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Volumn 40, Issue 6, 2012, Pages 1492-1497

'Bac' to the future: Bioengineering lantibiotics for designer purposes

Author keywords

Antimicrobial peptide; Bacteriocin; Bioengineering; Lantibiotic; Mutagenesis; Nisin

Indexed keywords

BACTERIOCIN; LANTIBIOTIC; NISIN; NISIN A; NISIN Z; UNCLASSIFIED DRUG;

EID: 84870182562     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120193     Document Type: Conference Paper
Times cited : (20)

References (51)
  • 1
    • 0023912839 scopus 로고
    • Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings
    • Schnell, N., Entian, K.D., Schneider, U., Gotz, F., Zahner, H., Kellner, R. and Jung, G. (1988) Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature 333, 276-278
    • (1988) Nature , vol.333 , pp. 276-278
    • Schnell, N.1    Entian, K.D.2    Schneider, U.3    Gotz, F.4    Zahner, H.5    Kellner, R.6    Jung, G.7
  • 2
    • 35848941716 scopus 로고    scopus 로고
    • Lantibiotics: Peptides of diverse structure and function
    • DOI 10.1146/annurev.micro.61.080706.093501
    • Willey, J.M. and van der Donk, W.A. (2007) Lantibiotics: peptides of diverse structure and function. Annu. Rev. Microbiol. 61, 477-501 (Pubitemid 350058218)
    • (2007) Annual Review of Microbiology , vol.61 , pp. 477-501
    • Willey, J.M.1    Van Der, D.W.A.2
  • 3
    • 38949166717 scopus 로고    scopus 로고
    • Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin
    • DOI 10.1007/s00018-007-7171-2
    • Lubelski, J., Rink, R., Khusainov, R., Moll, G.N. and Kuipers, O.P. (2008) Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin. Cell. Mol. Life Sci. 65, 455-476 (Pubitemid 351214649)
    • (2008) Cellular and Molecular Life Sciences , vol.65 , Issue.3 , pp. 455-476
    • Lubelski, J.1    Rink, R.2    Khusainov, R.3    Moll, G.N.4    Kuipers, O.P.5
  • 4
    • 65949089371 scopus 로고    scopus 로고
    • Lantibiotics: Mode of action, biosynthesis and bioengineering
    • Bierbaum, G. and Sahl, H.G. (2009) Lantibiotics: mode of action, biosynthesis and bioengineering. Curr. Pharm. Biotechnol. 10, 2-18
    • (2009) Curr. Pharm. Biotechnol. , vol.10 , pp. 2-18
    • Bierbaum, G.1    Sahl, H.G.2
  • 5
    • 84861649020 scopus 로고    scopus 로고
    • Discovery, biosynthesis, and engineering of lantipeptides
    • Knerr, P.J. and van der Donk, W.A. (2012) Discovery, biosynthesis, and engineering of lantipeptides. Annu. Rev. Biochem. 81, 479-505
    • (2012) Annu. Rev. Biochem. , vol.81 , pp. 479-505
    • Knerr, P.J.1    Van Der Donk, W.A.2
  • 7
    • 0000185593 scopus 로고
    • Limiting factors in the lactic fermentation
    • Rogers, L.A. and Whittier, E.O. (1928) Limiting factors in the lactic fermentation. J. Bacteriol. 16, 211-229
    • (1928) J. Bacteriol. , vol.16 , pp. 211-229
    • Rogers, L.A.1    Whittier, E.O.2
  • 8
    • 35748959374 scopus 로고    scopus 로고
    • Bacteriocin-based strategies for food biopreservation
    • DOI 10.1016/j.ijfoodmicro.2007.06.001, PII S0168160507003066, 20th International ICFMH Symposium on FOOD Microbiology 2006
    • Galvez, A., Abriouel, H., Lopez, R.L. and Ben Omar, N. (2007) Bacteriocin-based strategies for food biopreservation. Int. J. Food Microbiol. 120, 51-70 (Pubitemid 350051481)
    • (2007) International Journal of Food Microbiology , vol.120 , Issue.1-2 , pp. 51-70
    • Galvez, A.1    Abriouel, H.2    Lopez, R.L.3    Omar, N.B.4
  • 9
    • 0030059436 scopus 로고    scopus 로고
    • Three-dimensional structure of the lantibiotic nisin in the presence of membrane-mimetic micelles of dodecylphosphocholine and of sodium dodecylsulphate
    • Van Den Hooven, H.W., Doeland, C.C., Van De Kamp, M., Konings, R.N., Hilbers, C.W. and Van De Ven, F.J. (1996) Three-dimensional structure of the lantibiotic nisin in the presence of membrane-mimetic micelles of dodecylphosphocholine and of sodium dodecylsulphate. Eur. J. Biochem. 235, 382-393 (Pubitemid 26045454)
