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Volumn 27, Issue 1, 2013, Pages 43-50

Medroxyprogestogen enhances apoptosis of SKOV-3 cells via inhibition of the PI3K/Akt signaling pathway

Author keywords

Akt; Apoptosis; Medroxyprogestogen; Ovarian cancer; Phosphorylation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; GESTAGEN; MEDROXYPROGESTOGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 84878407678     PISSN: 16748301     EISSN: None     Source Type: Journal    
DOI: 10.7555/JBR.27.20120051     Document Type: Article
Times cited : (20)

References (30)
  • 2
    • 0037342761 scopus 로고    scopus 로고
    • Evaluation of complete surgical with pelvic and parataortic lymphadenectomy and paclitaxel plus carboplatin chemotherapy for improvement of survival in stage I ovarian clear cell carcinoma
    • Ho CM, Chien TY, Shih BY, Huang SH. Evaluation of complete surgical with pelvic and parataortic lymphadenectomy and paclitaxel plus carboplatin chemotherapy for improvement of survival in stage I ovarian clear cell carcinoma. Gynecol Oncol 2003; 88: 394-9.
    • (2003) Gynecol Oncol , vol.88 , pp. 394-399
    • Ho, C.M.1    Chien, T.Y.2    Shih, B.Y.3    Huang, S.H.4
  • 4
    • 0029029163 scopus 로고
    • Endometrial and ovarian cancer and oral contraceptives-findings in a large cohort study
    • Vessey MP, Painter R. Endometrial and ovarian cancer and oral contraceptives-findings in a large cohort study. Br J Cancer 1995; 71: 1340-2.
    • (1995) Br J Cancer , vol.71 , pp. 1340-1342
    • Vessey, M.P.1    Painter, R.2
  • 6
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • Adams JM, Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007; 26: 1324-37.
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 7
    • 0036849192 scopus 로고    scopus 로고
    • Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
    • Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, et al. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev cell 2002; 3: 631-43.
    • (2002) Dev cell , vol.3 , pp. 631-643
    • Datta, S.R.1    Ranger, A.M.2    Lin, M.Z.3    Sturgill, J.F.4    Ma, Y.C.5    Cowan, C.W.6
  • 8
    • 0036849099 scopus 로고    scopus 로고
    • Survival signaling goes BAD
    • Berqmann A. Survival signaling goes BAD. Dev Cell 2002; 3: 607-8.
    • (2002) Dev Cell , vol.3 , pp. 607-608
    • Berqmann, A.1
  • 9
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • del Peso L, González-García M, Page C, Herrera R, Nuez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997; 278: 687-9.
    • (1997) Science , vol.278 , pp. 687-689
    • del Peso, L.1    González-García, M.2    Page, C.3    Herrera, R.4    Nuez, G.5
  • 10
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couple's survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al. Akt phosphorylation of BAD couple's survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-41.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6
  • 11
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999; 286: 1358-62.
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 12
    • 23844538053 scopus 로고    scopus 로고
    • The FLT3 Internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112
    • Yang X, Liu L, Sternberg D, Tang L, Galinsky I, DeAngelo D. The FLT3 Internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112. Cancer Res 2005; 65: 7338-47.
    • (2005) Cancer Res , vol.65 , pp. 7338-7347
    • Yang, X.1    Liu, L.2    Sternberg, D.3    Tang, L.4    Galinsky, I.5    DeAngelo, D.6
  • 13
    • 0033635235 scopus 로고    scopus 로고
    • Interleukin-3-induced phos-phorylation of BAD through the protein kinase Akt
    • Datta SR, Katsov A, Hu L. Interleukin-3-induced phos-phorylation of BAD through the protein kinase Akt. Mol Cell 2000; 6: 41-51.
