메뉴 건너뛰기




Volumn 7, Issue 3, 2014, Pages 587-593

Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats

Author keywords

Apoptosis; Motor function; Neurotrophic factors; Spinal cord injury; Treadmill exercise

Indexed keywords


EID: 84893014340     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1451     Document Type: Article
Times cited : (76)

References (44)
  • 1
    • 0026326449 scopus 로고
    • Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
    • Tator CH and Fehlings MG: Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75: 15-26, 1991.
    • (1991) J Neurosurg , vol.75 , pp. 15-26
    • Tator, C.H.1    Fehlings, M.G.2
  • 2
    • 84876155955 scopus 로고    scopus 로고
    • Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampus
    • Hwang L, Choi IY, Kim SE, Ko IG, Shin MS, Kim CJ, Kim SH, Jin JJ, Chung JY and Yi JW: Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampus. Int J Mol Med 31: 1047-1056, 2013.
    • (2013) Int J Mol Med , vol.31 , pp. 1047-1056
    • Hwang, L.1    Choi, I.Y.2    Kim, S.E.3    Ko, I.G.4    Shin, M.S.5    Kim, C.J.6    Kim, S.H.7    Jin, J.J.8    Chung, J.Y.9    Yi, J.W.10
  • 4
    • 0031884393 scopus 로고    scopus 로고
    • Apoptosis in neurological disease
    • Savitz SI and Rosenbaum DM: Apoptosis in neurological disease. Neurosurgery 42: 555-574, 1998.
    • (1998) Neurosurgery , vol.42 , pp. 555-574
    • Savitz, S.I.1    Rosenbaum, D.M.2
  • 5
    • 84870291915 scopus 로고    scopus 로고
    • Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice
    • Sung YH, Kim SC, Hong HP, Park CY, Shin MS, Kim CJ, Seo JH, Kim DY, Kim DJ and Cho HJ: Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice. Life Sci 91: 1309-1316, 2012.
    • (2012) Life Sci , vol.91 , pp. 1309-1316
    • Sung, Y.H.1    Kim, S.C.2    Hong, H.P.3    Park, C.Y.4    Shin, M.S.5    Kim, C.J.6    Seo, J.H.7    Kim, D.Y.8    Kim, D.J.9    Cho, H.J.10
  • 6
    • 0031015075 scopus 로고    scopus 로고
    • Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
    • Crowe MJ, Bresnahan JC, Shuman SL, Masters JN and Beattie MS: Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 3: 73-76, 1997.
    • (1997) Nat Med , vol.3 , pp. 73-76
    • Crowe, M.J.1    Bresnahan, J.C.2    Shuman, S.L.3    Masters, J.N.4    Beattie, M.S.5
  • 10
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle RJ and Strasser A: The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9: 47-59, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 12
    • 10744224462 scopus 로고    scopus 로고
    • Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures
    • Tsuchiya D, Hong S, Matsumori Y, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS and Weinstein PR: Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures. Neurosurgery 53: 1179-1188, 2003.
    • (2003) Neurosurgery , vol.53 , pp. 1179-1188
    • Tsuchiya, D.1    Hong, S.2    Matsumori, Y.3    Kayama, T.4    Swanson, R.A.5    Dillman, W.H.6    Liu, J.7    Panter, S.S.8    Weinstein, P.R.9
  • 13
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore S: Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516, 2007.
    • (2007) Toxicol Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 14
    • 25144489068 scopus 로고    scopus 로고
    • Overview of cell death signaling pathways
    • Jin Z and El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol Ther 4: 139-163, 2005.
    • (2005) Cancer Biol Ther , vol.4 , pp. 139-163
    • Jin, Z.1    El-Deiry, W.S.2
  • 15
    • 0037346775 scopus 로고    scopus 로고
    • Macrophage signaling upon mycobacterial infection: The MAP kinases lead the way
