Urinary analysis of 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine by isotope-dilution LC-MS/MS with automated solid-phase extraction: Study of 8-oxo-7,8-dihydroguanine stability

Free Radical Biology and Medicine

Volumn 48, Issue 1, 2010, Pages 89-97

  Hu, Chiung Wen ^a   Chao, Mu Rong ^b   Sie, Ciao Han ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

8 OxoGua; Free radicals; LC MS MS; Online SPE; Oxidatively damaged DNA; Stability

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; DNA; METHANOL; SODIUM HYDROXIDE;

ADULT; ARTICLE; AUTOMATION; CONTROLLED STUDY; DILUTION; DNA DAMAGE; ELUTION; EXCISION REPAIR; FEMALE; HUMAN; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOLECULAR STABILITY; NORMAL HUMAN; OXIDATIVE STRESS; PH; PRIORITY JOURNAL; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; ROOM TEMPERATURE; SOLID PHASE EXTRACTION; THERMOSTABILITY; URINALYSIS;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; FEMALE; GUANINE; HUMANS; MALE; NITROGEN ISOTOPES; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 74149083811     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.10.029     Document Type: Article

References (33)

1. Cooke M.S., Olinski R., and Evans M.D. Does measurement of oxidative damage to DNA have clinical significance?. Clin. Chim. Acta 365 (2006) 30-49
2. Cadet J., Douki T., and Ravanat J.L. Oxidatively generated damage to the guanine moiety of DNA: mechanistic aspects and formation in cells. Acc. Chem. Res. 41 (2008) 1075-1083
3. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., and Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem 267 (1992) 166-172
4. Shigenaga M.K., Gimeno C.J., and Ames B.N. Urinary 8-hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proc. Natl. Acad. Sci. USA 86 (1989) 9697-9701
5. Fraga C.G., Shigenaga M.K., Park J.W., Degan P., and Ames B.N. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA 87 (1990) 4533-4537
6. Olinski R., Rozalski R., Gackowski D., Foksinski M., Siomek A., and Cooke M.S. Urinary measurement of 8-OxodG, 8-OxoGua, and 5HMUra: a noninvasive assessment of oxidative damage to DNA. Antioxid. Redox Signaling 8 (2006) 1011-1019
7. Cooke M.S., Olinski R., and Loft S. European Standards Committee on Urinary (DNA) Lesion Analysis. Measurement and meaning of oxidatively modified DNA lesions in urine. Cancer Epidemiol. Biomarkers Prev. 17 (2008) 3-14
8. Evans M.D., Dizdaroglu M., and Cooke M.S. Oxidative DNA damage and disease: induction, repair and significance. Mutat. Res. 567 (2004) 1-61
9. Gackowski D., Rozalski R., Roszkowski K., Jawien A., Foksiński M., and Olinski R. 8-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine levels in human urine do not depend on diet. Free Radic. Res 35 (2001) 825-832
10. Cooke M.S., Evans M.D., Dove R., Rozalski R., Gackowski D., Siomek A., Lunec J., and Olinski R. DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine. Mutat. Res 574 (2005) 58-66
11. Hu C.W., Wu M.T., Chao M.R., Pan C.H., Wang C.J., Swenberg J.A., and Wu K.Y. Comparison of analyses of urinary 8-hydroxy-2′-deoxyguanosine by isotope-dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme-linked immunosorbent assay. Rapid Commun. Mass Spectrom 18 (2004) 505-510
12. Evans M.D., Singh R., Mistry V., Sandhu K., Farmer P.B., and Cooke M.S. Analysis of urinary 8-oxo-7,8-dihydro-purine-2′-deoxyribonucleosides by LC-MS/MS and improved ELISA. Free Radic. Res 42 (2008) 831-840
13. Song M.F., Li Y.S., Ootsuyama Y., Kasai H., Kawai K., Ohta M., Eguchi Y., Yamato H., Matsumoto Y., Yoshida R., and Ogawa Y. Urea, the most abundant component in urine, cross-reacts with a commercial 8-OH-dG ELISA kit and contributes to overestimation of urinary 8-OH-dG. Free Radic. Biol. Med 47 (2009) 41-46
14. Cooke M.S. A commentary on "Urea, the most abundant component in urine, cross-reacts with a commercial 8-OH-dG ELISA kit and contributes to overestimation of urinary 8-OH-dG." What is ELISA detecting?. Free Radic. Biol. Med. 47 (2009) 30-31