    • (2000) Mol Cell , vol.6 , pp. 41-51
    • Datta, S.R.1    Katsov, A.2    Hu, L.3
  • 14
    • 0028809209 scopus 로고
    • A heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ. A heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 1995; 80: 285-91.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 15
    • 0036112509 scopus 로고    scopus 로고
    • Signal transduction targets in invasion
    • 200
    • Alessandro R, Kohn EC. Signal transduction targets in invasion. Clin Exp Metastasis 200; 19: 265-73.
    • Clin Exp Metastasis , vol.19 , pp. 265-273
    • Alessandro, R.1    Kohn, E.C.2
  • 16
    • 0035854823 scopus 로고    scopus 로고
    • Differential requirement for rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformation
    • Sachdev P, Jiang YX, Li W, Miki T, Maruta H, Nur-E-Kamal MS, et al. Differential requirement for rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformation. J Biol Chem 2001; 276: 26461-71.
    • (2001) J Biol Chem , vol.276 , pp. 26461-26471
    • Sachdev, P.1    Jiang, Y.X.2    Li, W.3    Miki, T.4    Maruta, H.5    Nur-E-Kamal, M.S.6
  • 17
    • 0034626695 scopus 로고    scopus 로고
    • Differential requirements of the MAP kinase and PI3 kinase signal-ing pathways in src-versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epi-thelial cells
    • Nguyen KT, Wang WJ, Chan JL, Wang LH. Differential requirements of the MAP kinase and PI3 kinase signal-ing pathways in src-versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epi-thelial cells. Oncogene 2000; 19: 5385-97.
    • (2000) Oncogene , vol.19 , pp. 5385-5397
    • Nguyen, K.T.1    Wang, W.J.2    Chan, J.L.3    Wang, L.H.4
  • 18
    • 0037124081 scopus 로고    scopus 로고
    • Distinct role of phosphatidylinositol 3-kinase and rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes
    • Sachdev LP, Zeng, Wang LH. Distinct role of phosphatidylinositol 3-kinase and rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes. J Biol Chem 2002; 277: 17638-48.
    • (2002) J Biol Chem , vol.277 , pp. 17638-17648
    • Sachdev, L.P.1    Zeng2    Wang, L.H.3
  • 19
    • 0037192825 scopus 로고    scopus 로고
    • The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in ros-induced cell transformation
    • Nguyen KT, Zong CS, Uttamsingh S, Sachdev P, Bhanot M, Le MT, et al. The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in ros-induced cell transformation. J Biol Chem 2002; 277: 11107-15.
    • (2002) J Biol Chem , vol.277 , pp. 11107-11115
    • Nguyen, K.T.1    Zong, C.S.2    Uttamsingh, S.3    Sachdev, P.4    Bhanot, M.5    Le, M.T.6
  • 20
    • 0037229714 scopus 로고    scopus 로고
    • Overexpression of AKT2/protein kinase bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    • Arboleda MJ, Lyons JF, Kabbinavar FF, Bray MR, Snow BE, Ayala R, et al. Overexpression of AKT2/protein kinase bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 2003; 63: 196-206.
    • (2003) Cancer Res , vol.63 , pp. 196-206
    • Arboleda, M.J.1    Lyons, J.F.2    Kabbinavar, F.F.3    Bray, M.R.4    Snow, B.E.5    Ayala, R.6
  • 21
    • 33846345880 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells
    • Brandi R Whitley, Lea M Beaulieu, Jennifer C, Church FC. Phosphatidylinositol 3-kinase/Akt regulates the balance between plasminogen activator inhibitor-1 and urokinase to promote migration of SKOV-3 ovarian cancer cells. Gynecol Oncol 2007; 104: 470-9.
    • (2007) Gynecol Oncol , vol.104 , pp. 470-479
    • Whitley, B.R.1    Beaulieu, L.M.2    Jennifer, C.3    Church, F.C.4
  • 22
    • 58149199104 scopus 로고    scopus 로고
    • Estrogen and progestin regulate metastasis the PI3K/AKT pathway in human ovarian cancer
    • Hua K, Feng W, Cao Q, Zhou X, Lu X, Feng Y. Estrogen and progestin regulate metastasis the PI3K/AKT pathway in human ovarian cancer. Int J Oncol 2008; 33: 959-67.