    • Schorey JS and Cooper AM: Macrophage signaling upon mycobacterial infection: the MAP kinases lead the way. Cell Microbiol 5: 133-142, 2003.
    • (2003) Cell Microbiol , vol.5 , pp. 133-142
    • Schorey, J.S.1    Cooper, A.M.2
  • 17
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241, 1997.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 18
    • 84870720211 scopus 로고    scopus 로고
    • Apoptosis induction of human prostate carcinoma DU145 cells by diallyl disulfide via modulation of JNK and PI3K/AKT signaling pathways
    • Shin DY, Kim GY, Lee JH, Choi BT, Yoo YH and Choi YH: Apoptosis induction of human prostate carcinoma DU145 cells by diallyl disulfide via modulation of JNK and PI3K/AKT signaling pathways. Int J Mol Sci 13: 14158-14171, 2012.
    • (2012) Int J Mol Sci , vol.13 , pp. 14158-14171
    • Shin, D.Y.1    Kim, G.Y.2    Lee, J.H.3    Choi, B.T.4    Yoo, Y.H.5    Choi, Y.H.6
  • 20
    • 84878407678 scopus 로고    scopus 로고
    • Medroxyprogestogen enhances apoptosis of SKOV-3 cells via inhibition of the PI3K/Akt signaling pathway
    • Li Y, Jiang Y, Wan Y, Zhang L, Tang W, Ma J, Wu S and Cheng W: Medroxyprogestogen enhances apoptosis of SKOV-3 cells via inhibition of the PI3K/Akt signaling pathway. Biomed Res 27: 43-50, 2013.
    • (2013) Biomed Res , vol.27 , pp. 43-50
    • Li, Y.1    Jiang, Y.2    Wan, Y.3    Zhang, L.4    Tang, W.5    Ma, J.6    Wu, S.7    Cheng, W.8
  • 21
    • 0035980149 scopus 로고    scopus 로고
    • Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3
    • Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA and Gardner TW: Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J Biol Chem 276: 32814-32821, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 32814-32821
    • Barber, A.J.1    Nakamura, M.2    Wolpert, E.B.3    Reiter, C.E.4    Seigel, G.M.5    Antonetti, D.A.6    Gardner, T.W.7
  • 22
    • 0036839596 scopus 로고    scopus 로고
    • Mechanisms of bFGF and NT-4 potentiation of necrotic neuronal death
    • Lobner D and Ali C: Mechanisms of bFGF and NT-4 potentiation of necrotic neuronal death. Brain Res 954: 42-50, 2002.
    • (2002) Brain Res , vol.954 , pp. 42-50
    • Lobner, D.1    Ali, C.2
  • 23
    • 0141705215 scopus 로고    scopus 로고
    • Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury
    • Zhou L and Shine HD: Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury. J Neurosci Res 74: 221-226, 2003.
    • (2003) J Neurosci Res , vol.74 , pp. 221-226
    • Zhou, L.1    Shine, H.D.2
  • 24
    • 0141956456 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and post-ischemic brain injury
    • Guan J, Bennet L, Gluckman PD and Gunn AJ: Insulin-like growth factor-1 and post-ischemic brain injury. Prog Neurobiol 70: 443-462, 2003.
    • (2003) Prog Neurobiol , vol.70 , pp. 443-462
    • Guan, J.1    Bennet, L.2    Gluckman, P.D.3    Gunn, A.J.4
  • 25
    • 3142546426 scopus 로고    scopus 로고
    • Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and phosphatidylinositol 3-kinase pathways
    • Pierchala BA, Ahrens RC, Paden AJ and Johnson EM Jr: Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and phosphatidylinositol 3-kinase pathways. J Biol Chem 279: 27986-27993, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 27986-27993
    • Pierchala, B.A.1    Ahrens, R.C.2    Paden, A.J.3    Johnson Jr., E.M.4
  • 26
    • 34548499151 scopus 로고    scopus 로고
    • Exercise builds brain health: Key roles of growth factor cascades and inflammation
    • Cotman CW, Berchtold NC and Christie LA: Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 30: 464-472, 2007.
    • (2007) Trends Neurosci , vol.30 , pp. 464-472
