Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 299-311

  Li, Zeng ^a   Tan, Jia Heng ^a   He, Jin Hui ^a   Long, Yi ^a   Ou, Tian Miao ^a   Li, Ding ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

G quadruplex DNA; Interaction; Quinazoline derivatives; Selectivity; Telomerase inhibition

Indexed keywords

AMIDE; GUANINE QUADRUPLEX; N (5 CHLORO 2 (4 (3 (DIMETHYLAMINO)PROPYLAMINO)QUINAZOLIN 2 YL)PHENYL) 3 (4 METHYLPIPERAZIN 1 YL)PROPANE AMIDE; QUINAZOLINE DERIVATIVE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG SELECTIVITY; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; SENESCENCE; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; TELOMERE SHORTENING;

BASE SEQUENCE; DNA; G-QUADRUPLEXES; HL-60 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; QUINAZOLINES; SPECTRUM ANALYSIS; TELOMERASE; TELOMERE; TELOMERE SHORTENING;

EID: 84855761960     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.057     Document Type: Article

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