Expression levels of the focal adhesion-associated proteins paxillin and p130CAS in canine and feline mammary tumors

Veterinary Research

Volumn 34, Issue 2, 2003, Pages 193-202

  Scibelli, Antonio ^a   D'Angelo, Danila ^a   Pelagalli, Alessandra ^a   Tafuri, Simona ^a   Avallone, Luigi ^a   Della Morte, Rossella ^a   Staiano, Norma ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cat; Dog; Mammary tumor; p130CAS; Paxillin

Indexed keywords

PAXILLIN; PROTEIN P130;

AGED; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER GROWTH; CANCER INVASION; CANCER STAGING; CANCER TISSUE; CAT; CELL MIGRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DOG; FOCAL ADHESION; NONHUMAN; PHENOTYPIC VARIATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; WESTERN BLOTTING;

ANIMALIA; CANIS FAMILIARIS; FELIDAE; FELIS CATUS;

EID: 0037361224     PISSN: 09284249     EISSN: None     Source Type: Journal    
DOI: 10.1051/vetres:2002066     Document Type: Article

References (29)

1. Ayaki M., Komatsu K., Mukai M., Murata K., Kameyama M., Ishiguro S., Miyoshi J., Tatsuta M., Nakamura H., Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas, Clin. Cancer Res. 7 (2001) 3106-3112.
2. Bouton A.H., Riggins R.B., Bruce-Staskal P.J., Functions of the adapter protein Cas: signal convergence and the determination of cellular responses, Oncogene 20 (2001) 6448-6458.
3. CAS as a mediator of focal adhesion kinase-promoted cell migration, J. Cell. Biol. 140 (1998) 211-221.
4. Cho S.Y., Klemke R.L., Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix, J. Cell. Biol. 149 (2000) 223-236.
5. Critchley D.R., Focal adhesions - the cytoskeletal connection, Curr. Opin. Cell. Biol. 12 (2000) 133-139.
6. Glenney J.R. Jr., Zokas L., Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton, J. Cell. Biol. 108 (1989) 2401-2408.
7. Hampe J.F., Misdorp W., Tumours and dysplasias of the mammary gland, Bull. W.H.O. 50 (1974) 111-113.
8. Honda H., Nakamoto T., Sakai R., Hirai H., p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts, Biochem. Biophys. Res. Commun. 262 (1999) 25-30.
9. Klemke R.L., Cai S., Giannini A.L., Gallagher P.J., de Lanerolle P., Cheresh D.A., Regulation of cell motility by mitogen-activated protein kinase, J. Cell. Biol. 137 (1997) 481-492.
10. Klemke R.L., Leng J., Molander R., Brooks P.C., Vuori K., Cheresh D.A., CAS/Crk coupling serves as a "molecular switch" for induction of cell migration, J. Cell. Biol. 140 (1998) 961-972.
11. Liu S., Thomas S.M., Woodside D.G., Rose D.M., Kiosses W.B., Pfaff M., Ginsberg M.H., Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses, Nature 402 (1999) 676-681.
12. Matsuda M., Mayer B.J., Hanafusa H., Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins, Mol. Cell. Biol. 11 (1991) 1607-1613.
13. Mielenz D., Hapke S., Poschl E., von Der Mark H., von Der Mark K., The integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk coupling, J. Biol. Chem. 276 (2001) 13417-13426.
14. Morrison W.B., Canine and feline mammary tumors, in: Lippincott Williams and Wilkins (Eds.), Cancer in dogs and cats, 1998, pp. 591-598.
15. CAS to focal adhesions, Mol. Cell. Biol. 17 (1997) 3884-3897.
16. Parsons J.T., Martin K.H., Slack J.K., Taylor J.M., Weed S.A., Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement, Oncogene 19 (2000) 5606-5613.
17. Petch L.A., Bockholt S.M., Bouton A., Parsons J.T., Burridge K., Adhesion-induced tyrosine phosphorylation of the p130 src substrate, J. Cell. Sci. 108 (1995) 1371-1379.
18. Poste G., Fidler I.G., The pathogenesis of cancer metastasis, Nature (Lond.) 283 (1980) 139-146.
19. Sakai R., Iwamatsu A., Hirano N., Ogawa S., Tanaka T., Mano H., Yazaki Y., Hirai H., A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner, EMBO J. 13 (1994) 3748-3756.
20. Salgia R., Li J.L., Lo S.H., Brunkhorst B., Kansas G.S., Sobhany E.S., Sun Y., Pisick E., Hallek M., Ernst T., Tantravahi R., Chen L.B., Griffin J.D., Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL, J. Biol. Chem. 270 (1995) 5039-5047.
21. Salgia R., Li J.L., Ewaniuk D.S., Wang Y.B., Sattler M., Chen W.C., Richards W., Pisik E., Shapiro G.I., Rollins B.J., Chen L.B., Griffin J.D., Sugarbaker D.J., Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility, Oncogene 18 (1999) 67-77.
22. Sattler M., Pisick E., Morrison P.T., Salgia R., Role of the cytoskeletal protein paxillin in oncogenesis, Crit. Rev. Oncog. 11 (2000) 63-76.
23. Schaller M.D., Paxillin: a focal adhesion-associated adaptor protein, Oncogene 20 (2001) 6459-6472.
24. Schlaepfer D.D., Hunter T., Focal adhesion kinase overexpression enhances Ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src, J. Biol. Chem. 272 (1997) 13189-13195.
25. Thomas J.W., Cooley M.A., Broome J.M., Salgia R., Griffin J.D., Lombardo C.R., Schaller M.D., The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin, J. Biol. Chem. 274 (1999) 36684-36692.
26. CAS signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases, Mol. Cell. Biol. 16 (1996) 2606-2613.
27. Weisberg E., Sattler M., Ewaniuk D.S., Salgia R., Role of focal adhesion proteins in signal transduction and oncogenesis, Crit. Rev. Oncog. 8 (1997) 343-358.
28. Yamaguchi R., Mazaki Y., Hirota K., Hashimoto S., Sabe H., Mitosis specific serine phosphorylation and down-regulation of one of the focal adhesion proteins, paxillin, Oncogene 15 (1997) 1753-1761.
29. Yano H., Uchida H., Iwasaki T., Mukai M., Akedo H., Nakamura K., Hashimoto S., Sabe H., Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation, Proc. Natl. Acad. Sci. USA 97 (2000) 9076-9081.