메뉴 건너뛰기




Volumn 81, Issue 4, 2013, Pages 1277-1286

A novel class of lipoprotein lipase-sensitive molecules mediates toll-like receptor 2 activation by Porphyromonas gingivalis

Author keywords

[No Author keywords available]

Indexed keywords

LIPID A; LIPOPOLYSACCHARIDE; LIPOPROTEIN LIPASE; TOLL LIKE RECEPTOR 2;

EID: 84875517343     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01036-12     Document Type: Article
Times cited : (72)

References (64)
  • 1
    • 77953616099 scopus 로고    scopus 로고
    • Periodontitis: a polymicrobial disruption of host homeostasis
    • Darveau RP. 2010. Periodontitis: a polymicrobial disruption of host homeostasis. Nat. Rev. Microbiol. 8:481-490.
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 481-490
    • Darveau, R.P.1
  • 3
    • 33845462504 scopus 로고    scopus 로고
    • TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption
    • Burns E, Bachrach G, Shapira L, Nussbaum G. 2006. TLR2 is required for the innate response to Porphyromonas gingivalis: activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption. J. Immunol. 177:8296-8300.
    • (2006) J. Immunol. , vol.177 , pp. 8296-8300
    • Burns, E.1    Bachrach, G.2    Shapira, L.3    Nussbaum, G.4
  • 5
    • 34848908962 scopus 로고    scopus 로고
    • Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages
    • Wang M, Shakhatreh MA, James D, Liang S, Nishiyama S, Yoshimura F, Demuth DR, Hajishengallis G. 2007. Fimbrial proteins of porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages. J. Immunol. 179:2349-2358.
    • (2007) J. Immunol. , vol.179 , pp. 2349-2358
    • Wang, M.1    Shakhatreh, M.A.2    James, D.3    Liang, S.4    Nishiyama, S.5    Yoshimura, F.6    Demuth, D.R.7    Hajishengallis, G.8
  • 6
    • 0034307339 scopus 로고    scopus 로고
    • The Toll receptor family and microbial recognition
    • Medzhitov R, Janeway C, Jr. 2000. The Toll receptor family and microbial recognition. Trends Microbiol. 8:452-456.
    • (2000) Trends Microbiol. , vol.8 , pp. 452-456
    • Medzhitov, R.1    Janeway, C.Jr.2
  • 9
    • 34848855747 scopus 로고    scopus 로고
    • Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo
    • Hajishengallis G, Shakhatreh MA, Wang M, Liang S. 2007. Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J. Immunol. 179:2359-2367.
    • (2007) J. Immunol. , vol.179 , pp. 2359-2367
    • Hajishengallis, G.1    Shakhatreh, M.A.2    Wang, M.3    Liang, S.4
  • 10
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO. 2007. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130:1071-1082.
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.G.6    Lee, H.7    Lee, J.O.8
  • 14
    • 41649115159 scopus 로고    scopus 로고
    • TLR2-promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity
    • Zähringer U, Lindner B, Inamura S, Heine H, Alexander C. 2008. TLR2-promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity. Immunobiology 213:205-224.
    • (2008) Immunobiology , vol.213 , pp. 205-224
    • Zähringer, U.1    Lindner, B.2    Inamura, S.3    Heine, H.4    Alexander, C.5
  • 16
    • 0025098547 scopus 로고
    • Chemical, immunobiological and antigenic characterizations of lipopolysaccharides from Bacteroides gingivalis strains
    • Fujiwara T, Ogawa T, Sobue S, Hamada S. 1990. Chemical, immunobiological and antigenic characterizations of lipopolysaccharides from Bacteroides gingivalis strains. J. Gen. Microbiol. 136:319-326.
