Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease

Journal of Medicinal Chemistry

Volumn 57, Issue 2, 2014, Pages 298-308

  Rodrigues, Giseli Capaci ^a,b,c   Feijó, Daniel Ferreira ^b   Bozza, Marcelo Torres ^b   Pan, Peiwen ^d   Vullo, Daniela ^e   Parkkila, Seppo ^d   Supuran, Claudiu T ^e   Capasso, Clemente ^f   Aguiar, Alcino Palermo ^a   Vermelho, Alane Beatriz ^b  

^a MILITARY INSTITUTE OF ENGINEERING   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Inst Ciencias Exatas e da Natureza   (Brazil)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^e UNIVERSITY OF FLORENCE   (Italy)

^f INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 CHLOROPHENYL)N HYDROXY 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 (2 ETHOXYPHENYL) 4,5 DIHYDROISOXAZOLE 5 CARBOHYDRAZIDE; 3 (2 ETHOXYPHENYL)N HYDROXY 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 (2 FLUOROPHENYL)N HYDROXY 5 METHYL 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 (3 BROMOPHENYL)N HYDROXY 5 METHYL 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 (3 CHLOROPHENYL)N HYDROXY 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 (3 CHLOROPHENYL)N HYDROXY 5 METHYL 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 (3 ETHOXYPHENYL) 4,5 DIHYDROISOXAZOLE 5 CARBOHYDRAZIDE; 3 (3 FLUOROPHENYL)N HYDROXY 5 METHYL 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 (4 CHLOROPHENYL)N HYDROXY 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 (4 ETHOXYPHENYL)N HYDROXY 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; 3 [4 (BENZYLOXY)PHENYL]N HYDROXY 4,5 DIHYDROISOXAZOLE 5-CARBOXAMIDE; 3 PHENYL N HYDROXY 4,5 DIHYDROISOXAZOLE 5 CARBOXAMIDE; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; HYDROXAMIC ACID; HYDROXAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; MACROPHAGE; MOUSE; NONHUMAN; PARASITE LOAD; TRYPANOSOMA CRUZI;

ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL LINE, TUMOR; CHAGAS DISEASE; DRUG DESIGN; HUMANS; HYDROXAMIC ACIDS; ISOENZYMES; ISOXAZOLES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 84893073618     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400902y     Document Type: Article

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