Human neutrophils kill Bacillus anthracis

PLoS Pathogens

Volumn 1, Issue 3, 2005, Pages 0179-0186

  Mayer Scholl, Anne ^a   Hurwitz, Robert ^a   Brinkmann, Volker ^a   Schmid, Monika ^a   Jungblut, Peter ^a   Weinrauch, Yvette ^b   Zychlinsky, Arturo ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN;

ANIMAL; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL SPORE; CELL CULTURE; CELL GRANULE; CHEMISTRY; DISEASE MODEL; GROWTH, DEVELOPMENT AND AGING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; NEUTROPHIL; PHAGOCYTOSIS; PHYSIOLOGY; ULTRASTRUCTURE;

ALPHA-DEFENSINS; ANIMALS; BACILLUS ANTHRACIS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOPLASMIC GRANULES; DISEASE MODELS, ANIMAL; HUMANS; NEUTROPHILS; PHAGOCYTOSIS; SPORES, BACTERIAL;

EID: 33748793508     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.0010023     Document Type: Article

References (31)

1. Guidi-Rontani C, Weber-Levy M, Labruyere E, Mock M (1999) Germination of Bacillus anthracis spores within alveolar macrophages. Mol Microbiol 31: 9-17. (Pubitemid 29012143)
2. Guidi-Rontani C, Mock M (2002) Macrophage interactions. Curr Top Microbiol Immunol 271: 115-141.
3. Mock M, Fouet A (2001) Anthrax. Annu Rev Microbiol 55: 647-671.
4. Bradley KA, Mogridge J, Mourez M, Collier RJ, Young JA (2001) Identification of the cellular receptor for anthrax toxin. Nature 414: 225-229. (Pubitemid 33051239)
5. Leppla SH (1982) Anthrax toxin edema factor: A bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci U S A 79: 3162-3166.
6. Duesbery NS, Webb CP, Leppla SH, Gordon VM, Klimpel KR, et al. (1998) Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 280: 734-737.
7. Hampton MB, Kettle AJ, Winterbourn CC (1998) Inside the neutrophil phagosome: Oxidants, myeloperoxidase, and bacterial killing. Blood 92: 3007-3017.
8. Borregaard N, Cowland JB (1997) Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89: 3503-3521. (Pubitemid 27227073)
9. Lehrer RI, Ganz T (1999) Antimicrobial peptides in mammalian and insect host defense. Curr Opin Immunol 11: 23-27. (Pubitemid 29082332)
10. Lebowich RJ, McKillip BG, Conboy JR (1943) Cutaneous anthrax: A pathological study with clinical correlation. Am J Clin Pathol 13: 505-515.
11. Albrink WS, Brooks SM, Biron RE, Kopel M (1960) Human inhalation anthrax: A report of three fatal cases. Am J Pathol 36: 147-471.
12. Abramova FA, Grinberg LM, Yampolskaya OV, Walker DH (1993) Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979. Proc Natl Acad Sci U S A 90: 2291-2294.
13. Brachman PS (1980) Inhalation anthrax. Ann N Y Acad Sci 353: 83-93.
14. Meselson M, Guillemin J, Hugh-Jones M, Langmuir A, Popova I, et al. (1994) The Sverdlovsk anthrax outbreak of 1979. Science 266: 1202-1208.
15. Cromartie WJ, Bloom WL, Watson DW (1947) Studies in infection with Bacillus anthracis. J Infect Dis 80: 1-13.
16. Gleiser CA, Gochenour WS Jr., Ward MK (1968) Pulmonary lesions in dogs and pigs exposed to a cloud of anthrax spores. J Comp Pathol 78: 445-448.
17. Welkos SL, Trotter RW, Becker DM, Nelson GO (1989) Resistance to the Sterne strain of B. anthracis: Phagocytic cell responses of resistant and susceptible mice. Microb Pathog 7: 15-35.
18. Ireland JA, Hanna PC (2002) Macrophage-enhanced germination of Bacillus anthracis endospores requires gerS. Infect Immun 70: 5870-5872.
19. Cross AR, Jones OT (1986) The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils: Specific labelling of a component polypeptide of the oxidase. Biochem J 237: 111-116.
20. O'Brien J, Friedlander A, Dreier T, Ezzell J, Leppla S (1985) Effects of anthrax toxin components on human neutrophils. Infect Immun 47: 306-310. (Pubitemid 15194628)
21. Drysdale M, Heninger S, Hutt J, Chen Y, Lyons CR, et al. (2005) Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax. Embo J 24: 221-227. (Pubitemid 40188479)
22. Keppie J, Harris-Smith PW, Smith H (1963) The chemical basis of the virulence of Bacillus anthracis. Ix. Its aggressins and their mode of action. Br J Exp Pathol 44: 446-453.
23. Makino S, Watarai M, Cheun HI, Shirahata T, Uchida I (2002) Effect of the lower molecular capsule released from the cell surface of Bacillus anthracis on the pathogenesis of anthrax. J Infect Dis 186: 227-233. (Pubitemid 34765511)
24. Alexeyev OA, Morozov VG, Suzdaltseva TV, Mishukov AS, Steinberg LA (1994) Impaired neutrophil function in the cutaneous form of anthrax. Infection 22: 281-282.
25. Kristian SA, Durr M, Van Strijp JA, Neumeister B, Peschel A (2003) MprFmediated lysinylation of phospholipids in Staphylococcus aureus leads to protection against oxygen-independent neutrophil killing. Infect Immun 71: 546-549. (Pubitemid 36026063)
26. Ganz T (2003) Defensins: Antimicrobial peptides of innate immunity. Nat Rev Immunol 3: 710-720. (Pubitemid 41070812)
27. Ganz T, Lehrer RI (1995) Defensins. Pharmacol Ther 66: 191-205.
28. Peschel A, Collins LV (2001) Staphylococcal resistance to antimicrobial peptides of mammalian and bacterial origin. Peptides 22: 1651-1659. (Pubitemid 32918244)
29. Boyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl 97: 77-89.
30. Dahlgren C, Karlsson A (1999) Respiratory burst in human neutrophils. J Immunol Methods 232: 3-14.
31. Weiss J, Elsbach P, Olsson I, Odeberg H (1978) Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. J Biol Chem 253: 2664-2672. (Pubitemid 8328425)