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Volumn 126, Issue 10, 2004, Pages 3062-3063

Enantioselective Molecular Recognition between β-Sheets

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BETA SHEET; BINDING KINETICS; CHIRALITY; ENANTIOSELECTIVITY; EQUILIBRIUM CONSTANT; MOLECULAR RECOGNITION; MOLECULAR SIZE; PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 1642388486     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja031632z     Document Type: Article
Times cited : (60)

References (13)
  • 6
    • 0026742584 scopus 로고
    • (a) Petsko, G. A. Science 1992, 256, 1403-1404.
    • (1992) Science , vol.256 , pp. 1403-1404
    • Petsko, G.A.1
  • 12
    • 1642269072 scopus 로고    scopus 로고
    • note
    • Although the low concentration of heterochiral dimer precludes rigorously establishing the precise mode of heterochiral interaction (e.g., through NOE studies), it is difficult to envision a mode of dimerization other than antiparallel β-sheet formation that would be sufficiently strong to provide slow exchange on the NMR time scale under the conditions of these experiments. Because alternative modes of heterochiral interaction cannot be precluded rigorously, the value of 0.6-0.8 kcal/mol per interacting residue should be taken as a lower limit for the preference of antiparallel homochiral β-sheet formation over antiparallel heterochiral β-sheet formation.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.