    • Cotman, C.W.1    Berchtold, N.C.2    Christie, L.A.3
  • 27
    • 0012849885 scopus 로고    scopus 로고
    • Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease
    • Tillerson JL, Caudle WM, Reverón ME and Miller GW: Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease. Neuroscience 119: 899-911, 2003.
    • (2003) Neuroscience , vol.119 , pp. 899-911
    • Tillerson, J.L.1    Caudle, W.M.2    Reverón, M.E.3    Miller, G.W.4
  • 28
    • 1642544036 scopus 로고    scopus 로고
    • Voluntary exercise following traumatic brain injury: Brain-derived neurotrophic factor upregulation and recovery of function
    • Griesbach GS, Hovda DA, Molteni R, Wu A and Gomez-Pinilla F: Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience 125: 129-139, 2004.
    • (2004) Neuroscience , vol.125 , pp. 129-139
    • Griesbach, G.S.1    Hovda, D.A.2    Molteni, R.3    Wu, A.4    Gomez-Pinilla, F.5
  • 29
    • 43649090254 scopus 로고    scopus 로고
    • Treadmill training after spinal cord hemisection in mice promotes axonal sprouting and synapse formation and improves motor recovery
    • Goldshmit Y, Lythgo N, Galea MP and Turnley AM: Treadmill training after spinal cord hemisection in mice promotes axonal sprouting and synapse formation and improves motor recovery. J Neurotrauma 25: 449-465, 2008.
    • (2008) J Neurotrauma , vol.25 , pp. 449-465
    • Goldshmit, Y.1    Lythgo, N.2    Galea, M.P.3    Turnley, A.M.4
  • 30
    • 50249102744 scopus 로고    scopus 로고
    • BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats
    • Ying Z, Roy RR, Zhong H, Zdunowski S, Edgerton VR and Gomez-Pinilla F: BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Neuroscience 155: 1070-1078, 2008.
    • (2008) Neuroscience , vol.155 , pp. 1070-1078
    • Ying, Z.1    Roy, R.R.2    Zhong, H.3    Zdunowski, S.4    Edgerton, V.R.5    Gomez-Pinilla, F.6
  • 31
    • 34447643571 scopus 로고    scopus 로고
    • Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury
    • Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ and Oh TH: Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury. J Neurosci 27: 7751-7761, 2007.
    • (2007) J Neurosci , vol.27 , pp. 7751-7761
    • Yune, T.Y.1    Lee, J.Y.2    Jung, G.Y.3    Kim, S.J.4    Jiang, M.H.5    Kim, Y.C.6    Oh, Y.J.7    Markelonis, G.J.8    Oh, T.H.9
  • 32
    • 84856234094 scopus 로고    scopus 로고
    • The grid-walking test: Assessment of sensorimotor deficits after moderate or severe dopamine depletion by 6-hydroxydopamine lesions in the dorsal striatum and medial forebrain bundle
    • Chao OY, Pum ME, Li JS and Huston JP: The grid-walking test: assessment of sensorimotor deficits after moderate or severe dopamine depletion by 6-hydroxydopamine lesions in the dorsal striatum and medial forebrain bundle. Neuroscience 202: 318-325, 2012.
    • (2012) Neuroscience , vol.202 , pp. 318-325
    • Chao, O.Y.1    Pum, M.E.2    Li, J.S.3    Huston, J.P.4
  • 33
    • 33746666526 scopus 로고    scopus 로고
    • Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats
    • de Leon RD and Acosta CN: Effect of robotic-assisted treadmill training and chronic quipazine treatment on hindlimb stepping in spinally transected rats. J Neurotrauma 23: 1147-1163, 2006.
    • (2006) J Neurotrauma , vol.23 , pp. 1147-1163
    • de Leon, R.D.1    Acosta, C.N.2
  • 34
    • 34247129522 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: Roles in plasticity, neurodegeneration and neuroprotection
    • Hennigan A, O'Callaghan RM and Kelly AM: Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection. Biochem Soc Trans 35: 424-427, 2007.
    • (2007) Biochem Soc Trans , vol.35 , pp. 424-427
