-
1
-
-
84866378204
-
Therapeutic evolution and the challenge of rational medicine
-
Greene JA, Jones DS, Podolsky SH. Therapeutic evolution and the challenge of rational medicine. N. Engl. J. Med. 367(12), 1077-1082 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, Issue.12
, pp. 1077-1082
-
-
Greene, J.A.1
Jones, D.S.2
Podolsky, S.H.3
-
4
-
-
41949130070
-
Improved survival in multiple myeloma and the impact of novel therapies
-
Kumar SK, Rajkumar SV, Dispenzieri A et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood 111(5), 2516-2520 (2008).
-
(2008)
Blood
, vol.111
, Issue.5
, pp. 2516-2520
-
-
Kumar, S.K.1
Rajkumar, S.V.2
Dispenzieri, A.3
-
5
-
-
84860711612
-
Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study
-
Kumar SK, Lee JH, Lahuerta JJ et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study. Leukemia 26(5), 1153 (2012).
-
(2012)
Leukemia
, vol.26
, Issue.5
, pp. 1153
-
-
Kumar, S.K.1
Lee, J.H.2
Lahuerta, J.J.3
-
6
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70 (2000).
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
7
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 144(5), 646-674 (2011).
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
8
-
-
56449128746
-
New drugs in multiple myeloma: Mechanisms of action and phase I/II clinical findings
-
Ocio EM, Mateos MV, Maiso P, Pandiella A, San-Miguel JF. New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings. Lancet Oncol. 9(12), 1157-1165 (2008).
-
(2008)
Lancet Oncol
, vol.9
, Issue.12
, pp. 1157-1165
-
-
Ocio, E.M.1
Mateos, M.V.2
Maiso, P.3
Pandiella, A.4
San-Miguel, J.F.5
-
10
-
-
84873598748
-
Targeted therapy of multiple myeloma
-
Dolloff NG, Talamo G. Targeted therapy of multiple myeloma. Adv. Exp. Med. Biol. 779, 197-221 (2013).
-
(2013)
Adv. Exp. Med. Biol.
, vol.779
, pp. 197-221
-
-
Dolloff, N.G.1
Talamo, G.2
-
11
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 61(7), 3071-3076 (2001).
-
(2001)
Cancer Res
, vol.61
, Issue.7
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
-
12
-
-
0036735298
-
Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
-
Leblanc R, Catley LP, Hideshima T et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res. 62(17), 4996-5000 (2002).
-
(2002)
Cancer Res
, vol.62
, Issue.17
, pp. 4996-5000
-
-
Leblanc, R.1
Catley, L.P.2
Hideshima, T.3
-
13
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N. Engl. J. Med. 348(26), 2609-2617 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, Issue.26
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
14
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
Richardson PG, Sonneveld P, Schuster MW et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N. Engl. J. Med. 352(24), 2487-2498 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, Issue.24
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
-
15
-
-
35148825003
-
Extended follow-up of a phase 3 trial in relapsed multiple myeloma: Final time-to-event results of the APEX trial
-
Richardson PG, Sonneveld P, Schuster M et al. Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the APEX trial. Blood 110(10), 3557-3560 (2007).
-
(2007)
Blood
, vol.110
, Issue.10
, pp. 3557-3560
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.3
-
16
-
-
0033152760
-
Proteasome inhibitors: A novel class of potent and effective antitumor agents
-
Adams J, Palombella VJ, Sausville EA et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 59(11), 2615-2622 (1999).
-
(1999)
Cancer Res
, vol.59
, Issue.11
, pp. 2615-2622
-
-
Adams, J.1
Palombella, V.J.2
Sausville, E.A.3
-
17
-
-
0030016595
-
Structure and functions of the 20S and 26S proteasomes
-
Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65, 801-847 (1996).
-
(1996)
Annu. Rev. Biochem.
, vol.65
, pp. 801-847
-
-
Coux, O.1
Tanaka, K.2
Goldberg, A.L.3
-
18
-
-
0032867676
-
The 26S proteasome: A molecular machine designed for controlled proteolysis
-
Voges D, Zwickl P, Baumeister W. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu. Rev. Biochem. 68, 1015-1068 (1999).
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 1015-1068
-
-
Voges, D.1
Zwickl, P.2
Baumeister, W.3
-
19
-
-
0029042511
-
Crystal structure of the 20S proteasome from the archaeon T. Acidophilum at 3.4 A resolution
-
Lowe J, Stock D, Jap B, Zwickl P, Baumeister W, Huber R. Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. Science 268(5210), 533-539 (1995).
-
(1995)
Science
, vol.268
, Issue.5210
, pp. 533-539
-
-
Lowe, J.1
Stock, D.2
Jap, B.3
Zwickl, P.4
Baumeister, W.5
Huber, R.6
-
20
-
-
0036103598
-
The structure of the mammalian 20S proteasome at 2.75 A resolution
-
Unno M, Mizushima T, Morimoto Y et al. The structure of the mammalian 20S proteasome at 2.75 A resolution. Structure 10(5), 609-618 (2002).
-
(2002)
Structure
, vol.10
, Issue.5
, pp. 609-618
-
-
Unno, M.1
Mizushima, T.2
Morimoto, Y.3
-
21
-
-
2442515965
-
Proteasome function in antigen presentation: Immunoproteasome complexes, Peptide production, and interactions with viral proteins
-
Rivett AJ, Hearn AR. Proteasome function in antigen presentation: immunoproteasome complexes, Peptide production, and interactions with viral proteins. Curr. Protein Pept. Sci. 5(3), 153-161 (2004).
-
(2004)
Curr. Protein Pept. Sci.
, vol.5
, Issue.3
, pp. 153-161
-
-
Rivett, A.J.1
Hearn, A.R.2
-
22
-
-
1042278905
-
Proteasome and peptidase function in MHC-class-I-mediated antigen presentation
-
Kloetzel PM, Ossendorp F. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr. Opin. Immunol. 16(1), 76-81 (2004).
-
(2004)
Curr. Opin. Immunol.
, vol.16
, Issue.1
, pp. 76-81
-
-
Kloetzel, P.M.1
Ossendorp, F.2
-
23
-
-
0242496212
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
-
Mitsiades N, Mitsiades CS, Poulaki V et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc. Natl Acad. Sci. USA 99(22), 14374-14379 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, Issue.22
, pp. 14374-14379
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
24
-
-
0037441760
-
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
-
Hideshima T, Mitsiades C, Akiyama M et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood 101(4), 1530-1534 (2003).
-
(2003)
Blood
, vol.101
, Issue.4
, pp. 1530-1534
-
-
Hideshima, T.1
Mitsiades, C.2
Akiyama, M.3
-
26
-
-
0346333293
-
The proteasome as a target for cancer therapy
-
Voorhees PM, Dees EC, O'Neil B, Orlowski RZ. The proteasome as a target for cancer therapy. Clin. Cancer Res. 9(17), 6316-6325 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, Issue.17
, pp. 6316-6325
-
-
Voorhees, P.M.1
Dees, E.C.2
O'Neil, B.3
Orlowski, R.Z.4
-
27
-
-
33746228127
-
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
-
Carvalho P, Goder V, Rapoport TA. Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126(2), 361-373 (2006).
-
(2006)
Cell
, vol.126
, Issue.2
, pp. 361-373
-
-
Carvalho, P.1
Goder, V.2
Rapoport, T.A.3
-
28
-
-
36249022073
-
Ubiquitin receptors and ERAD: A network of pathways to the proteasome
-
Raasi S, Wolf DH. Ubiquitin receptors and ERAD: a network of pathways to the proteasome. Semin. Cell Dev. Biol. 18(6), 780-791 (2007).
-
(2007)
Semin. Cell Dev. Biol.
, vol.18
, Issue.6
, pp. 780-791
-
-
Raasi, S.1
Wolf, D.H.2
-
29
-
-
0033595893
-
How NF-kappaB is activated: The role of the IkappaB kinase (IKK) complex
-
Karin M. How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene 18(49), 6867-6874 (1999).
-
(1999)
Oncogene
, vol.18
, Issue.49
, pp. 6867-6874
-
-
Karin, M.1
-
30
-
-
0032873880
-
Immune regulation in multiple myeloma: The host-tumour conflict
-
Cook G, Campbell JD. Immune regulation in multiple myeloma: the host-tumour conflict. Blood Rev. 13(3), 151-162 (1999).
-
(1999)
Blood Rev
, vol.13
, Issue.3
, pp. 151-162
-
-
Cook, G.1
Campbell, J.D.2
-
31
-
-
84877146756
-
Regulating the regulators in cancer-immunosuppression in multiple myeloma (MM)
-
Feyler S, Selby PJ, Cook G. Regulating the regulators in cancer-immunosuppression in multiple myeloma (MM). Blood Rev. 27(3), 155-164 (2013).
-
(2013)
Blood Rev
, vol.27
, Issue.3
, pp. 155-164
-
-
Feyler, S.1
Selby, P.J.2
Cook, G.3
-
32
-
-
33644757687
-
Tumor evasion of the immune system: Inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma
-
Wang S, Yang J, Qian J, Wezeman M, Kwak LW, Yi Q. Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma. Blood 107(6), 2432-2439 (2006).
-
(2006)
Blood
, vol.107
, Issue.6
, pp. 2432-2439
-
-
Wang, S.1
Yang, J.2
Qian, J.3
Wezeman, M.4
Kwak, L.W.5
Yi, Q.6
-
33
-
-
0035880229
-
Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: Identification of prognostic factors in a phase 2 study of patients
-
Barlogie B, Desikan R, Eddlemon P et al. Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of patients. Blood 98(2), 492-494 (2001).
