Issue.10 , pp. 1941-1953
    • Belkaid, Y.1    Kamhawi, S.2    Modi, G.3    Valenzuela, J.4    Noben-Trauth, N.5    Rowton, E.6    Ribeiro, J.7    Sacks, D.L.8
  • 27
    • 0034680892 scopus 로고    scopus 로고
    • Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies
    • 10.1126/science.290.5495.1351 11082061
    • Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies. Kamhawi S, Belkaid Y, Modi G, Rowton E, Sacks D, Science 2000 290 5495 1351 1354 10.1126/science.290.5495.1351 11082061
    • (2000) Science , vol.290 , Issue.5495 , pp. 1351-1354
    • Kamhawi, S.1    Belkaid, Y.2    Modi, G.3    Rowton, E.4    Sacks, D.5
  • 29
    • 67249085574 scopus 로고    scopus 로고
    • Sand Fly Salivary Proteins Induce Strong Cellular Immunity in a Natural Reservoir of Visceral Leishmaniasis with Adverse Consequences for Leishmania
    • 10.1371/journal.ppat.1000441 19461875
    • Sand Fly Salivary Proteins Induce Strong Cellular Immunity in a Natural Reservoir of Visceral Leishmaniasis with Adverse Consequences for Leishmania. Collin N, Gomes R, Teixeira C, Cheng L, Laughinghouse A, Ward JM, Elnaiem DE, Fischer L, Valenzuela JG, Kamhawi S, PLoS Pathog 2009 5 5 1000441 10.1371/journal.ppat.1000441 19461875
    • (2009) PLoS Pathog , vol.5 , Issue.5 , pp. 51000441
    • Collin, N.1    Gomes, R.2    Teixeira, C.3    Cheng, L.4    Laughinghouse, A.5    Ward, J.M.6    Elnaiem, D.E.7    Fischer, L.8    Valenzuela, J.G.9    Kamhawi, S.10
  • 30
    • 0021095696 scopus 로고
    • A simple technique for mass rearing Lutzomyia longipalpis and Phlebotomus papatasi (Diptera: Psychodidae) in the laboratory
    • 6644754
    • A simple technique for mass rearing Lutzomyia longipalpis and Phlebotomus papatasi (Diptera: Psychodidae) in the laboratory. Modi GB, Tesh RB, J Med Entomol 1983 20 5 568 569 6644754
    • (1983) J Med Entomol , vol.20 , Issue.5 , pp. 568-569
    • Modi, G.B.1    Tesh, R.B.2
  • 31
    • 0038235210 scopus 로고    scopus 로고
    • Anti-complement activity in the saliva of phlebotomine sand flies and other haematophagous insects
    • 10.1017/S0031182003003329 12885192
    • Anti-complement activity in the saliva of phlebotomine sand flies and other haematophagous insects. Cavalcante RR, Pereira MH, Gontijo NF, Parasitology 2003 127 1 87 93 10.1017/S0031182003003329 12885192
    • (2003) Parasitology , vol.127 , Issue.1 , pp. 87-93
    • Cavalcante, R.R.1    Pereira, M.H.2    Gontijo, N.F.3
  • 34
    • 0027573325 scopus 로고
    • Development of eosinophilia in dogs intradermically inoculated with sand fly saliva and Leishmania (Leishmania) chagasi stationary-phase promastigotes
    • 10.1590/S0074-02761993000200012 8107586
    • Development of eosinophilia in dogs intradermically inoculated with sand fly saliva and Leishmania (Leishmania) chagasi stationary-phase promastigotes. Paranhos M, dos Santos WC, Sherlock I, Oliveira GG, de Carvalho LC, Mem Inst Oswaldo Cruz 1993 88 2 249 251 10.1590/S0074-02761993000200012 8107586
    • (1993) Mem Inst Oswaldo Cruz , vol.88 , Issue.2 , pp. 249-251
    • Paranhos, M.1    Dos Santos, W.C.2    Sherlock, I.3    Oliveira, G.G.4    De Carvalho, L.C.5
  • 38
    • 33645108429 scopus 로고    scopus 로고
    • The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission
    • 16542315
    • The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission. Titus RG, Bishop JV, Mejia JS, Parasite Immunol 2006 28 4 131 141 16542315
    • (2006) Parasite Immunol , vol.28 , Issue.4 , pp. 131-141
    • Titus, R.G.1    Bishop, J.V.2    Mejia, J.S.3
  • 39
    • 0142026114 scopus 로고    scopus 로고
    • Vaccines in leishmaniasis: Advances in the last five years
    • 10.1586/14760584.2.5.705 14711330
    • Vaccines in leishmaniasis: advances in the last five years. Brodskyn C, de Oliveira CI, Barral A, Barral-Netto M, Expert Rev Vaccines 2003 2 5 705 717 10.1586/14760584.2.5.705 14711330
    • (2003) Expert Rev Vaccines , vol.2 , Issue.5 , pp. 705-717
    • Brodskyn, C.1    De Oliveira, C.I.2    Barral, A.3    Barral-Netto, M.4
  • 40
    • 0033635179 scopus 로고    scopus 로고
    • The biological and immunomodulatory properties of sand fly saliva and its role in the establishment of Leishmania infections
    • 10.1016/S1286-4579(00)01331-9 11137049
    • The biological and immunomodulatory properties of sand fly saliva and its role in the establishment of Leishmania infections. Kamhawi S, Microbes Infect 2000 2 14 1765 1773 10.1016/S1286-4579(00)01331-9 11137049
    • (2000) Microbes Infect , vol.2 , Issue.14 , pp. 1765-1773
    • Kamhawi, S.1
  • 41
    • 33746296447 scopus 로고    scopus 로고
    • Is it possible to develop panarthropod vaccines?
