Oral transmission of Chagas disease: Typing of Trypanosoma cruzi from five outbreaks occurred in Venezuela shows multiclonal and common infections in patients, vectors and reservoirs

Infection, Genetics and Evolution

Volumn 17, Issue , 2013, Pages 113-122

  Munoz Calderon A ^a   Diaz Bello Z ^a   Valladares, B ^b   Noya, O ^a   Lopez M C ^c   Alarcon de Noya B ^a   Thomas, M C ^c  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

^c INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

Chagas disease; DTU; Haplotipe; IS LR motif; Oral transmission; Trypanosoma cruzi

Indexed keywords

RNA 18S;

ADULT; ARTICLE; CHAGAS DISEASE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CARRIER; EPIDEMIC; EXON; GENOTYPE; HAPLOTYPE; HUMAN; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PARASITE TRANSMISSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VENEZUELA; ZOONOSIS;

ANIMALS; BASE SEQUENCE; CHAGAS DISEASE; DISEASE OUTBREAKS; DISEASE RESERVOIRS; DISEASE VECTORS; EXONS; GENOTYPE; HAPLOTYPES; HUMANS; MICROSATELLITE REPEATS; MOLECULAR TYPING; RNA, SPLICED LEADER; TRYPANOSOMA CRUZI; VENEZUELA;

EID: 84877154830     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2013.03.036     Document Type: Article

References (35)