-
(2001)
Blood
, vol.98
, Issue.2
, pp. 492-494
-
-
Barlogie, B.1
Desikan, R.2
Eddlemon, P.3
-
34
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma
-
Singhal S, Mehta J, Desikan R et al. Antitumor activity of thalidomide in refractory multiple myeloma. N. Engl. J. Med. 341(21), 1565-1571 (1999).
-
(1999)
N. Engl. J. Med.
, vol.341
, Issue.21
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
-
35
-
-
36349010285
-
Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
-
Weber DM, Chen C, Niesvizky R et al. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N. Engl. J. Med. 357(21), 2133-2142 (2007).
-
(2007)
N. Engl. J. Med.
, vol.357
, Issue.21
, pp. 2133-2142
-
-
Weber, D.M.1
Chen, C.2
Niesvizky, R.3
-
36
-
-
36349023319
-
Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma
-
Dimopoulos M, Spencer A, Attal M et al. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N. Engl. J. Med. 357(21), 2123-2132 (2007).
-
(2007)
N. Engl. J. Med.
, vol.357
, Issue.21
, pp. 2123-2132
-
-
Dimopoulos, M.1
Spencer, A.2
Attal, M.3
-
37
-
-
70450230539
-
Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
-
Dimopoulos MA, Chen C, Spencer A et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia 23(11), 2147-2152 (2009).
-
(2009)
Leukemia
, vol.23
, Issue.11
, pp. 2147-2152
-
-
Dimopoulos, M.A.1
Chen, C.2
Spencer, A.3
-
38
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366(26), 2455-2465 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
39
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
40
-
-
79960218752
-
Immunosuppressive effects of multiple myeloma are overcome by PD-L1 blockade
-
Hallett WH, Jing W, Drobyski WR, Johnson BD. Immunosuppressive effects of multiple myeloma are overcome by PD-L1 blockade. Biol. Blood Marrow Transplant. 17(8), 1133-1145 (2011).
-
(2011)
Biol. Blood Marrow Transplant.
, vol.17
, Issue.8
, pp. 1133-1145
-
-
Hallett, W.H.1
Jing, W.2
Drobyski, W.R.3
Johnson, B.D.4
-
41
-
-
0037126021
-
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
-
Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl Acad. Sci. USA 99(19), 12293-12297 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, Issue.19
, pp. 12293-12297
-
-
Iwai, Y.1
Ishida, M.2
Tanaka, Y.3
Okazaki, T.4
Honjo, T.5
Minato, N.6
-
42
-
-
84878099006
-
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma
-
Kearl TJ, Jing W, Gershan JA, Johnson BD. Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma. J. Immunol. 190(11), 5620-5628 (2013).
-
(2013)
J. Immunol.
, vol.190
, Issue.11
, pp. 5620-5628
-
-
Kearl, T.J.1
Jing, W.2
Gershan, J.A.3
Johnson, B.D.4
-
43
-
-
79957891364
-
PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/ myeloma fusion vaccine
-
Rosenblatt J, Glotzbecker B, Mills H et al. PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/ myeloma fusion vaccine. J. Immunother. 34(5), 409-418 (2011).
-
(2011)
J. Immunother.
, vol.34
, Issue.5
, pp. 409-418
-
-
Rosenblatt, J.1
Glotzbecker, B.2
Mills, H.3
-
44
-
-
78751510278
-
Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma
-
Rosenblatt J, Vasir B, Uhl L et al. Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma. Blood 117(2), 393-402 (2011).
-
(2011)
Blood
, vol.117
, Issue.2
, pp. 393-402
-
-
Rosenblatt, J.1
Vasir, B.2
Uhl, L.3
-
45
-
-
84869093412
-
Multiple myeloma induces the immunosuppressive capacity of distinct myeloid-derived suppressor cell subpopulations in the bone marrow
-
Van Valckenborgh E, Schouppe E, Movahedi K et al. Multiple myeloma induces the immunosuppressive capacity of distinct myeloid-derived suppressor cell subpopulations in the bone marrow. Leukemia 26(11), 2424-2428 (2012).
-
(2012)
Leukemia
, vol.26
, Issue.11
, pp. 2424-2428
-
-
Van Valckenborgh, E.1
Schouppe, E.2
Movahedi, K.3
-
46
-
-
84879452593
-
Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans
-
Gorgun GT, Whitehill G, Anderson JL et al. Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans. Blood 121(15), 2975-2987 (2013).
-
(2013)
Blood
, vol.121
, Issue.15
, pp. 2975-2987
-
-
Gorgun, G.T.1
Whitehill, G.2
Anderson, J.L.3
-
47
-
-
78149270433
-
Increased level of both CD4+FOXP3+ regulatory T cells and CD14+HLA-DR(-)/ low myeloid-derived suppressor cells and decreased level of dendritic cells in patients with multiple myeloma
-
Brimnes MK, Vangsted AJ, Knudsen LM et al. Increased level of both CD4+FOXP3+ regulatory T cells and CD14+HLA-DR(-)/ low myeloid-derived suppressor cells and decreased level of dendritic cells in patients with multiple myeloma. Scand. J. Immunol. 72(6), 540-547 (2010).
-
(2010)
Scand. J. Immunol.
, vol.72
, Issue.6
, pp. 540-547
-
-
Brimnes, M.K.1
Vangsted, A.J.2
Knudsen, L.M.3
-
48
-
-
84875442375
-
Myeloid-derived suppressor cells regulate growth of multiple myeloma by inhibiting T cells in bone marrow
-
Ramachandran IR, Martner A, Pisklakova A et al. Myeloid-derived suppressor cells regulate growth of multiple myeloma by inhibiting T cells in bone marrow. J. Immunol. 190(7), 3815-3823 (2013).
-
(2013)
J. Immunol.
, vol.190
, Issue.7
, pp. 3815-3823
-
-
Ramachandran, I.R.1
Martner, A.2
Pisklakova, A.3
-
49
-
-
84893769637
-
Lenalidomide enhances the protective effect of a therapeutic vaccine and reverses immune suppression in mice bearing established lymphomas
-
doi:10.1038/leu.2013.177 Epub ahead of print
-
Sakamaki I, Kwak LW, Cha SC et al. Lenalidomide enhances the protective effect of a therapeutic vaccine and reverses immune suppression in mice bearing established lymphomas. Leukemia doi:10.1038/leu.2013.177 (2013) (Epub ahead of print).
-
(2013)
Leukemia
-
-
Sakamaki, I.1
Kwak, L.W.2
Cha, S.C.3
-
50
-
-
84859842179
-
Compartment-specific bioluminescence imaging platform for the high-throughput evaluation of antitumor immune function
-
Mcmillin DW, Delmore J, Negri JM et al. Compartment-specific bioluminescence imaging platform for the high-throughput evaluation of antitumor immune function. Blood 119(15), e131-e138 (2012).
-
(2012)
Blood
, vol.119
, Issue.15
-
-
McMillin, D.W.1
Delmore, J.2
Negri, J.M.3
-
51
-
-
79951494668
-
Initial genome sequencing and analysis of multiple myeloma
-
Chapman MA, Lawrence MS, Keats JJ et al. Initial genome sequencing and analysis of multiple myeloma. Nature 471(7339), 467-472 (2011).
-
(2011)
Nature
, vol.471
, Issue.7339
, pp. 467-472
-
-
Chapman, M.A.1
Lawrence, M.S.2
Keats, J.J.3
-
52
-
-
22044440425
-
Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
-
Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J Jr. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 106(1), 296-303 (2005).
-
(2005)
Blood
, vol.106
, Issue.1
, pp. 296-303
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
Zhan, F.3
Sawyer, J.4
Barlogie, B.5
Shaughnessy, Jr.J.6
-
53
-
-
84859027788
-
A Phase i study of PD 0332991: Complete CDK4/6 inhibition and tumor response in sequential combination with bortezomib and dexamethasone for relapsed and refractory multiple myeloma
-
Niesvizky R, Lentzsch S, Badros AZ et al. A Phase I study of PD 0332991: complete CDK4/6 inhibition and tumor response in sequential combination with bortezomib and dexamethasone for relapsed and refractory multiple myeloma. ASH Annual Meeting Abstracts 116(21), 860 (2010).
-
(2010)
ASH Annual Meeting Abstracts
, vol.116
, Issue.21
, pp. 860
-
-
Niesvizky, R.1
Lentzsch, S.2
Badros, A.Z.3
-
54
-
-
84893278448
-
Phase i study of aurora kinase inhibitor mln8237 and bortezomib in relapsed or refractory multiple myeloma
-
Stewart AK, Vij R, Laubach JP et al. Phase I study of aurora kinase inhibitor mln8237 and bortezomib in relapsed or refractory multiple myeloma. ASH Annual Meeting Abstracts 120(21), 1859 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 1859
-
-
Stewart, A.K.1
Vij, R.2
Laubach, J.P.3
-
55
-
-
77950542260
-
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity
-
Mcmillin DW, Delmore J, Weisberg E et al . Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nature Med. 16(4), 483-489 (2010).
