D-polyglutamine amyloid recruits l-polyglutamine monomers and kills cells

Journal of Molecular Biology

Volumn 426, Issue 4, 2014, Pages 816-829

  Kar, Karunakar ^a   Arduini, Irene ^a   Drombosky, Kenneth W ^a   Van Der Wel, Patrick C A ^a   Wetzel, Ronald ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

chiral cross seeding; Huntington's disease; recruitment; rippled sheet; toxicity

Indexed keywords

AMYLOID; MONOMER; POLYGLUTAMINE; SYNTHETIC PEPTIDE; DEXTRO POLYGLUTAMINE AMYLOID; GLUTAMINE; LEVO POLYGLUTAMINE MONOMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAG REPEAT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DEGENERATIVE DISEASE; FLUORESCENCE MICROSCOPY; FOURIER TRANSFORMATION; HUNTINGTON CHOREA; IN VITRO STUDY; INFRARED SPECTROSCOPY; NEUROLOGIC DISEASE; NONHUMAN; PC12 CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; CELL AGGREGATION; CELL KILLING; CELL MEDIATED CYTOTOXICITY; CHIRALITY; PC12 CELL LINE; STEREOCHEMISTRY;

CHIRAL CROSS-SEEDING; DLS; DYNAMIC LIGHT SCATTERING; ELECTRON MICROSCOPY; EM; FOURIER TRANSFORM INFRARED; FTIR; HD; HUNTINGTON'S DISEASE; PBS; PHOSPHATE-BUFFERED SALINE; RECRUITMENT; RIPPLED Β-SHEET; TOXICITY;

AMINO ACID SEQUENCE; AMYLOID; ANIMALS; HUNTINGTON DISEASE; ISOMERISM; KINETICS; MOLECULAR SEQUENCE DATA; PC12 CELLS; PEPTIDES; PROTEIN CONFORMATION; RATS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84893649786     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.11.019     Document Type: Article

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