Co-delivery of PDTC and doxorubicin by multifunctional micellar nanoparticles to achieve active targeted drug delivery and overcome multidrug resistance

Biomaterials

Volumn 31, Issue 21, 2010, Pages 5634-5642

  Fan, Li ^a   Li, Fei ^a   Zhang, Haitao ^a   Wang, Yukun ^a   Cheng, Chong ^a   Li, Xiaoye ^a   Gu, Chun hu ^b   Yang, Qian ^a   Wu, Hong ^a   Zhang, Shengyong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Active target; DOX; Folate chitosan; Micelles; PDTC

Indexed keywords

ACIDIC ENVIRONMENT; ACTIVE TARGET; AVERAGE PARTICLE SIZE; BLOOD STREAMS; CELLULAR UPTAKE EFFICIENCY; DELIVERY SYSTEMS; DOX; DOXORUBICIN; DRUG CONTENT; DRUG RELEASE; FLOW CYTOMETRY ANALYSIS; FOLATE RECEPTOR; FOLATE-CHITOSAN; GOOD STABILITY; LIVER CANCERS; MICELLAR NANOPARTICLES; MULTIDRUG RESISTANCE; PH SENSITIVE; PH-RESPONSIVE; PYRROLIDINEDITHIOCARBAMATE; SELF-ASSEMBLED; SYSTEMIC CIRCULATION; TARGETED DRUG DELIVERY;

CHITIN; CHITOSAN; DRUG DELIVERY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; NANOPARTICLES; SYNTHESIS (CHEMICAL);

MICELLES;

CHITOSAN; COPOLYMER; DOXORUBICIN; FOLATE RECEPTOR; FOLIC ACID; NANOCARRIER; NANOPARTICLE; PYRROLIDINE DITHIOCARBAMATE;

ACIDITY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; DRUG SYNTHESIS; DRUG TARGETING; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; LIVER CANCER; MICELLE; MULTIDRUG RESISTANCE; NANOENCAPSULATION; NUCLEAR MAGNETIC RESONANCE; PARTICLE SIZE; PH MEASUREMENT; PRIORITY JOURNAL; SYSTEMIC CIRCULATION;

ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; CHITOSAN; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, MULTIPLE; FOLIC ACID; HUMANS; MATERIALS TESTING; MICELLES; MOLECULAR STRUCTURE; NANOPARTICLES; PYRROLIDINES; THIOCARBAMATES;

EID: 77953027741     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.03.066     Document Type: Article

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