-
(2010)
Nature Med
, vol.16
, Issue.4
, pp. 483-489
-
-
McMillin, D.W.1
Delmore, J.2
Weisberg, E.3
-
56
-
-
30844443493
-
A phase II trial of imatinib in patients with refractory/relapsed myeloma
-
Dispenzieri A, Gertz MA, Lacy MQ et al. A phase II trial of imatinib in patients with refractory/relapsed myeloma. Leuk. Lymphoma 47(1), 39-42 (2006).
-
(2006)
Leuk. Lymphoma
, vol.47
, Issue.1
, pp. 39-42
-
-
Dispenzieri, A.1
Gertz, M.A.2
Lacy, M.Q.3
-
57
-
-
59249093777
-
Dasatinib in relapsed or plateau-phase multiple myeloma
-
Wildes TM, Procknow E, Gao F, Dipersio JF, Vij R. Dasatinib in relapsed or plateau-phase multiple myeloma. Leuk. Lymphoma 50(1), 137-140 (2009).
-
(2009)
Leuk. Lymphoma
, vol.50
, Issue.1
, pp. 137-140
-
-
Wildes, T.M.1
Procknow, E.2
Gao, F.3
Dipersio, J.F.4
Vij, R.5
-
58
-
-
78650137838
-
Dasatinib in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma: Preliminary results of a phase i study
-
Facon T, Leleu X, Stewart AK et al. Dasatinib in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma: preliminary results of a phase I study. ASH Annual Meeting Abstracts 114(22), 1876 (2009).
-
(2009)
ASH Annual Meeting Abstracts
, vol.114
, Issue.22
, pp. 1876
-
-
Facon, T.1
Leleu, X.2
Stewart, A.K.3
-
59
-
-
80052269008
-
The addition of bevacizumab (B) to lenalidomide and low dose dexamethasone does not significantly increase response in relapsed or refractory multiple myeloma (NCI#7317)
-
Callander NS, Markovina S, Juckett MB et al. The addition of bevacizumab (B) to lenalidomide and low dose dexamethasone does not significantly increase response in relapsed or refractory multiple myeloma (NCI#7317). ASH Annual Meeting Abstracts 114(22), 3885 (2009).
-
(2009)
ASH Annual Meeting Abstracts
, vol.114
, Issue.22
, pp. 3885
-
-
Callander, N.S.1
Markovina, S.2
Juckett, M.B.3
-
60
-
-
49249125421
-
Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma
-
Lacy MQ, Alsina M, Fonseca R et al. Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma. J.Clin. Oncol. 26(19), 3196-3203 (2008).
-
(2008)
J.Clin. Oncol.
, vol.26
, Issue.19
, pp. 3196-3203
-
-
Lacy, M.Q.1
Alsina, M.2
Fonseca, R.3
-
61
-
-
79955805214
-
Phase i study of the anti insulin-like growth factor receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma
-
Moreau P, Cavallo F, Leleu X et al. Phase I study of the anti insulin-like growth factor receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma. Leukemia 25(5), 872-874 (2011).
-
(2011)
Leukemia
, vol.25
, Issue.5
, pp. 872-874
-
-
Moreau, P.1
Cavallo, F.2
Leleu, X.3
-
62
-
-
84893296613
-
A Phase II clinical trial of the anti-egfr antibody cetuximab in patients with refractory or relapsed multiple myeloma: Final results
-
Von Tresckow B, Boll B, Eichenauer DA et al. A Phase II clinical trial of the anti-egfr antibody cetuximab in patients with refractory or relapsed multiple myeloma: final results. ASH Annual Meeting Abstracts 118(21), 3965 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 3965
-
-
Von Tresckow, B.1
Boll, B.2
Eichenauer, D.A.3
-
63
-
-
79959361375
-
A phase i safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma
-
Ghobrial IM, Munshi NC, Harris BN et al. A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma. Am. J. Hematol. 86(7), 573-578 (2011).
-
(2011)
Am. J. Hematol.
, vol.86
, Issue.7
, pp. 573-578
-
-
Ghobrial, I.M.1
Munshi, N.C.2
Harris, B.N.3
-
64
-
-
84893230311
-
A Phase 2, Multicenter, Nonrandomized, open-label study of dovitinib (TKI258) in patients with relapsed or refractory multiple myeloma with or without t(4;14) translocation
-
Scheid C, Reece D, Beksac M et al. A Phase 2, Multicenter, Nonrandomized, open-label study of dovitinib (TKI258) in patients with relapsed or refractory multiple myeloma with or without t(4;14) translocation. ASH Annual Meeting Abstracts 120(21), 4055 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 4055
-
-
Scheid, C.1
Reece, D.2
Beksac, M.3
-
65
-
-
84893211413
-
A Phase i study of the safety and pharmacokinetics of escalating doses of MFGR1877S, a fibroblast growth factor receptor 3 (FGFR3) antibody, in patients with relapsed or refractory t(4;14)-positive multiple myeloma
-
Trudel S, Bergsagel PL, Singhal S et al. A Phase I study of the safety and pharmacokinetics of escalating doses of MFGR1877S, a fibroblast growth factor receptor 3 (FGFR3) antibody, in patients with relapsed or refractory t(4;14)-positive multiple myeloma. ASH Annual Meeting Abstracts 120(21), 4029 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 4029
-
-
Trudel, S.1
Bergsagel, P.L.2
Singhal, S.3
-
66
-
-
48249092502
-
FGFR3 tyrosine kinase inhibitor AB1010 as treatment of t(4;14) multiple myeloma
-
128a-Abstract 413
-
Arnulf B, Ghez D, Leblond V et al. FGFR3 tyrosine kinase inhibitor AB1010 as treatment of t(4;14) multiple myeloma. Blood 110(11), 128a-Abstract 413 (2007).
-
(2007)
Blood
, vol.110
, Issue.11
-
-
Arnulf, B.1
Ghez, D.2
Leblond, V.3
-
67
-
-
79953814654
-
RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5
-
Zhu YX, Tiedemann R, Shi CX et al. RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5. Blood 117(14), 3847-3857 (2011).
-
(2011)
Blood
, vol.117
, Issue.14
, pp. 3847-3857
-
-
Zhu, Y.X.1
Tiedemann, R.2
Shi, C.X.3
-
68
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata CM, Davis RE, Demchenko Y et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 12(2), 115-130 (2007).
-
(2007)
Cancer Cell
, vol.12
, Issue.2
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
-
69
-
-
38049152900
-
PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma
-
Harvey RD, Lonial S. PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma. Future Oncol. 3(6), 639-647 (2007).
-
(2007)
Future Oncol
, vol.3
, Issue.6
, pp. 639-647
-
-
Harvey, R.D.1
Lonial, S.2
-
70
-
-
80053203115
-
The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma
-
Gera J, Lichtenstein A. The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma. Leuk. Lymphoma 52(10), 1857-1866 (2011).
-
(2011)
Leuk. Lymphoma
, vol.52
, Issue.10
, pp. 1857-1866
-
-
Gera, J.1
Lichtenstein, A.2
-
71
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Thoreen CC et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137(5), 873-886 (2009).
-
(2009)
Cell
, vol.137
, Issue.5
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
-
72
-
-
56449092331
-
Multi-center phase II study of perifosine (KRX-0401) alone and in combination with dexamethasone (dex) for patients with relapsed or relapsed/refractory multiple myeloma (MM): Promising activity as combination therapy with manageable toxicity
-
353a-Abstract 1164
-
Richardson P, Lonial S, Jakubowiak A et al. Multi-center phase II study of perifosine (KRX-0401) alone and in combination with dexamethasone (dex) for patients with relapsed or relapsed/refractory multiple myeloma (MM): promising activity as combination therapy with manageable toxicity. Blood 110(11), 353a-Abstract 1164 (2007).
-
(2007)
Blood
, vol.110
, Issue.11
-
-
Richardson, P.1
Lonial, S.2
Jakubowiak, A.3
-
73
-
-
81155151824
-
Perifosine plus bortezomib and dexamethasone in patients with relapsed/ refractory multiple myeloma previously treated with bortezomib: Results of a multicenter phase I/II trial
-
Richardson PG, Wolf J, Jakubowiak A et al. Perifosine plus bortezomib and dexamethasone in patients with relapsed/ refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial. J. Clin. Oncol. 29(32), 4243-4249 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.32
, pp. 4243-4249
-
-
Richardson, P.G.1
Wolf, J.2
Jakubowiak, A.3
-
74
-
-
84864322405
-
Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: A Phase i multiple myeloma research consortium study
-
Jakubowiak AJ, Richardson PG, Zimmerman T et al. Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: a Phase I multiple myeloma research consortium study. Br.J. Haematol. 158(4), 472-480 (2012).
-
(2012)
Br.J. Haematol.
, vol.158
, Issue.4
, pp. 472-480
-
-
Jakubowiak, A.J.1
Richardson, P.G.2
Zimmerman, T.3
-
75
-
-
84895829899
-
Single-agent everolimus (RAD001) in patients with relapsed or refractory multiple myeloma: Final results of a phase i study
-
Guenther A, Baumann P, Burger R, Klapper W, Schmidmaier R, Gramatzki M. Single-agent everolimus (RAD001) in patients with relapsed or refractory multiple myeloma: final results of a phase I study. ASCO Meeting Abstracts 28(15 Suppl.)
-
ASCO Meeting Abstracts
, vol.28
, Issue.15 SUPPL..