15. Suzuki J., Inoue Y., and Suzuki S. Changes in the urinary excretion level of 8-hydroxyguanine by exposure to reactive oxygen-generating substances. Free Radic. Biol. Med 18 (1995) 431-436
16. Malayappan B., Garrett T.J., Segal M., and Leeuwenburgh C. Urinary analysis of 8-oxoguanine, 8-oxoguanosine, Fapy-guanine and 8-oxo-2′-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress. J. Chromatogr. A 1167 (2007) 54-62
17. Helbock H.J., Beckman K.B., Shigenaga M.K., Walter P.B., Woodall A.A., Yeo H.C., and Ames B.N. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxoguanine. Proc. Natl. Acad. Sci. USA 95 (1998) 288-293
18. Mateos R., and Bravo L. Chromatographic and electrophoretic methods for the analysis of biomarkers of oxidative damage to macromolecules (DNA, lipids, and proteins). J. Sep. Sci 30 (2007) 175-191
19. Singh R., and Farmer P.B. Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection. Carcinogenesis 27 (2006) 178-196
20. Hu C.W., Wang C.J., Chang L.W., and Chao M.R. Clinical-scale high-throughput analysis of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine by isotope-dilution liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction. Clin. Chem 52 (2006) 1381-1388
21. Yang Y.D. Simultaneous determination of creatine, uric acid, creatinine and hippuric acid in urine by high performance liquid chromatography. Biomed. Chromatogr 12 (1998) 47-49
22. Weimann A., Belling D., and Poulsen H.E. Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry. Nucleic Acids Res 30 (2002) E7
23. Hamberg M., and Zhang L.Y. Quantitative determination of 8-hydroxyguanine and guanine by isotope dilution mass spectrometry. Anal. Biochem 229 (1995) 336-344
24. Wujcik C.E., and Kadar E.P. Reduction of in-source collision-induced dissociation and thermolysis of sulopenem prodrugs for quantitative liquid chromatography/electrospray ionization mass spectrometric analysis by promoting sodium adduct formation. Rapid Commun. Mass Spectrom 22 (2008) 3195-3206
25. van Hout M.W., Niederlander H.A., de Zeeuw R.A., and de Jong G.J. Ion suppression in the determination of clenbuterol in urine by solid-phase extraction atmospheric pressure chemical ionisation ion-trap mass spectrometry. Rapid Commun. Mass Spectrom 17 (2003) 245-250
26. Gellekink H., van Oppenraaij-Emmerzaal D., van Rooij A., Struys E.A., den Heijer M., and Blom H.J. Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. Clin. Chem 51 (2005) 1487-1492
27. Stokvis E., Rosing H., and Beijnen J.H. Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?. Rapid Commun. Mass Spectrom. 19 (2005) 401-407
28. Rebelo I.A., Piedade J.A., and Oliveira-Brett A.M. Development of an HPLC method with electrochemical detection of femtomoles of 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine in the presence of uric acid. Talanta 63 (2004) 323-331
29. Svoboda P., Maekawa M., Kawai K., Tominaga T., Savela K., and Kasai H. Urinary 8-hydroxyguanine may be a better marker of oxidative stress than 8-hydroxydeoxyguanosine in relation to the life spans of various species. Antioxid. Redox Signaling 8 (2006) 985-992
30. Ravanat J.L., Guicherd P., Tuce Z., and Cadet J. Simultaneous determination of five oxidative DNA lesions in human urine. Chem. Res. Toxicol 12 (1999) 802-808
31. Roszkowski K., Gackowski D., Rozalski R., Dziaman T., Siomek A., Guz J., Szpila A., Foksinski M., and Olinski R. Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism. Int. J. Cancer 123 (2008) 1964-1967
32. Rozalski R., Gackowski D., Roszkowski K., Foksinski M., and Olinski R. The level of 8-hydroxyguanine, a possible repair product of oxidative DNA damage, is higher in urine of cancer patients than in control subjects. Cancer Epidemiol. Biomarkers Prev 11 (2002) 1072-1075
33. Dianov G., Bischoff C., Piotrowski J., and Bohr V.A. Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts. J. Biol. Chem 273 (1998) 33811-33816