Evaluation of 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole as a novel anti-inflammatory drug candidate

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Vicentino, Amanda Roberta Revoredo ^a   Carneiro, Vitor Coutinho ^a   de Amarante, Anderson Mendonça ^a   Benjamim, Claudia Farias ^a   de Aguiar, Alcino Palermo ^b   Fantappié, Marcelo Rosado ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b MILITARY INSTITUTE OF ENGINEERING   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 CHLOROPHENYL) 5 (4 PYRIDYL) 4,5 DIHYDROISOXAZOLE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; DIMETHYL SULFOXIDE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ISOXAZOLE DERIVATIVE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITROGEN; OXYGEN; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; DRUG STRUCTURE; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE MIGRATION; MACROPHAGE; MOUSE; NONHUMAN; PERITONEAL CAVITY; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN LOCALIZATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL MOVEMENT; DINOPROSTONE; ENZYME ACTIVATION; FEMALE; HMGB1 PROTEIN; INTERLEUKIN-6; ISOXAZOLES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PERITONITIS; PYRIDINES; SIGNAL TRANSDUCTION; THIOGLYCOLATES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84862497969     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039104     Document Type: Article

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