Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 11, 2009, Pages 3023-3026

  Tapadar, Subhasish ^a   He, Rong ^a   Luchini, Doris N ^b   Billadeau, Daniel D ^b   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b MAYO CLINIC   (United States)

Author keywords

HDAC; HDAC inhibitor; Isoform; Pancreatic cancer

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; ISOXAZOLE; ZINC;

ARTICLE; CANCER CELL CULTURE; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; PANCREAS CANCER;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; ISOXAZOLES; ZINC;

EID: 65149094611     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.058     Document Type: Article

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