Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi

Clinical and Experimental Immunology

Volumn 146, Issue 2, 2006, Pages 303-311

  Reis, A B ^a,b,d   Teixeira Carvalho, A ^a,b   Giunchetti, R C ^a,b   Guerra, L L ^b   Carvalho, M G ^c   Mayrink, W ^c   Genaro, O ^c   Correa Oliveira R ^b   Martins Filho, O A ^b  

^a FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^d Campus Universitário Morro Do Cruzeiro ^*  (Brazil)

Author keywords

Bone marrow parasitism; Canine visceral leishmaniasis; Clinical status; T cell subsets

Indexed keywords

CD45 ANTIGEN; CD45RA ANTIGEN; CD45RB ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BONE MARROW; BRAZIL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; DOG DISEASE; FEMALE; IMMUNOPHENOTYPING; LEISHMANIA CHAGASI; LEISHMANIASIS; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MONOCYTE; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE SUBPOPULATION;

ANEMIA; ANIMALS; ANTIGENS, CD45; B-LYMPHOCYTES; BONE MARROW; CD8-POSITIVE T-LYMPHOCYTES; DOG DISEASES; DOGS; FEMALE; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOPHENOTYPING; LEISHMANIA; LEISHMANIASIS, VISCERAL; LEUKOCYTES; LEUKOPENIA; LYMPHOCYTE COUNT; MALE; MONOCYTES; T-LYMPHOCYTE SUBSETS;

EID: 33750038264     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2006.03206.x     Document Type: Article

References (29)

1. Laison R, Shaw JJ. Evolution, classification and geographical distribution. In: Peters W, Killick-Kendrick R eds. The leishmaniasis in biology and medicine. London: Academic Press, 1987:1-20.
2. Tesh RB. Control of zoonotic visceral leishmaniasis: is it time to changes strategies? Am J Trop Med Hyg 1995; 52:287-92.
3. Molina R, Amela C, Nieto J et al. Infectivity of dogs naturally infected with Leishmania infantum to colonized Phlebotomus perniciosus. Trans R Soc Trop Med Hyg 1994; 88:491-3.
4. Molina R, Lohse JM, Pulido F et al. Infection of sand flies by humans coinfected with Leishmania infantum and human immunodeficiency virus. Am J Trop Med Hyg 1999; 60:51-3.
5. Guarga JL, Moreno J, Lucientes J et al. Canine leishmaniasis transmission: higher infectivity amongst naturally infected dogs to sand flies is associated with lower proportions of T helper cells. Res Vet Sci 2000; 69:249-53.
6. Faldyna M, Sinkora J, Knotigova P et al. Lymphatic organ development in dogs: major lymphocyte subsets and activity. Vet Immunol Immunopathol 2005; 104:239-47.
7. Williams DL. Studies of canine leucocyte antigens: a significant advance in canine immunology. The Vet J 1997; 153:31-9.
8. Mancianti F, Meciani N. Studies on canine leishmaniasis control. 1. Evolution of infection of different clinical forms of canine leishmaniasis following antimonial treatment. Trans R Soc Trop Med Hyg 1988; 82:566-7.
9. Reis AB, Martins-Filho OA, Teixeira-Carvalho A et al. Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Res Vet Sci 2006; 81:68-75.
10. Reis AB, Teixeira-Carvalho A, Vale AM et al. Isotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in brazilian dogs naturally infected by Leishmania (Leishmania) chagasi. Vet Immunol Immunopathol 2006; 112:102-16.
11. Pinelli E, Ellick-Kendrick R, Wagenaar J et al. Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum. Infect Immun 1994; 62:229-35.
12. Keenan CM, Hendricks LD, Lightner L et al. Visceral leishmaniasis in the German shepherd dog-II. Pathol Vet Pathol 1984; 21:80-6.
13. Brandonisio O, Ceci L, Cedola MC et al. Phagocytosis of Leishmania infantum promastigotes by monocytes isolated from Leishmania infected dogs. Microbiológica 1986; 9:173-8.
14. Panaro MA, Lisi S, Mitolo V et al. Evaluation of killing, superoxide anion and nitric oxide production by Leishmania infantum-infected dog monocytes. Cytobios 1998; 95:151-60.
15. Abranches P, Santos-Gomes GM, Rachamin N et al. An experimental model for canine visceral leishmaniasis. Parasite Immunol 1991; 13:537-50.
16. Martinez-Moreno A, Martinez-Cruz MS, Blanco A et al. Immunological and histological study of T- and B- lymphocyte activity in canine visceral leishmaniasis. Vet Immunol Immunopathol 1993; 51:49-59.
17. Pinelli E, Gonzalo RM, Boog CJP et al. Leishmania infantum-specific T cell lines derived from asymptomatic dogs that lyse infected macrophages in a major histocompatibility complex-restricted manner. Eur J Immunol 1995; 25:1594-600.
18. Bourdoiseau G, Bonnefont C, Hoareau E et al. Specific IgG1 and IgG2 antibody and lymphocyte subset levels in naturally Leishmania infantum-infected treated and untreated dogs. Vet Immunol Immunopathol 1997; 59:21-30.
19. Reis AB, Carneiro CM, Carvalho MG et al. Establishment of a microplate assay for flow cytometric assessment and it is use for the evaluation of age-related phenotypic changes in canine whole blood leukocytes. Vet Immunol Immunopathol 2005; 103:173-85.
20. Byrne KM, Reinhart GA, Hayek MG. Standardized flow cytometry gating in veterinary medicine. Meth Cell Sci 2000; 22:191-8.
21. Scott P, Pearce E, Cheever AW et al. Role of cytokines and CD4+ T cell subsets in the regulation of parasite immunity disease. Immunol Ver 1989; 112:161-82.
22. Liew FY. Regulation of cell-mediated immunity in leishmaniasis. Curr Top Microbiol Immunol 1990; 155:53-64.
23. Pinelli E. Cytokines in canine visceral leishmaniasis. In: Schijns VECJ, Horzinek MC, eds. Cytokines in veterinary medicine. Utrecht University, Netherlands 1997: 217-47.
24. Barrouin-Melo SM, Laranjeira DF, Santos SO et al. A standardized cytological and immunochemical method for the analysis of fine-needle spleen aspirates: assessment of leukocyte population changes in canine visceral leishmaniosis. Vet Immunol Immunopathol 2006; 111:251-61.
25. Cobbold S, Metcalfe S. Monoclonal antibodies that define canine homologues of human CD antigens. Summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens 1994; 43:137-54.
26. Holmes MA, Lunn DP. Variations of MHC II expression on canine lymphocytes with age. Tissue Antigens 1994; 43:179-83.
27. Zuckermann FA, Peavey C, Schnitzlein WM et al. Definition of the specificity of monoclonal antibodies against porcine CD45 and CD45R: report from the CD45/CD45R and CD44 subgroup of the Second International Swine CD Workshop. Vet Immunol Immunopathol 1998; 60:367-87.
28. Gomes-Pereira S, Rodrigues OR, Santos-Gomes GM. Dynamics of CD62L/CD45RB CD4+ and CD8+ lymphocyte subsets in hepatic and splenic tissues during murine visceral leishmaniasis. Immunol Lett 2004; 95:63-70.
29. Tipold A, Moore P, Jungi TW et al. Lymphocyte subsets and CD45RA positive T-cells in normal canine cerebrospinal fluid. J Neuroimmunol 1998; 82:90-5.