Expression of Pla2g2a prevents carcinogenesis in Muc2-deficient mice

Cancer Science

Volumn 99, Issue 11, 2008, Pages 2113-2119

  Fijneman, R J A ^a   Peham, J R ^a   van de Wiel, M A ^a   Meijer, G A ^a   Matise, I ^b   Velcich, A ^c   Cormier, R T ^d  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MINNESOTA   (United States)

^c ALBERT EINSTEIN CANCER CENTER   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN 2; PHOSPHOLIPASE; PROTEIN PLA2G2A; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CANCER INVASION; CANCER PREVENTION; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLORECTAL ADENOCARCINOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE TARGETING; GOBLET CELL; HISTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; TRANSGENIC MOUSE; TUMOR RESISTANCE; TUMOR VOLUME; UPREGULATION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE EXPRESSION; GROUP II PHOSPHOLIPASES A2; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUCIN-2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 55449111092     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00924.x     Document Type: Article

References (49)

1. Velcich A, Palumbo L, Selleri L, Evans G, Augenlicht L. Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus. J Biol Chem 1997; 272: 7968-76.
2. Augenlicht LH, Mariadason JM, Wilson A et al. Short chain fatty acids and colon cancer. J Nutr 2002; 132 (12): 3804S-8S.
3. Van Klinken BJ-W, Einerhand AWC, Duits LA et al. Gastrointestinal expression and partial cDNA cloning of murine Muc2. Am J Physiol 1999; 276: G115-24.
4. Gum JR, Hicks JW, Gillespie A-M et al. Goblet cell-specific expression mediated by the MUC2 mucin gene promoter in the intestine of transgenic mice. Am J Physiol 1999; 276: G666-76.
5. Gratchev A, Siedow A, Bumke-Vogt C et al. Regulation of the intestinal mucin MUC2 gene expression in vivo: Evidence for the role of promoter methylation. Cancer Lett 2001; 168: 71-80.
6. Kim DH, Kim JW, Cho JH et al. Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum. Int J Oncol 2005; 27: 957-64.
7. Iwase T, Kushima R, Mukaisho K, Mitsufuji S, Okanoue T, Hattori T. Overexpression of CD10 and reduced MUC2 expression correlate with the development and progression of colorectal neoplasms. Pathol Res Pract 2005; 201: 83-91.
8. Kim YS. Altered glycosylation of mucin glycoproteins in colonic neoplasia. J Cell Biochem 1992; S16G: 91-6.
9. Li A, Goto M, Horinouchi M et al. Expression of MUC1 and MUC2 mucins and relationship with cell proliferative activity in human colorectal neoplasia. Pathol Int 2001; 51 (11): 853-60.
10. Baldus SE, Hanisch FG, Putz C et al. Immunoreactivity of Lewis blood group and mucin peptide core antigens: Correlations with grade of dysplasia and malignant transformation in the colorectal adenoma-carcinoma sequence. Histol Histopathol 2002; 17: 191-8.
11. Hara A, Saegusa M, Mitomi H et al. Colonic mucin-carbohydrate components in colorectal tumors and their possible relationship to MUC2, p53 and DCC immunoreactivities. Pathol Res Pract 2000; 196: 159-66.
12. Byrd JC, Bresalier RS. Mucins and mucin binding proteins in colorectal cancer. Cancer Metast Rev 2004; 23: 77-99.
13. Biemer-Huttmann A-E, Walsh MD, McGuckin MA et al. Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clin Cancer Res 2000; 6: 1909-16.
14. Li D, Semba S, Wu M, Yokozaki H. Molecular pathological subclassification of mucinous adenocarcinoma of the colorectum. Pathol Int 2005; 55: 766-74.
15. Park SY, Lee HS, Choe G, Chung JH, Kim WH. Clinicopathological characteristics, microsatellite instability, and expression of mucin core proteins and p53 in colorectal mucinous adenocarcinomas in relation to location. Virchows Arch 2006 (Apri 28).[Epub ahead of print].
16. Pastrello C, Santarosa M, Fornasarig M et al. MUC gene abnormalities in sporadic and hereditary mucinous colon cancers with microsatellite instability. Dis Markers 2005, 121-6.
17. Sylvester PA, Myerscough N, Warren BF et al. Differential expression of the chromosome 11 mucin genes in colorectal cancer. J Pathol 2001; 195: 327-35.
18. Inaba T, Sano H, Kawahito Y et al. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. Proc Natl Acad Sci USA 2003; 100: 2736-41.
19. Velcich A, Yang W, Heyer J et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 2002; 295: 1726-9.
20. -/- mice. Am J Path 2005; 166: 1239-46.
