Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 8, 2012, Pages

  Ma, Jihua ^a   Luo, Antao ^a   Wu, Lin ^b   Wan, Wei ^a   Zhang, Peihua ^a   Ren, Zhiqiang ^a   Zhang, Shuo ^a   Qian, Chunping ^a   Shryock, John C ^c   Belardinelli, Luiz ^c  

^a WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b PEKING UNIVERSITY   (China)

^c Gilead Sciences ^*  (United States)

Author keywords

Calcium overload; Cardiomyocyte; Patch clamp technique; Signal transduction; Sodium channel

Indexed keywords

BISINDOLYLMALEIMIDE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PROTEIN KINASE C; SODIUM ION;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART VENTRICLE; HEART VENTRICLE OVERLOAD; INHIBITION KINETICS; MOLECULAR DYNAMICS; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; SODIUM CURRENT; STEADY STATE; WHOLE CELL;

ANIMALS; BENZYLAMINES; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; FEMALE; HEART VENTRICLES; INDOLES; MALE; MALEIMIDES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MYOCYTES, CARDIAC; PEPTIDES; PROTEIN KINASE C; RABBITS; SODIUM; SODIUM CHANNELS; SULFONAMIDES;

ORYCTOLAGUS CUNICULUS;

EID: 84859748901     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00374.2011     Document Type: Article

References (53)

