메뉴 건너뛰기




Volumn 306, Issue 3, 2014, Pages

Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats

Author keywords

De novo lipogenesis; Exercise training; Hepatic mitochondria; Metformin; Nonalcoholic fatty liver disease; Otsuka Long Evans Tokushima Fatty rats

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A CARBOXYLASE; CD36 ANTIGEN; CITRATE SYNTHASE; DIACYLGLYCEROL; DIACYLGLYCEROL ACYLTRANSFERASE 2; DIGLYCERIDE ACYLTRANSFERASE 1; FATTY ACID SYNTHASE; GLUCOSE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE 1; INSULIN; MESSENGER RNA; METFORMIN; PALMITIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84893388150     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00427.2013     Document Type: Article
Times cited : (62)

References (55)
  • 1
    • 0014576426 scopus 로고
    • Metabolic differentiation of distinct muscle types at the level of enzymatic organization
    • Bass A, Brdiczka D, Eyer P, Hofer S, Pette D. Metabolic differentiation of distinct muscle types at the level of enzymatic organization. Eur J Biochem 10: 198-206, 1969.
    • (1969) Eur J Biochem , vol.10 , pp. 198-206
    • Bass, A.1    Brdiczka, D.2    Eyer, P.3    Hofer, S.4    Pette, D.5
  • 2
    • 38449086259 scopus 로고    scopus 로고
    • Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes
    • Basu R, Shah P, Basu A, Norby B, Dicke B, Chandramouli V, Cohen O, Landau BR, Rizza RA. Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes. Diabetes 57: 24-31, 2008.
    • (2008) Diabetes , vol.57 , pp. 24-31
    • Basu, R.1    Shah, P.2    Basu, A.3    Norby, B.4    Dicke, B.5    Chandramouli, V.6    Cohen, O.7    Landau, B.R.8    Rizza, R.A.9
  • 5
    • 0034595862 scopus 로고    scopus 로고
    • Metformin treatment enhances insulinstimulated glucose transport in skeletal muscle of Sprague-Dawley rats
    • Borst SE, Snellen HG, Lai HL. Metformin treatment enhances insulinstimulated glucose transport in skeletal muscle of Sprague-Dawley rats. Life Sci 67: 165-174, 2000.
    • (2000) Life Sci , vol.67 , pp. 165-174
    • Borst, S.E.1    Snellen, H.G.2    Lai, H.L.3
  • 6
    • 79955457155 scopus 로고    scopus 로고
    • Short-term weight loss and hepatic triglyceride reduction: Evidence of a metabolic advantage with dietary carbohydrate restriction
    • Browning JD, Baker JA, Rogers T, Davis J, Satapati S, Burgess SC. Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction. Am J Clin Nutr 93: 1048-1052, 2011.
    • (2011) Am J Clin Nutr , vol.93 , pp. 1048-1052
    • Browning, J.D.1    Baker, J.A.2    Rogers, T.3    Davis, J.4    Satapati, S.5    Burgess, S.C.6
  • 9
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115: 1343-1351, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 10
    • 77957785801 scopus 로고    scopus 로고
    • Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease
    • Elias MC, Parise ER, de Carvalho L, Szejnfeld D, Netto JP. Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease. Nutrition 26: 1094-1099, 2010.
    • (2010) Nutrition , vol.26 , pp. 1094-1099
    • Elias, M.C.1    Parise, E.R.2    de Carvalho, L.3    Szejnfeld, D.4    Netto, J.P.5
  • 11
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43: S99-S112, 2006.
    • (2006) Hepatology , vol.43
    • Farrell, G.C.1    Larter, C.Z.2
  • 12
    • 0033008628 scopus 로고    scopus 로고
    • An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats
    • Faure P, Rossini E, Wiernsperger N, Richard MJ, Favier A, Halimi S. An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats. Diabetes 48: 353-357, 1999.
    • (1999) Diabetes , vol.48 , pp. 353-357
    • Faure, P.1    Rossini, E.2    Wiernsperger, N.3    Richard, M.J.4    Favier, A.5    Halimi, S.6
  • 14
    • 67649829768 scopus 로고    scopus 로고
    • Nonalcoholic hepatic steatosis in Zucker diabetic rats: Spontaneous evolution and effects of metformin and fenofibrate
    • Forcheron F, Abdallah P, Basset A, del Carmine P, Haffar G, Beylot M. Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate. Obesity (Silver Spring) 17: 1381-1389, 2009.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1381-1389
    • Forcheron, F.1    Abdallah, P.2    Basset, A.3    del Carmine, P.4    Haffar, G.5    Beylot, M.6
  • 16
    • 49549092262 scopus 로고    scopus 로고
    • Effect of exercise on 24-month weight loss maintenance in overweight women
    • discussion 1559-1560
    • Jakicic JM, Marcus BH, Lang W, Janney C. Effect of exercise on 24-month weight loss maintenance in overweight women. Arch Intern Med 168: 1550-1559; discussion 1559-1560, 2008.
    • (2008) Arch Intern Med , vol.168 , pp. 1550-1559
    • Jakicic, J.M.1    Marcus, B.H.2    Lang, W.3    Janney, C.4
  • 20
    • 79959459359 scopus 로고    scopus 로고
    • Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    • Kim E, Liu NC, Yu IC, Lin HY, Lee YF, Sparks JD, Chen LM, Chang C. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity. Diabetes 60: 1493-1503, 2011.
    • (2011) Diabetes , vol.60 , pp. 1493-1503
    • Kim, E.1    Liu, N.C.2    Yu, I.C.3    Lin, H.Y.4    Lee, Y.F.5    Sparks, J.D.6    Chen, L.M.7    Chang, C.8
  • 24
    • 84868009842 scopus 로고    scopus 로고
    • Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: A randomized, controlled trial
    • Lee S, Bacha F, Hannon T, Kuk JL, Boesch C, Arslanian S. Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. Diabetes 61: 2787-2795, 2012.
    • (2012) Diabetes , vol.61 , pp. 2787-2795
    • Lee, S.1    Bacha, F.2    Hannon, T.3    Kuk, J.L.4    Boesch, C.5    Arslanian, S.6
  • 29
    • 84859096202 scopus 로고    scopus 로고
    • Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes
    • Malin SK, Gerber R, Chipkin SR, Braun B. Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes. Diabetes Care 35: 131-136, 2012.
    • (2012) Diabetes Care , vol.35 , pp. 131-136
    • Malin, S.K.1    Gerber, R.2    Chipkin, S.R.3    Braun, B.4
  • 30
    • 84876293806 scopus 로고    scopus 로고
    • Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults
    • Malin SK, Nightingale J, Choi SE, Chipkin SR, Braun B. Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults. Obesity (Silver Spring) 21: 93-100, 2013.
    • (2013) Obesity (Silver Spring) , vol.21 , pp. 93-100
    • Malin, S.K.1    Nightingale, J.2    Choi, S.E.3    Chipkin, S.R.4    Braun, B.5
  • 32
    • 54049100065 scopus 로고    scopus 로고
    • Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes
    • Matsumoto T, Noguchi E, Ishida K, Kobayashi T, Yamada N, Kamata K. Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes. Am J Physiol Heart Circ Physiol 295: H1165-H1176, 2008.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Matsumoto, T.1    Noguchi, E.2    Ishida, K.3    Kobayashi, T.4    Yamada, N.5    Kamata, K.6
  • 34
    • 33845325347 scopus 로고    scopus 로고
    • Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors
    • Moran TH, Bi S. Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors. Philos Trans R Soc Lond B Biol Sci 361: 1211-1218, 2006.
    • (2006) Philos Trans R Soc Lond B Biol Sci , vol.361 , pp. 1211-1218
    • Moran, T.H.1    Bi, S.2
  • 35
    • 33746268381 scopus 로고    scopus 로고
    • Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: Developmental aspects
    • Moran TH, Bi S. Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects. Dev Psychobiol 48: 360-367, 2006.
    • (2006) Dev Psychobiol , vol.48 , pp. 360-367
    • Moran, T.H.1    Bi, S.2
  • 37
    • 77955690182 scopus 로고    scopus 로고
    • Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
    • Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 52: 774-788, 2010.
    • (2010) Hepatology , vol.52 , pp. 774-788
    • Neuschwander-Tetri, B.A.1
  • 38
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348: 607-614, 2000.
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 40
    • 80054687396 scopus 로고    scopus 로고
    • Does physical inactivity cause nonalcoholic fatty liver disease?
    • Rector RS, Thyfault JP. Does physical inactivity cause nonalcoholic fatty liver disease? J Appl Physiol 111: 1828-1835, 2011.
    • (2011) J Appl Physiol , vol.111 , pp. 1828-1835
    • Rector, R.S.1    Thyfault, J.P.2
  • 44
    • 39849099669 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and the metabolic syndrome: An update
    • Rector RS, Thyfault JP, Wei Y, Ibdah JA. Non-alcoholic fatty liver disease and the metabolic syndrome: an update. World J Gastroenterol 14: 185-192, 2008.
    • (2008) World J Gastroenterol , vol.14 , pp. 185-192
    • Rector, R.S.1    Thyfault, J.P.2    Wei, Y.3    Ibdah, J.A.4
  • 47
  • 49
    • 77957010982 scopus 로고
    • Citrate synthase
    • Srere PA. Citrate synthase. Meth Enzymol 13: 3-5, 1969.
    • (1969) Meth Enzymol , vol.13 , pp. 3-5
    • Srere, P.A.1
  • 50
    • 84861573124 scopus 로고    scopus 로고
    • Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease
    • Sullivan S, Kirk EP, Mittendorfer B, Patterson BW, Klein S. Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology 55: 1738-1745, 2012.
    • (2012) Hepatology , vol.55 , pp. 1738-1745
    • Sullivan, S.1    Kirk, E.P.2    Mittendorfer, B.3    Patterson, B.W.4    Klein, S.5
  • 51
    • 0027979127 scopus 로고
    • A mathematical model for the determination of total area under glucose tolerance and other metabolic curves
    • Tai MM. A mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care 17: 152-154, 1994.
    • (1994) Diabetes Care , vol.17 , pp. 152-154
    • Tai, M.M.1
  • 52
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
    • Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, Zenari L, Day C, Arcaro G. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 30: 1212-1218, 2007.
    • (2007) Diabetes Care , vol.30 , pp. 1212-1218
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Tessari, R.5    Zenari, L.6    Day, C.7    Arcaro, G.8
  • 53
    • 68949181550 scopus 로고    scopus 로고
    • Specific role for acyl CoA: Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
    • Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV Jr. Specific role for acyl CoA: Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Hepatology 50: 434-442, 2009.
    • (2009) Hepatology , vol.50 , pp. 434-442
    • Villanueva, C.J.1    Monetti, M.2    Shih, M.3    Zhou, P.4    Watkins, S.M.5    Bhanot, S.6    Farese Jr., R.V.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.