The association between BMI and plasma cytokine levels in patients with acute lung injury

Chest

Volumn 138, Issue 3, 2010, Pages 568-577

  Stapleton, Renee D ^a   Dixon, Anne E ^a   Parsons, Polly E ^a   Ware, Lorraine B ^b   Suratt, Benjamin T ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; SURFACTANT PROTEIN D; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; VON WILLEBRAND FACTOR; AUTACOID; BIOLOGICAL MARKER;

ACUTE LUNG INJURY; ADULT; ARTICLE; BODY MASS; CLINICAL ASSESSMENT; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; FEMALE; HUMAN; INFLAMMATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; VENTILATOR; AGED; BLOOD; BODY WEIGHT; COHORT ANALYSIS; COMPLICATION; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; RISK FACTOR;

ACUTE LUNG INJURY; ADULT; AGED; BIOLOGICAL MARKERS; BODY MASS INDEX; COHORT STUDIES; CYTOKINES; FEMALE; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; OBESITY; RETROSPECTIVE STUDIES; RISK FACTORS; THINNESS;

EID: 77956807510     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.10-0014     Document Type: Article

References (48)

1. Yudkin JS. Adipose tissue, insulin action and vascular disease: inflammatory signals. Int J Obes Relat Metab Disord. 2003;27(Suppl 3):S25-S28.
2. Shore SA, Johnston RA. Obesity and asthma. Pharmacol Ther. 2006;110(1):83-102.
3. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease:is interleukin-6 the link? Atherosclerosis. 2000;148(2):209-214.
4. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects:associations with obesity, insulin resistance, and endothelial dysfunction:a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol. 1999;19(4):972-978.
5. Tracy RP. Is visceral adiposity the "enemy within"? Arterioscler Thromb Vasc Biol. 2001;21(6):881-883.
6. Ramos EJ, Xu Y, Romanova I, et al. Is obesity an inflammatory disease? Surgery. 2003;134(2):329-335.
7. Lee YH, Nair S, Rousseau E, et al. Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians:increased expression of inflammation-related genes. Diabetologia. 2005;48(9):1776-1783.
8. Ware LB, Matthay MA. The acute respiratory distress syndrome . N Engl J Med. 2000;342(18):1334-1349.
9. Parsons PE, Eisner MD, Thompson BT, et al; NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med. 2005;33(1):1-6.
10. Meduri GU, Headley S, Kohler G, et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest. 1995;107(4): 1062-1073.
11. Hack CE, Hart M, van Schijndel RJ, et al. Interleukin-8 in sepsis:relation to shock and inflammatory mediators. Infect Immun. 1992;60(7):2835-2842.
12. Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med. 1993;119(8):771-778.
13. Pinsky MR, Vincent JL, Deviere J, Alegre M, Kahn RJ, Dupont E. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest. 1993;103(2):565-575. (Pubitemid 23070764)
14. Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med. 2007;35(8):1821-1828.
15. Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA. Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med. 2004;170(7):766-772.
16. Eisner MD, Parsons P, Matthay MA, Ware L, Greene K; Acute Respiratory Distress Syndrome Network. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax. 2003;58(11):983-988.
17. Calfee CS, Eisner MD, Ware LB, et al;Acute Respiratory Distress Syndrome Network, National Heart, Lung, and Blood Institute. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med. 2007;35(10):2243-2250.
18. Ware LB, Conner ER, Matthay MA. von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med. 2001;29(12): 2325-2331.
19. Ferrante AW Jr. Obesity-induced inflammation:a metabolic dialogue in the language of inflammation. J Intern Med. 2007; 262(4):408-414.
20. Morris AE, Stapleton RD, Rubenfeld GD, Hudson LD, Caldwell E, Steinberg KP. The association between body mass index and clinical outcomes in acute lung injury. Chest. 2007;131(2):342-348.
21. O'Brien JM Jr, Phillips GS, Ali NA, Lucarelli M, Marsh CB, Lemeshow S. Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med. 2006;34(3):738-744.
22. O'Brien JM Jr, Welsh CH, Fish RH, Ancukiewicz M, Kramer AM;National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. Excess body weight is not independently associated with outcome in mechanically ventilated patients with acute lung injury. Ann Intern Med. 2004;140(5):338-345.
23. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342(18): 1301-1308.
24. Brower RG, Lanken PN, MacIntyre N, et al; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004;351(4):327-336.
25. Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome:a randomized controlled trial. The ARDS Network. JAMA. 2000;283(15):1995-2002.
26. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2002;30(1):1-6.
27. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149(3 Pt 1):818-824.
28. Eisner MD, Thompson T, Hudson LD, et al; Acute Respiratory Distress Syndrome Network. Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001;164(2):231-236.
29. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20(6):864-874.
30. National Institutes of Health. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults - The Evidence Report. Obes Res. 1998; 6(Suppl 2):51S-209S.
31. Moss M, Guidot DM, Steinberg KP, et al. Diabetic patients have a decreased incidence of acute respiratory distress syndrome. Crit Care Med. 2000;28(7):2187-2192. (Pubitemid 30604414)
32. Knaus WA, Wagner DP, Draper EA, et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest. 1991;100(6):1619-1636.
33. Schoenfeld DA, Bernard GR;ARDS Network. Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med. 2002;30(8):1772-1777.
34. Bernard G. The Brussels Score. Sepsis. 1997;1(1):43-44.
35. Parsons PE, Matthay MA, Ware LB, Eisner MD;National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2005;288(3):L426-L431.
36. Bland JM, Altman DG. Multiple significance tests:the Bonferroni method. BMJ. 1995;310(6973):170.
37. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12): 1796-1808.
38. Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract. 2005;69(1):29-35.
39. Kim CS, Park HS, Kawada T, et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes(Lond). 2006;30(9):1347-1355.
40. Frank JA, Parsons PE, Matthay MA. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006;130(6): 1906-1914.
41. SoláE, Navarro S, Medina P, et al. Activated protein C levels in obesity and weight loss influence. Thromb Res. 2009; 123(5):697-700.
42. Akinnusi ME, Pineda LA, El Solh AA. Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Crit Care Med. 2008;36(1):151-158.
43. Oliveros H, Villamor E. Obesity and mortality in critically ill adults:a systematic review and meta-analysis. Obesity(Silver Spring). 2008;16(3):515-521. (Pubitemid 351328000)
44. Druml W. ICU patients: fatter is better? Intensive Care Med. 2008;34(11):1961-1963.
45. Mancuso P. Obesity and lung inflammation. J Appl Physiol. 2010;108(3):722-728.
46. Falagas ME, Kompoti M. Obesity and infection. Lancet Infect Dis. 2006;6(7):438-446.
47. Bañez LL, Hamilton RJ, Partin AW, et al. Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer. JAMA. 2007;298(19):2275-2280.
48. Bastard JP, Jardel C, Bruckert E, et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab. 2000;85(9):3338-3342.