    • (1990) J. Gen. Microbiol. , vol.136 , pp. 319-326
    • Fujiwara, T.1    Ogawa, T.2    Sobue, S.3    Hamada, S.4
  • 17
    • 0017835650 scopus 로고
    • Immunochemical and biologic studies of the lipopolysaccharide of Bacteroides melaninogenicus subspecies asaccharolyticus
    • Mansheim BJ, Onderdonk AB, Kasper DL. 1978. Immunochemical and biologic studies of the lipopolysaccharide of Bacteroides melaninogenicus subspecies asaccharolyticus. J. Immunol. 120:72-78.
    • (1978) J. Immunol. , vol.120 , pp. 72-78
    • Mansheim, B.J.1    Onderdonk, A.B.2    Kasper, D.L.3
  • 18
    • 0030014397 scopus 로고    scopus 로고
    • Differential induction of IL-1 beta and IL-6 production by the nontoxic lipid A from Porphyromonas gingivalis in comparison with synthetic Escherichia coli lipid A in human peripheral blood mononuclear cells
    • Ogawa T, Uchida H. 1996. Differential induction of IL-1 beta and IL-6 production by the nontoxic lipid A from Porphyromonas gingivalis in comparison with synthetic Escherichia coli lipid A in human peripheral blood mononuclear cells. FEMS Immunol. Med. Microbiol. 14:1-13.
    • (1996) FEMS Immunol. Med. Microbiol. , vol.14 , pp. 1-13
    • Ogawa, T.1    Uchida, H.2
  • 19
    • 33947127629 scopus 로고    scopus 로고
    • Hierarchical gene expression profiles of HUVEC stimulated by different lipid A structures obtained from Porphyromonas gingivalis and Escherichia coli
    • Chen C, Coats SR, Bumgarner RE, Darveau RP. 2007. Hierarchical gene expression profiles of HUVEC stimulated by different lipid A structures obtained from Porphyromonas gingivalis and Escherichia coli. Cell Microbiol. 9:1028-1038.
    • (2007) Cell Microbiol. , vol.9 , pp. 1028-1038
    • Chen, C.1    Coats, S.R.2    Bumgarner, R.E.3    Darveau, R.P.4
  • 21
    • 77955766793 scopus 로고    scopus 로고
    • Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis
    • Jain S, Darveau RP. 2010. Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis. Periodontol. 2000 54:53-70.
    • (2010) Periodontol. 2000 , vol.54 , pp. 53-70
    • Jain, S.1    Darveau, R.P.2
  • 22
    • 4544337512 scopus 로고    scopus 로고
    • Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4
    • Darveau RP, Pham TT, Lemley K, Reife RA, Bainbridge BW, Coats SR, Howald WN, Way SS, Hajjar AM. 2004. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect. Immun. 72:5041-5051.
    • (2004) Infect. Immun. , vol.72 , pp. 5041-5051
    • Darveau, R.P.1    Pham, T.T.2    Lemley, K.3    Reife, R.A.4    Bainbridge, B.W.5    Coats, S.R.6    Howald, W.N.7    Way, S.S.8    Hajjar, A.M.9
  • 25
    • 12844278116 scopus 로고    scopus 로고
    • Oral mucosal endotoxin tolerance induction in chronic periodontitis
    • Muthukuru M, Jotwani R, Cutler CW. 2005. Oral mucosal endotoxin tolerance induction in chronic periodontitis. Infect. Immun. 73:687-694.
    • (2005) Infect. Immun. , vol.73 , pp. 687-694
    • Muthukuru, M.1    Jotwani, R.2    Cutler, C.W.3
  • 26
    • 12844264795 scopus 로고    scopus 로고
    • Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein
    • Zhou Q, Desta T, Fenton M, Graves DT, Amar S. 2005. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect. Immun. 73:935-943.
    • (2005) Infect. Immun. , vol.73 , pp. 935-943
    • Zhou, Q.1    Desta, T.2    Fenton, M.3    Graves, D.T.4    Amar, S.5
  • 27
    • 0034662239 scopus 로고    scopus 로고
    • Repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
    • Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ. 2000. Repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 165:618-622.
