Saturation Mutagenesis of Lysine 12 Leads to the Identification of Derivatives of Nisin A with Enhanced Antimicrobial Activity

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Molloy, Evelyn M ^a   Field, Des ^a   O'Connor, Paula M ^b,c   Cotter, Paul D ^b,c   Hill, Colin ^a,b   Ross, R Paul ^b,c  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c TEAGASC FOOD RESEARCH CENTRE   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; LYSINE; NISIN; NISIN A; NISIN A K12A; NISIN A K12DHA; NISIN A K12DHB; NISIN A K12S; NISIN A K12T; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG STRUCTURE; ENTEROCOCCUS; LACTOCOCCUS; MUTAGENESIS; NONHUMAN; SITE SATURATION MUTAGENESIS; SPECIES DIFFERENTIATION; STAPHYLOCOCCUS; STREPTOCOCCUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; GRAM-POSITIVE BACTERIA; LYSINE; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NISIN;

EID: 84874929048     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058530     Document Type: Article

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