Enhanced 4T1 breast carcinoma anticancer activity by co-delivery of doxorubicin and curcumin with core-shell drug-carrier based on heparin modified poly(l-lactide) grafted polyethylenimine cationic nanoparticles

Journal of Biomedical Nanotechnology

Volumn 10, Issue 2, 2014, Pages 227-237

  Guo, Qingfa ^a   Li, Xiaolu ^b   Yang, Yi ^a   Wei, Jing ^a   Zhao, Qian ^a   Luo, Feng ^a   Qian, Zhiyong ^a  

^a SICHUAN UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Co Delivery; Curcumin; Doxorubicin; Nanoparticle; PEA; Tumor

Indexed keywords

ANTICANCER ACTIVITIES; CATIONIC NANOPARTICLES; CO DELIVERIES; CORE-SHELL NANOPARTICLES; CURCUMIN; DOXORUBICIN; INTRAVENOUS INJECTIONS; PEA;

MAMMALS; POLYSACCHARIDES; TRANSMISSION ELECTRON MICROSCOPY; TUMORS;

NANOPARTICLES;

CURCUMIN; DOXORUBICIN; NANOPARTICLE; POLYETHYLENEIMINE; POLYLACTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER SURVIVAL; CARDIOTOXICITY; CELL TRANSPORT; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TUMOR LEVEL; EMBRYO; FEMALE; FLOW CYTOMETRY; HEART MUSCLE INJURY; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; TUMOR GROWTH; ZETA POTENTIAL;

ANIMALS; BREAST NEOPLASMS; CATIONS; CELL DEATH; CELL LINE, TUMOR; CURCUMIN; DISEASE MODELS, ANIMAL; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; HEPARIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED BALB C; MYOCARDIUM; NANOPARTICLES; POLYESTERS; POLYETHYLENEIMINE; TISSUE DISTRIBUTION;

EID: 84893165645     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1785     Document Type: Article

References (46)

