Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 27, 2013, Pages 8859-8869

  Hu, Chiung Wen ^a   Lee, Huei ^b   Chen, Jian Lian ^c   Li, Yi Jie ^d   Chao, Mu Rong ^d,e  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d Chung Shan University Hospital   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

DNA lesions; DNAmethylation; Human lung; LC MS MS .DNA digestion

Indexed keywords

ALKYLATION; BIOLOGICAL ORGANS; DISEASES; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; PHASE SEPARATION; PHOSPHATASES; TISSUE;

8-OXO-7 , 8-DIHYDRO-2'- DEOXYGUANOSINE; DNA DIGESTION; DNA LESIONS; DNAMETHYLATION; HUMAN LUNG; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; ON-LINE SOLID PHASE EXTRACTION; SIMULTANEOUS MEASUREMENT;

DNA;

3 METHYLADENINE; 5 METHYLDEOXYCYTIDINE; 5-METHYLDEOXYCYTIDINE; 7 METHYLGUANINE; 7-METHYLGUANINE; ADENINE; DEOXYCYTIDINE; DNA; DRUG DERIVATIVE; FUNGAL PROTEIN; GUANINE; N3-METHYLADENINE; NUCLEASE P1, PENICILLIUM CITRINUM; NUCLEASE S1; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE;

ADENOCARCINOMA; AGED; ARTICLE; CHEMISTRY; DNA METHYLATION; FEMALE; HUMAN; INDICATOR DILUTION CURVE; ISOLATION AND PURIFICATION; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; LUNG TUMOR; MALE; METABOLISM; MIDDLE AGED; REPRODUCIBILITY; SOLID PHASE EXTRACTION; SQUAMOUS CELL CARCINOMA; TANDEM MASS SPECTROMETRY; TUMOR MICROENVIRONMENT;

ADENINE; ADENOCARCINOMA; AGED; CARCINOMA, SQUAMOUS CELL; CHROMATOGRAPHY, LIQUID; DEOXYCYTIDINE; DNA METHYLATION; DNA, NEOPLASM; FEMALE; FUNGAL PROTEINS; GUANINE; HUMANS; INDICATOR DILUTION TECHNIQUES; LIMIT OF DETECTION; LUNG NEOPLASMS; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SINGLE-STRAND SPECIFIC DNA AND RNA ENDONUCLEASES; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TUMOR MICROENVIRONMENT;

EID: 84893675090     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7305-3     Document Type: Article

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