    • (2000) J. Immunol. , vol.165 , pp. 618-622
    • Hirschfeld, M.1    Ma, Y.2    Weis, J.H.3    Vogel, S.N.4    Weis, J.J.5
  • 29
    • 0036849121 scopus 로고    scopus 로고
    • Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway
    • Ogawa T, Asai Y, Hashimoto M, Takeuchi O, Kurita T, Yoshikai Y, Miyake K, Akira S. 2002. Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway. Int. Immunol. 14:1325-1332.
    • (2002) Int. Immunol. , vol.14 , pp. 1325-1332
    • Ogawa, T.1    Asai, Y.2    Hashimoto, M.3    Takeuchi, O.4    Kurita, T.5    Yoshikai, Y.6    Miyake, K.7    Akira, S.8
  • 30
    • 34247854874 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent recognition of structurally different forms of chemically synthesized lipid As of Porphyromonas gingivalis
    • Sawada N, Ogawa T, Asai Y, Makimura Y, Sugiyama A. 2007. Toll-like receptor 4-dependent recognition of structurally different forms of chemically synthesized lipid As of Porphyromonas gingivalis. Clin. Exp. Immunol. 148:529-536.
    • (2007) Clin. Exp. Immunol. , vol.148 , pp. 529-536
    • Sawada, N.1    Ogawa, T.2    Asai, Y.3    Makimura, Y.4    Sugiyama, A.5
  • 31
    • 52649147064 scopus 로고    scopus 로고
    • Synthetic tetraacylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4
    • Zhang Y, Gaekwad J, Wolfert MA, Boons GJ. 2008. Synthetic tetraacylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4. Org. Biomol. Chem. 6:3371-3381.
    • (2008) Org. Biomol. Chem. , vol.6 , pp. 3371-3381
    • Zhang, Y.1    Gaekwad, J.2    Wolfert, M.A.3    Boons, G.J.4
  • 32
    • 0042315392 scopus 로고    scopus 로고
    • Murein lipoprotein, peptidoglycan- associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides
    • Hellman J, Tehan MM, Warren HS. 2003. Murein lipoprotein, peptidoglycan- associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides. J. Infect. Dis. 188: 286-289.
    • (2003) J. Infect. Dis. , vol.188 , pp. 286-289
    • Hellman, J.1    Tehan, M.M.2    Warren, H.S.3
  • 33
    • 0037090077 scopus 로고    scopus 로고
    • Two lipoproteins extracted from Escherichia coli K-12 LCD25 lipopolysaccharide are the major components responsible for Toll-like receptor 2-mediated signaling
    • Lee HK, Lee J, Tobias PS. 2002. Two lipoproteins extracted from Escherichia coli K-12 LCD25 lipopolysaccharide are the major components responsible for Toll-like receptor 2-mediated signaling. J. Immunol. 168: 4012-4017.
    • (2002) J. Immunol. , vol.168 , pp. 4012-4017
    • Lee, H.K.1    Lee, J.2    Tobias, P.S.3
  • 34
    • 5044249323 scopus 로고    scopus 로고
    • Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis
    • Hashimoto M, Asai Y, Ogawa T. 2004. Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis. Int. Immunol. 16:1431-1437.
    • (2004) Int. Immunol. , vol.16 , pp. 1431-1437
    • Hashimoto, M.1    Asai, Y.2    Ogawa, T.3
  • 35
    • 16244411282 scopus 로고    scopus 로고
    • Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling
    • Asai Y, Hashimoto M, Fletcher HM, Miyake K, Akira S, Ogawa T. 2005. Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling. Infect. Immun. 73:2157-2163.
    • (2005) Infect. Immun. , vol.73 , pp. 2157-2163
    • Asai, Y.1    Hashimoto, M.2    Fletcher, H.M.3    Miyake, K.4    Akira, S.5    Ogawa, T.6
  • 36
  • 37
    • 67749117911 scopus 로고    scopus 로고
    • Structural analysis of the core region of O-lipopolysaccharide of Porphyromonas gingivalis from mutants defective in O-antigen ligase and O-antigen polymerase
    • Paramonov NA, Aduse-Opoku J, Hashim A, Rangarajan M, Curtis MA. 2009. Structural analysis of the core region of O-lipopolysaccharide of Porphyromonas gingivalis from mutants defective in O-antigen ligase and O-antigen polymerase. J. Bacteriol. 191:5272-5282.