1. D. Wehrung and M. O. Oyewumi, Antitumor effect of novel gallium compounds and efficacy of nanoparticle-mediated gallium delivery in lung cancer. J. Biomed. Nanotechnol. 8, 161 (2012).
2. Q. Y. Zhang, N. He, L. Zhang, F. Zhu, Q. X. Chen, Y. Qin, Z. R. Zhang, Q. Zhang, S. Wang, and Q. He, The in vitro and in vivo study on self-nanoemulsifying drug delivery system (SNEDDS) based on insulin-phospholipid complex. J. Biomed. Nanotechnol. 8, 90 (2012).
3. R. F. Ozols, M. A. Bookman, R. C. Young, and N. Engl, Intraperitoneal chemotherapy for ovarian cancer. New Engl. J. Med. 354, 1641 (2006).
4. Y. Sadzuka, Y. Yamashita, and T. Sonobe, Effects of glutamate transporter inhibitors on the antitumor activity of doxorubicin. Clin. Cancer. Res. 8, 3943 (2002).
5. Y. Gao, L. Chen, W. Gu, Y. Xi, L. Lin, and Y. Li, Targeted nanoassembly loaded with docetaxel improves intracellular drug delivery and efficacy in murine breast cancer model. Mol. Pharmaceut. 5, 1044 (2008).
6. D. Armstrong, B. Bundy, L. Wenzel, H. Huang, R. Baergen, S. Lele, L. Copeland, J. Walker, and R. Burger, Intraperitoneal cisplatin and paclitaxel in ovarian cancer. New Engl. J. Med. 354, 34 (2006).
7. J. Lehar, A. S. Krueger, W. Avery, A. M. Heilbut, L. M. Johansen, E. R. Price, R. J. Rickles, G. F. Short III, J. E. Staunton, X. W. Jin, M. S. Lee, R. Z. Zimmermann, and A. A. Borisy, Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat. Biotechnol. 27, 659 (2009).
8. J. R. Sharom, D. S. Bellows, and M. Tyers, From large networks to small molecules. Curr. Opin. Chem. Biol. 8, 81 (2004).
9. W. G. Kaelin Jr, The concept of synthetic lethality in the context of anticancer therapy. Nat. Rev. Cancer. 5, 689 (2005).
10. C. T. Keith, A. A. Borisy, and B. R. Stockwell, Multicomponent therapeutics for networked systems. Nat. Rev. Drug Discov. 4, 71 (2005).
11. L. Hosseinzadeh, J. Behravan, F. Mosaffa, G. Bahrami, A. Bahrami, and G. Karimi, Curcumin potentiates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells through generation of reactive oxygen species. Food Chem. Toxicol. 49, 1102 (2011).
12. M. C. Cochran, J. Eisenbrey, R. O. Ouma, M. Soulen, and M. A. Wheatley, Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery. Int. J. Pharm. 414, 161 (2011).
13. W. Xiao, X. Chen, L. Yang, Y. Mao, Y. Wei, and L. Chen, Codelivery of doxorubicin and plasmid by a novel FGFR-mediated cationic liposome. Int. J. Pharm. 393, 119 (2010).
14. H. Wang, Y. Zhao, Y. Wu, Y. L. Hu, K. H. Nan, G. J. Nie, and H. Chen, Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials 32, 8281 (2011).
15. L. Fan, F. Li, H. Zhang, Y. Wang, C. Cheng, X. Y. Li, C. H. Gu, Q. Yang, H. Wu, and S. Y. Zhang, Co-delivery of PDTC and doxorubicin by multifunctional micellar nanoparticles to achieve active targeted drug delivery and overcome multidrug resistance. Biomaterials 31, 5634 (2010).
16. J. M. Li, Z. Y. He, S. Yu, S. Z. Li, Q. Ma, Y. Y. Yu, J. L. Zhang, R. Li, Y. Zheng, G. He, and X. R. Song, Micelles based on Methoxy Poly(Ethylene Glycol)-Cholesterol conjugate for controlled and targeted drug delivery of a poorly water soluble drug. J. Biomed. Nanotechnol. 8, 809 (2012).
17. L. M. Zhang, Z. X. Lu, Y. Y. Bai, T. Wang, Z. F. Wang, J. Chen, Y. Ding, F. Yang, Z. D. Xiao, S. H. Ju, J. J. Zhu, and N. Y. He, PEGylated denatured bovine serum albumin modified water soluble inorganic nanocrystals as multifunctional drug delivery platforms. J. Mater. Chem. B 1, 1289 (2013).
18. X. Peng, J. Wang, H. Song, D. X. Cui, L. Li, J. Li, L. H. Lin, J. Zhou, and Y. N. Liu, Optimized preparation of celastrol-loaded polymeric nanomicelles using rotatable central composite design and response surface methodogy. J. Biomed. Nanotechnol. 8, 491 (2012).
19. X. Y. Yang, Y. J. Liu, C. X. Liu, and N. Zhang, Biodegrable solid lipid nanoparticle flocculates for pulmonary delivery of insulin. J. Biomed. Nanotechnol. 8, 834 (2012).
20. R. Duncan, The dawning era of polymer therapeutics. Nat. Rev. Drug. Discv. 2, 347 (2003).
21. S. Dreis, F. Rothweiler, M. Michaelis, J. Cinatl Jr, J. Kreuter, and K. Langer, Preparation, characterization and maintenance of drug efficacy of doxorubicin-loaded human serum albumin(HSA) nanoparitlces. Int. J. Pharm. 341, 207 (2007).
22. L. M. Zhang, Z. X. Lu, X. L. Li, Y. Deng, F. Q. Zhang, C. Ma, and N. Y. He, Methoxy poly(ethylene glycol) conjugated denatured bovine serum albumin micelles for effective delivery of camptothecin. Polym. Chem. 3, 1958 (2012).
23. D. Lococo, C. E. Mora-Huertas, H. Fessi, I. Zaanoun, and A. Elaissari, Argan oil nanoemulsions as new hydrophobic drug-loaded delivery system for transdermal application. J. Biomed. Nanotechnol. 8, 843 (2012).