-
-
Guenther, A.1
Baumann, P.2
Burger, R.3
Klapper, W.4
Schmidmaier, R.5
Gramatzki, M.6
-
76
-
-
68649117850
-
Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma
-
Farag SS, Zhang S, Jansak BS et al. Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma. Leuk. Res. 33(11), 1475-1480 (2009).
-
(2009)
Leuk. Res.
, vol.33
, Issue.11
, pp. 1475-1480
-
-
Farag, S.S.1
Zhang, S.2
Jansak, B.S.3
-
77
-
-
79952042047
-
Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: A multicentre, phase 1/2, open-label, dose-escalation study
-
Ghobrial IM, Weller E, Vij R et al. Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study. Lancet Oncol. 12(3), 263-272 (2011).
-
(2011)
Lancet Oncol
, vol.12
, Issue.3
, pp. 263-272
-
-
Ghobrial, I.M.1
Weller, E.2
Vij, R.3
-
78
-
-
80053202500
-
Updated results of a phase i study of rad001 in combination with lenalidomide in patients with relapsed or refractory multiple myeloma with pharmacodynamic and pharmacokinetic analysis
-
Mahindra A, Richardson PG, Hari P et al. Updated results of a phase I study of rad001 in combination with lenalidomide in patients with relapsed or refractory multiple myeloma with pharmacodynamic and pharmacokinetic analysis. ASH Annual Meeting Abstracts 116(21), 3051 (2010).
-
(2010)
ASH Annual Meeting Abstracts
, vol.116
, Issue.21
, pp. 3051
-
-
Mahindra, A.1
Richardson, P.G.2
Hari, P.3
-
79
-
-
84893267145
-
Biomarker correlation with outcomes in patients with relapsed or refractory multiple myeloma on a Phase i study of everolimus in combination with lenalidomide
-
Yee AJ, Mahindra AK, Richardson PG et al. Biomarker correlation with outcomes in patients with relapsed or refractory multiple myeloma on a Phase I study of everolimus in combination with lenalidomide. ASH Annual Meeting Abstracts 118(21), 3966 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 3966
-
-
Yee, A.J.1
Mahindra, A.K.2
Richardson, P.G.3
-
80
-
-
80052756653
-
Phase i trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: Evidence for lenalidomide-CCI-779 interaction via P-glycoprotein
-
Hofmeister CC, Yang X, Pichiorri F et al. Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein. J. Clin. Oncol. 29(25), 3427-3434 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.25
, pp. 3427-3434
-
-
Hofmeister, C.C.1
Yang, X.2
Pichiorri, F.3
-
81
-
-
11144358447
-
Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
-
Alsina M, Fonseca R, Wilson EF et al. Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Blood 103(9), 3271-3277 (2004).
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3271-3277
-
-
Alsina, M.1
Fonseca, R.2
Wilson, E.F.3
-
82
-
-
84895835520
-
A phase II study of the MEK 1/2 inhibitor AZD6244 (Selumetinib, ARRY-142866) in relapsed or refractory multiple myeloma
-
Holkova B, Badros AZ, Geller R et al. A phase II study of the MEK 1/2 inhibitor AZD6244 (Selumetinib, ARRY-142866) in relapsed or refractory multiple myeloma. ASH Annual Meeting Abstracts 118(21)
-
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
-
-
Holkova, B.1
Badros, A.Z.2
Geller, R.3
-
83
-
-
84862507585
-
An open-label, single-arm, phase 2 (PX-171- 004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
-
Vij R, Wang M, Kaufman JL et al. An open-label, single-arm, phase 2 (PX-171- 004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma. Blood 119(24), 5661-5670 (2012).
-
(2012)
Blood
, vol.119
, Issue.24
, pp. 5661-5670
-
-
Vij, R.1
Wang, M.2
Kaufman, J.L.3
-
84
-
-
84867295563
-
A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
-
Siegel DS, Martin T, Wang M et al. A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood 120(14), 2817-2825 (2012).
-
(2012)
Blood
, vol.120
, Issue.14
, pp. 2817-2825
-
-
Siegel, D.S.1
Martin, T.2
Wang, M.3
-
85
-
-
84865552564
-
An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
-
Vij R, Siegel DS, Jagannath S et al. An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib. Br. J. Haematol. 158(6), 739-748 (2012).
-
(2012)
Br. J. Haematol.
, vol.158
, Issue.6
, pp. 739-748
-
-
Vij, R.1
Siegel, D.S.2
Jagannath, S.3
-
86
-
-
84893340223
-
Final results from the phase Ib/II study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in patients with relapsed or progressive multiple myeloma
-
Wang M, Martin T, Bensinger W et al. Final results from the phase Ib/II study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in patients with relapsed or progressive multiple myeloma. ASCO Meeting Abstracts 31(15 Suppl.), 8529 (2013).
-
(2013)
ASCO Meeting Abstracts
, vol.31
, Issue.15 SUPPL..
, pp. 8529
-
-
Wang, M.1
Martin, T.2
Bensinger, W.3
-
87
-
-
84863644110
-
A randomized, multicenter, phase (Ph) III study comparing carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (Dex) to LEN and Dex in patients (Pts) with relapsed multiple myeloma (MM)
-
Moreau P, Palumbo AP, Stewart AK et al. A randomized, multicenter, phase (Ph) III study comparing carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (Dex) to LEN and Dex in patients (Pts) with relapsed multiple myeloma (MM). ASCO Meeting Abstracts 29(15 Suppl.), TPS225 (2011).
-
(2011)
ASCO Meeting Abstracts
, vol.29
, Issue.15 SUPPL..
-
-
Moreau, P.1
Palumbo, A.P.2
Stewart, A.K.3
-
88
-
-
84857261392
-
Final results of a frontline phase 1/study of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in multiple myeloma (MM)
-
Jakubowiak AJ, Dytfeld D, Jagannath S et al. Final results of a frontline phase 1/study of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in multiple myeloma (MM). ASH Annual Meeting Abstracts 118(21), 631 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 631
-
-
Jakubowiak, A.J.1
Dytfeld, D.2
Jagannath, S.3
-
89
-
-
84895789901
-
Phase II clinical and correlative study of carfilzomib, lenalidomide, and dexamethasone followed by lenalidomide extended dosing (CRD-R) in newly diagnosed multiple myeloma (MM) patients
-
Abstract
-
Korde N, Zingone A, Kwok M et al. Phase II clinical and correlative study of carfilzomib, lenalidomide, and dexamethasone followed by lenalidomide extended dosing (CRD-R) in newly diagnosed multiple myeloma (MM) patients. Haematologica 98(s1), Abstract 228 (2013).
-
(2013)
Haematologica
, vol.98
, Issue.S1
, pp. 228
-
-
Korde, N.1
Zingone, A.2
Kwok, M.3
-
90
-
-
84879578512
-
Carfilzomib combined with thalidomide and dexamethasone (CTD) is an highly effective induction and consolidation treatment in newly diagnosed patients with multiple myeloma (MM) who are transplant candidate
-
Sonneveld P, Asselbergs E, Zweegman S et al. Carfilzomib combined with thalidomide and dexamethasone (CTD) is an highly effective induction and consolidation treatment in newly diagnosed patients with multiple myeloma (MM) who are transplant candidate. ASH Annual Meeting Abstracts 120(21), 333 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 333
-
-
Sonneveld, P.1
Asselbergs, E.2
Zweegman, S.3
-
91
-
-
84879569480
-
Results from the phase II dose expansion of cyclophosphamide, carfilzomib, thalidomide and dexamethasone (CYCLONE) in patients with newly diagnosed multiple myeloma
-
Mikhael JR, Reeder CB, Libby EN, Iii et al. Results from the phase II dose expansion of cyclophosphamide, carfilzomib, thalidomide and dexamethasone (CYCLONE) in patients with newly diagnosed multiple myeloma. ASH Annual Meeting Abstracts 120(21), 445 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 445
-
-
Mikhael, J.R.1
Reeder, C.B.2
En III, L.3
-
92
-
-
84893299544
-
Carfilzomib, cyclophosphamide and dexamethasone (CCD) for newly diagnosed multiple myeloma (MM) patients: Initial results of a multicenter, open label Phase II study
-
Abstract S578
-
Bringhen S, Cavallo F, Petrucci MT et al. Carfilzomib, cyclophosphamide and dexamethasone (CCD) for newly diagnosed multiple myeloma (MM) patients: initial results of a multicenter, open label Phase II study. Haematologica 98(S1), Abstract S578 (2013).
-
(2013)
Haematologica
, vol.98
, Issue.S1
-
-
Bringhen, S.1
Cavallo, F.2
Petrucci, M.T.3
-
93
-
-
84893247056
-
Effect of CMP, carfilzomib (CFZ) plus melphalan-prednisone (MP), on response rates in elderly patients (pts) with newly diagnosed multiple myeloma (NDMM): Results of a phase (Ph) I/II trial
-
Touzeau C, Kolb B, Hulin C et al. Effect of CMP, carfilzomib (CFZ) plus melphalan-prednisone (MP), on response rates in elderly patients (pts) with newly diagnosed multiple myeloma (NDMM): results of a phase (Ph) I/II trial. ASCO Meeting Abstracts 31(15 Suppl.), 8513 (2013).
-
(2013)
ASCO Meeting Abstracts
, vol.31
, Issue.15 SUPPL..