    • (1996) European Journal of Biochemistry , vol.235 , Issue.1-2 , pp. 382-393
    • Van Den, H.H.W.1    Doeland, C.C.M.2    Van De, K.M.3    Konings, R.N.H.4    Hilbers, C.W.5    Van De, V.F.J.M.6
  • 11
    • 0035910508 scopus 로고    scopus 로고
    • Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity
    • Wiedemann, I., Breukink, E., van Kraaij, C., Kuipers, O.P., Bierbaum, G., de Kruijff, B. and Sahl, H.G. (2001) Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. J. Biol. Chem. 276, 1772-1779 (Pubitemid 32109649)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.3 , pp. 1772-1779
    • Wiedemann, I.1    Breukink, E.2    Van Kraaij, C.3    Kuipers, O.P.4    Bierbaum, G.5    De Kruijff, B.6    Sahl, H.-G.7
  • 12
    • 0037044318 scopus 로고    scopus 로고
    • Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin
    • van Heusden, H.E., de Kruijff, B. and Breukink, E. (2002) Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin. Biochemistry 41, 12171-12178
    • (2002) Biochemistry , vol.41 , pp. 12171-12178
    • Van Heusden, H.E.1    De Kruijff, B.2    Breukink, E.3
  • 13
    • 0033579207 scopus 로고    scopus 로고
    • Use of the cell wail precursor lipid II by a pore-forming peptide antibiotic
    • DOI 10.1126/science.286.5448.2361
    • Breukink, E., Wiedemann, I., van Kraaij, C., Kuipers, O.P., Sahl, H. and de Kruijff, B. (1999) Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science 286, 2361-2364 (Pubitemid 30016902)
    • (1999) Science , vol.286 , Issue.5448 , pp. 2361-2364
    • Breukink, E.1    Wiedemann, I.2    Van Kraaij, C.3    Kuipers, O.P.4    Sahl, H.-G.5    De Kruijff, B.6
  • 14
    • 4444277132 scopus 로고    scopus 로고
    • Assembly and stability of nisin-Lipid II pores
    • DOI 10.1021/bi049476b
    • Hasper, H.E., de Kruijff, B. and Breukink, E. (2004) Assembly and stability of nisin-lipid II pores. Biochemistry 43, 11567-11575 (Pubitemid 39186978)
    • (2004) Biochemistry , vol.43 , Issue.36 , pp. 11567-11575
    • Hasper, H.E.1    De Kruijff, B.2    Breukink, E.3
  • 15
    • 33748766086 scopus 로고    scopus 로고
    • An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II
    • DOI 10.1126/science.1129818
    • Hasper, H.E., Kramer, N.E., Smith, J.L., Hillman, J.D., Zachariah, C., Kuipers, O.P., de Kruijff, B. and Breukink, E. (2006) An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II. Science 313, 1636-1637 (Pubitemid 44414037)
    • (2006) Science , vol.313 , Issue.5793 , pp. 1636-1637
    • Hasper, H.E.1    Kramer, N.E.2    Smith, J.L.3    Hillman, J.D.4    Zachariah, C.5    Kuipers, O.P.6    De Kruijff, B.7    Breukink, E.8
  • 16
    • 13844314218 scopus 로고    scopus 로고
    • Bacterial lantibiotics: Strategies to improve therapeutic potential
    • DOI 10.2174/1389203053027584
    • Cotter, P.D., Hill, C. and Ross, R.P. (2005) Bacterial lantibiotics: strategies to improve therapeutic potential. Curr. Protein Pept. Sci. 6, 61-75 (Pubitemid 40259802)
    • (2005) Current Protein and Peptide Science , vol.6 , Issue.1 , pp. 61-75
    • Cotter, P.D.1    Hill, C.2    Ross, R.P.3
  • 19
    • 79956161039 scopus 로고    scopus 로고
    • Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans
    • van Heel, A.J., Montalban-Lopez, M. and Kuipers, O.P. (2011) Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans. Expert Opin. Drug Metab. Toxicol. 7, 675-680
    • (2011) Expert Opin. Drug Metab. Toxicol. , vol.7 , pp. 675-680
    • Van Heel, A.J.1    Montalban-Lopez, M.2    Kuipers, O.P.3
  • 21
    • 69049102140 scopus 로고    scopus 로고
    • A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species
