Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1/CXCR4 axis

Blood

Volumn 123, Issue 3, 2014, Pages 428-441

  Zhang, Jing ^a   Ren, Xiangliang ^a   Shi, Wei ^a   Wang, Sihan ^a   Chen, Haixu ^a   Zhang, Bowen ^a   Wang, Zhidong ^b   Zhou, Yong ^a   Chen, Lin ^a   Zhang, Rui ^a   Lv, Yang ^a   Zhou, Junnian ^a   Nan, Xue ^a   He, Lijuan ^a   Yue, Wen ^a   Li, Yanhua ^a   Pei, Xuetao ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GELATINASE B; GRANULOCYTE COLONY STIMULATING FACTOR; HEMATOLOGIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PLERIXAFOR; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1ALPHA; TRIS[2 (DIMETHYLAMINO)ETHYL]AMINE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; CXCR4 PROTEIN, MOUSE; ETHYLAMINE; HETEROCYCLIC COMPOUND; STROMAL CELL DERIVED FACTOR 1; TRIS(2 (DIMETHYLAMINO)ETHYL)AMINE; TRIS(2-(DIMETHYLAMINO)ETHYL)AMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ADHESION; CELL LINEAGE; CELL MIGRATION; CELL POPULATION; COLONY FORMING UNIT; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; ENGRAFTMENT; ENZYME ACTIVATION; GRAFT RECIPIENT; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; LEUKOCYTE; LYMPHOCYTE COUNT; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL MOBILIZATION; ANIMAL; C57BL MOUSE; CELL MOTION; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; LEUKEMIA CELL LINE; METABOLISM; METHODOLOGY; TIME;

ANIMALS; CELL ADHESION; CELL MOVEMENT; CHEMOKINE CXCL12; ETHYLAMINES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HETEROCYCLIC COMPOUNDS; HUMANS; JURKAT CELLS; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; RECEPTORS, CXCR4; TIME FACTORS;

EID: 84893051744     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-04-498535     Document Type: Article

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