, pp. 8513
-
-
Touzeau, C.1
Kolb, B.2
Hulin, C.3
-
94
-
-
84876448482
-
Phase I/II study of panobinostat and carfilzomib in patients (pts) with relapsed or refractory multiple myeloma (MM), interim phase i safety analysis
-
Berdeja JG, Hart L, Lamar R, Murphy P, Morgan S, Flinn IW. Phase I/II study of panobinostat and carfilzomib in patients (pts) with relapsed or refractory multiple myeloma (MM), interim phase i safety analysis. ASH Annual Meeting Abstracts 120(21), 4048 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 4048
-
-
Berdeja, J.G.1
Hart, L.2
Lamar, R.3
Murphy, P.4
Morgan, S.5
Flinn, I.W.6
-
95
-
-
84876435699
-
Phase 1/1b Study of the efficacy and safety of the combination of panobinostat + carfilzomib in patients with relapsed and/or refractory multiple myeloma
-
Shah JJ, Thomas SK, Weber DM et al. Phase 1/1b Study of the efficacy and safety of the combination of panobinostat + carfilzomib in patients with relapsed and/or refractory multiple myeloma. ASH Annual Meeting Abstracts 120(21), 4081 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 4081
-
-
Shah, J.J.1
Thomas, S.K.2
Weber, D.M.3
-
96
-
-
84983187301
-
Phase i study of the combination of carfilzomib and panobinostat for patients with relapsed and refractory myeloma: A multicenter MMRC clinical trial
-
Abstract
-
Kauffman J, Zimmerman T, Jakubowiak A et al. Phase I study of the combination of carfilzomib and panobinostat for patients with relapsed and refractory myeloma: a multicenter MMRC clinical trial. Haematologica 98(S1), Abstract P771 (2013).
-
(2013)
Haematologica
, vol.98
, Issue.S1
, pp. 771
-
-
Kauffman, J.1
Zimmerman, T.2
Jakubowiak, A.3
-
97
-
-
84884221713
-
A multi-center phase I/II trial of carfilzomib and pomalidomide with dexamethasone (Car-Pom-d) in patients with relapsed/ refractory multiple myeloma
-
Shah JJ, Stadtmauer EA, Abonour R et al. A multi-center phase I/II trial of carfilzomib and pomalidomide with dexamethasone (Car-Pom-d) in patients with relapsed/ refractory multiple myeloma. ASH Annual Meeting Abstracts 120(21), 74 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 74
-
-
Shah, J.J.1
Stadtmauer, E.A.2
Abonour, R.3
-
98
-
-
84893327636
-
Phase 1 study of the novel kinesin spindle protein inhibitor arry-520 + carfilzomib(Car). in patients with relapsed and/or refractory multiple Myeloma (RRMM)
-
Abstract
-
Shah JJ, Thomas S, Weber DM, Wang M, Orlowski R. Phase 1 study of the novel kinesin spindle protein inhibitor arry-520 + carfilzomib(Car) In patients with relapsed and/or refractory multiple Myeloma (RRMM). Haematologica 98(S1), Abstract S579 (2013).
-
(2013)
Haematologica
, vol.98
, Issue.S1
-
-
Shah, J.J.1
Thomas, S.2
Weber, D.M.3
Wang, M.4
Orlowski, R.5
-
99
-
-
84886924807
-
Phase 1 Study of the novel kinesin spindle protein inhibitor ARRY-520 + carfilzomib in patients with relapsed and/or refractory multiple myeloma
-
Shah JJ, Weber DM, Thomas SK et al. Phase 1 Study of the novel kinesin spindle protein inhibitor ARRY-520 + carfilzomib in patients with relapsed and/or refractory multiple myeloma. ASH Annual Meeting Abstracts 120(21), 4082 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 4082
-
-
Shah, J.J.1
Weber, D.M.2
Thomas, S.K.3
-
100
-
-
84890429728
-
Treatment outcomes in patients with relapsed and refractory multiple myeloma and high-risk cytogenetics receiving single-agent carfilzomib in the PX-171-003- A1 study
-
doi:10.1038/leu.2013.152 Epub ahead of print
-
Jakubowiak AJ, Siegel DS, Martin T et al. Treatment outcomes in patients with relapsed and refractory multiple myeloma and high-risk cytogenetics receiving single-agent carfilzomib in the PX-171-003- A1 study. Leukemia doi:10.1038/ leu.2013.152 (2013) (Epub ahead of print).
-
(2013)
Leukemia
-
-
Jakubowiak, A.J.1
Siegel, D.S.2
Martin, T.3
-
101
-
-
84859760906
-
Integrated safety from phase 2 studies of monotherapy carfilzomib in patients with relapsed and refractory multiple myeloma (MM): An updated analysis
-
Singhal S, Siegel DS, Martin T et al. Integrated safety from phase 2 studies of monotherapy carfilzomib in patients with relapsed and refractory multiple myeloma (MM): an updated analysis. ASH Annual Meeting Abstracts 118(21), 1876 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 1876
-
-
Singhal, S.1
Siegel, D.S.2
Martin, T.3
-
102
-
-
84881480747
-
Carfilzomib in multiple myeloma patients with renal impairment: Pharmacokinetics and safety
-
doi:10.1038/leu.2013.29 Epub ahead of print
-
Badros AZ, Vij R, Martin T et al. Carfilzomib in multiple myeloma patients with renal impairment: pharmacokinetics and safety. Leukemia doi:10.1038/ leu.2013.29 (2013) (Epub ahead of print).
-
(2013)
Leukemia
-
-
Badros, A.Z.1
Vij, R.2
Martin, T.3
-
103
-
-
65649139708
-
Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)
-
Zhou HJ, Aujay MA, Bennett MK et al. Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J. Med. Chem. 52(9), 3028-3038 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, Issue.9
, pp. 3028-3038
-
-
Zhou, H.J.1
Aujay, M.A.2
Bennett, M.K.3
-
104
-
-
84886873220
-
A Phase 1b dose-escalation study of split-dose oprozomib (ONX0912) in patients with hematologic malignancies
-
Savona MR, Berdeja JG, Lee SJ et al. A Phase 1b dose-escalation study of split-dose oprozomib (ONX0912) in patients with hematologic malignancies. ASH Annual Meeting Abstracts 120(21), 203 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 203
-
-
Savona, M.R.1
Berdeja, J.G.2
Lee, S.J.3
-
105
-
-
84893289668
-
Clinical profile of once-daily, modified-release oprozomib tablets in patients with hematologic malignancies: Results of a phase 1b/2 trial
-
Abstract
-
Kaufman JL, Siegel D, Vij R et al. Clinical profile of once-daily, modified-release oprozomib tablets in patients with hematologic malignancies: results of a phase 1b/2 trial. Haematologica 98(S1), Abstract P233 (2013).
-
(2013)
Haematologica
, vol.98
, Issue.S1
, pp. 233
-
-
Kaufman, J.L.1
Siegel, D.2
Vij, R.3
-
106
-
-
84890568547
-
Weekly MLN9708, an investigational oral proteasome inhibitor (PI), in relapsed/ refractory multiple myeloma (MM): Results from a phase i study after full enrollment
-
Kumar S, Bensinger W, Zimmerman TM et al. Weekly MLN9708, an investigational oral proteasome inhibitor (PI), in relapsed/ refractory multiple myeloma (MM): Results from a phase I study after full enrollment. ASCO Meeting Abstracts 31(15 Suppl.)
-
ASCO Meeting Abstracts
, vol.31
, Issue.15 SUPPL..
-
-
Kumar, S.1
Bensinger, W.2
Zimmerman, T.M.3
-
107
-
-
84872886249
-
Phase i study of twice-weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients (pts) with relapsed and/or refractory multiple myeloma (MM)
-
Lonial S, Baz RC, Wang M et al. Phase I study of twice-weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients (pts) with relapsed and/or refractory multiple myeloma (MM). ASCO Meeting Abstracts 30(15 Suppl.)
-
ASCO Meeting Abstracts
, vol.30
, Issue.15 SUPPL..
-
-
Lonial, S.1
Baz, R.C.2
Wang, M.3
-
108
-
-
84874870079
-
Oral MLN9708, an investigational proteasome inhibitor, in combination with melphalan and prednisone in patients with previously untreated multiple myeloma: A phase 1 study
-
Abstract
-
San Miguel J, Hajek R, Spicka I et al. Oral MLN9708, an investigational proteasome inhibitor, in combination with melphalan and prednisone in patients with previously untreated multiple myeloma: a phase 1 study. Haematologica 97(s1), Abstract 293 (2012).
-
(2012)
Haematologica
, vol.97
, Issue.S1
, pp. 293
-
-
San Miguel, J.1
Hajek, R.2
Spicka, I.3
-
109
-
-
84879562212
-
A Phase 1/2 study of weekly MLN9708, an investigational oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM)
-
Kumar SK, Berdeja JG, Niesvizky R et al. A Phase 1/2 study of weekly MLN9708, an investigational oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM). ASH Annual Meeting Abstracts 120(21), 332 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 332
-
-
Kumar, S.K.1
Berdeja, J.G.2
Niesvizky, R.3
-
110
-
-
84857919694
-
Phase 1 clinical evaluation of twice-weekly marizomib (NPI-0052), a novel proteasome inhibitor, in patients with relapsed/refractory multiple myeloma (MM)
-
Richardson PG, Spencer A, Cannell P et al. Phase 1 clinical evaluation of twice-weekly marizomib (NPI-0052), a novel proteasome inhibitor, in patients with relapsed/refractory multiple myeloma (MM). ASH Annual Meeting Abstracts 118(21), 302 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 302
-
-
Richardson, P.G.1
Spencer, A.2
Cannell, P.3
-
111
-
-
84877605245
-
Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib
-
Richardson PG, Siegel D, Baz R et al. Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib. Blood 121(11), 1961-1967 (2013).