    • (2009) J. Bacteriol. , vol.191 , pp. 5272-5282
    • Paramonov, N.A.1    Aduse-Opoku, J.2    Hashim, A.3    Rangarajan, M.4    Curtis, M.A.5
  • 39
    • 0033966030 scopus 로고    scopus 로고
    • Identification and cloning of genes from Porphyromonas gingivalis after mutagenesis with a modified Tn4400 transposon from Bacteroides fragilis
    • Chen T, Dong H, Tang YP, Dallas MM, Malamy MH, Duncan MJ. 2000. Identification and cloning of genes from Porphyromonas gingivalis after mutagenesis with a modified Tn4400 transposon from Bacteroides fragilis. Infect. Immun. 68:420-423.
    • (2000) Infect. Immun. , vol.68 , pp. 420-423
    • Chen, T.1    Dong, H.2    Tang, Y.P.3    Dallas, M.M.4    Malamy, M.H.5    Duncan, M.J.6
  • 40
    • 0032443225 scopus 로고    scopus 로고
    • Regulation of protease expression in Porphyromonas gingivalis
    • Tokuda M, Chen W, Karunakaran T, Kuramitsu HK. 1998. Regulation of protease expression in Porphyromonas gingivalis. Infect. Immun. 66: 5232-5237.
    • (1998) Infect. Immun. , vol.66 , pp. 5232-5237
    • Tokuda, M.1    Chen, W.2    Karunakaran, T.3    Kuramitsu, H.K.4
  • 41
    • 0027431995 scopus 로고
    • Molecular cloning and sequencing of the fimbrilin gene of Porphyromonas gingivalis strains and characterization of recombinant proteins
    • Fujiwara T, Morishima S, Takahashi I, Hamada S. 1993. Molecular cloning and sequencing of the fimbrilin gene of Porphyromonas gingivalis strains and characterization of recombinant proteins. Biochem. Biophys. Res. Commun. 197:241-247.
    • (1993) Biochem. Biophys. Res. Commun. , vol.197 , pp. 241-247
    • Fujiwara, T.1    Morishima, S.2    Takahashi, I.3    Hamada, S.4
  • 42
    • 0021678531 scopus 로고
    • Purification and characterization of a novel type of fimbriae from the oral anaerobe Bacteroides gingivalis
    • Yoshimura F, Takahashi K, Nodasaka Y, Suzuki T. 1984. Purification and characterization of a novel type of fimbriae from the oral anaerobe Bacteroides gingivalis. J. Bacteriol. 160:949-957.
    • (1984) J. Bacteriol. , vol.160 , pp. 949-957
    • Yoshimura, F.1    Takahashi, K.2    Nodasaka, Y.3    Suzuki, T.4
  • 44
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NFkappaB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. 2009. Regulation and function of NFkappaB transcription factors in the immune system. Annu. Rev. Immunol. 27:693-733.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 45
    • 0035184263 scopus 로고    scopus 로고
    • Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2
    • Asai Y, Ohyama Y, Gen Ogawa KT. 2001. Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2. Infect. Immun. 69:7387-7395.
    • (2001) Infect. Immun. , vol.69 , pp. 7387-7395
    • Asai, Y.1    Ohyama, Y.2    Gen Ogawa, K.T.3
  • 47
    • 33748691037 scopus 로고    scopus 로고
    • Correlation between chemical structure and biological activities of Porphyromonas gingivalis synthetic lipopeptide derivatives
    • Makimura Y, Asai Y, Taiji Y, Sugiyama A, Tamai R, Ogawa T. 2006. Correlation between chemical structure and biological activities of Porphyromonas gingivalis synthetic lipopeptide derivatives. Clin. Exp. Immunol. 146:159-168.
