Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis

European Journal of Immunology

Volumn 44, Issue 2, 2014, Pages 321-327

  Chen, Grace Y ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

Cancer; Immune regulation; Immune responses; Inflammation; Innate immunity

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR 12; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR 6; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CLEARANCE; BACTERIAL INFECTION; BACTERIAL SURVIVAL; BACTERIAL TRANSLOCATION; CARCINOGENESIS; COLITIS; CYTOKINE PRODUCTION; CYTOPLASM; DISEASE SEVERITY; ENZYMATIC DEGRADATION; ENZYME PHOSPHORYLATION; EPITHELIUM; GASTROINTESTINAL INFECTION; GENE EXPRESSION PROFILING; HEMATOPOIETIC CELL; HEREDITY; HOMEOSTASIS; HOST RESISTANCE; HOST SUSCEPTIBILITY; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; INNATE IMMUNITY; INTESTINE; INTESTINE FLORA; IRRITABLE COLON; KLEBSIELLA PNEUMONIAE; LUCIFERASE ASSAY; LUNG INFECTION; MACROPHAGE; MICROBIAL COMMUNITY; MORTALITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OLIGOMERIZATION; PHENOTYPE; PRIORITY JOURNAL; PROTECTION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMALL INTESTINE DISEASE; YERSINIA PESTIS;

CANCER; IMMUNE REGULATION; IMMUNE RESPONSES; INFLAMMATION; INNATE IMMUNITY;

COLITIS; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INTESTINES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; SIGNAL TRANSDUCTION;

EID: 84893545999     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344135     Document Type: Article

References (41)

1. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. and Medzhitov, R., Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004. 118: 229-241.
2. Chen, G. Y., Shaw, M. H., Redondo, G. and Nunez, G., The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res. 2008. 68: 10060-10067.
3. Couturier-Maillard, A., Secher, T., Rehman, A., Normand, S., De Arcangelis, A., Haesler, R., Huot, L. et al., NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J. Clin. Invest. 2013 123: 700-711.
4. Zaki, M. H., Boyd, K. L., Vogel, P., Kastan, M. B., Lamkanfi, M. and Kanneganti, T. D., The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010. 32: 379-391.
5. Zaki, M. H., Vogel, P., Body-Malapel, M., Lamkanfi, M. and Kanneganti, T. D., IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J. Immunol. 2010. 185: 4912-4920.
6. Allen, I. C., TeKippe, E. M., Woodford, R. M., Uronis, J. M., Holl, E. K., Rogers, A. B., Herfarth, H. H. et al., The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J. Exp. Med. 2010. 207: 1045-1056.
7. Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R. et al., NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011. 145: 745-757.
8. Chen, G. Y., Liu, M., Wang, F., Bertin, J. and Nunez, G., A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 2011. 186: 7187-7194.
9. Normand, S., Delanoye-Crespin, A., Bressenot, A., Huot, L., Grandjean, T., Peyrin-Biroulet, L., Lemoine, Y. et al., Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl. Acad Sci. USA 2011. 108: 9601-9606.
10. Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T. D., Ozoren, N., Jagirdar, R., Inohara, N. et al., Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 2006. 7: 576-582.
11. Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K. et al., Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 2003. 278: 5509-5512.
12. Chen, G. Y. and Nunez, G., Sterile inflammation: sensing and reacting to damage. Nat. Rev. Immunol. 2010. 10: 826-837.
13. Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P. C., Chen, F. F., Ogura, Y. et al., An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J. Biol. Chem. 2000. 275: 27823-27831.
14. Ting, J. P., Lovering, R. C., Alnemri, E. S., Bertin, J., Boss, J. M., Davis, B. K., Flavell, R. A. et al., The NLR gene family: a standard nomenclature. Immunity 2008. 28: 285-287.
15. Allen, I. C., Wilson, J. E., Schneider, M., Lich, J. D., Roberts, R. A., Arthur, J. C., Woodford, R. M. et al., NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kappaB signaling. Immunity 2012. 36: 742-754.
16. Zaki, M. H., Vogel, P., Malireddi, R. K., Body-Malapel, M., Anand, P. K., Bertin, J., Green, D. R., et al., The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 2011. 20: 649-660.
17. Couturier-Maillard, A., Secher, T., Rehman, A., Normand, S., De Arcangelis, A., Haesler, R., Huot, L. et al., NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J. Clin. Invest. 2013. 123: 700-711.
18. Hu, B., Elinav, E., Huber, S., Booth, C. J., Strowig, T., Jin, C., Eisenbarth, S. C. et al., Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc. Natl. Acad Sci. USA 2010. 107: 21635-21640.
19. Wang, L., Manji, G. A., Grenier, J. M., Al-Garawi, A., Merriam, S., Lora, J. M., Geddes, B. J. et al., PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J. Biol. Chem. 2002. 277: 29874-29880.
20. Grenier, J. M., Wang, L., Manji, G. A., Huang, W. J., Al-Garawi, A., Kelly, R., Carlson, A. et al., Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS. Lett. 2002. 530: 73-78.
21. Srinivasula, S. M., Poyet, J. L., Razmara, M., Datta, P., Zhang, Z. and Alnemri, E. S., The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J. Biol. Chem. 2002. 277: 21119-21122.
22. Lamkanfi, M., Kanneganti, T. D., Van Damme, P., Vanden Berghe, T., Vanoverberghe, I., Vandekerckhove, J., Vandenabeele, P. et al., Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol. Cell. Proteomics 2008. 7: 2350-2363.
23. Fernandes-Alnemri, T. and Alnemri, E. S., Assembly, purification, and assay of the activity of the ASC pyroptosome. Methods Enzymol. 2008. 442: 251-270.
24. Vladimer, G. I., Weng, D., Paquette, S. W., Vanaja, S. K., Rathinam, V. A., Aune, M. H., Conlon, J. E. et al., The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 2012. 37: 96-107.
25. Anand, P. K., Malireddi, R. K., Lukens, J. R., Vogel, P., Bertin, J., Lamkanfi, M. and Kanneganti, T. D., NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 2012. 488: 389-393.
26. Williams, K. L., Lich, J. D., Duncan, J. A., Reed, W., Rallabhandi, P., Moore, C., Kurtz, S. et al. The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J. Biol. Chem. 2005. 280: 39914-39924.
27. Lich, J. D., Williams, K. L., Moore, C. B., Arthur, J. C., Davis, B. K., Taxman, D. J. and Ting, J. P., Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J. Immunol. 2007. 178: 1256-1260.
28. Allen, I. C., McElvania-TeKippe, E., Wilson, J. E., Lich, J. D., Arthur, J. C., Sullivan, J. T., Braunstein, M. et al., Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis. PLoS One 2013. 8: e60842.
29. Garrett, W. S., Gallini, C. A., Yatsunenko, T., Michaud, M., DuBois, A., Delaney, M. L., Punit, S. et al., Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 2010. 8: 292-300.
30. Hu, B., Elinav, E., Huber, S., Strowig, T., Hao, L., Hafemann, A., Jin, C. et al., Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc. Natl. Acad. Sci. USA 2013. 110: 9862-9867.
31. Hirota, S. A., Ng, J., Lueng, A., Khajah, M., Parhar, K., Li, Y., Lam, V. et al., NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm. Bowel. Dis. 2011. 17: 1359-1372.
32. Ubeda, C., Lipuma, L., Gobourne, A., Viale, A., Leiner, I., Equinda, M., Khanin, R. et al., Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J. Exp. Med. 2012. 209: 1445-1456.
33. Sun, Y., Zhang, M., Chen, C. C., Gillilland, M., 3rd, Sun, X., El-Zaatari, M., Huffnagle, G. B. et al., Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology 2013. 144: 1478-1487.
34. Salcedo, R., Worschech, A., Cardone, M., Jones, Y., Gyulai, Z., Dai, R. M., Wang, E. et al., MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 2010. 207: 1625-1636.
35. Huber, S., Gagliani, N., Zenewicz, L. A., Huber, F. J., Bosurgi, L., Hu, B., Hedl, M. et al., IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 2012. 491: 259-263.
36. Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., Lehr, H. A. et al., STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 2009. 206: 1465-1472.
37. Witte, E., Witte, K., Warszawska, K., Sabat, R. and Wolk, K., Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection. Cytokine. Growth Factor Rev. 2010. 21: 365-379.
38. Kempster, S. L., Belteki, G., Forhead, A. J., Fowden, A. L., Catalano, R. D., Lam, B. Y., McFarlane, I. et al., Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 2011. 300: G253-263.
39. Dhawan, P. and Richmond, A., A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells. J. Biol. Chem. 2002. 277: 7920-7928.
40. Adli, M., Merkhofer, E., Cogswell, P. and Baldwin, A. S., IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. PLoS One 2010. 5: e9428.
41. Zarnegar, B., Yamazaki, S., He, J. Q. and Cheng, G., Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc. Natl. Acad. Sci. USA 2008. 105: 3503-3508.