    • Piper, C., Draper, L.A., Cotter, P.D., Ross, R.P. and Hill, C. (2009) A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species. J. Antimicrob. Chemother. 64, 546-551
    • (2009) J. Antimicrob. Chemother. , vol.64 , pp. 546-551
    • Piper, C.1    Draper, L.A.2    Cotter, P.D.3    Ross, R.P.4    Hill, C.5
  • 22
    • 0031821357 scopus 로고    scopus 로고
    • Activity of nisin against Streptococcus pneumoniae, in vitro, and in a mouse infection model [8]
    • Goldstein, B.P., Wei, J., Greenberg, K. and Novick, R. (1998) Activity of nisin against Streptococcus pneumoniae, in vitro, and in a mouse infection model. J. Antimicrob. Chemother. 42, 277-278 (Pubitemid 28393607)
    • (1998) Journal of Antimicrobial Chemotherapy , vol.42 , Issue.2 , pp. 277-278
    • Goldstein, B.P.1    Wei, J.2    Greenberg, K.3    Novick, R.4
  • 23
    • 0031949637 scopus 로고    scopus 로고
    • Antibacterial efficacy of nisin against multidrug-resistant Gram-positive pathogens
    • Severina, E., Severin, A. and Tomasz, A. (1998) Antibacterial efficacy of nisin against multidrug-resistant Gram-positive pathogens. J. Antimicrob. Chemother. 41, 341-347
    • (1998) J. Antimicrob. Chemother. , vol.41 , pp. 341-347
    • Severina, E.1    Severin, A.2    Tomasz, A.3
  • 25
    • 35948938492 scopus 로고    scopus 로고
    • Therapeutic effect of nisin Z on subclinical mastitis in lactating cows
    • DOI 10.1128/AAC.00629-07
    • Wu, J., Hu, S. and Cao, L. (2007) Therapeutic effect of nisin Z on subclinical mastitis in lactating cows. Antimicrob. Agents Chemother. 51, 3131-3135 (Pubitemid 350067519)
    • (2007) Antimicrobial Agents and Chemotherapy , vol.51 , Issue.9 , pp. 3131-3135
    • Wu, J.1    Hu, S.2    Cao, L.3
  • 26
    • 48449097450 scopus 로고    scopus 로고
    • The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation
    • Fernandez, L., Delgado, S., Herrero, H., Maldonado, A. and Rodriguez, J.M. (2008) The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation. J. Hum. Lact. 24, 311-316
    • (2008) J. Hum. Lact. , vol.24 , pp. 311-316
    • Fernandez, L.1    Delgado, S.2    Herrero, H.3    Maldonado, A.4    Rodriguez, J.M.5
  • 27
    • 78649556678 scopus 로고    scopus 로고
    • The dawning of a 'Golden era' in lantibiotic bioengineering
    • Field, D., Hill, C., Cotter, P.D. and Ross, R.P. (2010) The dawning of a 'Golden era' in lantibiotic bioengineering. Mol. Microbiol. 78, 1077-1087
    • (2010) Mol. Microbiol. , vol.78 , pp. 1077-1087
    • Field, D.1    Hill, C.2    Cotter, P.D.3    Ross, R.P.4
  • 28
    • 0024590316 scopus 로고
    • Nisin, a peptide antibiotic: Cloning and sequencing of the nisA gene and posttranslational processing of its peptide product
    • Kaletta, C. and Entian, K.D. (1989) Nisin, a peptide antibiotic: cloning and sequencing of the nisA gene and posttranslational processing of its peptide product. J. Bacteriol. 171, 1597-1601 (Pubitemid 19080802)
    • (1989) Journal of Bacteriology , vol.171 , Issue.3 , pp. 1597-1601
    • Kaletta, C.1    Entian, K.-D.2
  • 29
    • 0026062942 scopus 로고
    • Identification and characterization of the lantibiotic nisin Z, a natural nisin variant
    • Mulders, J.W., Boerrigter, I.J., Rollema, H.S., Siezen, R.J. and de Vos, W.M. (1991) Identification and characterization of the lantibiotic nisin Z, a natural nisin variant. Eur. J. Biochem. 201, 581-584
    • (1991) Eur. J. Biochem. , vol.201 , pp. 581-584
    • Mulders, J.W.1    Boerrigter, I.J.2    Rollema, H.S.3    Siezen, R.J.4    De Vos, W.M.5
  • 30
    • 2442436623 scopus 로고    scopus 로고
    • Identification of the lantibiotic nisin Q, a new natural nisin variant produced by Lactococcus lactis 61-14 isolated from a river in Japan
    • Zendo, T., Fukao, M., Ueda, K., Higuchi, T., Nakayama, J. and Sonomoto, K. (2003) Identification of the lantibiotic nisin Q, a new natural nisin variant produced by Lactococcus lactis 61-14 isolated from a river in Japan. Biosci. Biotechnol. Biochem. 67, 1616-1619 (Pubitemid 39251809)