    • 10.1016/j.pt.2006.06.001 16784890
    • Is it possible to develop panarthropod vaccines? Mejia JS, Bishop JV, Titus RG, Trends Parasitol 2006 22 8 367 370 10.1016/j.pt.2006.06.001 16784890
    • (2006) Trends Parasitol , vol.22 , Issue.8 , pp. 367-370
    • Mejia, J.S.1    Bishop, J.V.2    Titus, R.G.3
  • 43
    • 58949098282 scopus 로고    scopus 로고
    • T-cell-derived cytokines, nitric oxide production by peripheral blood monocytes and seric anti-Leishmania (Leishmania) chagasi IgG subclass patterns following immunization against canine visceral leishmaniasis using Leishvaccine and Leishmune
    • 10.1016/j.vaccine.2008.11.104 19110023
    • T-cell-derived cytokines, nitric oxide production by peripheral blood monocytes and seric anti-Leishmania (Leishmania) chagasi IgG subclass patterns following immunization against canine visceral leishmaniasis using Leishvaccine and Leishmune. Araujo MS, de Andrade RA, Sathler-Avelar R, Teixeira-Carvalho A, Andrade MC, Vianna LR, Mayrink W, Reis AB, Malaquias LC, Mello MN, Martins-Filho OA, Vaccine 2009 27 1008 1017 10.1016/j.vaccine.2008.11.104 19110023
    • (2009) Vaccine , vol.27 , pp. 1008-1017
    • Araujo, M.S.1    De Andrade, R.A.2    Sathler-Avelar, R.3    Teixeira-Carvalho, A.4    Andrade, M.C.5    Vianna, L.R.6    Mayrink, W.7    Reis, A.B.8    Malaquias, L.C.9    Mello, M.N.10    Martins-Filho, O.A.11
  • 44
    • 34248674887 scopus 로고    scopus 로고
    • Immunoglobulin G subclass distribution in canine leishmaniosis: A review and analysis of pitfalls in interpretation
    • 10.1016/j.vetpar.2007.03.037 17467176
    • Immunoglobulin G subclass distribution in canine leishmaniosis: a review and analysis of pitfalls in interpretation. Day MJ, Vet Parasitol 2007 147 2 8 10.1016/j.vetpar.2007.03.037 17467176
    • (2007) Vet Parasitol , vol.147 , pp. 2-8
    • Day, M.J.1
  • 45
    • 42449124036 scopus 로고    scopus 로고
    • Despite Leishvaccine and Leishmune trigger distinct immune profiles, their ability to activate phagocytes and CD8+ T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis
    • 10.1016/j.vaccine.2008.02.044 18395948
    • Despite Leishvaccine and Leishmune trigger distinct immune profiles, their ability to activate phagocytes and CD8+ T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis. Araujo MS, de Andrade RA, Vianna LR, Mayrink W, Reis AB, Sathler-Avelar R, Teixeira-Carvalho A, Andrade MC, Mello MN, Martins-Filho OA, Vaccine 2008 26 2211 2224 10.1016/j.vaccine.2008.02.044 18395948
    • (2008) Vaccine , vol.26 , pp. 2211-2224
    • Araujo, M.S.1    De Andrade, R.A.2    Vianna, L.R.3    Mayrink, W.4    Reis, A.B.5    Sathler-Avelar, R.6    Teixeira-Carvalho, A.7    Andrade, M.C.8    Mello, M.N.9    Martins-Filho, O.A.10
  • 46
    • 33750038264 scopus 로고    scopus 로고
    • Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi
    • 10.1111/j.1365-2249.2006.03206.x 17034583
    • Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi. Reis AB, Teixeira-Carvalho A, Giunchetti RC, Guerra LL, Carvalho MG, Mayrink W, Genaro O, Corrêa-Oliveira R, Martins-Filho OA, Clin Exp Immunol 2006 146 303 311 10.1111/j.1365-2249.2006.03206.x 17034583
    • (2006) Clin Exp Immunol , vol.146 , pp. 303-311
    • Reis, A.B.1    Teixeira-Carvalho, A.2    Giunchetti, R.C.3    Guerra, L.L.4    Carvalho, M.G.5    Mayrink, W.6    Genaro, O.7    Corrêa-Oliveira, R.8    Martins-Filho, O.A.9
  • 49
    • 0028347754 scopus 로고
    • A canine CD8+ cytotoxic T-cell line specific for Leishmania infantum infected macrophages
    • 10.1111/j.1399-0039.1994.tb02321.x 8091417
