Transcriptome profiling of malignant transformed rat hepatic stem-like cells by aflatoxin B1

Neoplasma

Volumn 61, Issue 2, 2014, Pages 193-204

  Yang, L ^a   Ji, J ^a   Chen, Z ^b   Wang, Haiyong ^a   Li, Junwen ^b  

^a TIANJIN UNIVERSITY   (China)

^b INSTITUTE OF HEALTH AND ENVIRONMENTAL MEDICINE   (China)

Author keywords

Aflatoxin B1; Hepatic progenitor cells; Malignant transformation; Transcriptome profiles

Indexed keywords

AFLATOXIN B1; AGAR; ALPHA ACTININ 1; BETA3 INTEGRIN; BONE MORPHOGENETIC PROTEIN 2; BRADYKININ B1 RECEPTOR; CAVEOLIN 2; CBL PROTEIN; COLLAGEN TYPE 2; CXCL1 CHEMOKINE; CYCLIN D2; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; FRACTALKINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INHIBIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN BID; SCLEROPROTEIN; SONIC HEDGEHOG PROTEIN; THYMOSIN BETA4; TRANSCRIPTION FACTOR 7; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; WNT PROTEIN; WNT5A PROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CANCER STEM CELL; CELL MOTION; CELL TRANSFORMATION; COLONY FORMATION; CONTROLLED STUDY; DOSE RESPONSE; FOCAL ADHESION; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE MUTATION; GENE ONTOLOGY; GENETIC REGULATION; IMMUNE RESPONSE; LIVER CELL CARCINOMA; MALIGNANT TRANSFORMATION; MICROARRAY ANALYSIS; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

AFLATOXIN B1, HEPATIC PROGENITOR CELLS, TRANSCRIPTOME PROFILES, MALIGNANT TRANSFORMATION;

AFLATOXIN B1; ANIMALS; CARCINOGENESIS; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; NEOPLASTIC STEM CELLS; RATS; SIGNAL TRANSDUCTION;

EID: 84893171878     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2014_025     Document Type: Article

References (50)