1. Alarcón de Noya B., Colmenares C., Ruiz-Guevara R., Díaz-Bello Z., Noya O. La transmisión oral de la Enfermedad de Chagas. Rev. Fac. Med. 2010, 33:78-86.
2. Alarcón de Noya B., Díaz-Bello Z., Colmenares C., Ruiz-Guevara R., Mauriello L., Zavala-Jaspe R., Suarez J.A., Abate T., Naranjo L., Paiva M., Rivas L., Castro J., Márques J., Mendoza I., Acquatella H., Torres J., Noya O. Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas. Venezuela. J. Infect. Dis. 2010, 201:1308-1315.
3. Alarcón de Noya B., Díaz-Bello Z., Colmenares C., Ruiz-Guevara R., Medina K., Noya-Alarcón O., Muñoz A., Losada S., Abate T., Ramírez J.L., Noya O. Clinical and laboratory follow-up of the two largest oral outbreaks of Chagas disease. En: XVIII International Congress for Tropical Medicine and Malaria and XLVIII Congress of the Brazilian Society of Tropical Medicine; Rio de Janeiro. Brasil 2012, I:97-98.
4. Burgos J.M., Diez M., Vigliano C., Bisio M., Risso M., Duffy T., Cura C., Brusses B., Favaloro L., Leguizamon M.S., Lucero R.H., Laguens R., Levin M.J., Favaloro R., Schijman A.G. Molecular identification of Trypanosoma cruzi Discrete Typing Units in end-stage chronic Chagas heart disease and reactivation after heart transplantation. Clin. Infect. Dis. 2010, 51:485-495.
5. Campbell D.A., Thomas S., Sturm N.R. Transcription in kinetoplastid protozoa: why be normal?. Microbes Infect. 2003, 5:1231-1240.
6. Carrasco H.J., Torrellas A., Garcia C., Segovia M., Feliciangeli M.D. Risk of Trypanosoma cruzi I (Kinetoplastida: Trypanosomatidae) transmission by Panstrongylus geniculatus (Hemiptera: Reduviidae) in Caracas (Metropolitan District) and neighboring States, Venezuela. Int. J. Parasitol. 2005, 35:1379-1384.
7. Clark C.G., Pung O.J. Host specificity of ribosomal DNA variation in sylvatic Trypanosoma cruzi from North America. Mol. Biochem. Parasitol. 1994, 66:175-179.
8. Cura C.I., Mejía-Jaramillo A.M., Duffy T., Burgos J.M., Rodriguero M., Cardinal M.V., Kjos S., Gurgel-Gonçalves R., Blanchet D., De Pablos L.M., Tomasini N., da Silva A., Russomando G., Cuba C.A., Aznar C., Abate T., Levin M.J., Osuna A., Gürtler R.E., Diosque P., Solari A., Triana-Chávez O., Schijman A.G. Trypanosoma cruzi I genotypes in different geographic regions and transmission cycles based on a microsatellite motif of the spliced leader genes. Int. J. Parasitol. 2010, 40:1599-1607.
9. De Castro S., de Meirelles M. Effects of drugs on Trypanosoma cruzi and on its interaction with heart muscle cell "in vitro". Mem. Inst. Oswaldo Cruz. 1987, 82:209-218.
10. Dias J.C.P., Coura J.R. Epidemiologia. Clínica e Terapêutica da Doença de Chagas: uma Abordagem Prática para o Clínico Geral 1997, 33-66. Fiocruz, Rio de Janeiro. J.C.P. Dias, J.R. Coura (Eds.).
11. Dias J.P., Bastos C., Araújo E., Mascarenhas A.V., Martins Netto E., Grassi F., Silva M., Tatto E., Mendonça J., Araújo R.F., Shikanai-Yasuda M.A., Aras R. Acute Chagas disease outbreak associated with oral transmission. Rev. Soc. Bras. Med. Trop. 2008, 41:296-300.
12. Díaz-Bello Z., Thomas M.C., López M.C., Zavala-Jaspe R., Noya O., Alarcón de Noya B., Abate T. Trypanosoma cruzi genotyping supports a common source of infection in a school-related oral outbreak of acute Chagas disease in Venezuela. Epidemiol Infect. 2013, 2:1-7.
13. Falla A., Herrera C., Fajardo A., Montilla M., Vallejo G.A., Guhl F. Haplotype identification within Trypanosoma cruzi I in Colombian isolates from several reservoirs, vectors and humans. Acta Trop. 2009, 110:15-21.
14. Fernandes O., Sturm N.R., Derre R., Campbell D.A. The mini-exon gene: a genetic marker for zymodeme III of Trypanosoma cruzi. Mol. Biochem. Parasito. 1998, 95:129-133.
15. Fitzpatrick S., Feliciangeli M.D., Sanchez-Martin M.J., Monteiro F.A., Miles M.A. Molecular genetics reveal that sylvatic Rhodnius prolixus do colonize rural houses. PLoS Negl. Trop. Dis. 2008, 2:e210. 10.1371/journal.pntd.0000210.
16. Franco-Paredes C., Von A., Hidron A., Rodríguez-Morales A.J., Tellez I., Barragán M., Jones M., Náquira C.G., Mendez J. Chagas disease: an impediment in achieving the Millennium Development Goals in Latin America. BMC Int. Health. Hum. Rights. 2007, 7:7.
17. Herrera L., Urdaneta-Morales S. Synanthropic rodent reservoirs of Trypanosoma cruzi in the valley of Caracas, Venezuela. Rev. Inst. Med. Trop. São Paulo 1997, 39:279-282.
18. Herrera L., Xavier S., Viegas C., Martinez C., Cotias P., Carrasco H., Urdaneta-Morales S., Jansen A.M. Trypanosoma cruzi in a caviomorph rodent: parásitological and pathological features of the experimental infection of Thrichomys apereoides (Rodentia, Echimyidae). Exp. Parasitol. 2004, 107:78-88.
19. Herrera C., Bargues M.D., Fajardo A., Montilla M., Triana O., Vallejo G.A., Guhl F. Identifying four Trypanosoma cruzi I isolate haplotypes from different geographic regions in Colombia. Infect Genet Evol. 2007, 7:535-539.
20. Herrera C., Guhl F., Falla A., Fajardo A., Montilla M., Vallejo G.A., Bargues M.D. Genetic variability and phylogenetic relationships within Trypanosoma cruzi I isolated in Colombia based on miniexon gene sequences. J. Parasitol. Res. 2009, 89:7364.
21. Luna K.P., Hernández I.P., Rueda C.M., Zorro M.M., Croft S.L., Escobar P. In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole. Biomédica. 2009, 29:448-455.
22. Macedo A.M., Pena S.D.J. Genetic variability of Trypanosoma cruzi: implications for the pathogenesis of Chagas disease. Parasitol. Today 1998, 14:119-123.
23. Maguire J.H., Hoff R., Sleigh A.C., Mott K.E., Ramos N.B., Sherlock I.A. An outbreak of Chagas' disease in south western Bahia, Brazil. Am. J. Trop. Med. Hyg. 1986, 35:931-936.
24. Miles M.A., Llewellyn M.S., Lewis M.D., Yeo M., Baleela R., Fitzpatrick S., Gaunt M.W., Mauricio I.L. The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future. Parasitol. 2009, 136:1509-1528.
25. Moncayo A., Silveira A.C. Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy. Mem. Inst. Oswaldo Cruz. 2009, 104:17-30.
26. Noireau F., Diosque P., Jansen A.M. Trypanosoma cruzi: adaptation to its vectors and its hosts. Vet. Res. 2009, 40:26.
27. O'Connor O., Bosseno M.F., Barnabé C., Douzery E.J., Brenière S.F. Genetic clustering of Trypanosoma cruzi I lineage evidenced by intergenic mini-exon gene sequencing. Infect. Genet. Evol. 2007, 7:587-593.
28. Rassi A, Rassi A., Marin-neto J.A. Chagas disease. Lancet 2010, 375:1388-1402.
29. Shikanai-Yasuda M.A., Marcondes C.B., Guedes L.A., Siqueira G.S., Barone A.A., Dias J.C., Amato Neto V., Tolezano J.E., Peres B.A., Arruda Júnior E.R. Possible oral transmission of acute Chagaś disease in Brazil. Rev. Inst. Med. Trop. Sao Paulo 1991, 33:351-357.
30. Souto R.P., Fernandes O., Macedo A.M., Campbell D.A., Zingales B. DNA markers define two major phylogenetic lineages of Trypanosoma cruzi. Mol. Biochem. Parasitol. 1996, 83:141-152.
31. Thomas S., Westenberger S.J., Campbell D.A., Sturm N.R. Intragenomic spliced leader RNA array analysis of kinetoplastids reveals unexpected transcribed region diversity in Trypanosoma cruzi. Gene. 2005, 352:100-108.
32. Thompson J.D., Higgins D.G., Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 1994, 22:4673-4680.
33. Toledo M., Pereira M.E.S., Brener Z. Efects of immunosupression on the especific treatment of mice experimentally infected with Trypanosoma cruzi. Mem. Inst. Oswaldo Cruz. 1990, 85:100.
34. Xavier S.C., Vaz V.C., D'Andrea P.S., Herrera L., Emperaire L., Alves J.R., Fernandes O., Ferreira L.F., Jansen A.M. Mapping of the distribution of Trypanosoma cruzi infection among small Wild mammals in a conservation unit and its surroundings (northeast-Brazil). Parasitol. Int. 2007, 56:119-128.
35. Zingales B., Andrade S.G., Briones M.R., Campbell D.A., Chiari E., Fernandes O., Guhl F., Lages-Silva E., Macedo A.M., Machado C.R., Miles M.A., Romanha A.J., Sturm N.R., Tibayrenc M., Schijman A.G. A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI. Mem. Inst. Oswaldo Cruz. 2009, 104:1051-1054.