Activity and export of engineered nisin-(1-22) analogs

Polymers

Volumn 3, Issue 3, 2011, Pages 1282-1296

  Plat, Annechien ^a   Kuipers, Anneke ^a   de Lange, Jacobien G ^a   Moll, Gert N ^a   Rink, Rick ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Cyclization; Lactococcus; Lantibiotic; Nisin; Peptide

Indexed keywords

ANTI-MICROBIAL ACTIVITY; C-TERMINUS; IN-VITRO; LACTOCOCCUS; LACTOCOCCUS LACTIS; LANTIBIOTICS; NISIN; PEPTIDE ANTIBIOTICS; POSITIVELY CHARGED; PRODUCTION LEVEL; TARGET STRAIN;

CYCLIZATION; FOOD PRESERVATIVES; PEPTIDES;

ANTIBIOTICS;

EID: 83655202970     PISSN: None     EISSN: 20734360     Source Type: Journal    
DOI: 10.3390/polym3031282     Document Type: Article

References (35)

1. Gross, E.; Morell, J.L. The Structure of Nisin. J. Am. Chem. Soc. 1971, 93, 4634-4635.
2. Rogers, L.A. The Inhibiting Effect of Streptococcus Lactis on Lactobacillus Bulgaricus. J. Bacteriol. 1928, 16, 321-325.
3. Delves-Broughton, J.; Blackburn, P.; Evans, R.J.; Hugenholtz, J. Applications of the Bacteriocin, Nisin. Anton. Leeuwenhoek 1996, 69, 193-202.
4. Kramer, N.E.; Hasper, H.E.; van den Bogaard, P.T.; Morath, S.; de Kruijff, B.; Hartung, T.; Smid, E.J.; Breukink, E.; Kok, J.; Kuipers, O.P. Increased D-Alanylation of Lipoteichoic Acid and a Thickened Septum are Main Determinants in the Nisin Resistance Mechanism of Lactococcus Lactis. Microbiology 2008, 154, 1755-1762
5. Gravesen, A.; Sorensen, K.; Aarestrup, F.M.; Knochel, S. Spontaneous Nisin-Resistant Listeria Monocytogenes Mutants with Increased Expression of a Putative Penicillin-Binding Protein and their Sensitivity to various Antibiotics. Microb. Drug Resist. 2001, 7, 127-135.
6. Lubelski, J.; Rink, R.; Khusainov, R.; Moll, G.N.; Kuipers, O.P. Biosynthesis, Immunity, Regulation, Mode of Action and Engineering of the Model Lantibiotic Nisin. Cell Mol. Life Sci. 2008, 65, 455-476.
7. Schnell, N.; Entian, K.D.; Schneider, U.; Gotz, F.; Zahner, H.; Kellner, R.; Jung, G. Prepeptide Sequence of Epidermin, a Ribosomally Synthesized Antibiotic with Four Sulphide-Rings. Nature 1988, 333, 276-278.
8. Rink, R.; Wierenga, J.; Kuipers, A.; Kluskens, L.D.; Driessen, A.J.; Kuipers, O.P.; Moll, G.N. Dissection and Modulation of the Four Distinct Activities of Nisin by Mutagenesis of Rings A and B and by C-Terminal Truncation. Appl. Environ. Microbiol. 2007, 73, 5809-5816.
9. Chan, W.C.; Leyland, M.; Clark, J.; Dodd, H.M.; Lian, L.Y.; Gasson, M.J.; Bycroft, B.W.; Roberts, G.C. Structure-Activity Relationships in the Peptide Antibiotic Nisin: Antibacterial Activity of Fragments of Nisin. FEBS Lett. 1996, 390, 129-132.
10. Hasper, H.E.; Kramer, N.E.; Smith, J.L.; Hillman, J.D.; Zachariah, C.; Kuipers, O.P.; de Kruijff, B.; Breukink, E. An Alternative Bactericidal Mechanism of Action for Lantibiotic Peptides that Target Lipid II. Science 2006, 313, 1636-1637.
11. Brotz, H.; Josten, M.; Wiedemann, I.; Schneider, U.; Gotz, F.; Bierbaum, G.; Sahl, H.G. Role of Lipid-Bound Peptidoglycan Precursors in the Formation of Pores by Nisin, Epidermin and Other Lantibiotics. Mol. Microbiol. 1998, 30, 317-327.
12. Breukink, E.; Wiedemann, I.; van Kraaij, C.; Kuipers, O.P.; Sahl, H.; de Kruijff, B. Use of the Cell Wall Precursor Lipid II by a Pore-Forming Peptide Antibiotic. Science 1999, 286, 2361-2364.
13. Breukink, E.; van Heusden, H.E.; Vollmerhaus, P.J.; Swiezewska, E.; Brunner, L.; Walker, S.; Heck, A.J.; de Kruijff, B. Lipid II is an Intrinsic Component of the Pore Induced by Nisin in Bacterial Membranes. J. Biol. Chem. 2003, 278, 19898-19903.
14. Hasper, H.E.; de Kruijff, B.; Breukink, E. Assembly and Stability of Nisin-Lipid II Pores. Biochemistry 2004, 43, 11567-11575.
15. Terzaghi, B.E.; Sandine, W.E. Improved Medium for Lactic Streptococci and Their Bacteriophages. Appl. Microbiol. 1975, 29, 807-813.
16. Jensen, P.R.; Hammer, K. Minimal Requirements for Exponential Growth of Lactococcus Lactis. Appl. Environ. Microbiol. 1993, 59, 4363-4366.