    • (2006) Clin. Exp. Immunol. , vol.146 , pp. 159-168
    • Makimura, Y.1    Asai, Y.2    Taiji, Y.3    Sugiyama, A.4    Tamai, R.5    Ogawa, T.6
  • 48
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911-917.
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 49
    • 84857174056 scopus 로고    scopus 로고
    • Free lipid A isolated from Porphyromonas gingivalis lipopolysaccharide is contaminated with phosphorylated dihydroceramide lipids: recovery in diseased dental samples
    • Nichols FC, Bajrami B, Clark RB, Housley W, Yao X. 2012. Free lipid A isolated from Porphyromonas gingivalis lipopolysaccharide is contaminated with phosphorylated dihydroceramide lipids: recovery in diseased dental samples. Infect. Immun. 80:860-874.
    • (2012) Infect. Immun. , vol.80 , pp. 860-874
    • Nichols, F.C.1    Bajrami, B.2    Clark, R.B.3    Housley, W.4    Yao, X.5
  • 50
    • 0036460675 scopus 로고    scopus 로고
    • Lipoprotein lipase: structure, function, regulation, and role in disease
    • Mead JR, Irvine SA, Ramji DP. 2002. Lipoprotein lipase: structure, function, regulation, and role in disease. J. Mol. Med. 80:753-769. 51. Kovacs-Simon A, Titball RW, Michell SL. 2011. Lipoproteins of bacterial pathogens. Infect. Immun. 79:548-561.
    • (2002) J. Mol. Med. , vol.80 , pp. 753-769
    • Mead, J.R.1    Irvine, S.A.2    Ramji, D.P.3
  • 52
    • 78650866068 scopus 로고    scopus 로고
    • The lipid A phosphate position determines differential host Toll-like receptor 4 responses to phylogenetically related symbiotic and pathogenic bacteria
    • Coats SR, Berezow AB, To TT, Jain S, Bainbridge BW, Banani KP, Darveau RP. 2011. The lipid A phosphate position determines differential host Toll-like receptor 4 responses to phylogenetically related symbiotic and pathogenic bacteria. Infect. Immun. 79:203-210.
    • (2011) Infect. Immun. , vol.79 , pp. 203-210
    • Coats, S.R.1    Berezow, A.B.2    To, T.T.3    Jain, S.4    Bainbridge, B.W.5    Banani, K.P.6    Darveau, R.P.7
  • 53
    • 0027995345 scopus 로고
    • Elimination of trace endotoxin protein from rough chemotype LPS
    • Manthey CL, Vogel SN. 1994. Elimination of trace endotoxin protein from rough chemotype LPS. J. Endotoxin Res. 1:84-91.
    • (1994) J. Endotoxin Res. , vol.1 , pp. 84-91
    • Manthey, C.L.1    Vogel, S.N.2
  • 54
    • 6344241451 scopus 로고    scopus 로고
    • A regulation cascade controls expression of Porphyromonas gingivalis fimbriae via the FimR response regulator
    • Nishikawa K, Yoshimura F, Duncan MJ. 2004. A regulation cascade controls expression of Porphyromonas gingivalis fimbriae via the FimR response regulator. Mol. Microbiol. 54:546-560.
    • (2004) Mol. Microbiol. , vol.54 , pp. 546-560
    • Nishikawa, K.1    Yoshimura, F.2    Duncan, M.J.3
  • 55
    • 84865566769 scopus 로고    scopus 로고
    • Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages
    • Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T. 2012. Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages. Microbes Infect. 14:916-921.
    • (2012) Microbes Infect. , vol.14 , pp. 916-921
    • Shimada, E.1    Kataoka, H.2    Miyazawa, Y.3    Yamamoto, M.4    Igarashi, T.5
  • 56
    • 77954762140 scopus 로고    scopus 로고
    • Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2
    • Aoki Y, Tabeta K, Murakami Y, Yoshimura F, Yamazaki K. 2010. Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2. Biochem. Biophys. Res. Commun. 398:86-91.