1. BOSCH FX, RIBES J, CLERIES R, DIAZ M Epidemiology of hepatocellular carcinoma. Clin Liver Dis 2005; 9: 191-211. http://dx.doi.org/10.1016/j.cld.2004.12.009
2. LIU Y, WU F Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 2010; 118: 818-824. http://dx.doi.org/10.1289/ehp.0901388
3. IARC Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monogr Eval Carcinog Risk Chem Hum 1993; 397-444.
4. GROOPMAN JD, SCHOLL P, WANG JS Epidemiology of human aflatoxin exposures and their relationship to liver cancer. Prog Clin Biol Res 1996; 395: 211-222.
5. BRESSAC B, KEW M, WANDS J, OZTURK M Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991; 350: 429-431. http://dx.doi.org/10.1038/350429a0
6. ROSKAMS TA, LIBBRECHT L and DESMET VJ Progenitor cells in diseased human liver. Semin Liver Dis 2003; 23: 385-396. http://dx.doi.org/10.1055/s-2004-815564
7. ROSKAMS T Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 2006; 25: 3818-3822. http://dx.doi.org/10.1038/sj.onc.1209558
8. TSAO MS, SMITH JD, NELSON KG, GRISHAM JW A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells. Exp Cell Res 1984; 154: 38-52. http://dx.doi.org/10.1016/0014-4827(84)90666-9
9. BREDFELDT TG, JAGADISH B, EBLIN KE, MASH EA, GANDOLFI AJ Monomethylarsonous acid induces transformation of human bladder cells. Toxicol Appl Pharmacol 2006; 216: 69-79. http://dx.doi.org/10.1016/j.taap.2006.04.011
10. HUANG DA W, SHERMAN BT, LEMPICKI RA Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
11. HUANG DA W, SHERMAN BT, LEMPICKI RA Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37: 1-13. http://dx.doi.org/10.1093/nar/gkn923
12. ASHBURNER M, BALL CA, BLAKE JA, BOTSTEIN D, BUTLER H, et al. Gene ontology: tool for the unification of biology. Nat Genet 2000; 25: 25-29. http://dx.doi.org/10.1038/75556
13. OGATA H, GOTO S, SATO K, FUJIBUCHI W, BONO H, et al. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res 1999; 27: 29-34. http://dx.doi.org/10.1093/nar/27.1.29
14. CHIBA T, ZHENG YW, KITA K, YOKOSUKA O, SAISHO H, et al. Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology 2007; 133: 937-950. http://dx.doi.org/10.1053/j.gastro.2007.06.016
15. SUZUKI A, SEKIYA S, ONISHI M, OSHIMA N, KIYONARI H, et al. Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver. Hepatology 2008; 48: 1964-1978. http://dx.doi.org/10.1002/hep.22558
16. Dumble ML, Croager EJ, Yeoh GCT, Quail EA Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis 2002; 23: 435-445. http://dx.doi.org/10.1093/carcin/23.3.435
17. YAM JW, TSE EY, NG IO Role and significance of focal adhesion proteins in hepatocellular carcinoma. J Gastroenterol Hepatol 2009; 24: 520-530. http://dx.doi.org/10.1111/j.1440-1746.2009.05813.x
18. WIECHEN K, DIATCHENKO L, AGOULNIK A, SCHARFF KM, SCHOBER H, et al. Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. Am J Pathol 2001; 159: 1635-1643. http://dx.doi.org/10.1016/S0002-9440(10)63010-6
19. FIUCCI G, RAVID D, REICH R, LISCOVITCH M Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 2002; 21: 2365-2375. http://dx.doi.org/10.1038/sj.onc.1205300
20. MONGROO PS, JOHNSTONE CN, NARUSZEWICZ I, LEUNG-HAGESTEIJN C, SUNG RK, et al. Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer. Oncogene 2004; 23: 8959-8970. http://dx.doi.org/10.1038/sj.onc.1208112
21. SALGIA R, LI JL, EWANIUK DS, WANG YB, SATTLER M, et al. Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility. Oncogene 1999; 18: 67-77. http://dx.doi.org/10.1038/sj.onc.1202273
22. SCIBELLI A, D'ANGELO D, PELAGALLI A, TAFURI S, AVALLONE L, et al. Expression levels of the focal adhesionassociated proteins paxillin and p130CAS in canine and feline mammary tumors. Vet Res 2003; 34: 193-202. http://dx.doi.org/10.1051/vetres:2002066
23. LAMBRECHTS A, VAN TROYS M, AMPE C The actin cytoskeleton in normal and pathological cell motility. Int J Biochem Cell Biol 2004; 36: 1890-1909. http://dx.doi.org/10.1016/j.biocel.2004.01.024
24. KWIATKOWSKI DJ Functions of gelsolin: motility, signaling, apoptosis, cancer. Curr Opin Cell Biol 1999; 11: 103-108. http://dx.doi.org/10.1016/S0955-0674(99)80012-X
25. ZINDY PJ, L'HELGOUALC'H A, BONNIER D, LE BECHEC A, BOURD-BOITIN K, et al. Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis. Hepatology 2006; 44: 1296-1307. http://dx.doi.org/10.1002/hep.21367
26. HSIAO HL, WANG WS, CHEN PM, SU Y Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively. Carcinogenesis 2006; 27: 936-944. http://dx.doi.org/10.1093/carcin/bgi316
27. ELLIOTT RL, BLOBE GC Role of transforming growth factor Beta in human cancer. J Clin Oncol 2005; 23: 2078-2093. http://dx.doi.org/10.1200/JCO.2005.02.047