17. Rink, R.; Kuipers, A.; de Boef, E.; Leenhouts, K.J.; Driessen, A.J.; Moll, G.N.; Kuipers, O.P. Lantibiotic Structures as Guidelines for the Design of Peptides that can be Modified by Lantibiotic Enzymes. Biochemistry 2005, 44, 8873-8882.
18. Kuipers, O.P.; de Ruyter, P.G.; Kleerebezem, M.; de Vos, W.M. Controlled Overproduction of Proteins by Lactic Acid Bacteria. Trends Biotechnol. 1997, 15, 135-140.
19. Leenhouts, K.; Bolhuis, A.; Venema, G.; Kok, J. Construction of a Food-Grade Multiple-Copy Integration System for Lactococcus Lactis. Appl. Microbiol. Biotechnol. 1998, 49, 417-423.
20. Kuipers, A.; de Boef, E.; Rink, R.; Fekken, S.; Kluskens, L.D.; Driessen, A.J.; Leenhouts, K.; Kuipers, O.P.; Moll, G.N. NisT, the Transporter of the Lantibiotic Nisin, can Transport Fully Modified, Dehydrated, and Unmodified Prenisin and Fusions of the Leader Peptide with Non-Lantibiotic Peptides. J. Biol. Chem. 2004, 279, 22176-22182.
21. Sambrook, J.; Fritsch, E.F.; Maniatis, T. Molecular Cloning: A Laboratory Manual; Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, USA, 1989; p. 545.
22. Holo, H.; Nes, I.F. Transformation of Lactococcus by Electroporation. Methods Mol. Biol. 1995, 47, 195-199.
23. Plat, A.; Kluskens, L.D.; Kuipers, A.; Rink, R.; Moll, G.N. Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage. Appl. Environ. Microbiol. 2011, 77, 604-611.
24. Schagger, H.; von Jagow, G. Tricine-Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis for the Separation of Proteins in the Range from 1 to 100 kDa. Anal. Biochem. 1987, 166, 368-379.
25. Rasband, W.S. ImageJ; U. S. National Institutes of Health: Bethesda, MA, USA, 1997-2011; Available online: http://imagej.nih.gov/ij/ (accessed on 11 August 2011).
26. Moll, G.N.; Roberts, G.C.; Konings, W.N.; Driessen, A.J. Mechanism of Lantibiotic-Induced Pore-Formation. Antonie Van Leeuwenhoek 1996, 69, 185-191.
27. Hsu, S.T.; Breukink, E.; Tischenko, E.; Lutters, M.A.; de Kruijff, B.; Kaptein, R.; Bonvin, A.M.; van Nuland, N.A. The Nisin-Lipid II Complex Reveals a Pyrophosphate Cage that Provides a Blueprint for Novel Antibiotics. Nat. Struct. Mol. Biol. 2004, 11, 963-967.
28. Bonelli, R.R.; Schneider, T.; Sahl, H.G.; Wiedemann, I. Insights into in vivo Activities of Lantibiotics from Gallidermin and Epidermin Mode-of-Action Studies. Antimicrob. Agents Chemother. 2006, 50, 1449-1457.
29. Kupke, T.; Stevanovic, S.; Sahl, H.G.; Gotz, F. Purification and Characterization of EpiD, a Flavoprotein Involved in the Biosynthesis of the Lantibiotic Epidermin. J. Bacteriol. 1992, 174, 5354-5361.
30. Van Kraaij, C.; Breukink, E.; Rollema, H.S.; Siezen, R.J.; Demel, R.A.; De Kruijff, B.; Kuipers, O.P. Influence of Charge Differences in the C-Terminal Part of Nisin on Antimicrobial Activity and Signaling Capacity. Eur. J. Biochem. 1997, 247, 114-120.
31. Breukink, E.; van Kraaij, C.; Demel, R.A.; Siezen, R.J.; Kuipers, O.P.; de Kruijff, B. The C-Terminal Region of Nisin is Responsible for the Initial Interaction of Nisin with the Target Membrane. Biochemistry 1997, 36, 6968-6976.
32. Rollema, H.S.; Kuipers, O.P.; Both, P.; de Vos, W.M.; Siezen, R.J. Improvement of Solubility and Stability of the Antimicrobial Peptide Nisin by Protein Engineering. Appl. Environ. Microbiol. 1995, 61, 2873-2878.
33. Demel, R.A.; Peelen, T.; Siezen, R.J.; De Kruijff, B.; Kuipers, O.P. Nisin Z, Mutant Nisin Z. Lacticin 481 Interactions with Anionic Lipids Correlate with Antimicrobial Activity. A Monolayer Study. Eur. J. Biochem. 1996, 235, 267-274.
34. van Kraaij, C.; Breukink, E.; Noordermeer, M.A.; Demel, R.A.; Siezen, R.J.; Kuipers, O.P.; de Kruijff, B. Pore Formation by Nisin Involves Translocation of Its C-Terminal Part across the Membrane. Biochemistry 1998, 37, 16033-16040.
35. Moll, G.N.; Clark, J.; Chan, W.C.; Bycroft, B.W.; Roberts, G.C.; Konings, W.N.; Driessen, A.J. Role of Transmembrane pH Gradient and Membrane Binding in Nisin Pore Formation. J. Bacteriol. 1997, 179, 135-140