    • A canine CD8+ cytotoxic T-cell line specific for Leishmania infantum infected macrophages. Pinelli E, Boog CJ, Rutten VP, Van DB, Bernadina WE, Ruitenberg EJ, Tissue Antigens 1994 43 189 192 10.1111/j.1399-0039.1994.tb02321. x 8091417
    • (1994) Tissue Antigens , vol.43 , pp. 189-192
    • Pinelli, E.1    Boog, C.J.2    Rutten, V.P.3    Van, D.B.4    Bernadina, W.E.5    Ruitenberg, E.J.6
  • 50
    • 0027979703 scopus 로고
    • Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum
    • 8262632
    • Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum. Pinelli E, Killick-Kendrick R, Wagenaar J, Bernadina W, Del Real G, Ruitenberg J, Infect Immun 1994 62 229 235 8262632
    • (1994) Infect Immun , vol.62 , pp. 229-235
    • Pinelli, E.1    Killick-Kendrick, R.2    Wagenaar, J.3    Bernadina, W.4    Del Real, G.5    Ruitenberg, J.6
  • 51
    • 11144341234 scopus 로고    scopus 로고
    • Cytokines in canine visceral leishmaniasis
    • Netherlands: Utrecht University Schijns HM
    • Cytokines in canine visceral leishmaniasis. Pinelli E, Cytokines in veterinary medicine Netherlands: Utrecht University, Schijns HM, 1997 217 247
    • (1997) Cytokines in Veterinary Medicine , pp. 217-247
    • Pinelli, E.1
  • 52
    • 0029068371 scopus 로고
    • Leishmania infantum-specific T cell lines derived from asymptomatic dogs that lyse infected macrophages in a major histocompatibility complex-restricted manner
    • 10.1002/eji.1830250619 7614987
    • Leishmania infantum-specific T cell lines derived from asymptomatic dogs that lyse infected macrophages in a major histocompatibility complex-restricted manner. Pinelli E, Gonzalo RM, Boog CJ, Rutten VP, Gebhard D, Del Real G, Ruitenberg J, Eur J Immunol 1995 25 1594 1600 10.1002/eji.1830250619 7614987
    • (1995) Eur J Immunol , vol.25 , pp. 1594-1600
    • Pinelli, E.1    Gonzalo, R.M.2    Boog, C.J.3    Rutten, V.P.4    Gebhard, D.5    Del Real, G.6    Ruitenberg, J.7
  • 54
    • 18844422476 scopus 로고    scopus 로고
    • Detailed analysis of an experimental challenge model for Leishmania infantum (Jpc strain) in dogs
    • 15893068
    • Detailed analysis of an experimental challenge model for Leishmania infantum (Jpc strain) in dogs. Poot J, Rogers ME, Bates PA, Vermeulen A, Vet Parasitol 2005 130 1-2 41 53 15893068
    • (2005) Vet Parasitol , vol.130 , Issue.1-2 , pp. 41-53
    • Poot, J.1    Rogers, M.E.2    Bates, P.A.3    Vermeulen, A.4
  • 56
    • 67650915063 scopus 로고    scopus 로고
    • Vector transmission of Leishmania abrogates vaccine-induced protective immunity
    • 10.1371/journal.ppat.1000484 19543375
    • Vector transmission of Leishmania abrogates vaccine-induced protective immunity. Peters NC, Kimblin N, Secundino N, Kamhawi S, Lawyer P, Sacks DL, PLoS Pathog 2009 5 1000484 10.1371/journal.ppat.1000484 19543375
    • (2009) PLoS Pathog , vol.5 , pp. 51000484
    • Peters, N.C.1    Kimblin, N.2    Secundino, N.3    Kamhawi, S.4    Lawyer, P.5    Sacks, D.L.6
  • 57
    • 33751002987 scopus 로고    scopus 로고
    • Leishmania DNA load and cytokine expression levels in asymptomatic naturally infected dogs
    • 10.1016/j.vetpar.2006.06.028 16920264
    • Leishmania DNA load and cytokine expression levels in asymptomatic naturally infected dogs. Manna L, Reale S, Viola E, Vitale F, Foglia Manzillo V, Pavone LM, Caracappa S, Gravino AE, Vet Parasitol 2006 142 271 280 10.1016/j.vetpar.2006.06.028 16920264
    • (2006) Vet Parasitol , vol.142 , pp. 271-280
    • Manna, L.1    Reale, S.2    Viola, E.3    Vitale, F.4    Foglia Manzillo, V.5    Pavone, L.M.6    Caracappa, S.7    Gravino, A.E.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.