Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice

Pharmacological Research

Volumn 80, Issue , 2014, Pages 52-65

  Nicolussi, Simon ^a   Viveros Paredes, Juan Manuel ^a   Gachet, María Salomé ^a   Rau, Mark ^a   Flores Soto, Mario Eduardo ^b   Blunder, Martina ^c   Gertsch, Jürg ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF GUADALAJARA   (Mexico)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Anandamide uptake; Cannabimimetic; Endocannabinoid system; Endocannabinoid transport inhibition; Guineensine

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ACYLGLYCEROL LIPASE; AMIDE; ANANDAMIDE; BRACHYSTAMIDE B; CANNABINOID RECEPTOR; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FATTY ACID AMIDASE; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 5; GUINEENSINE; N (3 FURYLMETHYL)ARACHIDONAMIDE; NATURAL PRODUCT; OMDM 2; RETROFRACTAMIDE A; RETROFRACTAMIDE B; RIMONABANT; UNCLASSIFIED DRUG; 2-ARACHIDONYLGLYCEROL; ACYLGLYCEROL; ALKENE; AMIDASE; ANALGESIC AGENT; ARACHIDONIC ACID DERIVATIVE; CANNABINOID RECEPTOR ANTAGONIST; ENDOCANNABINOID; FABP5 PROTEIN, MOUSE; FATTY-ACID AMIDE HYDROLASE; FUSED HETEROCYCLIC RINGS; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; SERHL PROTEIN, MOUSE; SERINE PROTEINASE; TUMOR PROTEIN;

ANALGESIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLACK PEPPER; CANNABIMIMETIC ACTIVITY; CATALEPSY; CELL TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; FRUIT; HUMAN; HUMAN CELL; HYPOTHERMIA; IC 50; INHIBITION KINETICS; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ROTAROD TEST; STRUCTURE ACTIVITY RELATION; TETRAD TEST; ANIMAL; BAGG ALBINO MOUSE; BRAIN; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PIPER (PLANT); TRANSPORT AT THE CELLULAR LEVEL; U937 CELL LINE;

ALKENES; AMIDOHYDROLASES; ANALGESICS; ANIMALS; ARACHIDONIC ACIDS; BIOLOGICAL TRANSPORT; BRAIN; CANNABINOID RECEPTOR ANTAGONISTS; CATALEPSY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCANNABINOIDS; FATTY ACID-BINDING PROTEINS; GLYCERIDES; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; HYPOTHERMIA; LOCOMOTION; MALE; MICE; MICE, INBRED BALB C; MONOACYLGLYCEROL LIPASES; NEOPLASM PROTEINS; PIPER; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RECEPTORS, CANNABINOID; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

EID: 84893051949     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.12.010     Document Type: Article

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