-
(2013)
Blood
, vol.121
, Issue.11
, pp. 1961-1967
-
-
Richardson, P.G.1
Siegel, D.2
Baz, R.3
-
112
-
-
73849086725
-
Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma
-
Lacy MQ, Hayman SR, Gertz MA et al. Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma. J. Clin. Oncol. 27(30), 5008-5014 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.30
, pp. 5008-5014
-
-
Lacy, M.Q.1
Hayman, S.R.2
Gertz, M.A.3
-
113
-
-
78149468560
-
Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)
-
Lacy MQ, Hayman SR, Gertz MA et al. Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM). Leukemia 24(11), 1934-1939 (2010).
-
(2010)
Leukemia
, vol.24
, Issue.11
, pp. 1934-1939
-
-
Lacy, M.Q.1
Hayman, S.R.2
Gertz, M.A.3
-
114
-
-
84884702342
-
Pomalidomide Plus Low-Dose Dexamethasone (Pom/Dex) in Relapsed Myeloma: Long Term Follow up and Factors Predicing Outcome in 345 Patients
-
Lacy MQ, Kumar SK, Laplant BR et al. Pomalidomide Plus Low-Dose Dexamethasone (Pom/Dex) in Relapsed Myeloma: Long Term Follow up and Factors Predicing Outcome in 345 Patients. ASH Annual Meeting Abstracts 120(21), 201 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 201
-
-
Lacy, M.Q.1
Kumar, S.K.2
Laplant, B.R.3
-
115
-
-
80052937408
-
Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: Comparison of 2 dosing strategies in dual-refractory disease
-
Lacy MQ, Allred JB, Gertz MA et al. Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory disease. Blood 118(11), 2970-2975 (2011).
-
(2011)
Blood
, vol.118
, Issue.11
, pp. 2970-2975
-
-
Lacy, M.Q.1
Allred, J.B.2
Gertz, M.A.3
-
116
-
-
84877622448
-
Pomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide-refractory multiple myeloma: Intergroupe Francophone du Myelome 2009-02
-
Leleu X, Attal M, Arnulf B et al. Pomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide-refractory multiple myeloma: Intergroupe Francophone du Myelome 2009-02. Blood 121(11), 1968-1975 (2013).
-
(2013)
Blood
, vol.121
, Issue.11
, pp. 1968-1975
-
-
Leleu, X.1
Attal, M.2
Arnulf, B.3
-
117
-
-
84888042523
-
MM-003: A phase III, multicenter, randomized, open-label study of pomalidomide (POM) plus low-dose dexamethasone (LoDEX) versus high-dose dexamethasone (HiDEX) in relapsed/ refractory multiple myeloma (RRMM)
-
San-Miguel JF, Weisel KC, Moreau P et al. MM-003: A phase III, multicenter, randomized, open-label study of pomalidomide (POM) plus low-dose dexamethasone (LoDEX) versus high-dose dexamethasone (HiDEX) in relapsed/ refractory multiple myeloma (RRMM). ASCO Meeting Abstracts 31(15 Suppl.)
-
ASCO Meeting Abstracts
, vol.31
, Issue.15 SUPPL..
-
-
San-Miguel, J.F.1
Weisel, K.C.2
Moreau, P.3
-
118
-
-
84893241637
-
MM-005: A Phase i Trial of Pomalidomide Bortezomib and Low-dose Dexamethasone (PVD) in Relapsed Andor Refractory Multiple Myeloma (RRMM)
-
Richardson PGG, Hofmeister CC, Siegel DSD et al. MM-005: A phase I trial of pomalidomide, bortezomib, and low-dose dexamethasone (PVD) in relapsed and/or refractory multiple myeloma (RRMM). ASCO Meeting Abstracts 31(15 Suppl.)
-
ASCO Meeting Abstracts
, vol.31
, Issue.15 SUPPL..
-
-
Pgg, R.1
Hofmeister, C.C.2
Dsd, S.3
-
119
-
-
84877136004
-
ClaPD (Clarithromycin, Pomalidomide, Dexamethasone) therapy in relapsed or refractory multiple myeloma
-
Mark TM, Boyer A, Rossi AC et al. ClaPD (Clarithromycin, Pomalidomide, Dexamethasone) therapy in relapsed or refractory multiple myeloma. ASH Annual Meeting Abstracts 120(21), 77 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 77
-
-
Mark, T.M.1
Boyer, A.2
Rossi, A.C.3
-
120
-
-
84884699765
-
Oral weekly cyclophosphamide in combination with pomalidomide and dexamethasone for relapsed and refractory myeloma: Report of the dose escalation cohort
-
Baz R, Shain KH, Alsina M et al. Oral weekly cyclophosphamide in combination with pomalidomide and dexamethasone for relapsed and refractory myeloma: report of the dose escalation cohort. ASH Annual Meeting Abstracts 120(21), 4062 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 4062
-
-
Baz, R.1
Shain, K.H.2
Alsina, M.3
-
121
-
-
84893334640
-
Salvage treatment with pomalidomide- cyclophosphamide-prednisone produces similar outcomes as compared to prior therapies in patients with relapsed/refractory multiple myeloma
-
Abstract
-
Larocca A, Montefusco V, Oliva S et al. Salvage treatment with pomalidomide- cyclophosphamide-prednisone produces similar outcomes as compared to prior therapies in patients with relapsed/refractory multiple myeloma. Haematologica 98(s1), Abstract P245 (2013).
-
(2013)
Haematologica
, vol.98
, Issue.S1
, pp. 245
-
-
Larocca, A.1
Montefusco, V.2
Oliva, S.3
-
122
-
-
84893335552
-
A phase I/II study (NCT01541332) of pomalidomide (POM), dexamethasone (DEX), and pegylated liposomal doxorubicin (PLD) for patients with relapsed/refractory (R/R) multiple myeloma (MM)
-
Hilger JD, Berenson JR, Klein LM et al. A phase I/II study (NCT01541332) of pomalidomide (POM), dexamethasone (DEX), and pegylated liposomal doxorubicin (PLD) for patients with relapsed/refractory (R/R) multiple myeloma (MM). ASCO Meeting Abstracts 31 (15 Suppl.), 8598 (2013).
-
(2013)
ASCO Meeting Abstracts
, vol.31
, Issue.15 SUPPL..
, pp. 8598
-
-
Hilger, J.D.1
Berenson, J.R.2
Klein, L.M.3
-
123
-
-
31344443373
-
Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone-a randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO)
-
Ponisch W, Mitrou PS, Merkle K et al. Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone-a randomized phase III study of the East German Study Group of Hematology and Oncology (OSHO). J. Cancer Res. Clin. Oncol. 132(4), 205-212 (2006).
-
(2006)
J. Cancer Res. Clin. Oncol.
, vol.132
, Issue.4
, pp. 205-212
-
-
Ponisch, W.1
Mitrou, P.S.2
Merkle, K.3
-
124
-
-
54249151785
-
Bortezomib in Combination with Bendamustine and Prednisone in the Treatment of Patients with Refractory/ Relapsed Multiple Myeloma
-
Poenisch W, Bourgeois M, Wang S-Y et al. Bortezomib in Combination with Bendamustine and Prednisone in the Treatment of Patients with Refractory/ Relapsed Multiple Myeloma. ASH Annual Meeting Abstracts 110(11), 2723 (2007).
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, Issue.11
, pp. 2723
-
-
Poenisch, W.1
Bourgeois, M.2
Wang, S.-Y.3
-
125
-
-
84870748976
-
Bortezomib-bendamustine-dexamethasone in patients with relapsed/refractory multiple myeloma (MM) shows marked efficacy and is well tolerated, but assessment of PNP symptoms shows significant discrepancies between patients and physicians
-
Ludwig H, Kasparu H, Linkesch W et al. Bortezomib-bendamustine- dexamethasone in patients with relapsed/refractory multiple myeloma (MM) shows marked efficacy and is well tolerated, but assessment of PNP symptoms shows significant discrepancies between patients and physicians. ASH Annual Meeting Abstracts 118(21), 2928 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 2928
-
-
Ludwig, H.1
Kasparu, H.2
Linkesch, W.3
-
126
-
-
84885624990
-
Combination therapy of bortezomib with bendamustin in elderly patients with advanced multiple myeloma. Clinical observation
-
Hrusovsky I, Heidtmann H-H. Combination therapy of bortezomib with bendamustin in elderly patients with advanced multiple myeloma. clinical observation. ASH Annual Meeting Abstracts 110(11), 4851 (2007).
-
(2007)
ASH Annual Meeting Abstracts
, vol.110
, Issue.11
, pp. 4851
-
-
Hrusovsky, I.1
Heidtmann, H.-H.2
-
127
-
-
84885631854
-
Bendamustine bortezomib and dexamethasone (BVD) in elderly mm progressive after 1st line therapy (IFM 2009-01 Trial): Predictive factors of defavourable outcome
-
Abstract
-
Rodon P, Hulin C, Pegourie B et al. Bendamustine, bortezomib and dexamethasone (BVD) in elderly mm progressive after 1st line therapy (IFM 2009-01 Trial): predictive factors of defavourable outcome. Haematologica 98(S1), Abstract P231 (2013).
