53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes

Gynecologic Oncology

Volumn 128, Issue 3, 2013, Pages 493-499

  Pennington, Kathryn P ^a   Wickramanayake, Anneka ^a   Norquist, Barbara M ^a   Pennil, Christopher C ^a   Garcia, Rochelle L ^a   Agnew, Kathy J ^a   Taniguchi, Toshiyasu ^b   Welcsh, Piri ^a   Swisher, Elizabeth M ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

53BP1; BRCA1; BRCA2; Homologous recombination; Non homologous endjoining; Ovarian carcinoma

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PLATINUM; PROTEIN; PROTEIN 53BP1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; DNA END JOINING REPAIR; FEMALE; GENE EXPRESSION; GENE MUTATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

BRCA1 PROTEIN; BRCA2 PROTEIN; FALLOPIAN TUBE NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MIDDLE AGED; MUTATION; NEOPLASM RECURRENCE, LOCAL; OVARIAN NEOPLASMS; PERITONEAL NEOPLASMS; PROGNOSIS; RNA, MESSENGER;

EID: 84873726399     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2012.12.007     Document Type: Article

References (27)

1. H. Farmer, N. McCabe, C.J. Lord, A.N. Tutt, D.A. Johnson, and T.B. Richardson Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921
2. N. McCabe, N.C. Turner, C.J. Lord, K. Kluzek, A. Bialkowska, and S. Swift Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition Cancer Res 66 2006 8109 8115
3. T. Taniguchi, M. Tischkowitz, N. Ameziane, S.V. Hodgson, C.G. Mathew, and H. Joenje Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors Nat Med 9 2003 568 574
4. A. Bothmer, D.F. Robbiani, M. Di Virgilio, S.F. Bunting, I.A. Klein, and N. Feldhahn Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1 Mol Cell 42 2011 319 329
5. S.F. Bunting, E. Callen, N. Wong, H.T. Chen, F. Polato, and A. Gunn 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks Cell 141 2010 243 254
6. S. Difilippantonio, E. Gapud, N. Wong, C.Y. Huang, G. Mahowald, and H.T. Chen 53BP1 facilitates long-range DNA end-joining during V(D)J recombination Nature 456 2008 529 533
7. I.M. Ward, B. Reina-San-Martin, A. Olaru, K. Minn, K. Tamada, and J.S. Lau 53BP1 is required for class switch recombination J Cell Biol 165 2004 459 464
8. A. Xie, A. Hartlerode, M. Stucki, S. Odate, N. Puget, and A. Kwok Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair Mol Cell 28 2007 1045 1057
9. P. Bouwman, A. Aly, J.M. Escandell, M. Pieterse, J. Bartkova, and H. van der Gulden 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers Nat Struct Mol Biol 17 2010 688 695
10. S.F. Bunting, E. Callen, M.L. Kozak, J.M. Kim, N. Wong, and A.J. Lopez-Contreras BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair Mol Cell 46 2012 125 135
11. K.L. Bolton, G. Chenevix-Trench, C. Goh, S. Sadetzki, S.J. Ramus, and B.Y. Karlan Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer JAMA 307 2012 382 390
12. A. Chetrit, G. Hirsh-Yechezkel, Y. Ben-David, F. Lubin, E. Friedman, and S. Sadetzki Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer J Clin Oncol 26 2008 20 25
13. K. Alsop, S. Fereday, C. Meldrum, A. deFazio, C. Emmanuel, and J. George BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group J Clin Oncol 30 2012 2654 2663
14. E.M. Swisher, R.M. Gonzalez, T. Taniguchi, R.L. Garcia, T. Walsh, and B.A. Goff Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas Mol Cancer 8 2009 48
15. A. Catteau, W.H. Harris, C.F. Xu, and E. Solomon Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics Oncogene 18 1999 1957 1965
16. R.L. Baldwin, E. Nemeth, H. Tran, H. Shvartsman, I. Cass, and S. Narod BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study Cancer Res 60 2000 5329 5333
17. G. Strathdee, K. Appleton, M. Illand, D.W. Millan, J. Sargent, and J. Paul Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes Am J Pathol 158 2001 1121 1127
18. J.M. Teodoridis, J. Hall, S. Marsh, H.D. Kannall, C. Smyth, and J. Curto CpG island methylation of DNA damage response genes in advance ovarian cancer Cancer Res 65 2005 8961 8967
19. The Cancer Genome Atlas Research Network Integrated genomic analyses of ovarian carcinoma Nature 474 2011 609 615
20. M. Thrall, H.H. Gallion, R. Kryscio, M. Kapali, D.K. Armstrong, and J.A. DeLoia BRCA1 expression in a large series of sporadic ovarian carcinomas: a Gynecologic Oncology Group study Int J Gynecol Cancer 16 2006 166 171
21. T. Walsh, S. Casadei, M.K. Lee, C.C. Pennil, A.S. Nord, and A.M. Thornton Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing Proc Natl Acad Sci U S A 108 2011 18032 18037
22. L.B. Schultz, N.H. Chehab, A. Malikzay, and T.D. Halazonetis p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks J Cell Biol 151 2000 1381 1390
23. J. Bartkova, Z. Horejsi, M. Sehested, J.M. Nesland, E. Rajpert-De Meyts, and N.E. Skakkebaek DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumors Oncogene 26 2007 7414 7422
24. C.A. Wilson, L. Ramos, M.R. Villasenor, K.H. Anders, M.F. Press, and K. Clarke Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas Nat Genet 21 1999 236 240
25. B. Norquist, K.A. Wurz, C.C. Pennil, R. Garcia, J. Gross, and W. Sakai Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas J Clin Oncol 29 2011 3008 3015
26. J. Kang, A.D. D'Andrea, and D. Kozono A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy J Natl Cancer Inst 104 2012 670 681
27. A.G. Patel, J.N. Sarkaria, and S.H. Kaufmann Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells Proc Natl Acad Sci U S A 108 2011 3406 3411