Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: Involvement of tubulin polymerization inhibition

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 6, 2009, Pages 1235-1251

  Viola, Giampietro ^a   Cecconet, Laura ^a   Leszl, Anna ^a   Basso, Giuseppe ^a   Brun, Paola ^a   Salvador, Alessia ^a   Dall'Acqua, Francesco ^a   Diana, Patrizia ^b   Barraja, Paola ^b   Cirrincione, Girolamo ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Antimitotic; Apoptosis; G2 M block; Mitochondrial depolarization; Pyrrolotetrazinones; Tubulin

Indexed keywords

ANTIMITOTIC AGENT; BETA ACTIN; CASPASE 3; DOXORUBICIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; PYRROLE DERIVATIVE; PYRROLOTETRAZINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LIVER CELL CARCINOMA; MALE; MEMBRANE DEPOLARIZATION; MICROTUBULE ASSEMBLY; MITOCHONDRION; MITOSIS INDEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; DACARBAZINE; GENE EXPRESSION; HUMANS; JURKAT CELLS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICROTUBULES; MITOCHONDRIA; PHOSPHATIDYLSERINES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TUBULIN; TUBULIN MODULATORS;

EID: 69049093766     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-0994-9     Document Type: Article

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