-
(2013)
Haematologica
, vol.98
, Issue.S1
, pp. 231
-
-
Rodon, P.1
Hulin, C.2
Pegourie, B.3
-
128
-
-
52649146310
-
Combined bendamustine, prednisolone and thalidomide for refractory or relapsed multiple myeloma after autologous stem-cell transplantation or conventional chemotherapy: Results of a Phase i clinical trial
-
Ponisch W, Rozanski M, Goldschmidt H et al. Combined bendamustine, prednisolone and thalidomide for refractory or relapsed multiple myeloma after autologous stem-cell transplantation or conventional chemotherapy: results of a Phase I clinical trial. Br. J. Haematol. 143(2), 191-200 (2008).
-
(2008)
Br. J. Haematol.
, vol.143
, Issue.2
, pp. 191-200
-
-
Ponisch, W.1
Rozanski, M.2
Goldschmidt, H.3
-
129
-
-
81155134123
-
Bendamustine in combination with thalidomide and dexamethasone is an effective therapy for myeloma patients with end stage renal disease
-
Ramasamy K, Hazel B, Mahmood S, Corderoy S, Schey S. Bendamustine in combination with thalidomide and dexamethasone is an effective therapy for myeloma patients with end stage renal disease. Br. J. Haematol. 155(5), 632-634 (2011).
-
(2011)
Br. J. Haematol.
, vol.155
, Issue.5
, pp. 632-634
-
-
Ramasamy, K.1
Hazel, B.2
Mahmood, S.3
Corderoy, S.4
Schey, S.5
-
130
-
-
84856301250
-
Bendamustine, thalidomide and dexamethasone is an effective salvage regimen for advanced stage multiple myeloma
-
author reply
-
Grey-Davies E, Bosworth JL, Boyd KD et al. Bendamustine, thalidomide and dexamethasone is an effective salvage regimen for advanced stage multiple myeloma. Br. J. Haematol. 156(4), 552-555, author reply
-
Br. J. Haematol.
, vol.156
, Issue.4
, pp. 552-555
-
-
Grey-Davies, E.1
Bosworth, J.L.2
Boyd, K.D.3
-
131
-
-
84861208513
-
Combination of bendamustine, lenalidomide, and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: Results of phase 1/2 open-label, dose escalation study
-
Lentzsch S, O'sullivan A, Kennedy RC et al. Combination of bendamustine, lenalidomide, and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: results of phase 1/2 open-label, dose escalation study. Blood 119(20), 4608-4613 (2012).
-
(2012)
Blood
, vol.119
, Issue.20
, pp. 4608-4613
-
-
Lentzsch, S.1
O'Sullivan, A.2
Kennedy, R.C.3
-
132
-
-
84879841581
-
Lenalidomide, Bendamustine and Prednisolone exhibits a favourable safety and efficacy profile in relapsed or refractory multiple myeloma: Final results of a phase 1 clinical trial OSHO - #077
-
Ponisch W, Heyn S, Beck J et al. Lenalidomide, Bendamustine and Prednisolone exhibits a favourable safety and efficacy profile in relapsed or refractory multiple myeloma: final results of a phase 1 clinical trial OSHO - #077. Br. J. Haematol. 162(2), 202-209 (2013).
-
(2013)
Br. J. Haematol.
, vol.162
, Issue.2
, pp. 202-209
-
-
Ponisch, W.1
Heyn, S.2
Beck, J.3
-
133
-
-
84878968738
-
In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells
-
Chauhan D, Ray A, Viktorsson K et al. In vitro and In vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin. Cancer Res. 19(11), 3019-3031 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, Issue.11
, pp. 3019-3031
-
-
Chauhan, D.1
Ray, A.2
Viktorsson, K.3
-
134
-
-
33746319879
-
Rituximab treatment provides no clinical benefit in patients with pretreated advanced multiple myeloma
-
Zojer N, Kirchbacher K, Vesely M, Hubl W, Ludwig H. Rituximab treatment provides no clinical benefit in patients with pretreated advanced multiple myeloma. Leuk. Lymphoma 47(6), 1103-1109 (2006).
-
(2006)
Leuk. Lymphoma
, vol.47
, Issue.6
, pp. 1103-1109
-
-
Zojer, N.1
Kirchbacher, K.2
Vesely, M.3
Hubl, W.4
Ludwig, H.5
-
135
-
-
33947424417
-
Rituximab in CD20 positive multiple myeloma
-
Moreau P, Voillat L, Benboukher L et al. Rituximab in CD20 positive multiple myeloma. Leukemia 21(4), 835-836 (2007).
-
(2007)
Leukemia
, vol.21
, Issue.4
, pp. 835-836
-
-
Moreau, P.1
Voillat, L.2
Benboukher, L.3
-
136
-
-
84864118302
-
A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma
-
Zonder JA, Mohrbacher AF, Singhal S et al. A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma. Blood 120(3), 552-559 (2012).
-
(2012)
Blood
, vol.120
, Issue.3
, pp. 552-559
-
-
Zonder, J.A.1
Mohrbacher, A.F.2
Singhal, S.3
-
137
-
-
84863919927
-
Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma
-
Lonial S, Vij R, Harousseau JL et al. Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma. J. Clin. Oncol. 30(16), 1953-1959 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.16
, pp. 1953-1959
-
-
Lonial, S.1
Vij, R.2
Harousseau, J.L.3
-
138
-
-
84879565775
-
A Phase 2 study of elotuzumab (Elo) in combination with lenalidomide and low-dose dexamethasone (Ld) in patients (pts) with relapsed/refractory multiple myeloma (R/R MM): Updated results
-
Richardson PG, Jagannath S, Moreau P et al. A Phase 2 study of elotuzumab (Elo) in combination with lenalidomide and low-dose dexamethasone (Ld) in patients (pts) with relapsed/refractory multiple myeloma (R/R MM): updated results. ASH Annual Meeting Abstracts 120(21), 202 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 202
-
-
Richardson, P.G.1
Jagannath, S.2
Moreau, P.3
-
139
-
-
84878159958
-
Daratumumab, a CD38 monoclonal antibody in patients with multiple myeloma - Data from a dose-escalation phase I/II study
-
Plesner T, Lokhorst H, Gimsing P, Nahi H, Lisby S, Richardson PG. Daratumumab, a CD38 monoclonal antibody in patients with multiple myeloma - data from a dose-escalation phase I/II study. ASH Annual Meeting Abstracts 120(21), 73 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 73
-
-
Plesner, T.1
Lokhorst, H.2
Gimsing, P.3
Nahi, H.4
Lisby, S.5
Richardson, P.G.6
-
140
-
-
84890560780
-
Phase I/II dose-escalation study of daratumumab in patients with relapsed or refractory multiple myeloma
-
Lokhorst HM, Plesner T, Gimsing P et al. Phase I/II dose-escalation study of daratumumab in patients with relapsed or refractory multiple myeloma. ASCO Meeting Abstracts 31(15 Suppl.), 8512 (2013).
-
(2013)
ASCO Meeting Abstracts
, vol.31
, Issue.15 SUPPL..
, pp. 8512
-
-
Lokhorst, H.M.1
Plesner, T.2
Gimsing, P.3
-
141
-
-
74049113834
-
A phase II multiple dose clinical trial of histone deacetylase inhibitor ITF2357 in patients with relapsed or progressive multiple myeloma
-
Galli M, Salmoiraghi S, Golay J et al. A phase II multiple dose clinical trial of histone deacetylase inhibitor ITF2357 in patients with relapsed or progressive multiple myeloma. Ann. Hematol. 89(2), 185-190 (2010).
-
(2010)
Ann. Hematol.
, vol.89
, Issue.2
, pp. 185-190
-
-
Galli, M.1
Salmoiraghi, S.2
Golay, J.3
-
142
-
-
78650992102
-
Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma
-
Niesvizky R, Ely S, Mark T et al. Phase 2 trial of the histone deacetylase inhibitor romidepsin for the treatment of refractory multiple myeloma. Cancer 117(2), 336-342 (2011).
-
(2011)
Cancer
, vol.117
, Issue.2
, pp. 336-342
-
-
Niesvizky, R.1
Ely, S.2
Mark, T.3
-
143
-
-
39749103428
-
Phase i trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma
-
Richardson P, Mitsiades C, Colson K et al. Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma. Leuk. Lymphoma 49(3), 502-507 (2008).
-
(2008)
Leuk. Lymphoma
, vol.49
, Issue.3
, pp. 502-507
-
-
Richardson, P.1
Mitsiades, C.2
Colson, K.3
-
144
-
-
84862878624
-
Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma
-
Wolf JL, Siegel D, Goldschmidt H et al. Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma. Leuk. Lymphoma 53(9), 1820-1823 (2012).