    • Hennigan, A.1    O'Callaghan, R.M.2    Kelly, A.M.3
  • 35
    • 84888206250 scopus 로고    scopus 로고
    • Statins enhance expression of growth factors and activate the PI3K/Akt-mediated signaling pathway after experimental intracerebral hemorrhage
    • Yang D, Han Y, Zhang J, Chopp M and Seyfried DM: Statins enhance expression of growth factors and activate the PI3K/Akt-mediated signaling pathway after experimental intracerebral hemorrhage. World J Neurosci 2: 74-80, 2012.
    • (2012) World J Neurosci , vol.2 , pp. 74-80
    • Yang, D.1    Han, Y.2    Zhang, J.3    Chopp, M.4    Seyfried, D.M.5
  • 36
    • 84871432763 scopus 로고    scopus 로고
    • Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway
    • Yao RQ, Qi DS, Yu HL, Liu J, Yang LH and Wu XX: Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway. Neurochem Res 37: 2777-2786, 2012.
    • (2012) Neurochem Res , vol.37 , pp. 2777-2786
    • Yao, R.Q.1    Qi, D.S.2    Yu, H.L.3    Liu, J.4    Yang, L.H.5    Wu, X.X.6
  • 37
    • 0142106467 scopus 로고    scopus 로고
    • Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord
    • Ying Z, Roy RR, Edgerton VR and Gómez-Pinilla F: Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord. Brain Res 987: 93-99, 2003.
    • (2003) Brain Res , vol.987 , pp. 93-99
    • Ying, Z.1    Roy, R.R.2    Edgerton, V.R.3    Gómez-Pinilla, F.4
  • 38
    • 77956095537 scopus 로고    scopus 로고
    • Mitochondria and cell death: Outer membrane permeabilization and beyond
    • Tait SW and Green DR: Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11: 621-632, 2010.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 621-632
    • Tait, S.W.1    Green, D.R.2
  • 39
  • 40
    • 77951911859 scopus 로고    scopus 로고
    • Pi3k-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes
    • Chan G, Nogalski MT, Bentz GL, Smith MS, Parmater A and Yurochko AD: Pi3k-dependent upregulation of Mcl-1 by human cytomegalovirus is mediated by epidermal growth factor receptor and inhibits apoptosis in short-lived monocytes. J Immunol 184: 3213-3222, 2010.
    • (2010) J Immunol , vol.184 , pp. 3213-3222
    • Chan, G.1    Nogalski, M.T.2    Bentz, G.L.3    Smith, M.S.4    Parmater, A.5    Yurochko, A.D.6
  • 41
    • 18044394417 scopus 로고    scopus 로고
    • Exercise activates the phosphatidylinositol 3-kinase pathway
    • Chen M and Russo-Neustadt AA: Exercise activates the phosphatidylinositol 3-kinase pathway. Mol Brain Res 135: 181-193, 2005.
    • (2005) Mol Brain Res , vol.135 , pp. 181-193
    • Chen, M.1    Russo-Neustadt, A.A.2
  • 42
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • Cory S, Huang DC and Adams JM: The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590-8607, 2003.
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 43
    • 77957809120 scopus 로고    scopus 로고
    • Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats
    • Liu G, Keeler BE, Zhukareva V and Houlé JD: Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats. Exp Neurol 226: 200-206, 2010.
    • (2010) Exp Neurol , vol.226 , pp. 200-206
    • Liu, G.1    Keeler, B.E.2    Zhukareva, V.3    Houlé, J.D.4
  • 44
    • 0042703137 scopus 로고    scopus 로고
    • Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: Role of free radicals and the mitochondria
    • Upadhyay D, Panduri V, Ghio A and Kamp DW: Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria. Am J Respir Cell Mol Biol 29: 180-187, 2003.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 180-187
    • Upadhyay, D.1    Panduri, V.2    Ghio, A.3    Kamp, D.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.