    • (2003) Bioscience, Biotechnology and Biochemistry , vol.67 , Issue.7 , pp. 1616-1619
    • Zendo, T.1    Fukao, M.2    Ueda, K.3    Higuchi, T.4    Nakayama, J.5    Sonomoto, K.6
  • 31
    • 38349126997 scopus 로고    scopus 로고
    • Characterization of the structural gene encoding nisin F, a new lantibiotic produced by a Lactococcus lactis subsp. lactis isolate from freshwater catfish (Clarias gariepinus)
    • de Kwaadsteniet, M., Ten Doeschate, K. and Dicks, L.M. (2008) Characterization of the structural gene encoding nisin F, a new lantibiotic produced by a Lactococcus lactis subsp. lactis isolate from freshwater catfish (Clarias gariepinus). Appl. Environ. Microbiol. 74, 547-549
    • (2008) Appl. Environ. Microbiol. , vol.74 , pp. 547-549
    • De Kwaadsteniet, M.1    Ten Doeschate, K.2    Dicks, L.M.3
  • 32
    • 33144466523 scopus 로고    scopus 로고
    • Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis
    • DOI 10.1128/AEM.72.2.1148-1156.2006
    • Wirawan, R.E., Klesse, N.A., Jack, R.W. and Tagg, J.R. (2006) Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl. Environ. Microbiol. 72, 1148-1156 (Pubitemid 43271221)
    • (2006) Applied and Environmental Microbiology , vol.72 , Issue.2 , pp. 1148-1156
    • Wirawan, R.E.1    Klesse, N.A.2    Jack, R.W.3    Tagg, J.R.4
  • 33
    • 79955421170 scopus 로고    scopus 로고
    • Bioengineering of a nisin A-producing Lactococcus lactis to create isogenic strains producing the natural variants nisin F, Q and Z
    • Piper, C., Hill, C., Cotter, P.D. and Ross, R.P. (2011) Bioengineering of a nisin A-producing Lactococcus lactis to create isogenic strains producing the natural variants nisin F, Q and Z. Microb. Biotechnol. 4, 375-382
    • (2011) Microb. Biotechnol. , vol.4 , pp. 375-382
    • Piper, C.1    Hill, C.2    Cotter, P.D.3    Ross, R.P.4
  • 34
    • 0034887091 scopus 로고    scopus 로고
    • Comparison of the activity spectra against pathogens of bacterial strains producing a mutacin or a lantibiotic
    • DOI 10.1139/cjm-47-4-322
    • Morency, H., Mota-Meira, M., LaPointe, G., Lacroix, C. and Lavoie, M.C. (2001) Comparison of the activity spectra against pathogens of bacterial strains producing a mutacin or a lantibiotic. Can. J. Microbiol. 47, 322-331 (Pubitemid 32745023)
    • (2001) Canadian Journal of Microbiology , vol.47 , Issue.4 , pp. 322-331
    • Morency, H.1    Mota-Meira, M.2    LaPointe, G.3    Lacroix, C.4    Lavoie, M.C.5
  • 36
    • 0029093410 scopus 로고
    • Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering
    • Rollema, H.S., Kuipers, O.P., Both, P., de Vos, W.M. and Siezen, R.J. (1995) Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering. Appl. Environ. Microbiol. 61, 2873-2878
    • (1995) Appl. Environ. Microbiol. , vol.61 , pp. 2873-2878
    • Rollema, H.S.1    Kuipers, O.P.2    Both, P.3    De Vos, W.M.4    Siezen, R.J.5
  • 37
  • 39
    • 34648825064 scopus 로고    scopus 로고
    • Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation
    • DOI 10.1128/AEM.01104-07
    • Rink, R., Wierenga, J., Kuipers, A., Kluskens, L.D., Driessen, A.J., Kuipers, O.P. and Moll, G.N. (2007) Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation. Appl. Environ. Microbiol. 73, 5809-5816 (Pubitemid 47462992)
    • (2007) Applied and Environmental Microbiology , vol.73 , Issue.18 , pp. 5809-5816
    • Rink, R.1    Wierenga, J.2    Kuipers, A.3    Kluskens, L.D.4    Driessen, A.J.M.5    Kuipers, O.P.6    Moll, G.N.7
  • 40
    • 3142701459 scopus 로고    scopus 로고
    • Site-directed mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants
    • DOI 10.1007/s00253-004-1599-1