    • (2008) Int J Oncol , vol.33 , pp. 959-967
    • Hua, K.1    Feng, W.2    Cao, Q.3    Zhou, X.4    Lu, X.5    Feng, Y.6
  • 24
    • 62549088237 scopus 로고    scopus 로고
    • prognostic value of estrogen receptor and progesterone recepetor status in young Chinses ovarian carcinoma patients
    • Yang XY, Xi MR, Yang KX, Yu H. prognostic value of estrogen receptor and progesterone recepetor status in young Chinses ovarian carcinoma patients. Gynecol Oncol 2009; 113: 99-104.
    • (2009) Gynecol Oncol , vol.113 , pp. 99-104
    • Yang, X.Y.1    Xi, M.R.2    Yang, K.X.3    Yu, H.4
  • 25
    • 0034822379 scopus 로고    scopus 로고
    • High-dose progesterone inhibition of urokinase secretion and invasive activity by SKOV-3 ovarian carcinoma cell: evidence for a receptor independent nongenomic effect on the plasma membrane
    • McDonnel AC, Murdoch WJ. High-dose progesterone inhibition of urokinase secretion and invasive activity by SKOV-3 ovarian carcinoma cell: evidence for a receptor independent nongenomic effect on the plasma membrane. J Steroid Biochem Mol Biol 2001; 78: 185-91.
    • (2001) J Steroid Biochem Mol Biol , vol.78 , pp. 185-191
    • McDonnel, A.C.1    Murdoch, W.J.2
  • 26
    • 0042197413 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: a new molecular target for breast cancer
    • Mita MM, Mita A, Rowinsky EK. Mammalian target of rapamycin: a new molecular target for breast cancer. Clin Breast Cancer 2003; 4: 126-37.
    • (2003) Clin Breast Cancer , vol.4 , pp. 126-137
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 27
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of esca-lated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • Raymond E, Alexandre J, Faivre S, Vera K, Materman E, Boni J, et al. Safety and pharmacokinetics of esca-lated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004; 22: 2336-47.
    • (2004) J Clin Oncol , vol.22 , pp. 2336-2347
    • Raymond, E.1    Alexandre, J.2    Faivre, S.3    Vera, K.4    Materman, E.5    Boni, J.6
  • 28
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins MB, Hidalgo M, Stadler WM, Logan TF, Dutcher JP, Hudes GR, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004; 22: 909-18.
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3    Logan, T.F.4    Dutcher, J.P.5    Hudes, G.R.6
  • 29
    • 67649595826 scopus 로고    scopus 로고
    • Apoptosis and cancer: the genesis of a research field
    • Cotter TG. Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer 2009; 9: 501-7.
    • (2009) Nat Rev Cancer , vol.9 , pp. 501-507
    • Cotter, T.G.1
  • 30
    • 71549170831 scopus 로고    scopus 로고
    • Tangeretin Sensitizes Cisplatin-Resistant Human Ovarian Cancer Cells through Down-regulation of Phosphoinositide 3-Kinase/Akt Signaling Pathway
    • Arafa el-SA, Zhu Q, Barakat BM, Wani G, Zhao Q, El-Mahdy MA, et al. Tangeretin Sensitizes Cisplatin-Resistant Human Ovarian Cancer Cells through Down-regulation of Phosphoinositide 3-Kinase/Akt Signaling Pathway. Cancer Res 2009; 69: 105-8.
    • (2009) Cancer Res , vol.69 , pp. 105-108
    • Arafa, S.A.1    Zhu, Q.2    Barakat, B.M.3    Wani, G.4    Zhao, Q.5    El-Mahdy, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.