1. Ahern GP, Hsu SF, Klyachko VA, Jackson MB. Induction of persistent sodium current by exogenous and endogenous nitric oxide. J Biol Chem 275: 28810-28815, 2000.
2. Antzelevitch C. Electrical heterogeneity, cardiac arrhythmias, and the sodium channel. Circ Res 87: 910-914, 2000.
3. + current in mouse neocortical slices. J Neurophysiol 80: 1547-1551, 1998.
4. + current in rat and mouse sensory neurones. J Physiol 567: 851-867, 2005.
5. Belardinelli L, Antzelevitch C, Fraser H. Inhibition of late (sustained/ persistent) sodium current: a potential drug target to reduce intracellular sodium-dependent calcium overload and its detrimental effects on cardiomyocyte function. Eur Heart J 6, Suppl 1: 13-17, 2004.
6. Belardinelli L, Shryock JC, Fraser H. Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine. Heart 92, Suppl 4: iv6-iv14, 2006.
7. + regulation in cardiac myocytes. Cardiovasc Res 57: 897-912, 2003.
8. Butwell NB, Ramasamy R, Lazar I, Sherry AD, Malloy CR. Effect of lidocaine on contracture, intracellular sodium, and pH in ischemic rat hearts. Am J Physiol Heart Circ Physiol 264: H1884-H1889, 1993.
9. Cass A, Dalmark M. Equilibrium dialysis of ions in nystatin-treated red cells. Nature 244: 47-49, 1973.
10. Dai Y, Jordan LM, Fedirchuk B. Modulation of transient and persistent inward currents by activation of protein kinase C in spinal ventral neurons of the neonatal rat. J Neurophysiol 101: 112-128, 2009.
11. Dhalla NS, Adameova A, Kaur M. Role of catecholamine oxidation in sudden cardiac death. Fundam Clin Pharmacol 24: 539-546, 2010.
12. + entry. J Mol Cell Cardiol 30: 829-835, 1998.
13. Filipovic D, Hayslett JP. Correlation of open cell-attached and excised patch clamp techniques. J Membr Biol 148: 79-82, 1995.
14. + currents increases the excitability of rat neocortical pyramidal neurones. J Physiol 528: 291-304, 2000.
15. Haigney MC, Lakatta EG, Stern MD, Silverman HS. Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation 90: 391-399, 1994.
16. Hale SL, Shryock JC, Belardinelli L, Sweeney M, Kloner RA. Late sodium current inhibition as a new cardioprotective approach. J Mol Cell Cardiol 44: 954-967, 2008.
17. Hammarström AK, Gage PW. Nitric oxide increases persistent sodium current in rat hippocampal neurons. J Physiol 520: 451-461, 1999.
18. Hammarström AK, Gage PW. Hypoxia and persistent sodium current. Eur Biophys J 31: 323-330, 2002.
19. Horie M, Irisawa H, Noma A. Voltage-dependent magnesium block of adenosine-triphosphate-sensitive potassium channel in guinea-pig ventricular cells. J Physiol 387: 251-272, 1987.
20. Imahashi K, Kusuoka H, Hashimoto K, Yoshioka J, Yamaguchi H, Nishimura T. Intracellular sodium accumulation during ischemia as the substrate for reperfusion injury. Circ Res 84: 1401-1406, 1999.
21. Ju YK, Saint DA, Gage PW. Hypoxia increases persistent sodium current in rat ventricular myocytes. J Physiol 497: 337-347, 1996.
22. Liu JX, Tanonaka K, Ohtsuka Y, Sakai Y, Takeo S. Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class 1c antiarrhythmic agents. J Pharmacol Exp Ther 266: 1247-1254, 1993.
23. Luo A, Ma J, Zhang P, Zhou H, Wang W. Sodium channel gating modes during redox reaction. Cell Physiol Biochem 19: 9-20, 2007.
24. Ma JH, Luo AT, Zhang PH. Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes. Acta Pharmacol Sin 26: 828-834, 2005.
25. 2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: Similarities and differences. Am J Physiol Heart Circ Physiol 294: H1597-H1608, 2008.
26. Maltsev VA, Sabbah HN, Higgins RS, Silverman N, Lesch M, Undrovinas AI. Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes. Circulation 98: 2545-2552, 1998.
27. Numann R, Catterall WA, Scheuer T. Functional modulation of brain sodium channels by protein kinase C phosphorylation. Science 254: 115-118, 1991.
28. +]i handling in the failing human heart. Cardiovasc Res 57: 874-886, 2003.
29. + channel inactivation gate is required for modulation by protein kinase C. J Gen Physiol 108: 375-379, 1996.
30. Russell JM, Eaton DC, Brodwick MS. Effects of nystatin on membrane conductance and internal ion activities in Aplysia neurons. J Membr Biol 37: 137-156, 1977.
31. 2+-dependent signaling. Circ Res 76: 1-15, 1995.
32. + current during cardiac ischemia and hypoxia. J Cardiovasc Electrophysiol 17, Suppl 1: S96-S103, 2006.
33. Saint DA. The cardiac persistent sodium current: an appealing therapeutic target? Br J Pharmacol 153: 1133-1142, 2008.
34. Scirica BM, Morrow DA, Hod H, Murphy SA, Belardinelli L, Hedgepeth CM, Molhoek P, Verheugt FW, Gersh BJ, McCabe CH, Braunwald E. Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischemia in Non STElevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation 116: 1647-1652, 2007.
35. Silverman HS, Stern MD. Ionic basis of ischaemic cardiac injury: insights from cellular studies. Cardiovasc Res 28: 581-587, 1994.
36. Song Y, Shryock JC, Wagner S, Maier LS, Belardinelli L. Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J Pharmacol Exp Ther 318: 214-222, 2006.
37. + currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol 55: 2330-2342, 2010.
38. Steenbergen C, Murphy E, Levy L, London RE. Elevation in cytosolic free calcium concentration early in myocardial ischemia in perfused rat heart. Circ Res 60: 700-707, 1987.
39. Steinberg SF, Goldberg M, Rybin VO. Protein kinase C isoform diversity in the heart. J Mol Cell Cardiol 27: 141-153, 1995.
40. + channel in normal and failing human myocardium. J Mol Cell Cardiol 34: 1477-1489, 2002.
41. Undrovinas AI, Maltsev VA, Sabbah HH. Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current. Cell Mol Life Sci 55: 494-505, 1999.
42. Valdivia CR, Chu WW, Pu J, Foell JD, Haworth RA, Wolff MR, Kamp TJ, Makielski JC. Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J Mol Cell Cardiol 38: 475-483, 2005.
43. + during myocardial ischemia: consequences for post-ischemic recovery. J Mol Cell Cardiol 29: 85-96, 1997.
44. Vassalle M, Lin CI. Calcium overload and cardiac function. J Biomed Sci 11: 542-565, 2004.
45. Ver Donck L, Borgers M. Myocardial protection by R 56865: a new principle based on prevention of ion channel pathology. Am J Physiol Heart Circ Physiol 261: H1828-H1835, 1991.
46. Ver Donck L, Borgers M, Verdonck F. Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle. Cardiovasc Res 27: 349-357, 1993.
47. Wang W, Ma J, Zhang P, Luo A. Redox reaction modulates transient and persistent sodium current during hypoxia in guinea pig ventricular myocytes. Pflügers Arch 454: 461-475, 2007.
48. Ward CA, Giles WR. Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes. J Physiol 500: 631-642, 1997.
49. Ward CA, Moffat MP. Role of protein kinase C in mediating effects of hydrogen peroxide in guinea pig ventricular myocytes. J Mol Cell Cardiol 27: 1089-1097, 1995.
50. + current inactivation by stimulation of protein kinase C in cardiac cells. Circ Res 81: 380-386, 1997.
51. + channel required for modulation by protein kinase C. Science 254: 866-868, 1991.
52. Yamazaki T, Komuro I, Zou Y, Kudoh S, Shiojima I, Hiroi Y, Mizuno T, Aikawa R, Takano H, Yazaki Y. Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both α1- and β-adrenoceptors. Circulation 95: 1260-1268, 1997.
53. Zhou H, Ma JH, Zhang PH, Luo AT. Vitamin C pretreatment attenuates hypoxia-induced disturbance of sodium currents in guinea pig ventricular myocytes. J Membr Biol 211: 81-87, 2006.