Larger late sodium current density as well as greater sensitivities to ATX II and ranolazine in rabbit left atrial than left ventricular myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 3, 2014, Pages

  Luo, Antao ^a   Ma, Jihua ^a   Song, Yejia ^b   Qian, Chunping ^a   Wu, Ying ^a   Zhang, Peihua ^a   Wang, Leilei ^a   Fu, Chen ^a   Cao, Zhenzhen ^a   Shryock, John C ^c  

^a WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c Gilead Sciences ^*  (United States)

Author keywords

Cardiomyocyte; Late sodium current; Patch clamp technique; Regional differences

Indexed keywords

RANOLAZINE; SEA ANEMONE TOXIN;

ANIMAL CELL; ARTICLE; CELL ATTACHED PATCH CLAMP; CONTROLLED STUDY; DENSITY; FEMALE; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART MUSCLE CELL; MALE; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PULSE RATE; RABBIT; SENSITIVITY ANALYSIS; SINGLE CHANNEL PATCH CLAMP; SODIUM CURRENT; WHOLE CELL PATCH CLAMP;

CARDIOMYOCYTE; LATE SODIUM CURRENT; PATCH-CLAMP TECHNIQUE; REGIONAL DIFFERENCES;

ACETANILIDES; ACTION POTENTIALS; ANIMALS; CNIDARIAN VENOMS; HEART ATRIA; HEART VENTRICLES; MYOCYTES, CARDIAC; ORGAN SPECIFICITY; PIPERAZINES; RABBITS; SODIUM; SODIUM CHANNEL BLOCKERS;

EID: 84893417972     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00727.2013     Document Type: Article

References (28)

1. Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas A, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El-Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA. Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat. Am J Physiol Heart Circ Physiol 305: H1068-H1079, 2013.
2. Antzelevitch C. Electrical heterogeneity, cardiac arrhythmias, and the sodium channel. Circ Res 87: 964-965, 2000.
3. Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110: 904-910, 2004.
4. Antzelevitch C, Burashnikov A. Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation. Ann N Y Acad Sci 1188: 78-86, 2010.
5. Antzelevitch C, Burashnikov A. Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation. J Electrocardiol 42: 543-548, 2009.
6. Antzelevitch C, Dumaine R. Electrical heterogeneity in the heart: physiological, pharmacological and clinical implications. In: Handbook of Physiology, The Cardiovascular System, The Heart. Bethesda, MD: Am. Physiol. Soc., 2002, sect. 2, vol. I, p. 654-692.
7. Burashnikov A, Antzelevitch C. Atrial-selective sodium channel block for the treatment of atrial fibrillation. Expert Opin Emerg Drugs 14: 233-249, 2009.
8. Burashnikov A, Antzelevitch C. Atrial-selective sodium channel blockers: do they exist? J Cardiovasc Pharmacol 52: 121-128, 2008.
9. Burashnikov A, Di Diego JM, Sicouri S, Ferreiro M, Carlsson L, Antzelevitch C. Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation. Heart Rhythm 5: 1735-1742, 2008.
10. Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation 116: 1449-1457, 2007.
11. Fahmi AI, Patel M, Stevens EB, Fowden AL, John III JE, Lee K, Pinnock R, Morgan K, Jackson AP, Vandenberg JI. The sodium channel beta-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart. J Physiol 537: 693-700, 2001.
12. Guo D, Young L, Wu Y, Belardinelli L, Kowey PR, Yan GX. Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias. Am J Physiol Heart Circ Physiol 298: H1375-H1381, 2010.
13. Isenberg G, Ravens U. The effects of the Anemonia sulcata toxin (ATX II) on membrane currents of isolated mammalian myocytes. J Physiol 357: 127-149, 1984.
14. Johnson D, Montpetit ML, Stocker PJ, Bennett ES. The sialic acid component of the beta1 subunit modulates voltage-gated sodium channel function. J Biol Chem 279: 44303-44310, 2004.
15. Li GR, Lau CP, Shrier A. Heterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts. J Mol Cell Cardiol 34: 1185-1194, 2002.
16. Ma J, Luo A, Wu L, Wan W, Zhang P, Ren Z, Zhang S, Qian C, Shryock JC, Belardinelli L. Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes. Am J Physiol Cell Physiol 302: C1141-C1151, 2012.
17. Mishra S, Undrovinas NA, Maltsev VA, Reznikov V, Sabbah HN, Undrovinas A. Post-transcriptional silencing of SCN1B and SCN2B genes modulated late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure. Am J Physiol Heart Circ Physiol 301: H1596-H1605, 2011.
18. Murdock DK, Kersten M, Kaliebe J, Larrain G. The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: a review of experience with implications for possible "pill in the pocket" approach to atrial fibrillation. Indian Pacing Electrophysiol J 9: 260-267, 2009.
19. Nattel S. New ideas about atrial fibrillation 50 years on. Nature 415: 219-226, 2002.
20. Persson F, Andersson B, Duker G, Jacobson I, Carlsson L. Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and purkinje fibre. Eur J Pharmacol 558: 133-143, 2007.
21. V1. 5 expression. Cardiovasc Res 93: 12-23, 2012.
22. Na in the cardiomyocyte. Cardiovasc Res 99: 600-611, 2013.
23. Song Y, Shryock JC, Belardinelli L. A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes. Am J Physiol Heart Circ Physiol 297: H1254-H1262, 2009.
24. Song Y, Shryock JC, Belardinelli L. An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. Am J Physiol Heart Circ Physiol 294: H2031-H2039, 2008.
25. + currents in atrial fibrillation: effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol 55: 2330-2342, 2010.
26. + channel blockade by acute amiodarone. Cardiovasc Res 98: 136-144, 2013.
27. Ulbricht W, Schmidtmayer J. Modification of sodium channels in myelinated nerve by Anemonia sulcata toxin II. J Physiol (Paris) 77: 1103-1111, 1981.
28. Zipes DP. The seventh annual Gordon K. Moe Lecture. Atrial fibrillation: from cell to bedside. J Cardiovasc Electrophysiol 8: 927-938, 1997.