Intensive mutagenesis of the nisin hinge leads to the rational design of enhanced derivatives

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Healy, Brian ^a   Field, Des ^a   O'Connor, Paula M ^b,c   Hill, Colin ^a,b   Cotter, Paul D ^b,c   Ross, R Paul ^b,c  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c TEAGASC FOOD RESEARCH CENTRE   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

NISIN; NISIN DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; NISIN A;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; HINGE REGION; LACTOCOCCUS LACTIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS AGALACTIAE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; MICROBIAL SENSITIVITY TEST; MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS; NISIN;

EID: 84893177948     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079563     Document Type: Article

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