-
(2012)
Leuk. Lymphoma
, vol.53
, Issue.9
, pp. 1820-1823
-
-
Wolf, J.L.1
Siegel, D.2
Goldschmidt, H.3
-
145
-
-
84879592293
-
Rocilinostat (ACY-1215), a selective HDAC6 inhibitor, alone and in combination with bortezomib in multiple myeloma: Preliminary results from the first-in-humans phase I/II study
-
Raje N, Hari PN, Vogl DT et al. Rocilinostat (ACY-1215), a selective HDAC6 inhibitor, alone and in combination with bortezomib in multiple myeloma: preliminary results from the first-in-humans phase I/II study. ASH Annual Meeting Abstracts 120(21), 4061 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 4061
-
-
Raje, N.1
Hari, P.N.2
Vogl, D.T.3
-
146
-
-
84859719940
-
Vantage 088: Vorinostat in combination with bortezomib in patients with relapsed/refractory multiple myeloma: Results of a global, randomized phase 3 trial
-
Dimopoulos MA, Jagannath S, Yoon S-S et al. Vantage 088: vorinostat in combination with bortezomib in patients with relapsed/refractory multiple myeloma: results of a global, randomized phase 3 trial. ASH Annual Meeting Abstracts 118(21), 811 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 811
-
-
Dimopoulos, M.A.1
Jagannath, S.2
Yoon, S.-S.3
-
147
-
-
84861804180
-
Vantage 095: Vorinostat in combination with bortezomib in salvage multiple myeloma patients: Final study results of a global phase 2b trial
-
Siegel DS, Dimopoulos MA, Yoon S-S et al. Vantage 095: vorinostat in combination with bortezomib in salvage multiple myeloma patients: final study results of a global phase 2b trial. ASH Annual Meeting Abstracts 118(21), 480 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 480
-
-
Siegel, D.S.1
Dimopoulos, M.A.2
Yoon, S.-S.3
-
148
-
-
84857922830
-
PANORAMA 2: Panobinostat combined with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory multiple myeloma
-
Richardson PG, Alsina M, Weber D et al. PANORAMA 2: panobinostat combined with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory multiple myeloma. ASH Annual Meeting Abstracts 120(21), 634 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 634
-
-
Richardson, P.G.1
Alsina, M.2
Weber, D.3
-
149
-
-
84893291444
-
New drug partner for combination therapy in multiple myeloma (MM): Development of ACY-1215, a selective histone deacetylase inhibitor alone and in combination with bortezomib or lenalidomide
-
Abstract
-
Raje N, Mahindra A, Vogl D et al. New drug partner for combination therapy in multiple myeloma (MM): development Of ACY-1215, a selective histone deacetylase inhibitor alone and in combination with bortezomib or lenalidomide. Haematologica 98(S1), Abstract P765 (2013).
-
(2013)
Haematologica
, vol.98
, Issue.S1
, pp. 765
-
-
Raje, N.1
Mahindra, A.2
Vogl, D.3
-
150
-
-
84895785984
-
ARRY-520 Shows durable responses in patients with relapsed/refractory multiple myeloma in a phase 1 dose-escalation study
-
Shah JJ, Zonder J, Cohen A et al. ARRY-520 Shows durable responses in patients with relapsed/refractory multiple myeloma in a phase 1 dose-escalation study. ASH Annual Meeting Abstracts 118(21)
-
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
-
-
Shah, J.J.1
Zonder, J.2
Cohen, A.3
-
151
-
-
84886872506
-
The Novel KSP Inhibitor ARRY-520 Is Active Both with and without low-dose dexamethasone in patients with multiple myeloma refractory to bortezomib and
-
Shah JJ, Zonder JA, Cohen A et al. The Novel KSP Inhibitor ARRY-520 Is Active Both with and without low-dose dexamethasone in patients with multiple myeloma refractory to bortezomib and lenalidomide: results from a phase 2 study. ASH Annual Meeting Abstracts 120(21), 449 (2012).
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, Issue.21
, pp. 449
-
-
Shah, J.J.1
Zonder, J.A.2
Cohen, A.3
-
152
-
-
72549116835
-
A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
-
O'Connor OA, Stewart AK, Vallone M et al. A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin. Cancer Res. 15(22), 7085-7091 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.22
, pp. 7085-7091
-
-
O'Connor, O.A.1
Stewart, A.K.2
Vallone, M.3
-
153
-
-
84865712581
-
A phase i single-agent study of twice-weekly consecutive-day dosing of the proteasome inhibitor carfilzomib in patients with relapsed or refractory multiple myeloma or lymphoma
-
Alsina M, Trudel S, Furman RR et al. A phase I single-agent study of twice-weekly consecutive-day dosing of the proteasome inhibitor carfilzomib in patients with relapsed or refractory multiple myeloma or lymphoma. Clin. Cancer Res. 18(17), 4830-4840 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, Issue.17
, pp. 4830-4840
-
-
Alsina, M.1
Trudel, S.2
Furman, R.R.3
-
154
-
-
84867427641
-
An open-label single-arm pilot phase II study (PX-171-003-A0) of low-dose, single-agent carfilzomib in patients with relapsed and refractory multiple myeloma
-
Jagannath S, Vij R, Stewart AK et al. An open-label single-arm pilot phase II study (PX-171-003-A0) of low-dose, single-agent carfilzomib in patients with relapsed and refractory multiple myeloma. Clin. Lymphoma Myeloma Leuk. 12(5), 310-318 (2012).
-
(2012)
Clin. Lymphoma Myeloma Leuk.
, vol.12
, Issue.5
, pp. 310-318
-
-
Jagannath, S.1
Vij, R.2
Stewart, A.K.3
-
155
-
-
79955511317
-
Results of PX-171-003-A1, an open-label, single-arm, phase 2 (Ph 2) study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
-
Siegel DS, Martin T, Wang M et al. Results of PX-171-003-A1, an open-label, single-arm, phase 2 (Ph 2) study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). ASH Annual Meeting Abstracts 116(21), 985 (2010).
-
(2010)
ASH Annual Meeting Abstracts
, vol.116
, Issue.21
, pp. 985
-
-
Siegel, D.S.1
Martin, T.2
Wang, M.3
-
156
-
-
4344693453
-
Phase i study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma
-
Schey SA, Fields P, Bartlett JB et al. Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma. J. Clin. Oncol. 22(16), 3269-3276 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.16
, pp. 3269-3276
-
-
Schey, S.A.1
Fields, P.2
Bartlett, J.B.3
-
157
-
-
40449135275
-
Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation
-
Streetly MJ, Gyertson K, Daniel Y, Zeldis JB, Kazmi M, Schey SA. Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation. Br. J. Haematol. 141(1), 41-51 (2008).
-
(2008)
Br. J. Haematol.
, vol.141
, Issue.1
, pp. 41-51
-
-
Streetly, M.J.1
Gyertson, K.2
Daniel, Y.3
Zeldis, J.B.4
Kazmi, M.5
Schey, S.A.6
-
158
-
-
84857922830
-
Randomized, Open Label Phase 1/2 Study of Pomalidomide (POM) Alone or in combination with low-dose dexamethasone (LoDex) in patients (Pts) with relapsed and refractory multiple myeloma who have received prior treatment that includes lenalidomide (LEN) and bortezomib (BORT): Phase 2 results
-
Richardson PG, Siegel DS, Vij R et al. Randomized, Open Label Phase 1/2 Study of Pomalidomide (POM) Alone or in combination with low-dose dexamethasone (LoDex) in patients (Pts) with relapsed and refractory multiple myeloma who have received prior treatment that includes lenalidomide (LEN) and bortezomib (BORT): phase 2 results. ASH Annual Meeting Abstracts 118(21), 634 (2011).
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, Issue.21
, pp. 634
-
-
Richardson, P.G.1
Siegel, D.S.2
Vij, R.3
-
159
-
-
84887405002
-
Long-term safety and efficacy of pomalidomide (POM) with or without low-dose dexamethasone (LoDEX) in relapsed and refractory multiple myeloma (RRMM) patients enrolled in the MM-002 phase II trial
-
Siegel DSD, Richardson PGG, Vij R et al. Long-term safety and efficacy of pomalidomide (POM) with or without low-dose dexamethasone (LoDEX) in relapsed and refractory multiple myeloma (RRMM) patients enrolled in the MM-002 phase II trial. ASCO Meeting Abstracts 31(15 Suppl.), 8588 (2013).
-
(2013)
ASCO Meeting Abstracts
, vol.31
, Issue.15 SUPPL..
, pp. 8588
-
-
Dsd, S.1
Pgg, R.2
Vij, R.3
-
160
-
-
25444512381
-
The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy
-
Knop S, Straka C, Haen M, Schwedes R, Hebart H, Einsele H. The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy. Haematologica 90(9), 1287-1288 (2005).
-
(2005)
Haematologica
, vol.90
, Issue.9
, pp. 1287-1288
-
-
Knop, S.1
Straka, C.2
Haen, M.3
Schwedes, R.4
Hebart, H.5
Einsele, H.6
-
161
-
-
84872512168
-
Phase I/II trial assessing bendamustine plus bortezomib combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
-
Berenson JR, Yellin O, Bessudo A et al. Phase I/II trial assessing bendamustine plus bortezomib combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. Br. J. Haematol. 160(3), 321-330 (2013).
-
(2013)
Br. J. Haematol.
, vol.160
, Issue.3
, pp. 321-330
-
-
Berenson, J.R.1
Yellin, O.2
Bessudo, A.3
-
162
-
-
84876228632
-
Combined bendamustine, prednisone and bortezomib (BPV) in patients with relapsed or refractory multiple myeloma
-
Ponisch W, Bourgeois M, Moll B et al. Combined bendamustine, prednisone and bortezomib (BPV) in patients with relapsed or refractory multiple myeloma. J. Cancer Res. Clin. Oncol. 139(3), 499-508 (2013).
-
(2013)
J. Cancer Res. Clin. Oncol.
, vol.139
, Issue.3
, pp. 499-508
-
-
Ponisch, W.1
Bourgeois, M.2
Moll, B.3
|