21. Dietrich WF, Lander ES, Smith JS et al. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 1993; 75: 631-9.
22. AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64. Oncogene 2000; 19: 3182-92.
23. Gould KA, Luongo C, Moser AR et al. Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics 1996; 144: 1777-85.
24. Min-induced intestinal neoplasia. Cell 1995; 81: 957-66.
25. Cormier RT, Hong KH, Halberg RB et al. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet 1997; 17: 88-91.
26. Koo JS, Kim YD, Jetten AM, Belloni P, Nettesheim P. Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist. Exp Lung Res 2002; 28: 315-32.
27. Perrais M, Pigny P, Copin M-C, Aubert J-P, Van Seuningen I. Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. J Biol Chem 2002; 277: 32258-67.
28. Kim Y-D, Kwon E-J, Park D-W, Song S-Y, Yoon S-K, Baek S-H. Interleukin-1B induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol Pharmacol 2002; 62: 1112-18.
29. Velcich A, Augenlicht LH. Regulated expression of an intestinal mucin gene in HT29 colonic carcinoma cells. J Biol Chem 1993; 19: 13956-61.
30. Fleming N, Mellow L. Arachidonic acid stimulates intracellular calcium mobilization and regulates protein synthesis, ATP levels, and mucin secretion in submandibular gland cells. J Dent Res 1995; 74: 1295-302.
31. McAlpine CA, Barak Y, Matise I, Cormier. Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice. Int J Cancer 2006; 119: 2339-46.
32. Min/+ mouse model of colorectal cancer. Carcinogenesis 2005; 26: 587-95.
33. Sawaguchi A, Tojo H, Kawano JI, Okamoto M, Sugunuma T. Immunocytochemical demonstration of the secretory dynamics of zymogenic contents in rat gastric gland processed by high-pressure freezing/freeze substitution, with special references to phospholipase A(2) and phospholipase Cgamma1. Histochem Cell Biol 2001; 116: 361-9.
34. Lakatos PL, Altorjay I, Mandi Y et al. Interaction between seroreactivity to microbial antigens and genetics in Crohn's disease. is there a role for defensins? Tissue Antigens 2008 (Apri 7) [Epub ahead of print].
35. Kocsis AK, Lakatos PL, Somogyvari F et al. Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease. Scand J Gastroenterol 2007 (Oct 18): 1-9 [Epub ahead of print].
36. Pazgier M, Prahl A, Hoover DM, Lubkowski J. Studies of the biological properties of human β-defensin 1. J Biol Chem 2007; 282: 1819-29.
37. Tollin M, Bergman P, Svenberg T, Jornvall H, Gudmundsson GH, Agerberth B. Antimicrobial peptides in the first line defence of human colon mucosa. Peptides 2003; 24: 523-30.
38. Wehkamp J, Stange EF. A new look at Crohn's disease: Breakdown of the mucosal antibacterial defense. Ann NY Acad Sci 2006; 1072: 321-31.
39. Eckmann L. defence molecules in intestinal innate immunity against bacterial infections. Curr Opin Gastroenterol 2005; 21: 147-51.
40. Wu F, Chakravarti S. Differential expression of inflammatory and fibrogenic genes and their regulation by NF-kappaB inhibition in a mouse model of chronic colitis. J Immunol 2007; 179: 6988-7000.
41. Qiu L, List EO, Kopchick JJ. Differentially expressed proteins in the pancreas of diet-induced diabetic mice. Mol Cell Proteomics 2005; 4: 1311-18.
42. Gilham D, Labonte ED, Rojas JC, Jandacek RJ, Howles PN, Hui DY. Carboxyl ester lipase deficiency exacerbates dietary lipid absorption abnormalities and resistance to diet-induced obesity in pancreatic triglyceride lipase knockout mice. J Biol Chem 2007; 282: 24642-9.
43. Reuss R, Aberle S, Klingel K et al. The expression of the carboxyl ester lipase gene in pancreas and pancreatic adenocarcinomas. Int J Oncol 2006; 29: 649-54.
44. Hui DY, Howles PN. Molecular mechanisms of cholesterol absorption and transport in the intestine. Sem Cell Dev Biol 2005; 16: 183-92.
45. Lindner I, Helwig U, Rubin D et al. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. Mol Nutr Food Res 2005; 49: 972-6.
46. Szepessy E, Sahin-Toth M. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. Pancreatology 2006; 6: 117-22.
47. Whitcomb DC, Lowe ME. Human pancreatic digestive enzymes. Dig Dis Sci 2007; 52: 1-17.
48. Melgar S, Drmotova M, Rehnstrom E, Jansson L, Michaelsson E. Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis. Cytokine 2006; 35: 275-83.
49. Kabashima K, Saji T, Murata T et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest 2002; 109: 883-93.