28. ROTH-EICHHORN S, HEITMANN B, FLEMMING P, KUBICKA S, TRAUTWEIN C Evidence for the decreased expression of the latent TGF-beta binding protein and its splice form in human liver tumours. Scand J Gastroenterol 2001; 36: 1204-1210. http://dx.doi.org/10.1080/00365520152584851
29. KAMALIAN L, GOSNEY JR, FOROOTAN SS, FOSTER CS, BAO ZZ, et al. Increased expression of Id family proteins in small cell lung cancer and its prognostic significance. Clin Cancer Res 2008; 14: 2318-2325. http://dx.doi.org/10.1158/1078-0432.CCR-07-4716
30. YUEN HF, CHUA CW, CHAN YP, WONG YC, WANG X, et al. Id proteins expression in prostate cancer: high-level expression of Id-4 in primary prostate cancer is associated with development of metastases. Mod Pathol 2006; 19: 931-941. http://dx.doi.org/10.1038/modpathol.3800602
31. SARGIANNIDOU I, ZHOU J, TUSZYNSKI GP The role of thrombospondin-1 in tumor progression. Exp Biol Med (Maywood) 2001; 226: 726-733.
32. ALARMO EL, KALLIONIEMI A Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis? Endocr Relat Cancer 2010; 17: 123-139. http://dx.doi.org/10.1677/ERC-09-0273
33. GRUSCH M, DRUCKER C, PETER-VOROSMARTY B, ERLACH N, LACKNER A, et al. Deregulation of the activin/ follistatin system in hepatocarcinogenesis. J Hepatol 2006; 45: 673-680. http://dx.doi.org/10.1016/j.jhep.2006.06.014
34. HUANG P, HAN J, HUI L MAPK signaling in inflammationassociated cancer development. Protein Cell 2010; 1: 218-226. http://dx.doi.org/10.1007/s13238-010-0019-9
35. WAGNER EF, NEBREDA AR Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009; 9: 537-549. http://dx.doi.org/10.1038/nrc2694
36. DAS M, GARLICK DS, GREINER DL, DAVIS RJ The role of JNK in the development of hepatocellular carcinoma. Genes Dev 2011; 25: 634-645. http://dx.doi.org/10.1101/gad.1989311
37. CALOCA MJ, ZUGAZA JL, BUSTELO XR Exchange factors of the RasGRP family mediate Ras activation in the Golgi. J Biol Chem 2003; 278: 33465-33473. http://dx.doi.org/10.1074/jbc.M302807200
38. COSTANTINI S, DI BERNARDO G, CAMMAROTA M, CASTELLO G, COLONNA G Gene expression signature of human HepG2 cell line. Gene 2013; 518: 335-345. http://dx.doi.org/10.1016/j.gene.2012.12.106
39. FIJNEMAN RJ, PEHAM JR, VAN DE WIEL MA, MEIJER GA, MATISE I, et al. Expression of Pla2g2a prevents carcinogenesis in Muc2-deficient mice. Cancer Sci 2008; 99: 2113-2119. http://dx.doi.org/10.1111/j.1349-7006.2008.00924.x
40. YANG H, ROUSE J, LUKES L, LANCASTER M, VEENSTRA T, et al. Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis. Clin Exp Metastasis 2004; 21: 719-735. http://dx.doi.org/10.1007/s10585-004-8251-4
41. WU Y, ZUO J, JI G, SAIYIN H, LIU X, et al. Proapoptotic function of integrin beta(3) in human hepatocellular carcinoma cells. Clin Cancer Res 2009; 15: 60-69. http://dx.doi.org/10.1158/1078-0432.CCR-08-1028
42. SHIBUTA K, MORI M, SHIMODA K, INOUE H, MITRA P, et al. Regional expression of CXCL12/CXCR4 in liver and hepatocellular carcinoma and cell-cycle variation during in vitro differentiation. Jpn J Cancer Res 2002; 93: 789-797. http://dx.doi.org/10.1111/j.1349-7006.2002.tb01321.x
43. TANG L, HU HD, HU P, LAN YH, PENG ML, et al. Gene therapy with CX3CL1/Fractalkine induces antitumor immunity to regress effectively mouse hepatocellular carcinoma. Gene Ther 2007; 14: 1226-1234. http://dx.doi.org/10.1038/sj.gt.3302959
44. SGADARI C, ANGIOLILLO AL, CHERNEY BW, PIKE SE, FARBER JM, et al. Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo. Proc Natl Acad Sci USA 1996; 93: 13791-13796. http://dx.doi.org/10.1073/pnas.93.24.13791
45. BENGOCHEA A, DE SOUZA MM, LEFRANCOIS L, LE ROUX E, GALY O, et al. Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer 2008; 99: 143-150. http://dx.doi.org/10.1038/sj.bjc.6604422
46. MERRITT MA, PARSONS PG, NEWTON TR, MARTYN AC, WEBB PM, et al. Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer. BMC Cancer 2009; 9: 378. http://dx.doi.org/10.1186/1471-2407-9-378
47. ROOSE J, HULS G, VAN BEEST M, MOERER P, VAN DER HORN K, et al. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science 1999; 285: 1923-1926. http://dx.doi.org/10.1126/science.285.5435.1923
48. SAKAKURA C, HAGIWARA A, MIYAGAWA K, NAKASHIMA S, YOSHIKAWA T, et al. Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Int J Cancer 2005; 113: 221-228. http://dx.doi.org/10.1002/ijc.20551
49. MIYAGAWA K, SAKAKURA C, NAKASHIMA S, YOSHIKAWA T, KIN S, et al. Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of hepatocarcinogenesis. Anticancer Res 2006; 26: 3633-3643.
50. MARTINEZ SN, TUSSIWAND R, ZIEGLER P, MANZ MG, HEIDENREICH O Transient depletion of RUNX1/ RUNX1T1 by RNA interference delays tumour formation in vivo. Leukemia 2009; 23: 188-190. http://dx.doi.org/10.1038/leu.2008.157