    • Yuan, J., Zhang, Z.Z., Chen, X.Z., Yang, W. and Huan, L.D. (2004) Site-directed mutagenesis of the hinge region of nisin Z and properties of nisin Z mutants. Appl. Microbiol. Biotechnol. 64, 806-815 (Pubitemid 38918144)
    • (2004) Applied Microbiology and Biotechnology , vol.64 , Issue.6 , pp. 806-815
    • Yuan, J.1    Zhang, Z.-Z.2    Chen, X.-Z.3    Yang, W.4    Huan, L.-D.5
  • 41
    • 45149121558 scopus 로고    scopus 로고
    • The generation of nisin variants with enhanced activity against specific Gram-positive pathogens
    • DOI 10.1111/j.1365-2958.2008.06279.x
    • Field, D., Connor, P.M., Cotter, P.D., Hill, C. and Ross, R.P. (2008) The generation of nisin variants with enhanced activity against specific Gram-positive pathogens. Mol. Microbiol. 69, 218-230 (Pubitemid 351832767)
    • (2008) Molecular Microbiology , vol.69 , Issue.1 , pp. 218-230
    • Field, D.1    Connor, P.M.O.2    Cotter, P.D.3    Hill, C.4    Ross, R.P.5
  • 44
    • 74049115080 scopus 로고    scopus 로고
    • Follow the leader: The use of leader peptides to guide natural product biosynthesis
    • Oman, T.J. and van der Donk, W.A. (2010) Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat. Chem. Biol. 6, 9-18
    • (2010) Nat. Chem. Biol. , vol.6 , pp. 9-18
    • Oman, T.J.1    Van Der Donk, W.A.2
  • 45
    • 77950113113 scopus 로고    scopus 로고
    • Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence
    • Majchrzykiewicz, J.A., Lubelski, J., Moll, G.N., Kuipers, A., Bijlsma, J.J., Kuipers, O.P. and Rink, R. (2010) Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob. Agents Chemother. 54, 1498-1505
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1498-1505
    • Majchrzykiewicz, J.A.1    Lubelski, J.2    Moll, G.N.3    Kuipers, A.4    Bijlsma, J.J.5    Kuipers, O.P.6    Rink, R.7
  • 46
    • 77951666493 scopus 로고    scopus 로고
    • Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides
    • Moll, G.N., Kuipers, A. and Rink, R. (2010) Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides. Antonie Van Leeuwenhoek 97, 319-333
    • (2010) Antonie Van Leeuwenhoek , vol.97 , pp. 319-333
    • Moll, G.N.1    Kuipers, A.2    Rink, R.3
  • 47
    • 25444499680 scopus 로고    scopus 로고
    • Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin
    • DOI 10.1021/bi050805p
    • Kluskens, L.D., Kuipers, A., Rink, R., de Boef, E., Fekken, S., Driessen, A.J., Kuipers, O.P. and Moll, G.N. (2005) Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin. Biochemistry 44, 12827-12834 (Pubitemid 41377322)
    • (2005) Biochemistry , vol.44 , Issue.38 , pp. 12827-12834
    • Kluskens, L.D.1    Kuipers, A.2    Rink, R.3    De Boef, E.4    Fekken, S.5    Driessen, A.J.M.6    Kuipers, O.P.7    Moll, G.N.8
  • 50
    • 20544436705 scopus 로고    scopus 로고
    • Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes
    • DOI 10.1021/bi050081h
    • Rink, R., Kuipers, A., de Boef, E., Leenhouts, K.J., Driessen, A.J., Moll, G.N. and Kuipers, O.P. (2005) Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes. Biochemistry 44, 8873-8882 (Pubitemid 40840453)
    • (2005) Biochemistry , vol.44 , Issue.24 , pp. 8873-8882
    • Rink, R.1    Kuipers, A.2    De Boef, E.3    Leenhouts, K.J.4    Driessen, A.J.M.5    Moll, G.N.6    Kuipers, O.P.7
  • 51
    • 84867326984 scopus 로고    scopus 로고
    • Bioengineered nisin A derivatives with enhanced activity against both Gram positive and Gram negative pathogens
    • Field, D., Begley, M., O'Connor, P.M., Daly, K.M., Hugenholtz, F., Cotter, P.D., Hill, C. and Ross, R.P. (2012) Bioengineered nisin A derivatives with enhanced activity against both Gram positive and Gram negative pathogens. PLoS ONE 7, e46884
    • (2012) PLoS ONE , vol.7
    • Field, D.1    Begley, M.2    O'Connor, P.M.3    Daly, K.M.4    Hugenholtz, F.5    Cotter, P.D.6    Hill, C.7    Ross, R.P.8


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