24. I. B. Neagoe, C. Braicu, C. Matea, C. Bele, G. Florin, K. Gabriel, C. Veronica, and A. Irimie, Efficient siRNA delivery system using carboxilated single-wall carbon nanotubes in cancer treatment. J. Biomed. Nanotechnol. 8, 567 (2012).
25. L. M. Zhang, Z. L. Wang, Z. X. Lu, H. Shen, J. Huang, M. Liu, N. Y. He, and Z. J. Zhang, PEGylated reduced graphene oxied as a superior siRNA delivery system. J. Mater. Chem. B 1, 749 (2013).
26. Y. Sadzuka, M. Nagamine, T. Toyooka, Y. Ibuki, and T. Sonobe, Beneficial effects of curcumin on antitumor activity and adverse reactions of doxorubicin. Int. J. Pharm. 432, 42 (2012).
27. P. L. Lu, Y. C. Chen, T. W. Ou, H. H. Chen, H. C. Tsai, C. J. Wen, C. L. Lo, S. P. Wey, K. J. Lin, T. C. Yen, and G. H. Hsiue, Multifunctional hollow nanoparticles based on graft-diblock copolymers for doxorubicin delivery. Biomaterials 32, 2213 (2011).
28. A. Duvoix, R. Blasius, S. Delhalle, M. Schnekenburger, F. Morceau, E. Henry, M. Dicato, and M. Diederich, Chemopreventive and therapeutic effects of curcumin. Cancer Lett. 223, 181 (2005).
29. C. Y. Gong, S. Y. Deng, Q. J. Wu, M. L. Xiang, X. W. Wei, L. Li, X. Gao, B. L. Wang, L. Sun, Y. S. Chen, Y. C. Li, L. Liu, Z. Y. Qian, and Y. Q. Wei, Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials 34, 1413 (2013).
30. Z. Wang, Y. Zhang, S. Banerjee, Y. Li, and F. H. Sarkar, Notch- 1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 106, 2503 (2006).
31. R. Misra and S. K. Sahoo, Coformulation of doxorubicin and curcumin in poly (D, L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in k562 cells. Mol. Pharmaceutics 8, 852 (2011).
32. Y. Mizuno, H. Toshiro, S. Tachibana, K. Uragoh, K. Akazawa, and K. Ueda, Doxorubicin-heparin complex: reduction of cardiotoxicity. J. Cancer. Res. Clin. Oncol. 121, 469 (1995).
33. Q. F. Guo, T. T. Liu, X. Yan, X. H. Wang, S. Shi, F. Luo, and Z. Y. Qian, Synthesis and properties of a novel biodegradable poly(ester amine) copolymer based on poly(L-lactide) and low molecular weight polyethylenimine for gene delivery. Int. J. Nano. 6, 1641 (2011)
34. T. Trimaille, C. Pichot, and T. Delair, Surface functionalization of poly(D,L-lactic acid) nanoparticles with poly(ethylenimine) and plasmid DNA by the layer-by-layer approach. Colloids Surf. A 221, 39 (2003).
35. M. W. Benjamin and F. J. E. Johan, Responsive layer-by-layer materials for drug delivery. J. Control. Release 158, 2 (2012).
36. C. Y. Gong, P. W. Dong, S. Shi, S. Z. Fu, J. L. Yang, G. Guo, X. Zhao, Y. Q. Wei, and Z. Y. Qian, Thermosensitive PEG-PCL-PEG hydrogel controlled drug delivery system: sol-gel-sol transition and in vitro drug release study. J. Pharm. Sciences 98, 3707 (2009).
37. B. X. Xue, Y. J. Wang, X. H, Tang, P. Xie, Y. J. Wang, F. Luo, C.J. Wu, and Z. Y. Qian, Biodegradable self-assembled MPEG-PCL micelles for hydrophobic oridonin delivery in vitro. J. Biomed. Nanotechnol. 8, 80 (2012).
38. M. Prabaharan, J. J. Grailer, S. Pilla, D. A. Steeber, and S. Q. Gong, Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn® H40, poly(L-lactide) and poly(ethylene glycol) for tumor targeted drug delivery. Biomaterials 30, 3009 (2009).
39. M. Prabaharan, J. J. Grailer, S. Pilla, D. A. Steeber, and S. Q. Gong, Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery. Biomaterials 30, 5757 (2009).
40. J. H. Duan, H. M. Mansour, Y. D. Zhang, X. M. Deng, Y. X. Chen, J. W. Wang, Y. F. Pan, and J. F. Zhao, Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparitlces. Int. J. Pharm. 426, 193 (2012).
41. N. S. Rejinold, M. Muthunarayanan, V. V. Divyarani, P. R. Sreerekha, K. P. Chennazhi, S. V. Nair, H. Tamura, and R. Jayakumar, Curcumin-loaded biocompatible thermoresponsive polymeric nanoparticles for cancer drug delivery. J. Colloid. Interf. Sci. 360, 39 (2011).
42. R. B. Basser and M. D. Green, Strategies for prevention of anthracycline cardiotoxicity. Cancer Treat Rev. 19, 57 (1993).
43. J. J. Miao, F. M, Zhang, M. Takieddin, S. Mousa, and R. Linhardt, Adsorption of doxorubicin on poly(methyl methacrylate)-chitosan-heparin-coated activated carbon beads. Langmuir 28, 4396 (2012).
44. N. Y. Zhang, M. E. Klegerman, H. Deng, Y. Shi, E. Golunski, and Z. Q. An, Trastuzumab-doxorubicin conjugate provides enhanced anti-cancer potency and Reduced cardiotoxicity. J. Cancer. Therapy 4, 308 (2013).
45. W. C. She, N. Li, K. Luo, C. H. Guo, G. Wang, Y. Y. Geng, and Z. W. Gu, Dendronized heparin-doxorubicin conjugated based nanoparticle as pH-responsive drug delivery system for cancer therapy. Biomaterials 34, 2252 (2013).
46. K. Park, G. Y. Lee, Y. S. Kim, M. Yu, R. W. Park, I. S. Kim, S. Y. Kim, and Y. Byun, Heparin-deoxycholic acid chemical conjugate as an anticancer drug carrier and its antitumor activity. J. Control Release 114, 300 (2006).