Simultaneous determination of N7-alkylguanines in DNA by isotope-dilution LC-tandem MS coupled with automated solid-phase extraction and its application to a small fish model

Biochemical Journal

Volumn 402, Issue 3, 2007, Pages 483-490

  Chao, Mu Rong ^a   Wang, Chien Jen ^b   Yen, Cheng Chieh ^a   Yang, Hsi Hsien ^c   Lu, Yao Cheng ^a   Chang, Louis W ^b   Hu, Chiung Wen ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c CHAOYANG UNIVERSITY OF TECHNOLOGY   (Taiwan)

Author keywords

DNA alkylation; Liquid chromatography tandem MS (LC MS MS); N nitrosamine; On line solid phase extraction; Small fish model

Indexed keywords

DNA ALKYLATION; LIQUID CHROMATOGRAPHY TANDEM MS (LC-MS/MS); N-NITROSAMINE; ON LINE SOLID PHASE EXTRACTION; SMALL FISH MODELS;

DNA; FISH; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATHEMATICAL MODELS;

ENZYME KINETICS;

DIETHYLNITROSAMINE; DIMETHYLNITROSAMINE; DNA; GUANINE DERIVATIVE; N 7 ALKYLGUANINE DERIVATIVE; UNCLASSIFIED DRUG; ETHYLENE; ETHYLENE DERIVATIVE; GUANINE; ISOTOPE; LIVER EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; DNA ALKYLATION; FISH; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ALKYLATION; ANIMAL; ANIMAL MODEL; AUTOMATION; CHEMISTRY; CYPRINODONTIFORMES; INDICATOR DILUTION CURVE; LIVER; METABOLISM; METHODOLOGY;

ANIMALIA; GAMBUSIA AFFINIS;

ALKYLATION; ANIMALS; AUTOMATION; CHROMATOGRAPHY, LIQUID; CYPRINODONTIFORMES; DNA; ETHYLENES; GUANINE; INDICATOR DILUTION TECHNIQUES; ISOTOPES; LIVER; LIVER EXTRACTS; MODELS, ANIMAL; TANDEM MASS SPECTROMETRY;

EID: 33947200792     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20061447     Document Type: Article

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