    • (2010) Biochem. Biophys. Res. Commun. , vol.398 , pp. 86-91
    • Aoki, Y.1    Tabeta, K.2    Murakami, Y.3    Yoshimura, F.4    Yamazaki, K.5
  • 57
    • 78549271733 scopus 로고    scopus 로고
    • Recombinant Porphyromonas gingivalis FimA preproprotein expressed in Escherichia coli is lipidated and the mature or processed recombinant FimA protein forms a short filament in vitro
    • Shoji M, Yoshimura A, Yoshioka H, Takade A, Takuma Y, Yukitake H, Naito M, Hara Y, Yoshida Nakayama S-IK. 2010. Recombinant Porphyromonas gingivalis FimA preproprotein expressed in Escherichia coli is lipidated and the mature or processed recombinant FimA protein forms a short filament in vitro. Can. J. Microbiol. 56:959-967.
    • (2010) Can. J. Microbiol. , vol.56 , pp. 959-967
    • Shoji, M.1    Yoshimura, A.2    Yoshioka, H.3    Takade, A.4    Takuma, Y.5    Yukitake, H.6    Naito, M.7    Hara, Y.8    Yoshida Nakayama, S.-I.K.9
  • 58
    • 73549121929 scopus 로고    scopus 로고
    • Unique lipids from a common human bacterium represent a new class of Toll-like receptor 2 ligands capable of enhancing autoimmunity
    • Nichols FC, Housley WJ, O'Conor CA, Manning T, Wu S, Clark RB. 2009. Unique lipids from a common human bacterium represent a new class of Toll-like receptor 2 ligands capable of enhancing autoimmunity. Am. J. Pathol. 175:2430-2438.
    • (2009) Am. J. Pathol. , vol.175 , pp. 2430-2438
    • Nichols, F.C.1    Housley, W.J.2    O'Conor, C.A.3    Manning, T.4    Wu, S.5    Clark, R.B.6
  • 59
    • 49649123115 scopus 로고    scopus 로고
    • Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation
    • Machata S, Tchatalbachev S, Mohamed W, Jänsch Hain LT, Chakraborty T. 2008. Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation. J. Immunol. 181: 2028-2035.
    • (2008) J. Immunol. , vol.181 , pp. 2028-2035
    • Machata, S.1    Tchatalbachev, S.2    Mohamed, W.3    Jänsch Hain, L.T.4    Chakraborty, T.5
  • 60
    • 77956272227 scopus 로고    scopus 로고
    • Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity
    • doi:10.1371/journal.pone .0009323
    • Bagaitkar J, Demuth DR, Daep CA, Renaud DE, Pierce DL, Scott DA. 2010. Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity. PLoS One 5:e9323. doi:10.1371/journal.pone .0009323.
    • (2010) PLoS One , vol.5
    • Bagaitkar, J.1    Demuth, D.R.2    Daep, C.A.3    Renaud, D.E.4    Pierce, D.L.5    Scott, D.A.6
  • 61
    • 33846805500 scopus 로고    scopus 로고
    • Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae
    • Eskan MA, Hajishengallis G, Kinane DF. 2007. Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae. Infect. Immun. 75:892-898.
    • (2007) Infect. Immun. , vol.75 , pp. 892-898
    • Eskan, M.A.1    Hajishengallis, G.2    Kinane, D.F.3
  • 62
    • 28244498667 scopus 로고    scopus 로고
    • Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors
    • Hajishengallis G, Ratti P, Harokopakis E. 2005. Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors. J. Biol. Chem. 280:38902-38913.
    • (2005) J. Biol. Chem. , vol.280 , pp. 38902-38913
    • Hajishengallis, G.1    Ratti, P.2    Harokopakis, E.3
  • 63
    • 38849092080 scopus 로고    scopus 로고
    • Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components
    • Zhou Q, Amar S. 2007. Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components. J. Immunol. 179:7777-7790.
    • (2007) J. Immunol. , vol.179 , pp. 7777-7790
    • Zhou, Q.1    Amar, S.2
  • 64
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. 2011. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332:974-977.
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3    Tran, G.4    Jabri, B.5    Chatila, T.A.6    Mazmanian, S.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.